Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 45

1.

TORC1 inhibition enhances immune function and reduces infections in the elderly.

Mannick JB, Morris M, Hockey HP, Roma G, Beibel M, Kulmatycki K, Watkins M, Shavlakadze T, Zhou W, Quinn D, Glass DJ, Klickstein LB.

Sci Transl Med. 2018 Jul 11;10(449). pii: eaaq1564. doi: 10.1126/scitranslmed.aaq1564.

PMID:
29997249
2.

Aged neutrophils accumulate in lymphoid tissues from healthy elderly mice and infiltrate T- and B-cell zones.

Tomay F, Wells K, Duong L, Tsu JW, Dye DE, Radley-Crabb HG, Grounds MD, Shavlakadze T, Metharom P, Nelson DJ, Jackaman C.

Immunol Cell Biol. 2018 Mar 30. doi: 10.1111/imcb.12046. [Epub ahead of print]

PMID:
29603362
3.

Short-term Low-Dose mTORC1 Inhibition in Aged Rats Counter-Regulates Age-Related Gene Changes and Blocks Age-Related Kidney Pathology.

Shavlakadze T, Zhu J, Wang S, Zhou W, Morin B, Egerman MA, Fan L, Wang Y, Iartchouk O, Meyer A, Valdez RA, Mannick JB, Klickstein LB, Glass DJ.

J Gerontol A Biol Sci Med Sci. 2018 Jun 14;73(7):845-852. doi: 10.1093/gerona/glx249.

4.

Resistance wheel exercise from mid-life has minimal effect on sciatic nerves from old mice in which sarcopenia was prevented.

Krishnan VS, White Z, Terrill JR, Hodgetts SI, Fitzgerald M, Shavlakadze T, Harvey AR, Grounds MD.

Biogerontology. 2017 Oct;18(5):769-790. doi: 10.1007/s10522-017-9714-8. Epub 2017 Jun 8.

PMID:
28597407
5.

IGF1 stimulates greater muscle hypertrophy in the absence of myostatin in male mice.

Hennebry A, Oldham J, Shavlakadze T, Grounds MD, Sheard P, Fiorotto ML, Falconer S, Smith HK, Berry C, Jeanplong F, Bracegirdle J, Matthews K, Nicholas G, Senna-Salerno M, Watson T, McMahon CD.

J Endocrinol. 2017 Aug;234(2):187-200. doi: 10.1530/JOE-17-0032. Epub 2017 May 22.

PMID:
28533420
6.

Erratum to: Voluntary resistance wheel exercise from mid-life prevents sarcopenia and increases markers of mitochondrial function and autophagy in muscles of old male and female C57BL/6J mice.

White Z, Terrill J, White RB, McMahon C, Sheard P, Grounds MD, Shavlakadze T.

Skelet Muscle. 2017 Feb 15;7(1):4. doi: 10.1186/s13395-017-0120-3. No abstract available.

7.
8.

High mTORC1 signaling is maintained, while protein degradation pathways are perturbed in old murine skeletal muscles in the fasted state.

White Z, White RB, McMahon C, Grounds MD, Shavlakadze T.

Int J Biochem Cell Biol. 2016 Sep;78:10-21. doi: 10.1016/j.biocel.2016.06.012. Epub 2016 Jun 22.

PMID:
27343428
9.

The long and short of non-coding RNAs during post-natal growth and differentiation of skeletal muscles: Focus on lncRNA and miRNAs.

Butchart LC, Fox A, Shavlakadze T, Grounds MD.

Differentiation. 2016 Dec;92(5):237-248. doi: 10.1016/j.diff.2016.05.003. Epub 2016 Jun 10.

PMID:
27292314
10.

A Neurogenic Perspective of Sarcopenia: Time Course Study of Sciatic Nerves From Aging Mice.

Krishnan VS, White Z, McMahon CD, Hodgetts SI, Fitzgerald M, Shavlakadze T, Harvey AR, Grounds MD.

J Neuropathol Exp Neurol. 2016 May;75(5):464-78. doi: 10.1093/jnen/nlw019. Epub 2016 Mar 30.

PMID:
27030741
11.

GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration.

