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Rational Design of DNA-Expressed Stabilized Native-Like HIV-1 Envelope Trimers.

Aldon Y, McKay PF, Allen J, Ozorowski G, Felfödiné Lévai R, Tolazzi M, Rogers P, He L, de Val N, Fábián K, Scarlatti G, Zhu J, Ward AB, Crispin M, Shattock RJ.

Cell Rep. 2018 Sep 18;24(12):3324-3338.e5. doi: 10.1016/j.celrep.2018.08.051.


Structural Components for Amplification of Positive and Negative Strand VEEV Splitzicons.

Blakney AK, McKay PF, Shattock RJ.

Front Mol Biosci. 2018 Jul 26;5:71. doi: 10.3389/fmolb.2018.00071. eCollection 2018.


Unexpected synergistic HIV neutralization by a triple microbicide produced in rice endosperm.

Vamvaka E, Farré G, Molinos-Albert LM, Evans A, Canela-Xandri A, Twyman RM, Carrillo J, Ordóñez RA, Shattock RJ, O'Keefe BR, Clotet B, Blanco J, Khush GS, Christou P, Capell T.

Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7854-E7862. doi: 10.1073/pnas.1806022115. Epub 2018 Jul 30.


The Multifaceted Nature of Immunoglobulin A and Its Complex Role in HIV.

Lopez E, Shattock RJ, Kent SJ, Chung AW.

AIDS Res Hum Retroviruses. 2018 Sep;34(9):727-738. doi: 10.1089/AID.2018.0099. Epub 2018 Aug 27.


Combined Skin and Muscle DNA Priming Provides Enhanced Humoral Responses to a Human Immunodeficency Virus Type 1 Clade C Envelope Vaccine.

Cheeseman HM, Day S, McFarlane LR, Fleck S, Miller A, Cole T, Sousa-Santos N, Cope A, Cizmeci D, Tolazzi M, Hwekwete E, Hannaman D, Kratochvil S, McKay PF, Chung AW, Kent SJ, Cook A, Scarlatti G, Abraham S, Combadiere B, McCormack S, Lewis DJ, Shattock RJ.

Hum Gene Ther. 2018 Sep;29(9):1011-1028. doi: 10.1089/hum.2018.075.


One Size Does Not Fit All: The Effect of Chain Length and Charge Density of Poly(ethylene imine) Based Copolymers on Delivery of pDNA, mRNA, and RepRNA Polyplexes.

Blakney AK, Yilmaz G, McKay PF, Becer CR, Shattock RJ.

Biomacromolecules. 2018 Jul 9;19(7):2870-2879. doi: 10.1021/acs.biomac.8b00429. Epub 2018 May 3.


Optimising the collection of female genital tract fluid for cytokine analysis in pregnant women.

Short CS, Quinlan R, Bennett P, Shattock RJ, Taylor GP.

J Immunol Methods. 2018 Jul;458:15-20. doi: 10.1016/j.jim.2018.03.014. Epub 2018 Apr 3.


A systematic analysis of the expression of the anti-HIV VRC01 antibody in Pichia pastoris through signal peptide optimization.

Aw R, McKay PF, Shattock RJ, Polizzi KM.

Protein Expr Purif. 2018 Sep;149:43-50. doi: 10.1016/j.pep.2018.03.013. Epub 2018 Mar 27.


Optimisation of ex vivo memory B cell expansion/differentiation for interrogation of rare peripheral memory B cell subset responses.

Muir L, McKay PF, Petrova VN, Klymenko OV, Kratochvil S, Pinder CL, Kellam P, Shattock RJ.

Wellcome Open Res. 2017 Oct 5;2:97. doi: 10.12688/wellcomeopenres.11386.2. eCollection 2017.


Molecular Signatures of a TLR4 Agonist-Adjuvanted HIV-1 Vaccine Candidate in Humans.

Anderson J, Olafsdottir TA, Kratochvil S, McKay PF, Östensson M, Persson J, Shattock RJ, Harandi AM.

Front Immunol. 2018 Feb 26;9:301. doi: 10.3389/fimmu.2018.00301. eCollection 2018.


Corrigendum: Immunoglobulin G1 Allotype Influences Antibody Subclass Distribution in Response to HIV gp140 Vaccination.

Kratochvil S, McKay PF, Chung AW, Kent SJ, Gilmour J, Shattock RJ.

Front Immunol. 2018 Feb 27;9:342. doi: 10.3389/fimmu.2018.00342. eCollection 2018.


