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Autologous haematopoietic stem cell therapy for multiple sclerosis: a review for supportive care clinicians on behalf of the Autoimmune Diseases Working Party of the European Society for Blood and Marrow Transplantation.

Ismail A, Sharrack B, Saccardi R, Moore JJ, Snowden JA.

Curr Opin Support Palliat Care. 2019 Oct 9. doi: 10.1097/SPC.0000000000000466. [Epub ahead of print]


Reduced Myelin Signal in Normal-appearing White Matter in Neuromyelitis Optica Measured by 7T Magnetic Resonance Imaging.

Chou IJ, Tanasescu R, Mougin OE, Gowland PA, Tench CR, Whitehouse WP, Gran B, Nikfekr E, Sharrack B, Mazibrada G, Constantinescu CS.

Sci Rep. 2019 Oct 7;9(1):14378. doi: 10.1038/s41598-019-50928-0.


Autologous haematopoietic stem cell transplantation and other cellular therapy in multiple sclerosis and immune-mediated neurological diseases: updated guidelines and recommendations from the EBMT Autoimmune Diseases Working Party (ADWP) and the Joint Accreditation Committee of EBMT and ISCT (JACIE).

Sharrack B, Saccardi R, Alexander T, Badoglio M, Burman J, Farge D, Greco R, Jessop H, Kazmi M, Kirgizov K, Labopin M, Mancardi G, Martin R, Moore J, Muraro PA, Rovira M, Sormani MP, Snowden JA; European Society for Blood and Marrow Transplantation (EBMT) Autoimmune Diseases Working Party (ADWP) and the Joint Accreditation Committee of the International Society for Cellular Therapy (ISCT) and EBMT (JACIE).

Bone Marrow Transplant. 2019 Sep 26. doi: 10.1038/s41409-019-0684-0. [Epub ahead of print]


Multiple brain networks support processing speed abilities of patients with multiple sclerosis.

Manca R, Mitolo M, Stabile MR, Bevilacqua F, Sharrack B, Venneri A.

Postgrad Med. 2019 Sep;131(7):523-532. doi: 10.1080/00325481.2019.1663706. Epub 2019 Sep 16.


Cognitive speed and white matter integrity in secondary progressive multiple sclerosis.

Manca R, Stabile MR, Bevilacqua F, Cadorin C, Piccione F, Sharrack B, Venneri A.

Mult Scler Relat Disord. 2019 May;30:198-207. doi: 10.1016/j.msard.2019.02.021. Epub 2019 Feb 17.


Do Optic Canal Dimensions Measured on CT Influence the Degree of Papilloedema and Visual Dysfunction in Idiopathic Intracranial Hypertension?

Skipper NT, Igra MS, Littlewood R, Armitage P, Laud PJ, Mollan SP, Sharrack B, Pepper IM, Batty R, Connolly DJA, Hickman SJ.

Neuroophthalmology. 2018 Jun 26;43(1):3-9. doi: 10.1080/01658107.2018.1483406. eCollection 2019 Feb.


General information for patients and carers considering haematopoietic stem cell transplantation (HSCT) for severe autoimmune diseases (ADs): A position statement from the EBMT Autoimmune Diseases Working Party (ADWP), the EBMT Nurses Group, the EBMT Patient, Family and Donor Committee and the Joint Accreditation Committee of ISCT and EBMT (JACIE).

Jessop H, Farge D, Saccardi R, Alexander T, Rovira M, Sharrack B, Greco R, Wulffraat N, Moore J, Kazmi M, Badoglio M, Adams G, Verhoeven B, Murray J, Snowden JA.

Bone Marrow Transplant. 2019 Jul;54(7):933-942. doi: 10.1038/s41409-019-0430-7. Epub 2019 Jan 31. Review.


Effect of Nonmyeloablative Hematopoietic Stem Cell Transplantation vs Continued Disease-Modifying Therapy on Disease Progression in Patients With Relapsing-Remitting Multiple Sclerosis: A Randomized Clinical Trial.

Burt RK, Balabanov R, Burman J, Sharrack B, Snowden JA, Oliveira MC, Fagius J, Rose J, Nelson F, Barreira AA, Carlson K, Han X, Moraes D, Morgan A, Quigley K, Yaung K, Buckley R, Alldredge C, Clendenan A, Calvario MA, Henry J, Jovanovic B, Helenowski IB.

