Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 171

1.

The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes.

Luu M, Pautz S, Kohl V, Singh R, Romero R, Lucas S, Hofmann J, Raifer H, Vachharajani N, Carrascosa LC, Lamp B, Nist A, Stiewe T, Shaul Y, Adhikary T, Zaiss MM, Lauth M, Steinhoff U, Visekruna A.

Nat Commun. 2019 Feb 15;10(1):760. doi: 10.1038/s41467-019-08711-2.

2.

Recruitment of the protein phosphatase-1 catalytic subunit to promoters by the dual-function transcription factor RFX1.

Lubelsky Y, Shaul Y.

Biochem Biophys Res Commun. 2019 Feb 19;509(4):1015-1020. doi: 10.1016/j.bbrc.2019.01.011. Epub 2019 Jan 14.

PMID:
30654936
3.

Hippo Pathway Regulation by Tyrosine Kinases.

Reuven N, Shanzer M, Shaul Y.

Methods Mol Biol. 2019;1893:215-236. doi: 10.1007/978-1-4939-8910-2_17.

PMID:
30565137
4.

The Disordered Landscape of the 20S Proteasome Substrates Reveals Tight Association with Phase Separated Granules.

Myers N, Olender T, Savidor A, Levin Y, Reuven N, Shaul Y.

Proteomics. 2018 Nov;18(21-22):e1800076. doi: 10.1002/pmic.201800076. Epub 2018 Aug 8.

PMID:
30039638
5.

Oncogenic addiction to high 26S proteasome level.

Tsvetkov P, Adler J, Myers N, Biran A, Reuven N, Shaul Y.

Cell Death Dis. 2018 Jul 10;9(7):773. doi: 10.1038/s41419-018-0806-4.

6.

Microenvironmental Cues Determine Tumor Cell Susceptibility to Neutrophil Cytotoxicity.

Gershkovitz M, Fainsod-Levi T, Khawaled S, Shaul ME, Sionov RV, Cohen-Daniel L, Aqeilan RI, Shaul YD, Fridlender ZG, Granot Z.

Cancer Res. 2018 Sep 1;78(17):5050-5059. doi: 10.1158/0008-5472.CAN-18-0540. Epub 2018 Jul 2.

PMID:
29967257
7.

TRPM2 Mediates Neutrophil Killing of Disseminated Tumor Cells.

Gershkovitz M, Caspi Y, Fainsod-Levi T, Katz B, Michaeli J, Khawaled S, Lev S, Polyansky L, Shaul ME, Sionov RV, Cohen-Daniel L, Aqeilan RI, Shaul YD, Mori Y, Karni R, Fridlender ZG, Binshtok AM, Granot Z.

Cancer Res. 2018 May 15;78(10):2680-2690. doi: 10.1158/0008-5472.CAN-17-3614. Epub 2018 Feb 28.

8.

Correction for Aebersold et al., "Extracellular Signal-Regulated Kinase 1c (ERK1c), a Novel 42-Kilodalton ERK, Demonstrates Unique Modes of Regulation, Localization, and Function".

Aebersold DM, Shaul YD, Yung Y, Yarom N, Yao Z, Hanoch T, Seger R.

Mol Cell Biol. 2017 Aug 28;37(18). pii: e00322-17. doi: 10.1128/MCB.00322-17. Print 2017 Sep 15. No abstract available.

9.

The nonreceptor tyrosine kinase c-Src attenuates SCF(β-TrCP) E3-ligase activity abrogating Taz proteasomal degradation.

Shanzer M, Adler J, Ricardo-Lax I, Reuven N, Shaul Y.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1678-1683. doi: 10.1073/pnas.1610223114. Epub 2017 Feb 1.

10.

Corrigendum: A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.

Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R, Chen WW, Sullivan LB, Fiske BP, Cho S, Freinkman E, Birsoy K, Abu MR, Shaul YD, Liu CM, Zhou M, Koh MJ, Chung H, Davidson SM, Luengo A, Wang AQ, Xu X, Yasgar A, Liu L, Rai G, Westover KD, Heiden MG, Shen M, Gray NS, Boxer MB, Sabatini DM.

Nat Chem Biol. 2016 Jul 19;12(8):656. doi: 10.1038/nchembio0816-656. No abstract available.

PMID:
27434767
11.

c-Abl forces YAP to switch sides.

Keshet R, Reuven N, Shaul Y.

Mol Cell Oncol. 2015 Jan 23;2(3):e995006. doi: 10.4161/23723556.2014.995006. eCollection 2015 Jul-Sep.

12.

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.

Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R, Chen WW, Sullivan LB, Fiske BP, Cho S, Freinkman E, Birsoy K, Abu-Remaileh M, Shaul YD, Liu CM, Zhou M, Koh MJ, Chung H, Davidson SM, Luengo A, Wang AQ, Xu X, Yasgar A, Liu L, Rai G, Westover KD, Vander Heiden MG, Shen M, Gray NS, Boxer MB, Sabatini DM.

Nat Chem Biol. 2016 Jun;12(6):452-8. doi: 10.1038/nchembio.2070. Epub 2016 Apr 25. Erratum in: Nat Chem Biol. 2016 Jul 19;12 (8):656.

13.

MERAV: a tool for comparing gene expression across human tissues and cell types.

Shaul YD, Yuan B, Thiru P, Nutter-Upham A, McCallum S, Lanzkron C, Bell GW, Sabatini DM.

Nucleic Acids Res. 2016 Jan 4;44(D1):D560-6. doi: 10.1093/nar/gkv1337. Epub 2015 Nov 30.

14.

Co-expression of fibulin-5 and VEGF165 increases long-term patency of synthetic vascular grafts seeded with autologous endothelial cells.

Preis M, Schneiderman J, Koren B, Ben-Yosef Y, Levin-Ashkenazi D, Shapiro S, Cohen T, Blich M, Israeli-Amit M, Sarnatzki Y, Gershtein D, Shofti R, Lewis BS, Shaul Y, Flugelman MY.

Gene Ther. 2016 Mar;23(3):237-46. doi: 10.1038/gt.2015.104. Epub 2015 Dec 24.

PMID:
26588709
15.

A respiratory chain controlled signal transduction cascade in the mitochondrial intermembrane space mediates hydrogen peroxide signaling.

Patterson HC, Gerbeth C, Thiru P, Vögtle NF, Knoll M, Shahsafaei A, Samocha KE, Huang CX, Harden MM, Song R, Chen C, Kao J, Shi J, Salmon W, Shaul YD, Stokes MP, Silva JC, Bell GW, MacArthur DG, Ruland J, Meisinger C, Lodish HF.

Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):E5679-88. doi: 10.1073/pnas.1517932112. Epub 2015 Oct 5. Erratum in: Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):E2094.

16.

Hepatitis B virus induces RNR-R2 expression via DNA damage response activation.

Ricardo-Lax I, Ramanan V, Michailidis E, Shamia T, Reuven N, Rice CM, Shlomai A, Shaul Y.

J Hepatol. 2015 Oct;63(4):789-96. doi: 10.1016/j.jhep.2015.05.017. Epub 2015 May 27.

PMID:
26026873
17.

The Tyrosine Kinase c-Abl Promotes Homeodomain-interacting Protein Kinase 2 (HIPK2) Accumulation and Activation in Response to DNA Damage.

Reuven N, Adler J, Porat Z, Polonio-Vallon T, Hofmann TG, Shaul Y.

J Biol Chem. 2015 Jul 3;290(27):16478-88. doi: 10.1074/jbc.M114.628982. Epub 2015 May 5.

18.

Tyrosine phosphorylation of WW proteins.

Reuven N, Shanzer M, Shaul Y.