Egerman MA, Cadena SM, Gilbert JA, Meyer A, Nelson HN, Swalley SE, Mallozzi C, Jacobi C, Jennings LL, Clay I, Laurent G, Ma S, Brachat S, Lach-Trifilieff E, Shavlakadze T, Trendelenburg AU, Brack AS, Glass DJ.

Cell Metab. 2015 Jul 7;22(1):164-74. doi: 10.1016/j.cmet.2015.05.010. Epub 2015 May 19.

12.

Differential thiol oxidation of the signaling proteins Akt, PTEN or PP2A determines whether Akt phosphorylation is enhanced or inhibited by oxidative stress in C2C12 myotubes derived from skeletal muscle.

Tan PL, Shavlakadze T, Grounds MD, Arthur PG.

Int J Biochem Cell Biol. 2015 May;62:72-9. doi: 10.1016/j.biocel.2015.02.015. Epub 2015 Feb 28.

PMID:
25737250
13.

Effects of loaded voluntary wheel exercise on performance and muscle hypertrophy in young and old male C57Bl/6J mice.

Soffe Z, Radley-Crabb HG, McMahon C, Grounds MD, Shavlakadze T.

Scand J Med Sci Sports. 2016 Feb;26(2):172-88. doi: 10.1111/sms.12416. Epub 2015 Feb 4.

PMID:
25653015
14.

Molecular analyses provide insight into mechanisms underlying sarcopenia and myofibre denervation in old skeletal muscles of mice.

Barns M, Gondro C, Tellam RL, Radley-Crabb HG, Grounds MD, Shavlakadze T.

Int J Biochem Cell Biol. 2014 Aug;53:174-85. doi: 10.1016/j.biocel.2014.04.025. Epub 2014 May 13.

PMID:
24836906
15.

Lifelong exercise and locally produced insulin-like growth factor-1 (IGF-1) have a modest influence on reducing age-related muscle wasting in mice.

McMahon CD, Chai R, Radley-Crabb HG, Watson T, Matthews KG, Sheard PW, Soffe Z, Grounds MD, Shavlakadze T.

Scand J Med Sci Sports. 2014 Dec;24(6):e423-435. doi: 10.1111/sms.12200. Epub 2014 May 11.

PMID:
24814689
16.

Optical coherence tomography can assess skeletal muscle tissue from mouse models of muscular dystrophy by parametric imaging of the attenuation coefficient.

Klyen BR, Scolaro L, Shavlakadze T, Grounds MD, Sampson DD.

Biomed Opt Express. 2014 Mar 19;5(4):1217-32. doi: 10.1364/BOE.5.001217. eCollection 2014 Apr 1.

17.

Lipid accumulation in dysferlin-deficient muscles.

Grounds MD, Terrill JR, Radley-Crabb HG, Robertson T, Papadimitriou J, Spuler S, Shavlakadze T.

Am J Pathol. 2014 Jun;184(6):1668-76. doi: 10.1016/j.ajpath.2014.02.005. Epub 2014 Mar 29.

PMID:
24685690
18.

Protein thiol oxidation does not change in skeletal muscles of aging female mice.

Tohma H, El-Shafey AF, Croft K, Shavlakadze T, Grounds MD, Arthur PG.

Biogerontology. 2014 Feb;15(1):87-98. doi: 10.1007/s10522-013-9483-y. Epub 2013 Dec 6.

PMID:
24311290
19.

Visualizing and quantifying oxidized protein thiols in tissue sections: a comparison of dystrophic mdx and normal skeletal mouse muscles.

Iwasaki T, Terrill J, Shavlakadze T, Grounds MD, Arthur PG.

Free Radic Biol Med. 2013 Dec;65:1408-16. doi: 10.1016/j.freeradbiomed.2013.09.024. Epub 2013 Oct 3.

PMID:
24095851
20.

Quantitative assessment of muscle damage in the mdx mouse model of Duchenne muscular dystrophy using polarization-sensitive optical coherence tomography.

Yang X, Chin L, Klyen BR, Shavlakadze T, McLaughlin RA, Grounds MD, Sampson DD.

J Appl Physiol (1985). 2013 Nov 1;115(9):1393-401. doi: 10.1152/japplphysiol.00265.2013. Epub 2013 Aug 29.

21.

Impact of fasting on the rhythmic expression of myogenic and metabolic factors in skeletal muscle of adult mice.

