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Items: 1 to 50 of 143

1.

ELK1 has a dual activating and repressive role in human embryonic stem cells.

Prise I, Sharrocks AD.

Version 2. Wellcome Open Res. 2019 Jul 5 [revised 2019 Jan 1];4:41. doi: 10.12688/wellcomeopenres.15091.2. eCollection 2019.

2.

Geno2proteo, a Tool for Batch Retrieval of DNA and Protein Sequences from Any Genomic or Protein Regions.

Li Y, Aguilar-Martinez E, Sharrocks AD.

J Integr Bioinform. 2019 Jul 13;16(3). pii: /j/jib.2019.16.issue-3/jib-2018-0090/jib-2018-0090.xml. doi: 10.1515/jib-2018-0090.

3.

ZIC3 Controls the Transition from Naive to Primed Pluripotency.

Yang SH, Andrabi M, Biss R, Murtuza Baker S, Iqbal M, Sharrocks AD.

Cell Rep. 2019 Jun 11;27(11):3215-3227.e6. doi: 10.1016/j.celrep.2019.05.026.

4.

Identification of a primitive intestinal transcription factor network shared between esophageal adenocarcinoma and its precancerous precursor state.

Rogerson C, Britton E, Withey S, Hanley N, Ang YS, Sharrocks AD.

Genome Res. 2019 May;29(5):723-736. doi: 10.1101/gr.243345.118. Epub 2019 Apr 8.

5.

FOXK2 Transcription Factor and Its Emerging Roles in Cancer.

Nestal de Moraes G, Carneiro LDT, Maia RC, Lam EW, Sharrocks AD.

Cancers (Basel). 2019 Mar 20;11(3). pii: E393. doi: 10.3390/cancers11030393. Review.

6.

Author Correction: Authentication and characterisation of a new oesophageal adenocarcinoma cell line: MFD-1.

Garcia E, Hayden A, Birts C, Britton E, Rogerson C, Bleaney CW, Cowie A, Pickard K, Mellone M, Choh C, Derouet M, Duriez P, Noble F, White MJ, Primrose JN, Strefford JC, Rose-Zerilli M, Thomas GJ, Ang Y, Sharrocks AD, Fitzgerald RC, Underwood TJ; OCCAMS consortium.

Sci Rep. 2019 Jan 22;9(1):318. doi: 10.1038/s41598-018-37591-7.

7.

Classifying cells with Scasat, a single-cell ATAC-seq analysis tool.

Baker SM, Rogerson C, Hayes A, Sharrocks AD, Rattray M.

Nucleic Acids Res. 2019 Jan 25;47(2):e10. doi: 10.1093/nar/gky950.

8.

SUMOylation modulates FOXK2-mediated paclitaxel sensitivity in breast cancer cells.

Nestal de Moraes G, Ji Z, Fan LY, Yao S, Zona S, Sharrocks AD, Lam EW.

Oncogenesis. 2018 Mar 13;7(3):29. doi: 10.1038/s41389-018-0038-6.

9.

Open chromatin profiling identifies AP1 as a transcriptional regulator in oesophageal adenocarcinoma.

Britton E, Rogerson C, Mehta S, Li Y, Li X; OCCAMS consortium, Fitzgerald RC, Ang YS, Sharrocks AD.

PLoS Genet. 2017 Aug 31;13(8):e1006879. doi: 10.1371/journal.pgen.1006879. eCollection 2017 Aug.

10.

EINCR1 is an EGF inducible lincRNA overexpressed in lung adenocarcinomas.

Nowicki-Osuch K, Li Y, Challinor M, Gerrard DT, Hanley NA, Sharrocks AD.

PLoS One. 2017 Jul 21;12(7):e0181902. doi: 10.1371/journal.pone.0181902. eCollection 2017.

11.

RNF4 interacts with multiSUMOylated ETV4.

Aguilar-Martinez E, Guo B, Sharrocks AD.

Wellcome Open Res. 2017 Feb 17;1:3. doi: 10.12688/wellcomeopenres.9935.2. eCollection 2016.

12.

The Use of Multimeric Protein Scaffolds for Identifying Multi-SUMO Binding Proteins.

Aguilar-Martínez E, Sharrocks AD.

Methods Mol Biol. 2016;1475:195-204. doi: 10.1007/978-1-4939-6358-4_14.

PMID:
27631807
13.

Authentication and characterisation of a new oesophageal adenocarcinoma cell line: MFD-1.