Exp Biol Med (Maywood). 2015 Mar;240(3):375-82. doi: 10.1177/1535370214565991. Epub 2015 Jan 26. Review.

19.

c-Abl tyrosine kinase promotes adipocyte differentiation by targeting PPAR-gamma 2.

Keshet R, Bryansker Kraitshtein Z, Shanzer M, Adler J, Reuven N, Shaul Y.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16365-70. doi: 10.1073/pnas.1411086111. Epub 2014 Nov 3.

20.

The polyomavirus middle T-antigen oncogene activates the Hippo pathway tumor suppressor Lats in a Src-dependent manner.

Shanzer M, Ricardo-Lax I, Keshet R, Reuven N, Shaul Y.

Oncogene. 2015 Aug 6;34(32):4190-8. doi: 10.1038/onc.2014.347. Epub 2014 Nov 3.

PMID:
25362852
21.

c-Abl antagonizes the YAP oncogenic function.

Keshet R, Adler J, Ricardo Lax I, Shanzer M, Porat Z, Reuven N, Shaul Y.

Cell Death Differ. 2015 Jun;22(6):935-45. doi: 10.1038/cdd.2014.182. Epub 2014 Oct 31.

22.

Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition.

Shaul YD, Freinkman E, Comb WC, Cantor JR, Tam WL, Thiru P, Kim D, Kanarek N, Pacold ME, Chen WW, Bierie B, Possemato R, Reinhardt F, Weinberg RA, Yaffe MB, Sabatini DM.

Cell. 2014 Aug 28;158(5):1094-1109. doi: 10.1016/j.cell.2014.07.032.

23.

AMPK couples p73 with p53 in cell fate decision.

Adamovich Y, Adler J, Meltser V, Reuven N, Shaul Y.

Cell Death Differ. 2014 Sep;21(9):1451-9. doi: 10.1038/cdd.2014.60. Epub 2014 May 30.

24.

NADH binds and stabilizes the 26S proteasomes independent of ATP.

Tsvetkov P, Myers N, Eliav R, Adamovich Y, Hagai T, Adler J, Navon A, Shaul Y.

J Biol Chem. 2014 Apr 18;289(16):11272-81. doi: 10.1074/jbc.M113.537175. Epub 2014 Mar 4.

25.

Critical role for IL-1β in DNA damage-induced mucositis.

Kanarek N, Grivennikov SI, Leshets M, Lasry A, Alkalay I, Horwitz E, Shaul YD, Stachler M, Voronov E, Apte RN, Pagano M, Pikarsky E, Karin M, Ghosh S, Ben-Neriah Y.

Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):E702-11. doi: 10.1073/pnas.1322691111. Epub 2014 Jan 27.

26.

Second-generation Langerhans cells originating from epidermal precursors are essential for CD8+ T cell priming.

Elnekave M, Furmanov K, Shaul Y, Capucha T, Eli-Berchoer L, Zelentsova K, Clausen BE, Hovav AH.

J Immunol. 2014 Feb 15;192(4):1395-403. doi: 10.4049/jimmunol.1301143. Epub 2014 Jan 13.

27.

The Hippo pathway kinase Lats2 prevents DNA damage-induced apoptosis through inhibition of the tyrosine kinase c-Abl.

Reuven N, Adler J, Meltser V, Shaul Y.

Cell Death Differ. 2013 Oct;20(10):1330-40. doi: 10.1038/cdd.2013.83. Epub 2013 Jul 12.

28.

Dendritic cells and their role in periodontal disease.

Wilensky A, Segev H, Mizraji G, Shaul Y, Capucha T, Shacham M, Hovav AH.

Oral Dis. 2014 Mar;20(2):119-26. doi: 10.1111/odi.12122. Epub 2013 May 9. Review.

PMID:
23656605
29.

The protein level of PGC-1α, a key metabolic regulator, is controlled by NADH-NQO1.