A heterogeneous human immunodeficiency virus-like particle (VLP) formulation produced by a novel vector system.

Pankrac J, Klein K, McKay PF, King DFL, Bain K, Knapp J, Biru T, Wijewardhana CN, Pawa R, Canaday DH, Gao Y, Fidler S, Shattock RJ, Arts EJ, Mann JFS.

NPJ Vaccines. 2018 Jan 19;3:2. doi: 10.1038/s41541-017-0040-6. eCollection 2018.


Immunoglobulin G1 Allotype Influences Antibody Subclass Distribution in Response to HIV gp140 Vaccination.

Kratochvil S, McKay PF, Chung AW, Kent SJ, Gilmour J, Shattock RJ.

Front Immunol. 2017 Dec 20;8:1883. doi: 10.3389/fimmu.2017.01883. eCollection 2017. Erratum in: Front Immunol. 2018 Feb 27;9:342.


Localized cyclical variations in immunoproteins in the female genital tract and the implications on the design and assessment of mucosal infection and therapies.

Makinde J, Jones C, Bartolf A, Sibeko S, Baden S, Cosgrove C, Shattock RJ.

Am J Reprod Immunol. 2018 Feb;79(2). doi: 10.1111/aji.12801. Epub 2017 Dec 29.


Isolation and Characterization of Antigen-Specific Plasmablasts Using a Novel Flow Cytometry-Based Ig Capture Assay.

Pinder CL, Kratochvil S, Cizmeci D, Muir L, Guo Y, Shattock RJ, McKay PF.

J Immunol. 2017 Dec 15;199(12):4180-4188. doi: 10.4049/jimmunol.1701253. Epub 2017 Nov 8.


Combined skin and muscle vaccination differentially impact the quality of effector T cell functions: the CUTHIVAC-001 randomized trial.

Haidari G, Cope A, Miller A, Venables S, Yan C, Ridgers H, Reijonen K, Hannaman D, Spentzou A, Hayes P, Bouliotis G, Vogt A, Joseph S, Combadiere B, McCormack S, Shattock RJ.

Sci Rep. 2017 Oct 12;7(1):13011. doi: 10.1038/s41598-017-13331-1.


Innate activation of human primary epithelial cells broadens the host response to Mycobacterium tuberculosis in the airways.

Reuschl AK, Edwards MR, Parker R, Connell DW, Hoang L, Halliday A, Jarvis H, Siddiqui N, Wright C, Bremang S, Newton SM, Beverley P, Shattock RJ, Kon OM, Lalvani A.

PLoS Pathog. 2017 Sep 1;13(9):e1006577. doi: 10.1371/journal.ppat.1006577. eCollection 2017 Sep.


The synergistic effects of combining TLR ligand based adjuvants on the cytokine response are dependent upon p38/JNK signalling.

Fischetti L, Zhong Z, Pinder CL, Tregoning JS, Shattock RJ.

Cytokine. 2017 Nov;99:287-296. doi: 10.1016/j.cyto.2017.08.009. Epub 2017 Aug 18.


A Phase 1 Human Immunodeficiency Virus Vaccine Trial for Cross-Profiling the Kinetics of Serum and Mucosal Antibody Responses to CN54gp140 Modulated by Two Homologous Prime-Boost Vaccine Regimens.

Kratochvil S, McKay PF, Kopycinski JT, Bishop C, Hayes PJ, Muir L, Pinder CL, Cizmeci D, King D, Aldon Y, Wines BD, Hogarth PM, Chung AW, Kent SJ, Held K, Geldmacher C, Dally L, Santos NS, Cole T, Gilmour J, Fidler S, Shattock RJ.

Front Immunol. 2017 May 24;8:595. doi: 10.3389/fimmu.2017.00595. eCollection 2017.


Flow virometry analysis of envelope glycoprotein conformations on individual HIV virions.

Arakelyan A, Fitzgerald W, King DF, Rogers P, Cheeseman HM, Grivel JC, Shattock RJ, Margolis L.

Sci Rep. 2017 Apr 19;7(1):948. doi: 10.1038/s41598-017-00935-w.


Expressing anti-HIV VRC01 antibody using the murine IgG1 secretion signal in Pichia pastoris.

Aw R, McKay PF, Shattock RJ, Polizzi KM.

AMB Express. 2017 Dec;7(1):70. doi: 10.1186/s13568-017-0372-7. Epub 2017 Mar 24.