Shavlakadze T, Anwari T, Soffe Z, Cozens G, Mark PJ, Gondro C, Grounds MD.

Am J Physiol Cell Physiol. 2013 Jul 1;305(1):C26-35. doi: 10.1152/ajpcell.00027.2013. Epub 2013 Apr 17.

22.

Targeting macrophages rescues age-related immune deficiencies in C57BL/6J geriatric mice.

Jackaman C, Radley-Crabb HG, Soffe Z, Shavlakadze T, Grounds MD, Nelson DJ.

Aging Cell. 2013 Jun;12(3):345-57. doi: 10.1111/acel.12062. Epub 2013 Mar 27.

23.

Short-term feed deprivation rapidly induces the protein degradation pathway in skeletal muscles of young mice.

Shavlakadze T, Soffe Z, Anwari T, Cozens G, Grounds MD.

J Nutr. 2013 Apr;143(4):403-9. doi: 10.3945/jn.112.171967. Epub 2013 Feb 13.

PMID:
23406617
24.

New horizons in the pathogenesis, diagnosis and management of sarcopenia.

Sayer AA, Robinson SM, Patel HP, Shavlakadze T, Cooper C, Grounds MD.

Age Ageing. 2013 Mar;42(2):145-50. doi: 10.1093/ageing/afs191. Epub 2013 Jan 11. Review.

25.

An HMGA2-IGF2BP2 axis regulates myoblast proliferation and myogenesis.

Li Z, Gilbert JA, Zhang Y, Zhang M, Qiu Q, Ramanujan K, Shavlakadze T, Eash JK, Scaramozza A, Goddeeris MM, Kirsch DG, Campbell KP, Brack AS, Glass DJ.

Dev Cell. 2012 Dec 11;23(6):1176-88. doi: 10.1016/j.devcel.2012.10.019. Epub 2012 Nov 21. Erratum in: Dev Cell. 2013 Jan 14;24(1):112.

26.

Striking denervation of neuromuscular junctions without lumbar motoneuron loss in geriatric mouse muscle.

Chai RJ, Vukovic J, Dunlop S, Grounds MD, Shavlakadze T.

PLoS One. 2011;6(12):e28090. doi: 10.1371/journal.pone.0028090. Epub 2011 Dec 2.

27.

A single 30 min treadmill exercise session is suitable for 'proof-of concept studies' in adult mdx mice: a comparison of the early consequences of two different treadmill protocols.

Radley-Crabb H, Terrill J, Shavlakadze T, Tonkin J, Arthur P, Grounds M.

Neuromuscul Disord. 2012 Feb;22(2):170-82. doi: 10.1016/j.nmd.2011.07.008. Epub 2011 Aug 10.

PMID:
21835619
28.

Identification of muscle necrosis in the mdx mouse model of Duchenne muscular dystrophy using three-dimensional optical coherence tomography.

Klyen BR, Shavlakadze T, Radley-Crabb HG, Grounds MD, Sampson DD.

J Biomed Opt. 2011 Jul;16(7):076013. doi: 10.1117/1.3598842.

PMID:
21806274
29.

Quantification of ceroid and lipofuscin in skeletal muscle.

Tohma H, Hepworth AR, Shavlakadze T, Grounds MD, Arthur PG.

J Histochem Cytochem. 2011 Aug;59(8):769-79. doi: 10.1369/0022155411412185.

32.

A growth stimulus is needed for IGF-1 to induce skeletal muscle hypertrophy in vivo.

Shavlakadze T, Chai J, Maley K, Cozens G, Grounds G, Winn N, Rosenthal N, Grounds MD.

J Cell Sci. 2010 Mar 15;123(Pt 6):960-71. doi: 10.1242/jcs.061119. Epub 2010 Feb 23. Erratum in: J Cell Sci. 2013 Oct 1;126(Pt 19):4536.

33.

Delayed but excellent myogenic stem cell response of regenerating geriatric skeletal muscles in mice.

Shavlakadze T, McGeachie J, Grounds MD.

Biogerontology. 2010 Jun;11(3):363-76. doi: 10.1007/s10522-009-9260-0. Epub 2009 Dec 24.

PMID:
20033288
34.