Garcia E, Hayden A, Birts C, Britton E, Cowie A, Pickard K, Mellone M, Choh C, Derouet M, Duriez P, Noble F, White MJ, Primrose JN, Strefford JC, Rose-Zerilli M, Thomas GJ, Ang Y, Sharrocks AD, Fitzgerald RC, Underwood TJ; OCCAMS consortium.

Sci Rep. 2016 Sep 7;6:32417. doi: 10.1038/srep32417. Erratum in: Sci Rep. 2019 Jan 22;9(1):318.

14.

Erratum to: 'Deregulation of the FOXM1 target gene network and its coregulatory partners in oesophageal adenocarcinoma'.

Wiseman EF, Chen X, Han N, Webber A, Ji Z, Sharrocks AD, Ang YS.

Mol Cancer. 2016 Mar 2;15:21. doi: 10.1186/s12943-016-0506-6. No abstract available.

15.

Jun-Mediated Changes in Cell Adhesion Contribute to Mouse Embryonic Stem Cell Exit from Ground State Pluripotency.

Veluscek G, Li Y, Yang SH, Sharrocks AD.

Stem Cells. 2016 May;34(5):1213-24. doi: 10.1002/stem.2294. Epub 2016 Feb 13.

16.

Genome-wide binding studies reveal DNA binding specificity mechanisms and functional interplay amongst Forkhead transcription factors.

Chen X, Ji Z, Webber A, Sharrocks AD.

Nucleic Acids Res. 2016 Feb 29;44(4):1566-78. doi: 10.1093/nar/gkv1120. Epub 2015 Nov 17.

17.

FOXM1 and polo-like kinase 1 are co-ordinately overexpressed in patients with gastric adenocarcinomas.

Dibb M, Han N, Choudhury J, Hayes S, Valentine H, West C, Sharrocks AD, Ang YS.

BMC Res Notes. 2015 Nov 14;8:676. doi: 10.1186/s13104-015-1658-y.

18.

Protein kinase C coordinates histone H3 phosphorylation and acetylation.

Darieva Z, Webber A, Warwood S, Sharrocks AD.

Elife. 2015 Oct 15;4:e09886. doi: 10.7554/eLife.09886.

19.

JNK-associated Leucine Zipper Protein Functions as a Docking Platform for Polo-like Kinase 1 and Regulation of the Associating Transcription Factor Forkhead Box Protein K1.

Ramkumar P, Lee CM, Moradian A, Sweredoski MJ, Hess S, Sharrocks AD, Haines DS, Reddy EP.

J Biol Chem. 2015 Dec 4;290(49):29617-28. doi: 10.1074/jbc.M115.664649. Epub 2015 Oct 14.

20.

Forkhead box K2 modulates epirubicin and paclitaxel sensitivity through FOXO3a in breast cancer.

Nestal de Moraes G, Khongkow P, Gong C, Yao S, Gomes AR, Ji Z, Kandola N, Delbue D, Man EP, Khoo US, Sharrocks AD, Lam EW.

Oncogenesis. 2015 Sep 7;4:e167. doi: 10.1038/oncsis.2015.26.

21.

Screen for multi-SUMO-binding proteins reveals a multi-SIM-binding mechanism for recruitment of the transcriptional regulator ZMYM2 to chromatin.

Aguilar-Martinez E, Chen X, Webber A, Mould AP, Seifert A, Hay RT, Sharrocks AD.

Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):E4854-63. doi: 10.1073/pnas.1509716112. Epub 2015 Aug 17.

22.

Deregulation of the FOXM1 target gene network and its coregulatory partners in oesophageal adenocarcinoma.

Wiseman EF, Chen X, Han N, Webber A, Ji Z, Sharrocks AD, Ang YS.

Mol Cancer. 2015 Mar 26;14:69. doi: 10.1186/s12943-015-0339-8. Erratum in: Mol Cancer. 2016;15:21.

23.

The ubiquitin ligase UBE3A dampens ERK pathway signalling in HPV E6 transformed HeLa cells.

Aguilar-Martinez E, Morrisroe C, Sharrocks AD.

PLoS One. 2015 Mar 27;10(3):e0119366. doi: 10.1371/journal.pone.0119366. eCollection 2015.

24.

Changing partners: transcription factors form different complexes on and off chromatin.

Ji Z, Sharrocks AD.

Mol Syst Biol. 2015 Jan 21;11(1):782. doi: 10.15252/msb.20145936. No abstract available.

25.

Otx2 and Oct4 drive early enhancer activation during embryonic stem cell transition from naive pluripotency.

