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Supplementation with the Sialic Acid Precursor N-acetyl-D-Mannosamine Breaks the Link Between Obesity and Hypertension.

Peng J, Vongpatanasin W, Sacharidou A, Kifer D, Yuhanna IS, Banerjee S, Tanigaki K, Polasek O, Chu H, Sundgren NC, Rohatgi A, Chambliss KL, Lauc G, Mineo C, Shaul PW.

Circulation. 2019 Oct 10. doi: 10.1161/CIRCULATIONAHA.119.043490. [Epub ahead of print]


SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis.

Huang L, Chambliss KL, Gao X, Yuhanna IS, Behling-Kelly E, Bergaya S, Ahmed M, Michaely P, Luby-Phelps K, Darehshouri A, Xu L, Fisher EA, Ge WP, Mineo C, Shaul PW.

Nature. 2019 May;569(7757):565-569. doi: 10.1038/s41586-019-1140-4. Epub 2019 Apr 24.


Super-Resolution Ultrasound Imaging of Skeletal Muscle Microvascular Dysfunction in an Animal Model of Type 2 Diabetes.

Ghosh D, Peng J, Brown K, Sirsi S, Mineo C, Shaul PW, Hoyt K.

J Ultrasound Med. 2019 Oct;38(10):2589-2599. doi: 10.1002/jum.14956. Epub 2019 Jan 31.


Identifying genes with tri-modal association with survival and tumor grade in cancer patients.

Zhang M, Wang T, Sirianni R, Shaul PW, Xie Y.

BMC Bioinformatics. 2019 Jan 8;20(1):13. doi: 10.1186/s12859-018-2582-7.


Selective Nonnuclear Estrogen Receptor Activation Decreases Stroke Severity and Promotes Functional Recovery in Female Mice.

Selvaraj UM, Zuurbier KR, Whoolery CW, Plautz EJ, Chambliss KL, Kong X, Zhang S, Kim SH, Katzenellenbogen BS, Katzenellenbogen JA, Mineo C, Shaul PW, Stowe AM.

Endocrinology. 2018 Nov 1;159(11):3848-3859. doi: 10.1210/en.2018-00600.


Enhanced Liver Regeneration After Partial Hepatectomy in Sterol Regulatory Element-Binding Protein (SREBP)-1c-Null Mice is Associated with Increased Hepatocellular Cholesterol Availability.

Peng J, Yu J, Xu H, Kang C, Shaul PW, Guan Y, Zhang X, Su W.

Cell Physiol Biochem. 2018;47(2):784-799. doi: 10.1159/000490030. Epub 2018 May 22.


Antiphospholipid antibodies induce thrombosis by PP2A activation via apoER2-Dab2-SHC1 complex formation in endothelium.

Sacharidou A, Chambliss KL, Ulrich V, Salmon JE, Shen YM, Herz J, Hui DY, Terada LS, Shaul PW, Mineo C.

Blood. 2018 May 10;131(19):2097-2110. doi: 10.1182/blood-2017-11-814681. Epub 2018 Mar 2.


Hyposialylated IgG activates endothelial IgG receptor FcγRIIB to promote obesity-induced insulin resistance.

Tanigaki K, Sacharidou A, Peng J, Chambliss KL, Yuhanna IS, Ghosh D, Ahmed M, Szalai AJ, Vongpatanasin W, Mattrey RF, Chen Q, Azadi P, Lingvay I, Botto M, Holland WL, Kohler JJ, Sirsi SR, Hoyt K, Shaul PW, Mineo C.

J Clin Invest. 2018 Jan 2;128(1):309-322. doi: 10.1172/JCI89333. Epub 2017 Nov 27.


Cholesterol trafficking and raft-like membrane domain composition mediate scavenger receptor class B type 1-dependent lipid sensing in intestinal epithelial cells.

