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Items: 1 to 50 of 319

1.

Concomitant phytonutrient and transcriptome analysis of mature fruit and leaf tissues of tomato (Solanum lycopersicum L. cv. Oregon Spring) grown using organic and conventional fertilizer.

Sharpe RM, Gustafson L, Hewitt S, Kilian B, Crabb J, Hendrickson C, Jiwan D, Andrews P, Dhingra A.

PLoS One. 2020 Jan 13;15(1):e0227429. doi: 10.1371/journal.pone.0227429. eCollection 2020.

2.

Publisher Correction: Dibutyl phthalate induced testicular dysgenesis originates after seminiferous cord formation in rats.

Lara NLM, van den Driesche S, Macpherson S, França LR, Sharpe RM.

Sci Rep. 2019 Oct 28;9(1):15436. doi: 10.1038/s41598-019-43786-3.

3.

Long-term exposure to chemicals in sewage sludge fertilizer alters liver lipid content in females and cancer marker expression in males.

Filis P, Walker N, Robertson L, Eaton-Turner E, Ramona L, Bellingham M, Amezaga MR, Zhang Z, Mandon-Pepin B, Evans NP, Sharpe RM, Cotinot C, Rees WD, O'Shaughnessy P, Fowler PA.

Environ Int. 2019 Mar;124:98-108. doi: 10.1016/j.envint.2019.01.003. Epub 2019 Jan 11.

4.

Nodal Signaling Regulates Germ Cell Development and Establishment of Seminiferous Cords in the Human Fetal Testis.

Jørgensen A, Macdonald J, Nielsen JE, Kilcoyne KR, Perlman S, Lundvall L, Langhoff Thuesen L, Juul Hare K, Frederiksen H, Andersson AM, Skakkebæk NE, Juul A, Sharpe RM, Rajpert-De Meyts E, Mitchell RT.

Cell Rep. 2018 Nov 13;25(7):1924-1937.e4. doi: 10.1016/j.celrep.2018.10.064.

5.

DMRT1 repression using a novel approach to genetic manipulation induces testicular dysgenesis in human fetal gonads.

Macdonald J, Kilcoyne KR, Sharpe RM, Kavanagh Á, Anderson RA, Brown P, Smith LB, Jørgensen A, Mitchell RT.

Hum Reprod. 2018 Nov 1;33(11):2107-2121. doi: 10.1093/humrep/dey289.

6.

Fetal life shapes adult male reproductive function.

Sharpe RM.

Lancet Child Adolesc Health. 2018 Oct;2(10):695-696. doi: 10.1016/S2352-4642(18)30276-1. Epub 2018 Aug 30. No abstract available.

PMID:
30236372
7.

Effects of Exposure to Acetaminophen and Ibuprofen on Fetal Germ Cell Development in Both Sexes in Rodent and Human Using Multiple Experimental Systems.

Hurtado-Gonzalez P, Anderson RA, Macdonald J, van den Driesche S, Kilcoyne K, Jørgensen A, McKinnell C, Macpherson S, Sharpe RM, Mitchell RT.

Environ Health Perspect. 2018 Apr 16;126(4):047006. doi: 10.1289/EHP2307.

8.

Of mice and men: long-term safety of assisted reproduction treatments.

Sharpe RM.

Hum Reprod. 2018 May 1;33(5):793-796. doi: 10.1093/humrep/dey071. No abstract available.

PMID:
29635456
9.

'Man Up': the importance and strategy for placing male reproductive health centre stage in the political and research agenda.

Barratt CLR, De Jonge CJ, Sharpe RM.

Hum Reprod. 2018 Apr 1;33(4):541-545. doi: 10.1093/humrep/dey020.

10.

Programmed for sex: Nutrition-reproduction relationships from an inter-generational perspective.

Sharpe RM.

Reproduction. 2018 Feb;155(3):S1-S16. doi: 10.1530/REP-17-0537. Epub 2017 Dec 21. Review.

PMID:
29269516
11.