A Comparative Phase I Study of Combination, Homologous Subtype-C DNA, MVA, and Env gp140 Protein/Adjuvant HIV Vaccines in Two Immunization Regimes.

Joseph S, Quinn K, Greenwood A, Cope AV, McKay PF, Hayes PJ, Kopycinski JT, Gilmour J, Miller AN, Geldmacher C, Nadai Y, Ahmed MI, Montefiori DC, Dally L, Bouliotis G, Lewis DJ, Tatoud R, Wagner R, Esteban M, Shattock RJ, McCormack S, Weber J.

Front Immunol. 2017 Feb 22;8:149. doi: 10.3389/fimmu.2017.00149. eCollection 2017.


Intravaginal immunisation using a novel antigen-releasing ring device elicits robust vaccine antigen-specific systemic and mucosal humoral immune responses.

McKay PF, Mann JF, Pattani A, Kett V, Aldon Y, King D, Malcolm RK, Shattock RJ.

J Control Release. 2017 Mar 10;249:74-83. doi: 10.1016/j.jconrel.2017.01.018. Epub 2017 Jan 21.


Infection of rhesus macaques with a pool of simian immunodeficiency virus with the envelope genes from acute HIV-1 infections.

Krebs KC, Tian M, Asmal M, Ling B, Nelson K, Henry K, Gibson R, Li Y, Han W, Shattock RJ, Veazey RS, Letvin N, Arts EJ, Gao Y.

AIDS Res Ther. 2016 Nov 25;13(1):41. doi: 10.1186/s12981-016-0125-8.


Broadly Neutralizing Antibodies Display Potential for Prevention of HIV-1 Infection of Mucosal Tissue Superior to That of Nonneutralizing Antibodies.

Cheeseman HM, Olejniczak NJ, Rogers PM, Evans AB, King DF, Ziprin P, Liao HX, Haynes BF, Shattock RJ.

J Virol. 2016 Dec 16;91(1). pii: e01762-16. Print 2017 Jan 1.


A Multi-Component Prime-Boost Vaccination Regimen with a Consensus MOMP Antigen Enhances Chlamydia trachomatis Clearance.

Badamchi-Zadeh A, McKay PF, Korber BT, Barinaga G, Walters AA, Nunes A, Gomes JP, Follmann F, Tregoning JS, Shattock RJ.

Front Immunol. 2016 Apr 28;7:162. doi: 10.3389/fimmu.2016.00162. eCollection 2016.


Expression Profile of Human Fc Receptors in Mucosal Tissue: Implications for Antibody-Dependent Cellular Effector Functions Targeting HIV-1 Transmission.

Cheeseman HM, Carias AM, Evans AB, Olejniczak NJ, Ziprin P, King DF, Hope TJ, Shattock RJ.

PLoS One. 2016 May 10;11(5):e0154656. doi: 10.1371/journal.pone.0154656. eCollection 2016.


Comparative Immunogenicity of HIV-1 gp140 Vaccine Delivered by Parenteral, and Mucosal Routes in Female Volunteers; MUCOVAC2, A Randomized Two Centre Study.

Cosgrove CA, Lacey CJ, Cope AV, Bartolf A, Morris G, Yan C, Baden S, Cole T, Carter D, Brodnicki E, Shen X, Joseph S, DeRosa SC, Peng L, Yu X, Ferrari G, Seaman M, Montefiori DC, Frahm N, Tomaras GD, Stöhr W, McCormack S, Shattock RJ.

PLoS One. 2016 May 9;11(5):e0152038. doi: 10.1371/journal.pone.0152038. eCollection 2016.


CD71 targeting boosts immunogenicity of sublingually delivered influenza haemagglutinin antigen and protects against viral challenge in mice.

Mann JF, Tregoning JS, Aldon Y, Shattock RJ, McKay PF.

J Control Release. 2016 Jun 28;232:75-82. doi: 10.1016/j.jconrel.2016.04.022. Epub 2016 Apr 16.


Superior Efficacy of a Human Immunodeficiency Virus Vaccine Combined with Antiretroviral Prevention in Simian-Human Immunodeficiency Virus-Challenged Nonhuman Primates.

Le Grand R, Dereuddre-Bosquet N, Dispinseri S, Gosse L, Desjardins D, Shen X, Tolazzi M, Ochsenbauer C, Saidi H, Tomaras G, Prague M, Barnett SW, Thiebaut R, Cope A, Scarlatti G, Shattock RJ.