Morel E, Ghezzal S, Lucchi G, Truntzer C, Pais de Barros JP, Simon-Plas F, Demignot S, Mineo C, Shaul PW, Leturque A, Rousset M, Carrière V.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Feb;1863(2):199-211. doi: 10.1016/j.bbalip.2017.11.009. Epub 2017 Dec 2.


Toward optimization of in vivo super-resolution ultrasound imaging using size-selected microbubble contrast agents.

Ghosh D, Xiong F, Sirsi SR, Shaul PW, Mattrey RF, Hoyt K.

Med Phys. 2017 Dec;44(12):6304-6313. doi: 10.1002/mp.12606. Epub 2017 Oct 27.


Sirtuin1 Protects against Systemic Sclerosis-related Pulmonary Fibrosis by Decreasing Proinflammatory and Profibrotic Processes.

Chu H, Jiang S, Liu Q, Ma Y, Zhu X, Liang M, Shi X, Ding W, Zhou X, Zou H, Qian F, Shaul PW, Jin L, Wang J.

Am J Respir Cell Mol Biol. 2018 Jan;58(1):28-39. doi: 10.1165/rcmb.2016-0192OC.


17β-Estradiol Dysregulates Innate Immune Responses to Pseudomonas aeruginosa Respiratory Infection and Is Modulated by Estrogen Receptor Antagonism.

Abid S, Xie S, Bose M, Shaul PW, Terada LS, Brody SL, Thomas PJ, Katzenellenbogen JA, Kim SH, Greenberg DE, Jain R.

Infect Immun. 2017 Sep 20;85(10). pii: e00422-17. doi: 10.1128/IAI.00422-17. Print 2017 Oct.


27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy.

Oguro H, McDonald JG, Zhao Z, Umetani M, Shaul PW, Morrison SJ.

J Clin Invest. 2017 Sep 1;127(9):3392-3401. doi: 10.1172/JCI94027. Epub 2017 Aug 7.


Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis.

Worthmann A, John C, Rühlemann MC, Baguhl M, Heinsen FA, Schaltenberg N, Heine M, Schlein C, Evangelakos I, Mineo C, Fischer M, Dandri M, Kremoser C, Scheja L, Franke A, Shaul PW, Heeren J.

Nat Med. 2017 Jul;23(7):839-849. doi: 10.1038/nm.4357. Epub 2017 Jun 12.


Non-nuclear estrogen receptor alpha activation in endothelium reduces cardiac ischemia-reperfusion injury in mice.

Menazza S, Sun J, Appachi S, Chambliss KL, Kim SH, Aponte A, Khan S, Katzenellenbogen JA, Katzenellenbogen BS, Shaul PW, Murphy E.

J Mol Cell Cardiol. 2017 Jun;107:41-51. doi: 10.1016/j.yjmcc.2017.04.004. Epub 2017 Apr 27.


New Insights in the Pathophysiology of Antiphospholipid Syndrome.

Sacharidou A, Shaul PW, Mineo C.

Semin Thromb Hemost. 2018 Jul;44(5):475-482. doi: 10.1055/s-0036-1597286. Epub 2017 Jan 27. Review.


Nonnuclear Estrogen Receptor Activation Improves Hepatic Steatosis in Female Mice.

Chambliss KL, Barrera J, Umetani M, Umetani J, Kim SH, Madak-Erdogan Z, Huang L, Katzenellenbogen BS, Katzenellenbogen JA, Mineo C, Shaul PW.

Endocrinology. 2016 Oct;157(10):3731-3741. Epub 2016 Aug 23.


Identification of a Monoclonal Antibody That Attenuates Antiphospholipid Syndrome-Related Pregnancy Complications and Thrombosis.

Mineo C, Lanier L, Jung E, Sengupta S, Ulrich V, Sacharidou A, Tarango C, Osunbunmi O, Shen YM, Salmon JE, Brekken RA, Huang X, Thorpe PE, Shaul PW.