Yang SH, Kalkan T, Morissroe C, Marks H, Stunnenberg H, Smith A, Sharrocks AD.

Cell Rep. 2014 Jun 26;7(6):1968-81. doi: 10.1016/j.celrep.2014.05.037. Epub 2014 Jun 12.

26.

The forkhead transcription factor FOXK2 acts as a chromatin targeting factor for the BAP1-containing histone deubiquitinase complex.

Ji Z, Mohammed H, Webber A, Ridsdale J, Han N, Carroll JS, Sharrocks AD.

Nucleic Acids Res. 2014 Jun;42(10):6232-42. doi: 10.1093/nar/gku274. Epub 2014 Apr 19.

27.

WDR5, ASH2L, and RBBP5 control the efficiency of FOS transcript processing.

Teoh PL, Sharrocks AD.

Cell Mol Biol Lett. 2014 Jun;19(2):215-32. doi: 10.2478/s11658-014-0190-8. Epub 2014 Apr 9.

28.

MBD5 and MBD6 interact with the human PR-DUB complex through their methyl-CpG-binding domain.

Baymaz HI, Fournier A, Laget S, Ji Z, Jansen PW, Smits AH, Ferry L, Mensinga A, Poser I, Sharrocks A, Defossez PA, Vermeulen M.

Proteomics. 2014 Oct;14(19):2179-89. doi: 10.1002/pmic.201400013. Epub 2014 Apr 24.

PMID:
24634419
29.

PARP1 orchestrates variant histone exchange in signal-mediated transcriptional activation.

O'Donnell A, Yang SH, Sharrocks AD.

EMBO Rep. 2013 Dec;14(12):1084-91. doi: 10.1038/embor.2013.164. Epub 2013 Oct 22.

30.

Lre1 directly inhibits the NDR/Lats kinase Cbk1 at the cell division site in a phosphorylation-dependent manner.

Mancini Lombardi I, Palani S, Meitinger F, Darieva Z, Hofmann A, Sharrocks AD, Pereira G.

Curr Biol. 2013 Sep 23;23(18):1736-45. doi: 10.1016/j.cub.2013.07.032. Epub 2013 Aug 15.

31.

Ubc9 acetylation: a new route for achieving specificity in substrate SUMOylation.

Yang SH, Sharrocks AD.

EMBO J. 2013 Mar 20;32(6):773-4. doi: 10.1038/emboj.2013.21. Epub 2013 Feb 8. No abstract available.

32.

The ETS transcription factors ELK1 and GABPA regulate different gene networks to control MCF10A breast epithelial cell migration.

Odrowaz Z, Sharrocks AD.

PLoS One. 2012;7(12):e49892. doi: 10.1371/journal.pone.0049892. Epub 2012 Dec 20.

33.

A genome-wide RNAi screen reveals MAP kinase phosphatases as key ERK pathway regulators during embryonic stem cell differentiation.

Yang SH, Kalkan T, Morrisroe C, Smith A, Sharrocks AD.

PLoS Genet. 2012;8(12):e1003112. doi: 10.1371/journal.pgen.1003112. Epub 2012 Dec 13.

34.

MAP kinase signalling cascades and transcriptional regulation.

Yang SH, Sharrocks AD, Whitmarsh AJ.

Gene. 2013 Jan 15;513(1):1-13. doi: 10.1016/j.gene.2012.10.033. Epub 2012 Nov 1. Review.

PMID:
23123731
35.

The forkhead transcription factor FOXM1 controls cell cycle-dependent gene expression through an atypical chromatin binding mechanism.

Chen X, Müller GA, Quaas M, Fischer M, Han N, Stutchbury B, Sharrocks AD, Engeland K.

Mol Cell Biol. 2013 Jan;33(2):227-36. doi: 10.1128/MCB.00881-12. Epub 2012 Oct 29.

36.

The FOXM1-PLK1 axis is commonly upregulated in oesophageal adenocarcinoma.

Dibb M, Han N, Choudhury J, Hayes S, Valentine H, West C, Ang YS, Sharrocks AD.

Br J Cancer. 2012 Nov 6;107(10):1766-75. doi: 10.1038/bjc.2012.424. Epub 2012 Oct 4.

37.

Protein kinase C regulates late cell cycle-dependent gene expression.

Darieva Z, Han N, Warwood S, Doris KS, Morgan BA, Sharrocks AD.

Mol Cell Biol. 2012 Nov;32(22):4651-61. doi: 10.1128/MCB.06000-11. Epub 2012 Sep 10.

