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Items: 1 to 50 of 205

1.

SHARPIN at the nexus of integrin, immune, and inflammatory signaling in human platelets.

Kasirer-Friede A, Tjahjono W, Eto K, Shattil SJ.

Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):4983-4988. doi: 10.1073/pnas.1819156116. Epub 2019 Feb 25.

2.

uPAR isoform 2 forms a dimer and induces severe kidney disease in mice.

Wei C, Li J, Adair BD, Zhu K, Cai J, Merchant M, Samelko B, Liao Z, Koh KH, Tardi NJ, Dande RR, Liu S, Ma J, Dibartolo S, Hägele S, Peev V, Hayek SS, Cimbaluk DJ, Tracy M, Klein J, Sever S, Shattil SJ, Arnaout MA, Reiser J.

J Clin Invest. 2019 Apr 2;129(5):1946-1959. doi: 10.1172/JCI124793. eCollection 2019 Apr 2.

3.

NCCN Guidelines Insights: Cancer-Associated Venous Thromboembolic Disease, Version 2.2018.

Streiff MB, Holmstrom B, Angelini D, Ashrani A, Bockenstedt PL, Chesney C, Fanikos J, Fenninger RB, Fogerty AE, Gao S, Goldhaber SZ, Gundabolu K, Hendrie P, Lee AI, Lee JT, Mann J, McMahon B, Millenson MM, Morton C, Ortel TL, Ozair S, Paschal R, Shattil S, Siddiqi T, Smock KJ, Soff G, Wang TF, Williams E, Zakarija A, Hammond L, Dwyer MA, Engh AM.

J Natl Compr Canc Netw. 2018 Nov;16(11):1289-1303. doi: 10.6004/jnccn.2018.0084.

PMID:
30442731
4.

Rap1 binding to the talin 1 F0 domain makes a minimal contribution to murine platelet GPIIb-IIIa activation.

Lagarrigue F, Gingras AR, Paul DS, Valadez AJ, Cuevas MN, Sun H, Lopez-Ramirez MA, Goult BT, Shattil SJ, Bergmeier W, Ginsberg MH.

Blood Adv. 2018 Sep 25;2(18):2358-2368. doi: 10.1182/bloodadvances.2018020487.

5.

Optogenetic interrogation of integrin αVβ3 function in endothelial cells.

Liao Z, Kasirer-Friede A, Shattil SJ.

J Cell Sci. 2017 Oct 15;130(20):3532-3541. doi: 10.1242/jcs.205203. Epub 2017 Sep 1.

6.

Blood's 70th anniversary: musings of a Blood editor, 2003-2007.

Shattil SJ.

Blood. 2016 Jun 2;127(22):2649-51. doi: 10.1182/blood-2015-11-635755. No abstract available.

PMID:
27257172
7.

Integrin-based therapeutics: biological basis, clinical use and new drugs.

Ley K, Rivera-Nieves J, Sandborn WJ, Shattil S.

Nat Rev Drug Discov. 2016 Mar;15(3):173-83. doi: 10.1038/nrd.2015.10. Epub 2016 Jan 29. Review.

8.

Cancer-Associated Venous Thromboembolic Disease, Version 1.2015.

Streiff MB, Holmstrom B, Ashrani A, Bockenstedt PL, Chesney C, Eby C, Fanikos J, Fenninger RB, Fogerty AE, Gao S, Goldhaber SZ, Hendrie P, Kuderer N, Lee A, Lee JT, Lovrincevic M, Millenson MM, Neff AT, Ortel TL, Paschal R, Shattil S, Siddiqi T, Smock KJ, Soff G, Wang TF, Yee GC, Zakarija A, McMillian N, Engh AM.

J Natl Compr Canc Netw. 2015 Sep;13(9):1079-95.

PMID:
26358792
9.

Interaction of kindlin-2 with integrin β3 promotes outside-in signaling responses by the αVβ3 vitronectin receptor.

Liao Z, Kato H, Pandey M, Cantor JM, Ablooglu AJ, Ginsberg MH, Shattil SJ.

Blood. 2015 Mar 19;125(12):1995-2004. doi: 10.1182/blood-2014-09-603035. Epub 2015 Jan 13.

10.

Integrin αvβ3 drives slug activation and stemness in the pregnant and neoplastic mammary gland.

Desgrosellier JS, Lesperance J, Seguin L, Gozo M, Kato S, Franovic A, Yebra M, Shattil SJ, Cheresh DA.