JAMA. 2019 Jan 15;321(2):165-174. doi: 10.1001/jama.2018.18743.


Capecitabine leukoencephalopathy.

Yasiry Z, Obeda MS, Batty R, Sharrack B.

Pract Neurol. 2019 Jun;19(3):270-271. doi: 10.1136/practneurol-2018-002121. Epub 2019 Jan 5. No abstract available.


Novel genotype-phenotype and MRI correlations in a large cohort of patients with SPG7 mutations.

Hewamadduma CA, Hoggard N, O'Malley R, Robinson MK, Beauchamp NJ, Segamogaite R, Martindale J, Rodgers T, Rao G, Sarrigiannis P, Shanmugarajah P, Zis P, Sharrack B, McDermott CJ, Shaw PJ, Hadjivassiliou M.

Neurol Genet. 2018 Oct 24;4(6):e279. doi: 10.1212/NXG.0000000000000279. eCollection 2018 Dec. Erratum in: Neurol Genet. 2018 Dec 03;4(6):e300.


Animal models of multiple sclerosis: From rodents to zebrafish.

Burrows DJ, McGown A, Jain SA, De Felice M, Ramesh TM, Sharrack B, Majid A.

Mult Scler. 2019 Mar;25(3):306-324. doi: 10.1177/1352458518805246. Epub 2018 Oct 15.


Multiple Sclerosis-Secondary Progressive Multi-Arm Randomisation Trial (MS-SMART): a multiarm phase IIb randomised, double-blind, placebo-controlled clinical trial comparing the efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis.

Connick P, De Angelis F, Parker RA, Plantone D, Doshi A, John N, Stutters J, MacManus D, Prados Carrasco F, Barkhof F, Ourselin S, Braisher M, Ross M, Cranswick G, Pavitt SH, Giovannoni G, Gandini Wheeler-Kingshott CA, Hawkins C, Sharrack B, Bastow R, Weir CJ, Stallard N, Chandran S, Chataway J; UK Multiple Sclerosis Society Clinical Trials Network.

BMJ Open. 2018 Aug 30;8(8):e021944. doi: 10.1136/bmjopen-2018-021944.


Epstein Barr virus shedding in multiple sclerosis: Similar frequencies of EBV in saliva across separate patient cohorts.

Holden DW, Gold J, Hawkes CH, Giovannoni G, Saxton JM, Carter A, Sharrack B.

Mult Scler Relat Disord. 2018 Oct;25:197-199. doi: 10.1016/j.msard.2018.07.041. Epub 2018 Jul 27.


Autologous haematopoietic stem cell transplantation (aHSCT) for severe resistant autoimmune and inflammatory diseases - a guide for the generalist.

Snowden JA, Sharrack B, Akil M, Kiely DG, Lobo A, Kazmi M, Muraro PA, Lindsay JO.

Clin Med (Lond). 2018 Aug;18(4):329-334. doi: 10.7861/clinmedicine.18-4-329.


Characterisation of tissue-type metabolic content in secondary progressive multiple sclerosis: a magnetic resonance spectroscopic imaging study.

Marshall I, Thrippleton MJ, Bastin ME, Mollison D, Dickie DA, Chappell FM, Semple SIK, Cooper A, Pavitt S, Giovannoni G, Wheeler-Kingshott CAMG, Solanky BS, Weir CJ, Stallard N, Hawkins C, Sharrack B, Chataway J, Connick P, Chandran S; MS-SMART Trialists.

J Neurol. 2018 Aug;265(8):1795-1802. doi: 10.1007/s00415-018-8903-y. Epub 2018 May 30.


Brain connectivity and cognitive processing speed in multiple sclerosis: A systematic review.

Manca R, Sharrack B, Paling D, Wilkinson ID, Venneri A.

J Neurol Sci. 2018 May 15;388:115-127. doi: 10.1016/j.jns.2018.03.003. Epub 2018 Mar 2.


Effects of ATX-MS-1467 immunotherapy over 16 weeks in relapsing multiple sclerosis.

