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Transcriptomic analysis of human IL-7 receptor alpha low and high effector memory CD8+ T cells reveals an age-associated signature linked to influenza vaccine response in older adults.

Park HJ, Shin MS, Kim M, Bilsborrow JB, Mohanty S, Montgomery RR, Shaw AC, You S, Kang I.

Aging Cell. 2019 May 1:e12960. doi: 10.1111/acel.12960. [Epub ahead of print]


Dissecting alterations in human CD8+ T cells with aging by high-dimensional single cell mass cytometry.

Shin MS, Yim K, Moon K, Park HJ, Mohanty S, Kim JW, Montgomery RR, Shaw AC, Krishnaswamy S, Kang I.

Clin Immunol. 2019 Mar;200:24-30. doi: 10.1016/j.clim.2019.01.005. Epub 2019 Jan 16.


Impact of Aging and HIV Infection on the Function of the C-Type Lectin Receptor MINCLE in Monocytes.

Zapata HJ, Van Ness PH, Avey S, Siconolfi B, Allore HG, Tsang S, Wilson J, Barakat L, Mohanty S, Shaw AC.

J Gerontol A Biol Sci Med Sci. 2019 May 16;74(6):794-801. doi: 10.1093/gerona/gly209.


Integrating Storytelling into a Communication Skills Teaching Program for Medical Oncology Fellows.

Shaw AC, McQuade JL, Reilley MJ, Nixon B, Baile WF, Epner DE.

J Cancer Educ. 2018 Sep 15. doi: 10.1007/s13187-018-1428-3. [Epub ahead of print]


The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates.

Tsonkova VG, Sand FW, Wolf XA, Grunnet LG, Kirstine Ringgaard A, Ingvorsen C, Winkel L, Kalisz M, Dalgaard K, Bruun C, Fels JJ, Helgstrand C, Hastrup S, Öberg FK, Vernet E, Sandrini MPB, Shaw AC, Jessen C, Grønborg M, Hald J, Willenbrock H, Madsen D, Wernersson R, Hansson L, Jensen JN, Plesner A, Alanentalo T, Petersen MBK, Grapin-Botton A, Honoré C, Ahnfelt-Rønne J, Hecksher-Sørensen J, Ravassard P, Madsen OD, Rescan C, Frogne T.

Mol Metab. 2018 Feb;8:144-157. doi: 10.1016/j.molmet.2017.12.007. Epub 2017 Dec 19.


Aging impairs both primary and secondary RIG-I signaling for interferon induction in human monocytes.

Molony RD, Nguyen JT, Kong Y, Montgomery RR, Shaw AC, Iwasaki A.

Sci Signal. 2017 Dec 12;10(509). pii: eaan2392. doi: 10.1126/scisignal.aan2392.


Correction: Cathelicidin Insufficiency in Patients with Fatal Leptospirosis.

Lindow JC, Wunder EA Jr, Popper SJ, Min JN, Mannam P, Srivastava A, Yao Y, Hacker KP, Raddassi K, Lee PJ, Montgomery RR, Shaw AC, Hagan JE, Araújo GC, Nery N Jr, Relman DA, Kim CC, Reis MG, Ko AI.

PLoS Pathog. 2017 Sep 26;13(9):e1006646. doi: 10.1371/journal.ppat.1006646. eCollection 2017 Sep.


Multiple network-constrained regressions expand insights into influenza vaccination responses.

Avey S, Mohanty S, Wilson J, Zapata H, Joshi SR, Siconolfi B, Tsang S, Shaw AC, Kleinstein SH.

Bioinformatics. 2017 Jul 15;33(14):i208-i216. doi: 10.1093/bioinformatics/btx260.


β-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares.

Goldberg EL, Asher JL, Molony RD, Shaw AC, Zeiss CJ, Wang C, Morozova-Roche LA, Herzog RI, Iwasaki A, Dixit VD.

Cell Rep. 2017 Feb 28;18(9):2077-2087. doi: 10.1016/j.celrep.2017.02.004.