Dev Cell. 2014 Aug 11;30(3):295-308. doi: 10.1016/j.devcel.2014.06.005.

11.

The classical lancefield antigen of group a Streptococcus is a virulence determinant with implications for vaccine design.

van Sorge NM, Cole JN, Kuipers K, Henningham A, Aziz RK, Kasirer-Friede A, Lin L, Berends ETM, Davies MR, Dougan G, Zhang F, Dahesh S, Shaw L, Gin J, Cunningham M, Merriman JA, Hütter J, Lepenies B, Rooijakkers SHM, Malley R, Walker MJ, Shattil SJ, Schlievert PM, Choudhury B, Nizet V.

Cell Host Microbe. 2014 Jun 11;15(6):729-740. doi: 10.1016/j.chom.2014.05.009.

12.

C-terminal COOH of integrin β1 is necessary for β1 association with the kindlin-2 adapter protein.

Fitzpatrick P, Shattil SJ, Ablooglu AJ.

J Biol Chem. 2014 Apr 18;289(16):11183-93. doi: 10.1074/jbc.M113.535369. Epub 2014 Mar 5.

13.

ADAP interactions with talin and kindlin promote platelet integrin αIIbβ3 activation and stable fibrinogen binding.

Kasirer-Friede A, Kang J, Kahner B, Ye F, Ginsberg MH, Shattil SJ.

Blood. 2014 May 15;123(20):3156-65. doi: 10.1182/blood-2013-08-520627. Epub 2014 Feb 12.

14.

Cutaneous thrombosis in PNH.

Zhao H, Shattil S.

Blood. 2013 Nov 7;122(19):3249. No abstract available.

PMID:
24354009
15.

The mechanism of kindlin-mediated activation of integrin αIIbβ3.

Ye F, Petrich BG, Anekal P, Lefort CT, Kasirer-Friede A, Shattil SJ, Ruppert R, Moser M, Fässler R, Ginsberg MH.

Curr Biol. 2013 Nov 18;23(22):2288-2295. doi: 10.1016/j.cub.2013.09.050. Epub 2013 Nov 7.

16.

In vivo cleaved CDCP1 promotes early tumor dissemination via complexing with activated β1 integrin and induction of FAK/PI3K/Akt motility signaling.

Casar B, Rimann I, Kato H, Shattil SJ, Quigley JP, Deryugina EI.

Oncogene. 2014 Jan 9;33(2):255-68. doi: 10.1038/onc.2012.547. Epub 2012 Dec 3.

17.

The primacy of β1 integrin activation in the metastatic cascade.

Kato H, Liao Z, Mitsios JV, Wang HY, Deryugina EI, Varner JA, Quigley JP, Shattil SJ.

PLoS One. 2012;7(10):e46576. doi: 10.1371/journal.pone.0046576. Epub 2012 Oct 3.

18.

Kindlins, integrin activation and the regulation of talin recruitment to αIIbβ3.

Kahner BN, Kato H, Banno A, Ginsberg MH, Shattil SJ, Ye F.

PLoS One. 2012;7(3):e34056. doi: 10.1371/journal.pone.0034056. Epub 2012 Mar 23.

19.

EGFR-dependent pancreatic carcinoma cell metastasis through Rap1 activation.

Huang M, Anand S, Murphy EA, Desgrosellier JS, Stupack DG, Shattil SJ, Schlaepfer DD, Cheresh DA.

Oncogene. 2012 May 31;31(22):2783-93. doi: 10.1038/onc.2011.450. Epub 2011 Oct 3.

20.

Kindlin-2 regulates podocyte adhesion and fibronectin matrix deposition through interactions with phosphoinositides and integrins.

Qu H, Tu Y, Shi X, Larjava H, Saleem MA, Shattil SJ, Fukuda K, Qin J, Kretzler M, Wu C.

J Cell Sci. 2011 Mar 15;124(Pt 6):879-91. doi: 10.1242/jcs.076976. Epub 2011 Feb 15.

21.

Cyclic GMP and protein kinase G control a Src-containing mechanosome in osteoblasts.

Rangaswami H, Schwappacher R, Marathe N, Zhuang S, Casteel DE, Haas B, Chen Y, Pfeifer A, Kato H, Shattil S, Boss GR, Pilz RB.

Sci Signal. 2010 Dec 21;3(153):ra91. doi: 10.1126/scisignal.2001423.