Adamovich Y, Shlomai A, Tsvetkov P, Umansky KB, Reuven N, Estall JL, Spiegelman BM, Shaul Y.

Mol Cell Biol. 2013 Jul;33(13):2603-13. doi: 10.1128/MCB.01672-12. Epub 2013 May 6.

30.

A mutually inhibitory feedback loop between the 20S proteasome and its regulator, NQO1.

Moscovitz O, Tsvetkov P, Hazan N, Michaelevski I, Keisar H, Ben-Nissan G, Shaul Y, Sharon M.

Mol Cell. 2012 Jul 13;47(1):76-86. doi: 10.1016/j.molcel.2012.05.049.

31.

Determination of IUP based on susceptibility for degradation by default.

Tsvetkov P, Shaul Y.

Methods Mol Biol. 2012;895:3-18. doi: 10.1007/978-1-61779-927-3_1.

PMID:
22760308
32.

Thermo-resistant intrinsically disordered proteins are efficient 20S proteasome substrates.

Tsvetkov P, Myers N, Moscovitz O, Sharon M, Prilusky J, Shaul Y.

Mol Biosyst. 2012 Jan;8(1):368-73. doi: 10.1039/c1mb05283g. Epub 2011 Oct 25.

PMID:
22027891
33.

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer.

Possemato R, Marks KM, Shaul YD, Pacold ME, Kim D, Birsoy K, Sethumadhavan S, Woo HK, Jang HG, Jha AK, Chen WW, Barrett FG, Stransky N, Tsun ZY, Cowley GS, Barretina J, Kalaany NY, Hsu PP, Ottina K, Chan AM, Yuan B, Garraway LA, Root DE, Mino-Kenudson M, Brachtel EF, Driggers EM, Sabatini DM.

Nature. 2011 Aug 18;476(7360):346-50. doi: 10.1038/nature10350.

34.

Context-dependent resistance to proteolysis of intrinsically disordered proteins.

Suskiewicz MJ, Sussman JL, Silman I, Shaul Y.

Protein Sci. 2011 Aug;20(8):1285-97. doi: 10.1002/pro.657. Epub 2011 Jun 8. Review.

35.

The Hippo tumor suppressor pathway: a report on 'the Second Workshop On The Hippo tumor suppressor pathway'.

McNeill H, Sudol M, Halder G, Strano S, Blandino G, Shaul Y.

Cell Death Differ. 2011 Aug;18(8):1388-90. doi: 10.1038/cdd.2011.61. Epub 2011 May 13. No abstract available.

36.

BIM(EL), an intrinsically disordered protein, is degraded by 20S proteasomes in the absence of poly-ubiquitylation.

Wiggins CM, Tsvetkov P, Johnson M, Joyce CL, Lamb CA, Bryant NJ, Komander D, Shaul Y, Cook SJ.

J Cell Sci. 2011 Mar 15;124(Pt 6):969-77. doi: 10.1242/jcs.058438.

37.

Hepatocyte metabolic signalling pathways and regulation of hepatitis B virus expression.

Bar-Yishay I, Shaul Y, Shlomai A.

Liver Int. 2011 Mar;31(3):282-90. doi: 10.1111/j.1478-3231.2010.02423.x. Epub 2011 Jan 11. Review.

PMID:
21281428
38.

Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1-S6K pathway signaling.

Lindquist RA, Ottina KA, Wheeler DB, Hsu PP, Thoreen CC, Guertin DA, Ali SM, Sengupta S, Shaul YD, Lamprecht MR, Madden KL, Papallo AR, Jones TR, Sabatini DM, Carpenter AE.

Genome Res. 2011 Mar;21(3):433-46. doi: 10.1101/gr.111492.110. Epub 2011 Jan 14.

39.

E3 ligase STUB1/CHIP regulates NAD(P)H:quinone oxidoreductase 1 (NQO1) accumulation in aged brain, a process impaired in certain Alzheimer disease patients.