Cathelicidin Insufficiency in Patients with Fatal Leptospirosis.

Lindow JC, Wunder EA Jr, Popper SJ, Min JN, Mannam P, Srivastava A, Yao Y, Hacker KP, Raddassi K, Lee PJ, Montgomery RR, Shaw AC, Hagan JE, Araújo GC, Nery N Jr, Relman DA, Kim CC, Reis MG, Ko AI.

PLoS Pathog. 2016 Nov 3;12(11):e1005943. doi: 10.1371/journal.ppat.1005943. eCollection 2016 Nov. Erratum in: PLoS Pathog. 2017 Sep 26;13(9):e1006646.


Outcomes related to effective nurse supervision in long-term care homes: an integrative review.

McGilton KS, Chu CH, Shaw AC, Wong R, Ploeg J.

J Nurs Manag. 2016 Nov;24(8):1007-1026. doi: 10.1111/jonm.12419. Epub 2016 Aug 29. Review.


Energy and Nutrient Timing for Weight Control: Does Timing of Ingestion Matter?

McCrory MA, Shaw AC, Lee JA.

Endocrinol Metab Clin North Am. 2016 Sep;45(3):689-718. doi: 10.1016/j.ecl.2016.04.017. Review.


Host Resistance and Immune Aging.

Bandaranayake T, Shaw AC.

Clin Geriatr Med. 2016 Aug;32(3):415-32. doi: 10.1016/j.cger.2016.02.007. Epub 2016 May 25. Review.


Type II Turn of Receptor-bound Salmon Calcitonin Revealed by X-ray Crystallography.

Johansson E, Hansen JL, Hansen AM, Shaw AC, Becker P, Schäffer L, Reedtz-Runge S.

J Biol Chem. 2016 Jun 24;291(26):13689-98. doi: 10.1074/jbc.M116.726034. Epub 2016 May 4.


Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease.

Pillai PS, Molony RD, Martinod K, Dong H, Pang IK, Tal MC, Solis AG, Bielecki P, Mohanty S, Trentalange M, Homer RJ, Flavell RA, Wagner DD, Montgomery RR, Shaw AC, Staeheli P, Iwasaki A.

Science. 2016 Apr 22;352(6284):463-6. doi: 10.1126/science.aaf3926.



Shaw AC.

Methods Mol Biol. 2015;1343:v. No abstract available.


Multicolor Digital Flow Cytometry in Human Translational Immunology.

Joshi SR, Mohanty S, Shaw AC.

Methods Mol Biol. 2015;1343:53-64. doi: 10.1007/978-1-4939-2963-4_5.


DNA Methylation Regulates the Differential Expression of CX3CR1 on Human IL-7Rαlow and IL-7Rαhigh Effector Memory CD8+ T Cells with Distinct Migratory Capacities to the Fractalkine.

Shin MS, You S, Kang Y, Lee N, Yoo SA, Park K, Kang KS, Kim SH, Mohanty S, Shaw AC, Montgomery RR, Hwang D, Kang I.

J Immunol. 2015 Sep 15;195(6):2861-9. doi: 10.4049/jimmunol.1500877. Epub 2015 Aug 14.


Paradoxical changes in innate immunity in aging: recent progress and new directions.

Montgomery RR, Shaw AC.

J Leukoc Biol. 2015 Dec;98(6):937-43. doi: 10.1189/jlb.5MR0315-104R. Epub 2015 Jul 17. Review.


Phenotype and genotype in 103 patients with tricho-rhino-phalangeal syndrome.

Maas SM, Shaw AC, Bikker H, Lüdecke HJ, van der Tuin K, Badura-Stronka M, Belligni E, Biamino E, Bonati MT, Carvalho DR, Cobben J, de Man SA, Den Hollander NS, Di Donato N, Garavelli L, Grønborg S, Herkert JC, Hoogeboom AJ, Jamsheer A, Latos-Bielenska A, Maat-Kievit A, Magnani C, Marcelis C, Mathijssen IB, Nielsen M, Otten E, Ousager LB, Pilch J, Plomp A, Poke G, Poluha A, Posmyk R, Rieubland C, Silengo M, Simon M, Steichen E, Stumpel C, Szakszon K, Polonkai E, van den Ende J, van der Steen A, van Essen T, van Haeringen A, van Hagen JM, Verheij JB, Mannens MM, Hennekam RC.