22.

Integrin alphaV is necessary for gastrulation movements that regulate vertebrate body asymmetry.

Ablooglu AJ, Tkachenko E, Kang J, Shattil SJ.

Development. 2010 Oct;137(20):3449-58. doi: 10.1242/dev.045310. Epub 2010 Sep 15.

23.

What is vinculin needed for in platelets?

Mitsios JV, Prevost N, Kasirer-Friede A, Gutierrez E, Groisman A, Abrams CS, Wang Y, Litvinov RI, Zemljic-Harpf A, Ross RS, Shattil SJ.

J Thromb Haemost. 2010 Oct;8(10):2294-304. doi: 10.1111/j.1538-7836.2010.03998.x.

24.

Visualizing extravasation dynamics of metastatic tumor cells.

Stoletov K, Kato H, Zardouzian E, Kelber J, Yang J, Shattil S, Klemke R.

J Cell Sci. 2010 Jul 1;123(Pt 13):2332-41. doi: 10.1242/jcs.069443. Epub 2010 Jun 8.

25.

The final steps of integrin activation: the end game.

Shattil SJ, Kim C, Ginsberg MH.

Nat Rev Mol Cell Biol. 2010 Apr;11(4):288-300. doi: 10.1038/nrm2871. Review.

26.

Role for ADAP in shear flow-induced platelet mechanotransduction.

Kasirer-Friede A, Ruggeri ZM, Shattil SJ.

Blood. 2010 Mar 18;115(11):2274-82. doi: 10.1182/blood-2009-08-238238. Epub 2009 Dec 7.

27.

An integrin alpha(v)beta(3)-c-Src oncogenic unit promotes anchorage-independence and tumor progression.

Desgrosellier JS, Barnes LA, Shields DJ, Huang M, Lau SK, Prévost N, Tarin D, Shattil SJ, Cheresh DA.

Nat Med. 2009 Oct;15(10):1163-9. doi: 10.1038/nm.2009. Epub 2009 Sep 6.

28.

The beta3 integrin cytoplasmic tail: protein scaffold and control freak.

Shattil SJ.

J Thromb Haemost. 2009 Jul;7 Suppl 1:210-3. doi: 10.1111/j.1538-7836.2009.03397.x. Review.

29.

RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences.

Lee HS, Lim CJ, Puzon-McLaughlin W, Shattil SJ, Ginsberg MH.

J Biol Chem. 2009 Feb 20;284(8):5119-27. doi: 10.1074/jbc.M807117200. Epub 2008 Dec 19.

30.

Antithrombotic effects of targeting alphaIIbbeta3 signaling in platelets.

Ablooglu AJ, Kang J, Petrich BG, Ginsberg MH, Shattil SJ.

Blood. 2009 Apr 9;113(15):3585-92. doi: 10.1182/blood-2008-09-180687. Epub 2008 Nov 12.

31.

The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend.

Coller BS, Shattil SJ.

Blood. 2008 Oct 15;112(8):3011-25. doi: 10.1182/blood-2008-06-077891. Review.

32.

Group IVA cytosolic phospholipase A2 (cPLA2alpha) and integrin alphaIIbbeta3 reinforce each other's functions during alphaIIbbeta3 signaling in platelets.

Prévost N, Mitsios JV, Kato H, Burke JE, Dennis EA, Shimizu T, Shattil SJ.

Blood. 2009 Jan 8;113(2):447-57. doi: 10.1182/blood-2008-06-162032. Epub 2008 Oct 7.

33.

Microfluidic devices for studies of shear-dependent platelet adhesion.

Gutierrez E, Petrich BG, Shattil SJ, Ginsberg MH, Groisman A, Kasirer-Friede A.

Lab Chip. 2008 Sep;8(9):1486-95. doi: 10.1039/b804795b. Epub 2008 Jul 23.

34.

Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3.

Watanabe N, Bodin L, Pandey M, Krause M, Coughlin S, Boussiotis VA, Ginsberg MH, Shattil SJ.

J Cell Biol. 2008 Jun 30;181(7):1211-22. doi: 10.1083/jcb.200803094. Epub 2008 Jun 23.

35.

Differences in regulation of Drosophila and vertebrate integrin affinity by talin.

Helsten TL, Bunch TA, Kato H, Yamanouchi J, Choi SH, Jannuzi AL, Féral CC, Ginsberg MH, Brower DL, Shattil SJ.