Chataway J, Martin K, Barrell K, Sharrack B, Stolt P, Wraith DC; ATX-MS1467 Study Group.

Neurology. 2018 Mar 13;90(11):e955-e962. doi: 10.1212/WNL.0000000000005118. Epub 2018 Feb 21.


Gold nanoparticle-based colorimetric biosensors.

Aldewachi H, Chalati T, Woodroofe MN, Bricklebank N, Sharrack B, Gardiner P.

Nanoscale. 2017 Dec 21;10(1):18-33. doi: 10.1039/c7nr06367a. Review.


Blogs cannot separate wheat from chaff.

Burt RK, Snowden JA, Burman J, Oliveira MC, Sharrack B.

Science. 2017 Nov 3;358(6363):602. doi: 10.1126/science.aar2575. No abstract available.


Qualitative Investigation of Exercise Perceptions and Experiences in People With Multiple Sclerosis Before, During, and After Participation in a Personally Tailored Exercise Program.

Crank H, Carter A, Humphreys L, Snowdon N, Daley A, Woodroofe N, Sharrack B, Petty J, Saxton JM.

Arch Phys Med Rehabil. 2017 Dec;98(12):2520-2525. doi: 10.1016/j.apmr.2017.05.022. Epub 2017 Jun 22.


MiR-126 and miR-126* regulate shear-resistant firm leukocyte adhesion to human brain endothelium.

Cerutti C, Edwards LJ, de Vries HE, Sharrack B, Male DK, Romero IA.

Sci Rep. 2017 Mar 30;7:45284. doi: 10.1038/srep45284.


Gene expression profiling of the astrocyte transcriptome in multiple sclerosis normal appearing white matter reveals a neuroprotective role.

Waller R, Woodroofe MN, Wharton SB, Ince PG, Francese S, Heath PR, Cudzich-Madry A, Thomas RH, Rounding N, Sharrack B, Simpson JE.

J Neuroimmunol. 2016 Oct 15;299:139-146. doi: 10.1016/j.jneuroim.2016.09.010. Epub 2016 Sep 14.


Autologous hematopoietic cell transplantation in multiple sclerosis.

Bell SM, Sharrack B, Snowden JA.

Expert Opin Biol Ther. 2017 Jan;17(1):77-86. Epub 2016 Oct 14. Review.


Transport of Gold Nanoparticles by Vascular Endothelium from Different Human Tissues.

Gromnicova R, Kaya M, Romero IA, Williams P, Satchell S, Sharrack B, Male D.

PLoS One. 2016 Aug 25;11(8):e0161610. doi: 10.1371/journal.pone.0161610. eCollection 2016.


Haematopoietic stem cell transplantation in autoimmune diseases: From basic science to clinical practice.

Kelsey PJ, Oliveira MC, Badoglio M, Sharrack B, Farge D, Snowden JA.

Curr Res Transl Med. 2016 Apr-Jun;64(2):71-82. doi: 10.1016/j.retram.2016.03.003. Epub 2016 May 31. Review.


MicroRNA-155 contributes to shear-resistant leukocyte adhesion to human brain endothelium in vitro.

Cerutti C, Soblechero-Martin P, Wu D, Lopez-Ramirez MA, de Vries H, Sharrack B, Male DK, Romero IA.

Fluids Barriers CNS. 2016 May 31;13(1):8. doi: 10.1186/s12987-016-0032-3.


Deficiency in the mRNA export mediator Gle1 impairs Schwann cell development in the zebrafish embryo.

Seytanoglu A, Alsomali NI, Valori CF, McGown A, Kim HR, Ning K, Ramesh T, Sharrack B, Wood JD, Azzouz M.

Neuroscience. 2016 May 13;322:287-97. doi: 10.1016/j.neuroscience.2016.02.039. Epub 2016 Feb 24.


Localization and mobility of glucose-coated gold nanoparticles within the brain.

Gromnicova R, Yilmaz CU, Orhan N, Kaya M, Davies H, Williams P, Romero IA, Sharrack B, Male D.

Nanomedicine (Lond). 2016 Mar;11(6):617-25. doi: 10.2217/nnm.15.215. Epub 2016 Feb 25.