Eur J Med Genet. 2015 May;58(5):279-92. doi: 10.1016/j.ejmg.2015.03.002. Epub 2015 Mar 16.


Toscana virus encephalitis in a traveler returning to the United States.

Howell BA, Azar MM, Landry ML, Shaw AC.

J Clin Microbiol. 2015 Apr;53(4):1445-7. doi: 10.1128/JCM.03498-14. Epub 2015 Feb 11.


Aging-dependent alterations in gene expression and a mitochondrial signature of responsiveness to human influenza vaccination.

Thakar J, Mohanty S, West AP, Joshi SR, Ueda I, Wilson J, Meng H, Blevins TP, Tsang S, Trentalange M, Siconolfi B, Park K, Gill TM, Belshe RB, Kaech SM, Shadel GS, Kleinstein SH, Shaw AC.

Aging (Albany NY). 2015 Jan;7(1):38-52.


IL-6 receptor α defines effector memory CD8+ T cells producing Th2 cytokines and expanding in asthma.

Lee N, You S, Shin MS, Lee WW, Kang KS, Kim SH, Kim WU, Homer RJ, Kang MJ, Montgomery RR, Dela Cruz CS, Shaw AC, Lee PJ, Chupp GL, Hwang D, Kang I.

Am J Respir Crit Care Med. 2014 Dec 15;190(12):1383-94. doi: 10.1164/rccm.201403-0601OC.


Prolonged proinflammatory cytokine production in monocytes modulated by interleukin 10 after influenza vaccination in older adults.

Mohanty S, Joshi SR, Ueda I, Wilson J, Blevins TP, Siconolfi B, Meng H, Devine L, Raddassi K, Tsang S, Belshe RB, Hafler DA, Kaech SM, Kleinstein SH, Trentalange M, Allore HG, Shaw AC.

J Infect Dis. 2015 Apr 1;211(7):1174-84. doi: 10.1093/infdis/jiu573. Epub 2014 Nov 2.


Molecular and neurochemical biomarkers in Arctic beluga whales (Delphinapterus leucas) were correlated to brain mercury and selenium concentrations.

Ostertag SK, Shaw AC, Basu N, Chan HM.

Environ Sci Technol. 2014 Oct 7;48(19):11551-9. doi: 10.1021/es501369b. Epub 2014 Sep 12.


Keloids in Rubinstein-Taybi syndrome: a clinical study.

van de Kar AL, Houge G, Shaw AC, de Jong D, van Belzen MJ, Peters DJ, Hennekam RC.

Br J Dermatol. 2014 Sep;171(3):615-21. doi: 10.1111/bjd.13124. Epub 2014 Aug 21. Review.


Aging of the human innate immune system in HIV infection.

Zapata HJ, Shaw AC.

Curr Opin Immunol. 2014 Aug;29:127-36. doi: 10.1016/j.coi.2014.06.007. Epub 2014 Jul 2. Review.


Deletions in the 3' part of the NFIX gene including a recurrent Alu-mediated deletion of exon 6 and 7 account for previously unexplained cases of Marshall-Smith syndrome.

Schanze D, Neubauer D, Cormier-Daire V, Delrue MA, Dieux-Coeslier A, Hasegawa T, Holmberg EE, Koenig R, Krueger G, Schanze I, Seemanova E, Shaw AC, Vogt J, Volleth M, Reis A, Meinecke P, Hennekam RC, Zenker M.

Hum Mutat. 2014 Sep;35(9):1092-100. doi: 10.1002/humu.22603. Epub 2014 Jul 8.


Chitinase 3-like 1 suppresses injury and promotes fibroproliferative responses in Mammalian lung fibrosis.