Low-dose tamoxifen treatment in juvenile males has long-term adverse effects on the reproductive system: implications for inducible transgenics.

Patel SH, O'Hara L, Atanassova N, Smith SE, Curley MK, Rebourcet D, Darbey AL, Gannon AL, Sharpe RM, Smith LB.

Sci Rep. 2017 Aug 21;7(1):8991. doi: 10.1038/s41598-017-09016-4.

12.

Dibutyl phthalate induced testicular dysgenesis originates after seminiferous cord formation in rats.

Lara NLM, van den Driesche S, Macpherson S, França LR, Sharpe RM.

Sci Rep. 2017 May 31;7(1):2521. doi: 10.1038/s41598-017-02684-2. Erratum in: Sci Rep. 2019 Oct 28;9(1):15436.

13.

Animal models of maternal high fat diet exposure and effects on metabolism in offspring: a meta-regression analysis.

Ribaroff GA, Wastnedge E, Drake AJ, Sharpe RM, Chambers TJG.

Obes Rev. 2017 Jun;18(6):673-686. doi: 10.1111/obr.12524. Epub 2017 Mar 30. Review.

14.

Experimentally induced testicular dysgenesis syndrome originates in the masculinization programming window.

van den Driesche S, Kilcoyne KR, Wagner I, Rebourcet D, Boyle A, Mitchell R, McKinnell C, Macpherson S, Donat R, Shukla CJ, Jorgensen A, Meyts ER, Skakkebaek NE, Sharpe RM.

JCI Insight. 2017 Mar 23;2(6):e91204. doi: 10.1172/jci.insight.91204.

15.

Timing of Maternal Exposure and Foetal Sex Determine the Effects of Low-level Chemical Mixture Exposure on the Foetal Neuroendocrine System in Sheep.

Bellingham M, Fowler PA, MacDonald ES, Mandon-Pepin B, Cotinot C, Rhind S, Sharpe RM, Evans NP.

J Neuroendocrinol. 2016 Dec;28(12). doi: 10.1111/jne.12444.

16.

High-fat diet disrupts metabolism in two generations of rats in a parent-of-origin specific manner.

Chambers TJG, Morgan MD, Heger AH, Sharpe RM, Drake AJ.

Sci Rep. 2016 Aug 23;6:31857. doi: 10.1038/srep31857.

17.

CisSERS: Customizable In Silico Sequence Evaluation for Restriction Sites.

Sharpe RM, Koepke T, Harper A, Grimes J, Galli M, Satoh-Cruz M, Kalyanaraman A, Evans K, Kramer D, Dhingra A.

PLoS One. 2016 Apr 12;11(4):e0152404. doi: 10.1371/journal.pone.0152404. eCollection 2016.

18.

Dealing with phthalates in medical devices: a case of primum non nocere (first do no harm)?

Tasker RC, Sharpe RM.

Intensive Care Med. 2016 Apr;42(4):602-604. doi: 10.1007/s00134-016-4227-5. Epub 2016 Feb 3. No abstract available.

PMID:
26846518
19.

Analgesic exposure in pregnant rats affects fetal germ cell development with inter-generational reproductive consequences.

Dean A, van den Driesche S, Wang Y, McKinnell C, Macpherson S, Eddie SL, Kinnell H, Hurtado-Gonzalez P, Chambers TJ, Stevenson K, Wolfinger E, Hrabalkova L, Calarrao A, Bayne RA, Hagen CP, Mitchell RT, Anderson RA, Sharpe RM.

Sci Rep. 2016 Jan 27;6:19789. doi: 10.1038/srep19789.

20.

Toward a multi-country monitoring system of reproductive health in the context of endocrine disrupting chemical exposure.

Le Moal J, Sharpe RM, Jϕrgensen N, Levine H, Jurewicz J, Mendiola J, Swan SH, Virtanen H, Christin-Maître S, Cordier S, Toppari J, Hanke W; HURGENT Network.