PLoS One. 2016 Jul 27;11(7):e0158757. doi: 10.1371/journal.pone.0158757. eCollection 2016.


Design of pathway preferential estrogens that provide beneficial metabolic and vascular effects without stimulating reproductive tissues.

Madak-Erdogan Z, Kim SH, Gong P, Zhao YC, Zhang H, Chambliss KL, Carlson KE, Mayne CG, Shaul PW, Korach KS, Katzenellenbogen JA, Katzenellenbogen BS.

Sci Signal. 2016 May 24;9(429):ra53. doi: 10.1126/scisignal.aad8170.


Endothelial Fcγ Receptor IIB Activation Blunts Insulin Delivery to Skeletal Muscle to Cause Insulin Resistance in Mice.

Tanigaki K, Chambliss KL, Yuhanna IS, Sacharidou A, Ahmed M, Atochin DN, Huang PL, Shaul PW, Mineo C.

Diabetes. 2016 Jul;65(7):1996-2005. doi: 10.2337/db15-1605. Epub 2016 Apr 26.


Loss of Reelin protects against atherosclerosis by reducing leukocyte-endothelial cell adhesion and lesion macrophage accumulation.

Ding Y, Huang L, Xian X, Yuhanna IS, Wasser CR, Frotscher M, Mineo C, Shaul PW, Herz J.

Sci Signal. 2016 Mar 15;9(419):ra29. doi: 10.1126/scisignal.aad5578.


ApoE Receptor 2 Mediation of Trophoblast Dysfunction and Pregnancy Complications Induced by Antiphospholipid Antibodies in Mice.

Ulrich V, Gelber SE, Vukelic M, Sacharidou A, Herz J, Urbanus RT, de Groot PG, Natale DR, Harihara A, Redecha P, Abrahams VM, Shaul PW, Salmon JE, Mineo C.

Arthritis Rheumatol. 2016 Mar;68(3):730-739. doi: 10.1002/art.39453.


A Protein Kinase C Phosphorylation Motif in GLUT1 Affects Glucose Transport and is Mutated in GLUT1 Deficiency Syndrome.

Lee EE, Ma J, Sacharidou A, Mi W, Salato VK, Nguyen N, Jiang Y, Pascual JM, North PE, Shaul PW, Mettlen M, Wang RC.

Mol Cell. 2015 Jun 4;58(5):845-53. doi: 10.1016/j.molcel.2015.04.015. Epub 2015 May 14.


HDL cholesterol efflux capacity and cardiovascular events.

Rohatgi A, de Lemos JA, Shaul PW.

N Engl J Med. 2015 May 7;372(19):1871-2. doi: 10.1056/NEJMc1503139. No abstract available.


PDZK1 prevents neointima formation via suppression of breakpoint cluster region kinase in vascular smooth muscle.

Lee WR, Sacharidou A, Behling-Kelly E, Oltmann SC, Zhu W, Ahmed M, Gerard RD, Hui DY, Abe J, Shaul PW, Mineo C.

PLoS One. 2015 Apr 17;10(4):e0124494. doi: 10.1371/journal.pone.0124494. eCollection 2015.


Inhibition of ABCA1 protein degradation promotes HDL cholesterol efflux capacity and RCT and reduces atherosclerosis in mice.

Huang L, Fan B, Ma A, Shaul PW, Zhu H.

J Lipid Res. 2015 May;56(5):986-97. doi: 10.1194/jlr.M054742. Epub 2015 Mar 11.


Fcγ receptors and ligands and cardiovascular disease.

Tanigaki K, Sundgren N, Khera A, Vongpatanasin W, Mineo C, Shaul PW.

Circ Res. 2015 Jan 16;116(2):368-84. doi: 10.1161/CIRCRESAHA.116.302795. Review.


Role of the endothelium in the metabolic syndrome: IIB or not IIB.

Shaul PW.

Am J Med Sci. 2015 Jan;349(1):3-5. doi: 10.1097/MAJ.0000000000000402. No abstract available.