Zhou Y, Peng H, Sun H, Peng X, Tang C, Gan Y, Chen X, Mathur A, Hu B, Slade MD, Montgomery RR, Shaw AC, Homer RJ, White ES, Lee CM, Moore MW, Gulati M, Lee CG, Elias JA, Herzog EL.

Sci Transl Med. 2014 Jun 11;6(240):240ra76. doi: 10.1126/scitranslmed.3007096.


Human monocytes have increased IFN-γ-mediated IL-15 production with age alongside altered IFN-γ receptor signaling.

Lee N, Shin MS, Kang KS, Yoo SA, Mohanty S, Montgomery RR, Shaw AC, Kang I.

Clin Immunol. 2014 May-Jun;152(1-2):101-10. doi: 10.1016/j.clim.2014.03.003. Epub 2014 Mar 19.


Innate Immune Responses in the Neutrophils of Community Dwelling and Nursing Home Elders.

Juthani-Mehta M, Guo X, Shaw AC, Towle V, Ning Y, Wang X, Allore HG, Fikrig E, Montgomery RR.

J Aging Sci. 2014 Jan 27;2. pii: 1000115.


Age-dependent dysregulation of innate immunity.

Shaw AC, Goldstein DR, Montgomery RR.

Nat Rev Immunol. 2013 Dec;13(12):875-87. doi: 10.1038/nri3547. Epub 2013 Oct 25. Review.


Recombinant production of peptide C-terminal α-amides using an engineered intein.

Albertsen L, Shaw AC, Norrild JC, Strømgaard K.

Bioconjug Chem. 2013 Nov 20;24(11):1883-94. doi: 10.1021/bc4002689. Epub 2013 Nov 6.


Cytokine response signatures in disease progression and development of severe clinical outcomes for leptospirosis.

Reis EA, Hagan JE, Ribeiro GS, Teixeira-Carvalho A, Martins-Filho OA, Montgomery RR, Shaw AC, Ko AI, Reis MG.

PLoS Negl Trop Dis. 2013 Sep 19;7(9):e2457. doi: 10.1371/journal.pntd.0002457. eCollection 2013.


Statistical approaches for analyzing immunologic data of repeated observations: a practical guide.

Panda A, Chen S, Shaw AC, Allore HG.

J Immunol Methods. 2013 Dec 15;398-399:19-26. doi: 10.1016/j.jim.2013.09.004. Epub 2013 Sep 18. Review.


Chronic exposure to PCBs (Aroclor 1254) exacerbates obesity-induced insulin resistance and hyperinsulinemia in mice.

Gray SL, Shaw AC, Gagne AX, Chan HM.

J Toxicol Environ Health A. 2013;76(12):701-15. doi: 10.1080/15287394.2013.796503.


Top3β is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation.

Xu D, Shen W, Guo R, Xue Y, Peng W, Sima J, Yang J, Sharov A, Srikantan S, Yang J, Fox D 3rd, Qian Y, Martindale JL, Piao Y, Machamer J, Joshi SR, Mohanty S, Shaw AC, Lloyd TE, Brown GW, Ko MS, Gorospe M, Zou S, Wang W.

Nat Neurosci. 2013 Sep;16(9):1238-47. doi: 10.1038/nn.3479. Epub 2013 Aug 4.


An altered relationship of influenza vaccine-specific IgG responses with T cell immunity occurs with aging in humans.

Kang KS, Lee N, Shin MS, Kim SD, Yu Y, Mohanty S, Belshe RB, Montgomery RR, Shaw AC, Kang I.

Clin Immunol. 2013 May;147(2):79-88. doi: 10.1016/j.clim.2013.02.022. Epub 2013 Mar 15.


Dendritic cells in the circulation of women with preeclampsia demonstrate a pro-inflammatory bias secondary to dysregulation of TLR receptors.

Panda B, Panda A, Ueda I, Abrahams VM, Norwitz ER, Stanic AK, Young BC, Ecker JL, Altfeld M, Shaw AC, Rueda BR.