Eur J Public Health. 2016 Feb;26(1):76-83. doi: 10.1093/eurpub/ckv153. Epub 2015 Sep 1.

PMID:
26330492
21.

The war on error.

Evers JL, Sharpe RM, Somigliana E, Williams AC.

Hum Reprod. 2015 Aug;30(8):1747-8. doi: 10.1093/humrep/dev146. Epub 2015 Jun 24. No abstract available.

PMID:
26113660
22.

Prolonged exposure to acetaminophen reduces testosterone production by the human fetal testis in a xenograft model.

van den Driesche S, Macdonald J, Anderson RA, Johnston ZC, Chetty T, Smith LB, Mckinnell C, Dean A, Homer NZ, Jorgensen A, Camacho-Moll ME, Sharpe RM, Mitchell RT.

Sci Transl Med. 2015 May 20;7(288):288ra80. doi: 10.1126/scitranslmed.aaa4097.

23.

Developmental and Subcellular Organization of Single-Cell C₄ Photosynthesis in Bienertia sinuspersici Determined by Large-Scale Proteomics and cDNA Assembly from 454 DNA Sequencing.

Offermann S, Friso G, Doroshenk KA, Sun Q, Sharpe RM, Okita TW, Wimmer D, Edwards GE, van Wijk KJ.

J Proteome Res. 2015 May 1;14(5):2090-108. doi: 10.1021/pr5011907. Epub 2015 Apr 9.

PMID:
25772754
24.

Comparative effects of di(n-butyl) phthalate exposure on fetal germ cell development in the rat and in human fetal testis xenografts.

van den Driesche S, McKinnell C, Calarrão A, Kennedy L, Hutchison GR, Hrabalkova L, Jobling MS, Macpherson S, Anderson RA, Sharpe RM, Mitchell RT.

Environ Health Perspect. 2015 Mar;123(3):223-30. doi: 10.1289/ehp.1408248. Epub 2014 Dec 16.

25.

Anogenital distance plasticity in adulthood: implications for its use as a biomarker of fetal androgen action.

Mitchell RT, Mungall W, McKinnell C, Sharpe RM, Cruickshanks L, Milne L, Smith LB.

Endocrinology. 2015 Jan;156(1):24-31. doi: 10.1210/en.2014-1534.

26.

Dynamic changes in DNA modification states during late gestation male germ line development in the rat.

Rose CM, van den Driesche S, Sharpe RM, Meehan RR, Drake AJ.

Epigenetics Chromatin. 2014 Aug 7;7:19. doi: 10.1186/1756-8935-7-19. eCollection 2014.

27.

Lessons learned in andrology: learning from experience - getting it wrong is alright.

Sharpe RM.

Andrology. 2014 Sep;2(5):652-4. doi: 10.1111/j.2047-2927.2014.00242.x. No abstract available.

28.

Reproduction Symposium: does grazing on biosolids-treated pasture pose a pathophysiological risk associated with increased exposure to endocrine disrupting compounds?

Evans NP, Bellingham M, Sharpe RM, Cotinot C, Rhind SM, Kyle C, Erhard H, Hombach-Klonisch S, Lind PM, Fowler PA.

J Anim Sci. 2014 Aug;92(8):3185-98. doi: 10.2527/jas.2014-7763. Epub 2014 Jun 19. Review.

PMID:
24948646
29.

Fetal programming of adult Leydig cell function by androgenic effects on stem/progenitor cells.

Kilcoyne KR, Smith LB, Atanassova N, Macpherson S, McKinnell C, van den Driesche S, Jobling MS, Chambers TJ, De Gendt K, Verhoeven G, O'Hara L, Platts S, Renato de Franca L, Lara NL, Anderson RA, Sharpe RM.

Proc Natl Acad Sci U S A. 2014 May 6;111(18):E1924-32. doi: 10.1073/pnas.1320735111. Epub 2014 Apr 21.

30.

Regulation of the germ stem cell niche as the foundation for adult spermatogenesis: a role for miRNAs?

van den Driesche S, Sharpe RM, Saunders PT, Mitchell RT.