38.

ELK1 uses different DNA binding modes to regulate functionally distinct classes of target genes.

Odrowaz Z, Sharrocks AD.

PLoS Genet. 2012;8(5):e1002694. doi: 10.1371/journal.pgen.1002694. Epub 2012 May 10.

39.

Osteopontin is a novel downstream target of SOX9 with diagnostic implications for progression of liver fibrosis in humans.

Pritchett J, Harvey E, Athwal V, Berry A, Rowe C, Oakley F, Moles A, Mann DA, Bobola N, Sharrocks AD, Thomson BJ, Zaitoun AM, Irving WL, Guha IN, Hanley NA, Hanley KP.

Hepatology. 2012 Sep;56(3):1108-16. doi: 10.1002/hep.25758.

40.

Immediate-early gene activation by the MAPK pathways: what do and don't we know?

O'Donnell A, Odrowaz Z, Sharrocks AD.

Biochem Soc Trans. 2012 Feb;40(1):58-66. doi: 10.1042/BST20110636. Review.

PMID:
22260666
41.

The forkhead transcription factor FOXK2 promotes AP-1-mediated transcriptional regulation.

Ji Z, Donaldson IJ, Liu J, Hayes A, Zeef LA, Sharrocks AD.

Mol Cell Biol. 2012 Jan;32(2):385-98. doi: 10.1128/MCB.05504-11. Epub 2011 Nov 14. Erratum in: Mol Cell Biol. 2014 May;34(10):1892.

42.

PEA3/ETV4-related transcription factors coupled with active ERK signalling are associated with poor prognosis in gastric adenocarcinoma.

Keld R, Guo B, Downey P, Cummins R, Gulmann C, Ang YS, Sharrocks AD.

Br J Cancer. 2011 Jun 28;105(1):124-30. doi: 10.1038/bjc.2011.187. Epub 2011 Jun 14.

43.

Dynamic modification of the ETS transcription factor PEA3 by sumoylation and p300-mediated acetylation.

Guo B, Panagiotaki N, Warwood S, Sharrocks AD.

Nucleic Acids Res. 2011 Aug;39(15):6403-13. doi: 10.1093/nar/gkr267. Epub 2011 May 4.

44.

ETS-domain transcription factor Elk-1 mediates neuronal survival: SMN as a potential target.

Demir O, Aysit N, Onder Z, Turkel N, Ozturk G, Sharrocks AD, Kurnaz IA.

Biochim Biophys Acta. 2011 Jun;1812(6):652-62. doi: 10.1016/j.bbadis.2011.02.012. Epub 2011 Mar 17.

45.

A homeodomain transcription factor regulates the DNA replication checkpoint in yeast.

Purtill FS, Whitehall SK, Williams ES, McInerny CJ, Sharrocks AD, Morgan BA.

Cell Cycle. 2011 Feb 15;10(4):664-70. Epub 2011 Feb 15.

46.

The ERK MAP kinase-PEA3/ETV4-MMP-1 axis is operative in oesophageal adenocarcinoma.

Keld R, Guo B, Downey P, Gulmann C, Ang YS, Sharrocks AD.

Mol Cancer. 2010 Dec 9;9:313. doi: 10.1186/1476-4598-9-313.

47.

MAP Kinase: SUMO pathway interactions.

Yang SH, Sharrocks AD.

Methods Mol Biol. 2010;661:343-67. doi: 10.1007/978-1-60761-795-2_21.

PMID:
20811994
48.

Cell cycle-dependent regulation of the forkhead transcription factor FOXK2 by CDK·cyclin complexes.

Marais A, Ji Z, Child ES, Krause E, Mann DJ, Sharrocks AD.

J Biol Chem. 2010 Nov 12;285(46):35728-39. doi: 10.1074/jbc.M110.154005. Epub 2010 Sep 1.

49.

Emerging roles of SUMO modification in arthritis.

Yan D, Davis FJ, Sharrocks AD, Im HJ.

Gene. 2010 Oct 15;466(1-2):1-15. doi: 10.1016/j.gene.2010.07.003. Epub 2010 Jul 11. Review.

50.

A competitive transcription factor binding mechanism determines the timing of late cell cycle-dependent gene expression.

Darieva Z, Clancy A, Bulmer R, Williams E, Pic-Taylor A, Morgan BA, Sharrocks AD.

Mol Cell. 2010 Apr 9;38(1):29-40. doi: 10.1016/j.molcel.2010.02.030.

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