J Reprod Immunol. 2012 Jun;94(2):210-5. doi: 10.1016/j.jri.2012.01.008. Epub 2012 Mar 21.


The face in congenital melanocytic nevus syndrome.

Kinsler V, Shaw AC, Merks JH, Hennekam RC.

Am J Med Genet A. 2012 May;158A(5):1014-9. doi: 10.1002/ajmg.a.34217. Epub 2012 Mar 21.


The role of Toll-like receptors in age-associated lung diseases.

Volkova M, Zhang Y, Shaw AC, Lee PJ.

J Gerontol A Biol Sci Med Sci. 2012 Mar;67(3):247-53. doi: 10.1093/gerona/glr226. Epub 2012 Mar 5. Review.


Age-associated elevation in TLR5 leads to increased inflammatory responses in the elderly.

Qian F, Wang X, Zhang L, Chen S, Piecychna M, Allore H, Bockenstedt L, Malawista S, Bucala R, Shaw AC, Fikrig E, Montgomery RR.

Aging Cell. 2012 Feb;11(1):104-10. doi: 10.1111/j.1474-9726.2011.00759.x. Epub 2011 Nov 28.


'Til death do us part: memoir of a hospice chaplain.

Shaw AC.

J Pastoral Care Counsel. 2010 Fall;64(3):11.1-2. No abstract available.


Upregulation of MetC is essential for D-alanine-independent growth of an alr/dadX-deficient Escherichia coli strain.

Kang L, Shaw AC, Xu D, Xia W, Zhang J, Deng J, Wöldike HF, Liu Y, Su J.

J Bacteriol. 2011 Mar;193(5):1098-106. doi: 10.1128/JB.01027-10. Epub 2010 Dec 30.


Dysregulation of human Toll-like receptor function in aging.

Shaw AC, Panda A, Joshi SR, Qian F, Allore HG, Montgomery RR.

Ageing Res Rev. 2011 Jul;10(3):346-53. doi: 10.1016/j.arr.2010.10.007. Epub 2010 Nov 10. Review.


Phenotype and natural history in Marshall-Smith syndrome.

Shaw AC, van Balkom ID, Bauer M, Cole TR, Delrue MA, Van Haeringen A, Holmberg E, Knight SJ, Mortier G, Nampoothiri S, Pušeljić S, Zenker M, Cormier-Daire V, Hennekam RC.

Am J Med Genet A. 2010 Nov;152A(11):2714-26. doi: 10.1002/ajmg.a.33709.


Distinct effects of allelic NFIX mutations on nonsense-mediated mRNA decay engender either a Sotos-like or a Marshall-Smith syndrome.

Malan V, Rajan D, Thomas S, Shaw AC, Louis Dit Picard H, Layet V, Till M, van Haeringen A, Mortier G, Nampoothiri S, Puseljić S, Legeai-Mallet L, Carter NP, Vekemans M, Munnich A, Hennekam RC, Colleaux L, Cormier-Daire V.

Am J Hum Genet. 2010 Aug 13;87(2):189-98. doi: 10.1016/j.ajhg.2010.07.001. Epub 2010 Jul 30.


Aging of the innate immune system.

Shaw AC, Joshi S, Greenwood H, Panda A, Lord JM.

Curr Opin Immunol. 2010 Aug;22(4):507-13. doi: 10.1016/j.coi.2010.05.003. Review.


Backbone cyclic insulin.

Andersen AS, Palmqvist E, Bang S, Shaw AC, Hubalek F, Ribel U, Hoeg-Jensen T.

J Pept Sci. 2010 Sep;16(9):473-9. doi: 10.1002/psc.1264.


Descending brain neurons in larval lamprey: spinal projection patterns and initiation of locomotion.

Shaw AC, Jackson AW, Holmes T, Thurman S, Davis GR, McClellan AD.

Exp Neurol. 2010 Aug;224(2):527-41. doi: 10.1016/j.expneurol.2010.05.016. Epub 2010 May 25.

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