Semin Cell Dev Biol. 2014 May;29:76-83. doi: 10.1016/j.semcdb.2014.04.006. Epub 2014 Apr 6. Review.

31.

Intratubular germ cell neoplasia of the human testis: heterogeneous protein expression and relation to invasive potential.

Mitchell RT, Camacho-Moll M, Macdonald J, Anderson RA, Kelnar CJ, O'Donnell M, Sharpe RM, Smith LB, Grigor KM, Wallace WHB, Stoop H, Wolffenbuttel KP, Donat R, Saunders PT, Looijenga LH.

Mod Pathol. 2014 Sep;27(9):1255-1266. doi: 10.1038/modpathol.2013.246. Epub 2014 Jan 24.

32.

Human and ecological risk assessment of a crop protection chemical: a case study with the azole fungicide epoxiconazole.

Chambers JE, Greim H, Kendall RJ, Segner H, Sharpe RM, Van Der Kraak G.

Crit Rev Toxicol. 2014 Feb;44(2):176-210. doi: 10.3109/10408444.2013.855163. Epub 2013 Nov 25. Review.

PMID:
24274332
33.

A plea for risk assessment of endocrine disrupting chemicals.

Testai E, Galli CL, Dekant W, Marinovich M, Piersma AH, Sharpe RM.

Toxicology. 2013 Dec 6;314(1):51-9. doi: 10.1016/j.tox.2013.07.018. Epub 2013 Aug 11. Review.

PMID:
23939142
34.

Exposure to chemical cocktails before or after conception--- the effect of timing on ovarian development.

Bellingham M, Amezaga MR, Mandon-Pepin B, Speers CJ, Kyle CE, Evans NP, Sharpe RM, Cotinot C, Rhind SM, Fowler PA.

Mol Cell Endocrinol. 2013 Aug 25;376(1-2):156-72. doi: 10.1016/j.mce.2013.06.016. Epub 2013 Jun 20.

35.

Prostaglandins, masculinization and its disorders: effects of fetal exposure of the rat to the cyclooxygenase inhibitor- indomethacin.

Dean A, Mungall W, McKinnell C, Sharpe RM.

PLoS One. 2013 May 3;8(5):e62556. doi: 10.1371/journal.pone.0062556. Print 2013.

36.

Diethylstilboestrol exposure does not reduce testosterone production in human fetal testis xenografts.

Mitchell RT, Sharpe RM, Anderson RA, McKinnell C, Macpherson S, Smith LB, Wallace WH, Kelnar CJ, van den Driesche S.

PLoS One. 2013 Apr 19;8(4):e61726. doi: 10.1371/journal.pone.0061726. Print 2013.

37.

Clinical review: Anogenital distance or digit length ratio as measures of fetal androgen exposure: relationship to male reproductive development and its disorders.

Dean A, Sharpe RM.

J Clin Endocrinol Metab. 2013 Jun;98(6):2230-8. doi: 10.1210/jc.2012-4057. Epub 2013 Apr 8. Review.

PMID:
23569219
38.

Obesogens and obesity--an alternative view?

Sharpe RM, Drake AJ.

Obesity (Silver Spring). 2013 Jun;21(6):1081-3. doi: 10.1002/oby.20373.

39.

One decade after the discovery of single-cell C4 species in terrestrial plants: what did we learn about the minimal requirements of C4 photosynthesis?

Sharpe RM, Offermann S.

Photosynth Res. 2014 Feb;119(1-2):169-80. doi: 10.1007/s11120-013-9810-9. Epub 2013 Mar 14. Review.

PMID:
23494362
40.

The downside of 'inappropriate messaging': new insight into the development of testicular germ cell tumours in young men?

Sharpe RM, Mitchell RT.

J Pathol. 2013 Mar;229(4):497-501. doi: 10.1002/path.4167.

PMID:
23335366
41.

Perinatal germ cell development and differentiation in the male marmoset (Callithrix jacchus): similarities with the human and differences from the rat.