J Virol. 2016 May 12;90(11):5315-5328. doi: 10.1128/JVI.00230-16. Print 2016 Jun 1.


Cyanovirin-N produced in rice endosperm offers effective pre-exposure prophylaxis against HIV-1BaL infection in vitro.

Vamvaka E, Evans A, Ramessar K, Krumpe LR, Shattock RJ, O'Keefe BR, Christou P, Capell T.

Plant Cell Rep. 2016 Jun;35(6):1309-19. doi: 10.1007/s00299-016-1963-5. Epub 2016 Mar 23.


TLR4 and TLR7/8 Adjuvant Combinations Generate Different Vaccine Antigen-Specific Immune Outcomes in Minipigs when Administered via the ID or IN Routes.

McKay PF, King DF, Mann JF, Barinaga G, Carter D, Shattock RJ.

PLoS One. 2016 Feb 10;11(2):e0148984. doi: 10.1371/journal.pone.0148984. eCollection 2016.


Maraviroc and reverse transcriptase inhibitors combinations as potential preexposure prophylaxis candidates.

Herrera C, Armanasco N, García-Pérez J, Ziprin P, Olejniczak N, Alcamí J, Nuttall J, Shattock RJ.

AIDS. 2016 Apr 24;30(7):1015-25. doi: 10.1097/QAD.0000000000001043.


Immune Activation in the Female Genital Tract: Expression Profiles of Soluble Proteins in Women at High Risk for HIV Infection.

Francis SC, Hou Y, Baisley K, van de Wijgert J, Watson-Jones D, Ao TT, Herrera C, Maganja K, Andreasen A, Kapiga S, Coulton GR, Hayes RJ, Shattock RJ.

PLoS One. 2016 Jan 27;11(1):e0143109. doi: 10.1371/journal.pone.0143109. eCollection 2016.


Rice endosperm is cost-effective for the production of recombinant griffithsin with potent activity against HIV.

Vamvaka E, Arcalis E, Ramessar K, Evans A, O'Keefe BR, Shattock RJ, Medina V, Stöger E, Christou P, Capell T.

Plant Biotechnol J. 2016 Jun;14(6):1427-37. doi: 10.1111/pbi.12507. Epub 2016 Jan 23.


Short Communication: Limited Anti-HIV-1 Activity of Maraviroc in Mucosal Tissues.

Fletcher P, Herrera C, Armanasco N, Nuttall J, Shattock RJ.

AIDS Res Hum Retroviruses. 2016 Apr;32(4):334-8. doi: 10.1089/AID.2015.0315. Epub 2016 Jan 29.


Evaluation of mucosal adjuvants and immunization routes for the induction of systemic and mucosal humoral immune responses in macaques.

Veazey RS, Siddiqui A, Klein K, Buffa V, Fischetti L, Doyle-Meyers L, King DF, Tregoning JS, Shattock RJ.

Hum Vaccin Immunother. 2015;11(12):2913-22. doi: 10.1080/21645515.2015.1070998.


Plasmid DNA Vaccine Co-Immunisation Modulates Cellular and Humoral Immune Responses Induced by Intranasal Inoculation in Mice.

King DF, McKay PF, Mann JF, Jones CB, Shattock RJ.

PLoS One. 2015 Nov 6;10(11):e0141557. doi: 10.1371/journal.pone.0141557. eCollection 2015.


Intramuscular Immunisation with Chlamydial Proteins Induces Chlamydia trachomatis Specific Ocular Antibodies.

Badamchi-Zadeh A, McKay PF, Holland MJ, Paes W, Brzozowski A, Lacey C, Follmann F, Tregoning JS, Shattock RJ.

PLoS One. 2015 Oct 26;10(10):e0141209. doi: 10.1371/journal.pone.0141209. eCollection 2015.


HIV-1 CNS in vitro infectivity models based on clinical CSF samples.

Mora-Peris B, Winston A, Garvey L, Else LJ, Shattock RJ, Herrera C.

J Antimicrob Chemother. 2016 Jan;71(1):235-43. doi: 10.1093/jac/dkv326. Epub 2015 Oct 15.


Discrete partitioning of HIV-1 Env forms revealed by viral capture.

Stieh DJ, King DF, Klein K, Aldon Y, McKay PF, Shattock RJ.

Retrovirology. 2015 Sep 24;12:81. doi: 10.1186/s12977-015-0207-z.


Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques.