HDL cholesterol efflux capacity and incident cardiovascular events.

Rohatgi A, Khera A, Berry JD, Givens EG, Ayers CR, Wedin KE, Neeland IJ, Yuhanna IS, Rader DR, de Lemos JA, Shaul PW.

N Engl J Med. 2014 Dec 18;371(25):2383-93. doi: 10.1056/NEJMoa1409065. Epub 2014 Nov 18.


IgG receptor FcγRIIB plays a key role in obesity-induced hypertension.

Sundgren NC, Vongpatanasin W, Boggan BM, Tanigaki K, Yuhanna IS, Chambliss KL, Mineo C, Shaul PW.

Hypertension. 2015 Feb;65(2):456-62. doi: 10.1161/HYPERTENSIONAHA.114.04670. Epub 2014 Nov 3.


Antiphospholipid antibodies attenuate endothelial repair and promote neointima formation in mice.

Ulrich V, Konaniah ES, Lee WR, Khadka S, Shen YM, Herz J, Salmon JE, Hui DY, Shaul PW, Mineo C.

J Am Heart Assoc. 2014 Oct 14;3(5):e001369. doi: 10.1161/JAHA.114.001369.


Genetic variants of ApoE and ApoER2 differentially modulate endothelial function.

Ulrich V, Konaniah ES, Herz J, Gerard RD, Jung E, Yuhanna IS, Ahmed M, Hui DY, Mineo C, Shaul PW.

Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13493-8. doi: 10.1073/pnas.1402106111. Epub 2014 Sep 2.


The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha.

Umetani M, Ghosh P, Ishikawa T, Umetani J, Ahmed M, Mineo C, Shaul PW.

Cell Metab. 2014 Jul 1;20(1):172-82. doi: 10.1016/j.cmet.2014.05.013. Epub 2014 Jun 19.


Bazedoxifene and conjugated estrogen prevent diet-induced obesity, hepatic steatosis, and type 2 diabetes in mice without impacting the reproductive tract.

Barrera J, Chambliss KL, Ahmed M, Tanigaki K, Thompson B, McDonald JG, Mineo C, Shaul PW.

Am J Physiol Endocrinol Metab. 2014 Aug 1;307(3):E345-54. doi: 10.1152/ajpendo.00653.2013. Epub 2014 Jun 17.


Mutation of the palmitoylation site of estrogen receptor α in vivo reveals tissue-specific roles for membrane versus nuclear actions.

Adlanmerini M, Solinhac R, Abot A, Fabre A, Raymond-Letron I, Guihot AL, Boudou F, Sautier L, Vessières E, Kim SH, Lière P, Fontaine C, Krust A, Chambon P, Katzenellenbogen JA, Gourdy P, Shaul PW, Henrion D, Arnal JF, Lenfant F.

Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):E283-90. doi: 10.1073/pnas.1322057111. Epub 2013 Dec 26.


Recent insights into non-nuclear actions of estrogen receptor alpha.

Banerjee S, Chambliss KL, Mineo C, Shaul PW.

Steroids. 2014 Mar;81:64-9. doi: 10.1016/j.steroids.2013.11.002. Epub 2013 Nov 16. Review.


27-Hydroxycholesterol promotes cell-autonomous, ER-positive breast cancer growth.

Wu Q, Ishikawa T, Sirianni R, Tang H, McDonald JG, Yuhanna IS, Thompson B, Girard L, Mineo C, Brekken RA, Umetani M, Euhus DM, Xie Y, Shaul PW.

Cell Rep. 2013 Nov 14;5(3):637-45. doi: 10.1016/j.celrep.2013.10.006. Epub 2013 Nov 7.


LXRβ/estrogen receptor-α signaling in lipid rafts preserves endothelial integrity.

Ishikawa T, Yuhanna IS, Umetani J, Lee WR, Korach KS, Shaul PW, Umetani M.