Mol Biol Cell. 2008 Aug;19(8):3589-98. doi: 10.1091/mbc.E08-01-0085. Epub 2008 May 28.

36.

Roles of focal adhesion kinase (FAK) in megakaryopoiesis and platelet function: studies using a megakaryocyte lineage specific FAK knockout.

Hitchcock IS, Fox NE, Prévost N, Sear K, Shattil SJ, Kaushansky K.

Blood. 2008 Jan 15;111(2):596-604. Epub 2007 Oct 9.

37.

Platelet integrin adhesive functions and signaling.

Prévost N, Kato H, Bodin L, Shattil SJ.

Methods Enzymol. 2007;426:103-15. Review.

PMID:
17697882
38.

The antithrombotic potential of selective blockade of talin-dependent integrin alpha IIb beta 3 (platelet GPIIb-IIIa) activation.

Petrich BG, Fogelstrand P, Partridge AW, Yousefi N, Ablooglu AJ, Shattil SJ, Ginsberg MH.

J Clin Invest. 2007 Aug;117(8):2250-9.

39.
40.

Platelet integrins and immunoreceptors.

Kasirer-Friede A, Kahn ML, Shattil SJ.

Immunol Rev. 2007 Aug;218:247-64. Review.

PMID:
17624957
41.

Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption.

Zou W, Kitaura H, Reeve J, Long F, Tybulewicz VL, Shattil SJ, Ginsberg MH, Ross FP, Teitelbaum SL.

J Cell Biol. 2007 Mar 12;176(6):877-88.

42.

Bloodlines: the importance of mentoring for the future of hematology.

Kaushansky K, Shattil SJ.

Blood. 2007 Feb 15;109(4):1353-4. Epub 2006 Oct 17. No abstract available.

PMID:
17047145
43.

ADAP is required for normal alphaIIbbeta3 activation by VWF/GP Ib-IX-V and other agonists.

Kasirer-Friede A, Moran B, Nagrampa-Orje J, Swanson K, Ruggeri ZM, Schraven B, Neel BG, Koretzky G, Shattil SJ.

Blood. 2007 Feb 1;109(3):1018-25. Epub 2006 Sep 26.

44.

Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3.

Han J, Lim CJ, Watanabe N, Soriani A, Ratnikov B, Calderwood DA, Puzon-McLaughlin W, Lafuente EM, Boussiotis VA, Shattil SJ, Ginsberg MH.

Curr Biol. 2006 Sep 19;16(18):1796-806.

45.

Evidence for the requirement of ITAM domains but not SLP-76/Gads interaction for integrin signaling in hematopoietic cells.

Abtahian F, Bezman N, Clemens R, Sebzda E, Cheng L, Shattil SJ, Kahn ML, Koretzky GA.

Mol Cell Biol. 2006 Sep;26(18):6936-49.

46.

Matrix-specific suppression of integrin activation in shear stress signaling.

Orr AW, Ginsberg MH, Shattil SJ, Deckmyn H, Schwartz MA.

Mol Biol Cell. 2006 Nov;17(11):4686-97. Epub 2006 Aug 23.

47.

A role for PKCtheta in outside-in alpha(IIb)beta3 signaling.

Soriani A, Moran B, de Virgilio M, Kawakami T, Altman A, Lowell C, Eto K, Shattil SJ.

J Thromb Haemost. 2006 Mar;4(3):648-55.

48.

Megakaryocytes derived from human embryonic stem cells: a genetically tractable system to study megakaryocytopoiesis and integrin function.

Gaur M, Kamata T, Wang S, Moran B, Shattil SJ, Leavitt AD.

J Thromb Haemost. 2006 Feb;4(2):436-42.

49.

Amino acid changes in Drosophila alphaPS2betaPS integrins that affect ligand affinity.

Bunch TA, Helsten TL, Kendall TL, Shirahatti N, Mahadevan D, Shattil SJ, Brower DL.

J Biol Chem. 2006 Feb 24;281(8):5050-7. Epub 2005 Dec 21.

50.

PTP-1B is an essential positive regulator of platelet integrin signaling.

Arias-Salgado EG, Haj F, Dubois C, Moran B, Kasirer-Friede A, Furie BC, Furie B, Neel BG, Shattil SJ.

J Cell Biol. 2005 Aug 29;170(5):837-45. Epub 2005 Aug 22.

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