Tsvetkov P, Adamovich Y, Elliott E, Shaul Y.

J Biol Chem. 2011 Mar 18;286(11):8839-45. doi: 10.1074/jbc.M110.193276. Epub 2011 Jan 10.

40.

c-Abl tyrosine kinase in the DNA damage response: cell death and more.

Meltser V, Ben-Yehoyada M, Shaul Y.

Cell Death Differ. 2011 Jan;18(1):2-4. doi: 10.1038/cdd.2010.132. No abstract available.

41.

The role of p53 in nutrients levels.

Shaul Y, Reuven N.

Cell Cycle. 2010 Sep 15;9(18):3646-7. doi: 10.4161/cc.9.18.13222. Epub 2010 Sep 15. No abstract available.

PMID:
20930502
42.

c-Fos proteasomal degradation is activated by a default mechanism, and its regulation by NAD(P)H:quinone oxidoreductase 1 determines c-Fos serum response kinetics.

Adler J, Reuven N, Kahana C, Shaul Y.

Mol Cell Biol. 2010 Aug;30(15):3767-78. doi: 10.1128/MCB.00899-09. Epub 2010 May 24.

43.

Curcumin inhibits hepatitis B virus via down-regulation of the metabolic coactivator PGC-1alpha.

Rechtman MM, Har-Noy O, Bar-Yishay I, Fishman S, Adamovich Y, Shaul Y, Halpern Z, Shlomai A.

FEBS Lett. 2010 Jun 3;584(11):2485-90. doi: 10.1016/j.febslet.2010.04.067. Epub 2010 Apr 29. Erratum in: FEBS Lett. 2010 Jul 16;584(14):3239. Har-Noy, Ofir [added].

44.

Hepatitis B virus activates deoxynucleotide synthesis in nondividing hepatocytes by targeting the R2 gene.

Cohen D, Adamovich Y, Reuven N, Shaul Y.

Hepatology. 2010 May;51(5):1538-46. doi: 10.1002/hep.23519.

PMID:
20155784
45.

c-Abl downregulates the slow phase of double-strand break repair.

Meltser V, Ben-Yehoyada M, Reuven N, Shaul Y.

Cell Death Dis. 2010;1:e20. doi: 10.1038/cddis.2009.21.

46.

The Hippo tumor suppressor pathway: a brainstorming workshop.

Blandino G, Shaul Y, Strano S, Sudol M, Yaffe M.

Sci Signal. 2009 Nov 3;2(95):mr6. doi: 10.1126/scisignal.295mr6.

PMID:
19887678
47.

The nanny model for IDPs.

Tsvetkov P, Reuven N, Shaul Y.

Nat Chem Biol. 2009 Nov;5(11):778-81. doi: 10.1038/nchembio.233. No abstract available.

PMID:
19841623
48.

The "Trojan horse" model-delivery of anti-HBV small interfering RNAs by a recombinant HBV vector.

Shlomai A, Lubelsky Y, Har-Noy O, Shaul Y.

Biochem Biophys Res Commun. 2009 Dec 18;390(3):619-23. doi: 10.1016/j.bbrc.2009.10.016. Epub 2009 Oct 8.

PMID:
19818740
49.

Specific phosphorylation and activation of ERK1c by MEK1b: a unique route in the ERK cascade.

Shaul YD, Gibor G, Plotnikov A, Seger R.

Genes Dev. 2009 Aug 1;23(15):1779-90. doi: 10.1101/gad.523909.

50.

Susceptibility of p53 unstructured N terminus to 20 S proteasomal degradation programs the stress response.

Tsvetkov P, Reuven N, Prives C, Shaul Y.

J Biol Chem. 2009 Sep 25;284(39):26234-42. doi: 10.1074/jbc.M109.040493. Epub 2009 Jul 17.

Supplemental Content

Support Center