Phenytoin for neuroprotection in patients with acute optic neuritis: a randomised, placebo-controlled, phase 2 trial.

Raftopoulos R, Hickman SJ, Toosy A, Sharrack B, Mallik S, Paling D, Altmann DR, Yiannakas MC, Malladi P, Sheridan R, Sarrigiannis PG, Hoggard N, Koltzenburg M, Gandini Wheeler-Kingshott CA, Schmierer K, Giovannoni G, Miller DH, Kapoor R.

Lancet Neurol. 2016 Mar;15(3):259-69. doi: 10.1016/S1474-4422(16)00004-1. Epub 2016 Jan 26.


Participant recruitment into a randomised controlled trial of exercise therapy for people with multiple sclerosis.

Carter A, Humphreys L, Snowdon N, Sharrack B, Daley A, Petty J, Woodroofe N, Saxton J.

Trials. 2015 Oct 15;16:468. doi: 10.1186/s13063-015-0996-3.


Cognitive rehabilitation in multiple sclerosis: A systematic review.

Mitolo M, Venneri A, Wilkinson ID, Sharrack B.

J Neurol Sci. 2015 Jul 15;354(1-2):1-9. doi: 10.1016/j.jns.2015.05.004. Epub 2015 May 9. Review.


Association of nonmyeloablative hematopoietic stem cell transplantation with neurological disability in patients with relapsing-remitting multiple sclerosis.

Burt RK, Balabanov R, Han X, Sharrack B, Morgan A, Quigley K, Yaung K, Helenowski IB, Jovanovic B, Spahovic D, Arnautovic I, Lee DC, Benefield BC, Futterer S, Oliveira MC, Burman J.

JAMA. 2015 Jan 20;313(3):275-84. doi: 10.1001/jama.2014.17986.


Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation.

Wu D, Cerutti C, Lopez-Ramirez MA, Pryce G, King-Robson J, Simpson JE, van der Pol SM, Hirst MC, de Vries HE, Sharrack B, Baker D, Male DK, Michael GJ, Romero IA.

J Cereb Blood Flow Metab. 2015 Mar;35(3):412-23. doi: 10.1038/jcbfm.2014.207. Epub 2014 Dec 17.


We can compare the relative efficacy of multiple sclerosis medications by examining the results of independent clinical trials: yes.

Dahdaleh D, Sharrack B.

Mult Scler. 2015 Jan;21(1):35-6. doi: 10.1177/1352458514558678. Epub 2014 Nov 12. No abstract available.


Visual Outcomes from Shunting for Idiopathic Intracranial Hypertension.

Hickman SJ, Raoof N, Panesar H, McMullan JM, Pepper IM, Sharrack B.

Neuroophthalmology. 2014 Nov 12;38(6):310-319. eCollection 2014.


PTEN depletion decreases disease severity and modestly prolongs survival in a mouse model of spinal muscular atrophy.

Little D, Valori CF, Mutsaers CA, Bennett EJ, Wyles M, Sharrack B, Shaw PJ, Gillingwater TH, Azzouz M, Ning K.

Mol Ther. 2015 Feb;23(2):270-7. doi: 10.1038/mt.2014.209. Epub 2014 Nov 5.


MicroRNA-155 negatively affects blood-brain barrier function during neuroinflammation.

Lopez-Ramirez MA, Wu D, Pryce G, Simpson JE, Reijerkerk A, King-Robson J, Kay O, de Vries HE, Hirst MC, Sharrack B, Baker D, Male DK, Michael GJ, Romero IA.

FASEB J. 2014 Jun;28(6):2551-65. doi: 10.1096/fj.13-248880. Epub 2014 Mar 6.


Cost effectiveness of a pragmatic exercise intervention (EXIMS) for people with multiple sclerosis: economic evaluation of a randomised controlled trial.

Tosh J, Dixon S, Carter A, Daley A, Petty J, Roalfe A, Sharrack B, Saxton JM.

Mult Scler. 2014 Jul;20(8):1123-30. doi: 10.1177/1352458513515958. Epub 2014 Jan 13.


Pragmatic intervention for increasing self-directed exercise behaviour and improving important health outcomes in people with multiple sclerosis: a randomised controlled trial.