Use of pifithrin to inhibit p53-mediated signalling of TNF in dystrophic muscles of mdx mice.

Waters FJ, Shavlakadze T, McIldowie MJ, Piggott MJ, Grounds MD.

Mol Cell Biochem. 2010 Apr;337(1-2):119-31. doi: 10.1007/s11010-009-0291-2. Epub 2009 Oct 27.

PMID:
19859789
35.

Oxidative stress as a therapeutic target during muscle wasting: considering the complex interactions.

Arthur PG, Grounds MD, Shavlakadze T.

Curr Opin Clin Nutr Metab Care. 2008 Jul;11(4):408-16. doi: 10.1097/MCO.0b013e328302f3fe. Review.

PMID:
18542000
36.

Age influences the early events of skeletal muscle regeneration: studies of whole muscle grafts transplanted between young (8 weeks) and old (13-21 months) mice.

Smythe GM, Shavlakadze T, Roberts P, Davies MJ, McGeachie JK, Grounds MD.

Exp Gerontol. 2008 Jun;43(6):550-62. doi: 10.1016/j.exger.2008.02.005. Epub 2008 Feb 23.

PMID:
18364250
37.

Implications of cross-talk between tumour necrosis factor and insulin-like growth factor-1 signalling in skeletal muscle.

Grounds MD, Radley HG, Gebski BL, Bogoyevitch MA, Shavlakadze T.

Clin Exp Pharmacol Physiol. 2008 Jul;35(7):846-51. doi: 10.1111/j.1440-1681.2007.04868.x. Epub 2008 Jan 21. Review.

PMID:
18215180
38.

Muscle-specific overexpression of IGF-I improves E-C coupling in skeletal muscle fibers from dystrophic mdx mice.

Schertzer JD, van der Poel C, Shavlakadze T, Grounds MD, Lynch GS.

Am J Physiol Cell Physiol. 2008 Jan;294(1):C161-8. Epub 2007 Nov 7.

39.

Of bears, frogs, meat, mice and men: complexity of factors affecting skeletal muscle mass and fat.

Shavlakadze T, Grounds M.

Bioessays. 2006 Oct;28(10):994-1009. Review.

PMID:
16998828
40.

Rskalpha-actin/hIGF-1 transgenic mice with increased IGF-I in skeletal muscle and blood: impact on regeneration, denervation and muscular dystrophy.

Shavlakadze T, Boswell JM, Burt DW, Asante EA, Tomas FM, Davies MJ, White JD, Grounds MD, Goddard C.

Growth Horm IGF Res. 2006 Jun;16(3):157-73. Epub 2006 May 22.

PMID:
16716629
41.

Silencing TNFalpha activity by using Remicade or Enbrel blocks inflammation in whole muscle grafts: an in vivo bioassay to assess the efficacy of anti-cytokine drugs in mice.

Grounds MD, Davies M, Torrisi J, Shavlakadze T, White J, Hodgetts S.

Cell Tissue Res. 2005 Jun;320(3):509-15. Epub 2005 Apr 22.

PMID:
15846506
42.

Reconciling data from transgenic mice that overexpress IGF-I specifically in skeletal muscle.

Shavlakadze T, Winn N, Rosenthal N, Grounds MD.

Growth Horm IGF Res. 2005 Feb;15(1):4-18. Epub 2005 Jan 21. Review.

PMID:
15701567
43.

Insulin-like growth factor I slows the rate of denervation induced skeletal muscle atrophy.

Shavlakadze T, White JD, Davies M, Hoh JF, Grounds MD.

Neuromuscul Disord. 2005 Feb;15(2):139-46. Epub 2005 Jan 11.

PMID:
15694135
44.

Targeted expression of insulin-like growth factor-I reduces early myofiber necrosis in dystrophic mdx mice.

Shavlakadze T, White J, Hoh JF, Rosenthal N, Grounds MD.

Mol Ther. 2004 Nov;10(5):829-43.

45.

Early regeneration of whole skeletal muscle grafts is unaffected by overexpression of IGF-1 in MLC/mIGF-1 transgenic mice.

Shavlakadze T, Davies M, White JD, Grounds MD.

J Histochem Cytochem. 2004 Jul;52(7):873-83.

PMID:
15208354

Supplemental Content

Loading ...
Support Center