J Clin Invest. 2013 Aug;123(8):3488-97. doi: 10.1172/JCI66533. Epub 2013 Jul 8.


Regulation of signal transduction by HDL.

Mineo C, Shaul PW.

J Lipid Res. 2013 Sep;54(9):2315-24. doi: 10.1194/jlr.R039479. Epub 2013 May 18. Review.


Non-nuclear-initiated actions of the estrogen receptor protect cortical bone mass.

Bartell SM, Han L, Kim HN, Kim SH, Katzenellenbogen JA, Katzenellenbogen BS, Chambliss KL, Shaul PW, Roberson PK, Weinstein RS, Jilka RL, Almeida M, Manolagas SC.

Mol Endocrinol. 2013 Apr;27(4):649-56. doi: 10.1210/me.2012-1368. Epub 2013 Feb 26.


Point mutations in the ERα Gαi binding domain segregate nonnuclear from nuclear receptor function.

Wu Q, Chambliss K, Lee WR, Yuhanna IS, Mineo C, Shaul PW.

Mol Endocrinol. 2013 Jan;27(1):2-11. doi: 10.1210/me.2011-1378. Epub 2012 Dec 14.


C-reactive protein causes insulin resistance in mice through Fcγ receptor IIB-mediated inhibition of skeletal muscle glucose delivery.

Tanigaki K, Vongpatanasin W, Barrera JA, Atochin DN, Huang PL, Bonvini E, Shaul PW, Mineo C.

Diabetes. 2013 Mar;62(3):721-31. doi: 10.2337/db12-0133. Epub 2012 Oct 15.


Scavenger receptor class B type I is a plasma membrane cholesterol sensor.

Saddar S, Carriere V, Lee WR, Tanigaki K, Yuhanna IS, Parathath S, Morel E, Warrier M, Sawyer JK, Gerard RD, Temel RE, Brown JM, Connelly M, Mineo C, Shaul PW.

Circ Res. 2013 Jan 4;112(1):140-51. doi: 10.1161/CIRCRESAHA.112.280081. Epub 2012 Sep 28.


Novel biological functions of high-density lipoprotein cholesterol.

Mineo C, Shaul PW.

Circ Res. 2012 Sep 28;111(8):1079-90. Review.


Functions of scavenger receptor class B, type I in atherosclerosis.

Mineo C, Shaul PW.

Curr Opin Lipidol. 2012 Oct;23(5):487-93. doi: 10.1097/MOL.0b013e328357ba61. Review.


New Insights into the Molecular Basis of the Antiphospholipid Syndrome.

Mineo C, Shaul PW.

Drug Discov Today Dis Mech. 2011 Summer;8(1-2):e47-e52.


Regulation of eNOS in caveolae.

Mineo C, Shaul PW.

Adv Exp Med Biol. 2012;729:51-62. doi: 10.1007/978-1-4614-1222-9_4. Review.


Coupling of Fcγ receptor I to Fcγ receptor IIb by SRC kinase mediates C-reactive protein impairment of endothelial function.

Sundgren NC, Zhu W, Yuhanna IS, Chambliss KL, Ahmed M, Tanigaki K, Umetani M, Mineo C, Shaul PW.

Circ Res. 2011 Oct 28;109(10):1132-40. doi: 10.1161/CIRCRESAHA.111.254573. Epub 2011 Sep 22.


Inhaled nitric oxide and bronchopulmonary dysplasia.

Steinhorn RH, Shaul PW, deRegnier RA, Kennedy KA.

Pediatrics. 2011 Jul;128(1):e255-6; author reply e256-7. doi: 10.1542/peds.2011-1270A. No abstract available.


PON-dering differences in HDL function in coronary artery disease.

Mineo C, Shaul PW.

J Clin Invest. 2011 Jul;121(7):2545-8. doi: 10.1172/JCI57671. Epub 2011 Jun 23.

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