McKinnell C, Mitchell RT, Morris K, Anderson RA, Kelnar CJ, Wallace WH, Sharpe RM.

Hum Reprod. 2013 Apr;28(4):886-96. doi: 10.1093/humrep/des465. Epub 2013 Jan 15.

42.

Peri-conceptional changes in maternal exposure to sewage sludge chemicals disturbs fetal thyroid gland development in sheep.

Hombach-Klonisch S, Danescu A, Begum F, Amezaga MR, Rhind SM, Sharpe RM, Evans NP, Bellingham M, Cotinot C, Mandon-Pepin B, Fowler PA, Klonisch T.

Mol Cell Endocrinol. 2013 Mar 10;367(1-2):98-108. doi: 10.1016/j.mce.2012.12.022. Epub 2013 Jan 4.

43.

Differential mobility of pigment-protein complexes in granal and agranal thylakoid membranes of C₃ and C₄ plants.

Kirchhoff H, Sharpe RM, Herbstova M, Yarbrough R, Edwards GE.

Plant Physiol. 2013 Jan;161(1):497-507. doi: 10.1104/pp.112.207548. Epub 2012 Nov 12.

44.

Proposed role for COUP-TFII in regulating fetal Leydig cell steroidogenesis, perturbation of which leads to masculinization disorders in rodents.

van den Driesche S, Walker M, McKinnell C, Scott HM, Eddie SL, Mitchell RT, Seckl JR, Drake AJ, Smith LB, Anderson RA, Sharpe RM.

PLoS One. 2012;7(5):e37064. doi: 10.1371/journal.pone.0037064. Epub 2012 May 17.

45.

Sperm counts and fertility in men: a rocky road ahead. Science & Society Series on Sex and Science.

Sharpe RM.

EMBO Rep. 2012 May 1;13(5):398-403. doi: 10.1038/embor.2012.50. No abstract available.

46.

Effects of inducible nitric oxide synthase (iNOS) deficiency in mice on Sertoli cell proliferation and perinatal testis development.

Auharek SA, Lara NL, Avelar GF, Sharpe RM, França LR.

Int J Androl. 2012 Oct;35(5):741-51. doi: 10.1111/j.1365-2605.2012.01264.x. Epub 2012 Mar 15.

PMID:
22420564
47.

Inter-relationship between testicular dysgenesis and Leydig cell function in the masculinization programming window in the rat.

van den Driesche S, Kolovos P, Platts S, Drake AJ, Sharpe RM.

PLoS One. 2012;7(1):e30111. doi: 10.1371/journal.pone.0030111. Epub 2012 Jan 11.

48.

The effect of dihydrotestosterone exposure during or prior to the masculinization programming window on reproductive development in male and female rats.

Dean A, Smith LB, Macpherson S, Sharpe RM.

Int J Androl. 2012 Jun;35(3):330-9. doi: 10.1111/j.1365-2605.2011.01236.x. Epub 2012 Jan 17.

PMID:
22248293
49.

Do phthalates affect steroidogenesis by the human fetal testis? Exposure of human fetal testis xenografts to di-n-butyl phthalate.

Mitchell RT, Childs AJ, Anderson RA, van den Driesche S, Saunders PT, McKinnell C, Wallace WH, Kelnar CJ, Sharpe RM.

J Clin Endocrinol Metab. 2012 Mar;97(3):E341-8. doi: 10.1210/jc.2011-2411. Epub 2012 Jan 11.

PMID:
22238399
50.

Foetal and post-natal exposure of sheep to sewage sludge chemicals disrupts sperm production in adulthood in a subset of animals.

Bellingham M, McKinnell C, Fowler PA, Amezaga MR, Zhang Z, Rhind SM, Cotinot C, Mandon-Pepin B, Evans NP, Sharpe RM.

Int J Androl. 2012 Jun;35(3):317-29. doi: 10.1111/j.1365-2605.2011.01234.x. Epub 2011 Dec 13.

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