Santra S, Tomaras GD, Warrier R, Nicely NI, Liao HX, Pollara J, Liu P, Alam SM, Zhang R, Cocklin SL, Shen X, Duffy R, Xia SM, Schutte RJ, Pemble Iv CW, Dennison SM, Li H, Chao A, Vidnovic K, Evans A, Klein K, Kumar A, Robinson J, Landucci G, Forthal DN, Montefiori DC, Kaewkungwal J, Nitayaphan S, Pitisuttithum P, Rerks-Ngarm S, Robb ML, Michael NL, Kim JH, Soderberg KA, Giorgi EE, Blair L, Korber BT, Moog C, Shattock RJ, Letvin NL, Schmitz JE, Moody MA, Gao F, Ferrari G, Shaw GM, Haynes BF.

PLoS Pathog. 2015 Aug 3;11(8):e1005042. doi: 10.1371/journal.ppat.1005042. eCollection 2015 Aug.


HIV-DNA Given with or without Intradermal Electroporation Is Safe and Highly Immunogenic in Healthy Swedish HIV-1 DNA/MVA Vaccinees: A Phase I Randomized Trial.

Nilsson C, Hejdeman B, Godoy-Ramirez K, Tecleab T, Scarlatti G, Bråve A, Earl PL, Stout RR, Robb ML, Shattock RJ, Biberfeld G, Sandström E, Wahren B.

PLoS One. 2015 Jun 29;10(6):e0131748. doi: 10.1371/journal.pone.0131748. eCollection 2015.


Infection of ectocervical tissue and universal targeting of T-cells mediated by primary non-macrophage-tropic and highly macrophage-tropic HIV-1 R5 envelopes.

Peters PJ, Gonzalez-Perez MP, Musich T, Moore Simas TA, Lin R, Morse AN, Shattock RJ, Derdeyn CA, Clapham PR.

Retrovirology. 2015 Jun 9;12:48. doi: 10.1186/s12977-015-0176-2.


Inhibition of HIV-1 infection of primary CD4+ T-cells by gene editing of CCR5 using adenovirus-delivered CRISPR/Cas9.

Li C, Guan X, Du T, Jin W, Wu B, Liu Y, Wang P, Hu B, Griffin GE, Shattock RJ, Hu Q.

J Gen Virol. 2015 Aug;96(8):2381-93. doi: 10.1099/vir.0.000139. Epub 2015 Apr 8.


Binding of HIV-1 virions to α4β 7 expressing cells and impact of antagonizing α4β 7 on HIV-1 infection of primary CD4+ T cells.

Li C, Jin W, Du T, Wu B, Liu Y, Shattock RJ, Hu Q.

Virol Sin. 2014 Dec;29(6):381-92. doi: 10.1007/s12250-014-3525-8. Epub 2014 Dec 10. Erratum in: Virol Sin. 2015 Apr;30(2):162.


Tetherin restricts HSV-2 release and is counteracted by multiple viral glycoproteins.

Liu Y, Luo S, He S, Zhang M, Wang P, Li C, Huang W, Hu B, Griffin GE, Shattock RJ, Hu Q.

Virology. 2015 Jan 15;475:96-109. doi: 10.1016/j.virol.2014.11.005. Epub 2014 Nov 27.


Aggregate complexes of HIV-1 induced by multimeric antibodies.

Stieh DJ, King DF, Klein K, Liu P, Shen X, Hwang KK, Ferrari G, Montefiori DC, Haynes B, Pitisuttithum P, Kaewkungwal J, Nitayaphan S, Rerks-Ngarm S, Michael NL, Robb ML, Kim JH, Denny TN, Tomaras GD, Shattock RJ.

Retrovirology. 2014 Oct 2;11:78. doi: 10.1186/s12977-014-0078-8.


Effect of vaginal immunization with HIVgp140 and HSP70 on HIV-1 replication and innate and T cell adaptive immunity in women.

Lewis DJ, Wang Y, Huo Z, Giemza R, Babaahmady K, Rahman D, Shattock RJ, Singh M, Lehner T.

J Virol. 2014 Oct;88(20):11648-57. doi: 10.1128/JVI.01621-14. Epub 2014 Jul 9.


Comparative analysis of enzymatically produced novel linear DNA constructs with plasmids for use as DNA vaccines.

Walters AA, Kinnear E, Shattock RJ, McDonald JU, Caproni LJ, Porter N, Tregoning JS.

Gene Ther. 2014 Jul;21(7):645-52. doi: 10.1038/gt.2014.37. Epub 2014 May 15.

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