Carter A, Daley A, Humphreys L, Snowdon N, Woodroofe N, Petty J, Roalfe A, Tosh J, Sharrack B, Saxton JM.

Mult Scler. 2014 Jul;20(8):1112-22. doi: 10.1177/1352458513519354. Epub 2014 Jan 13.


Increased levels of interleukins 2 and 17 in the cerebrospinal fluid of patients with idiopathic intracranial hypertension.

Edwards LJ, Sharrack B, Ismail A, Tench CR, Gran B, Dhungana S, Brettschneider J, Tumani H, Constantinescu CS.

Am J Clin Exp Immunol. 2013 Oct 16;2(3):234-44. eCollection 2013.


Cytokine-induced changes in the gene expression profile of a human cerebral microvascular endothelial cell-line, hCMEC/D3.

Lopez-Ramirez MA, Male DK, Wang C, Sharrack B, Wu D, Romero IA.

Fluids Barriers CNS. 2013 Sep 19;10(1):27. doi: 10.1186/2045-8118-10-27.


Pragmatic exercise intervention in people with mild to moderate multiple sclerosis: a randomised controlled feasibility study.

Carter AM, Daley AJ, Kesterton SW, Woodroofe NM, Saxton JM, Sharrack B.

Contemp Clin Trials. 2013 Jul;35(2):40-7. doi: 10.1016/j.cct.2013.04.003. Epub 2013 Apr 21.


A genetic study of Wilson's disease in the United Kingdom.

Coffey AJ, Durkie M, Hague S, McLay K, Emmerson J, Lo C, Klaffke S, Joyce CJ, Dhawan A, Hadzic N, Mieli-Vergani G, Kirk R, Elizabeth Allen K, Nicholl D, Wong S, Griffiths W, Smithson S, Giffin N, Taha A, Connolly S, Gillett GT, Tanner S, Bonham J, Sharrack B, Palotie A, Rattray M, Dalton A, Bandmann O.

Brain. 2013 May;136(Pt 5):1476-87. doi: 10.1093/brain/awt035. Epub 2013 Mar 21.


Wegener's granulomatosis presenting with multiple cranial nerve palsies and pachymeningitis.

Iqbal AM, Blackburn D, Rafiq M, Sharrack B.

Pract Neurol. 2013 Jun;13(3):193-5. doi: 10.1136/practneurol-2012-000340. Epub 2013 Mar 13. No abstract available.


Autologous hematopoietic stem cell transplantation following pulsed cyclophosphamide in a severely disabled patient with malignant multiple sclerosis.

Alix JJ, Blackburn DJ, Sokhi D, Craven I, Sharrack B, Snowden JA.

J Neurol. 2013 Mar;260(3):914-6. doi: 10.1007/s00415-012-6796-8. Epub 2012 Dec 27. No abstract available.


Pragmatic exercise intervention for people with multiple sclerosis (ExIMS trial): study protocol for a randomised controlled trial.

Saxton JM, Carter A, Daley AJ, Snowdon N, Woodroofe MN, Petty J, Roalfe A, Tosh J, Sharrack B.

Contemp Clin Trials. 2013 Mar;34(2):205-11. doi: 10.1016/j.cct.2012.10.011. Epub 2012 Nov 1.


Concurrence of multiple sclerosis and amyotrophic lateral sclerosis in patients with hexanucleotide repeat expansions of C9ORF72.

Ismail A, Cooper-Knock J, Highley JR, Milano A, Kirby J, Goodall E, Lowe J, Scott I, Constantinescu CS, Walters SJ, Price S, McDermott CJ, Sawcer S, Compston DA, Sharrack B, Shaw PJ.

J Neurol Neurosurg Psychiatry. 2013 Jan;84(1):79-87. doi: 10.1136/jnnp-2012-303326. Epub 2012 Oct 20.


Role of caspases in cytokine-induced barrier breakdown in human brain endothelial cells.

Lopez-Ramirez MA, Fischer R, Torres-Badillo CC, Davies HA, Logan K, Pfizenmaier K, Male DK, Sharrack B, Romero IA.

J Immunol. 2012 Sep 15;189(6):3130-9. doi: 10.4049/jimmunol.1103460. Epub 2012 Aug 15.

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