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Items: 1 to 50 of 187

1.

Optimizing treatment protocols for spinal manipulative therapy: study protocol for a randomized trial.

Fritz JM, Sharpe JA, Lane E, Santillo D, Greene T, Kawchuk G.

Trials. 2018 Jun 4;19(1):306. doi: 10.1186/s13063-018-2692-6.

2.

Inositol trisphosphate receptor-mediated Ca2+ signalling stimulates mitochondrial function and gene expression in core myopathy patients.

Suman M, Sharpe JA, Bentham RB, Kotiadis VN, Menegollo M, Pignataro V, Molgó J, Muntoni F, Duchen MR, Pegoraro E, Szabadkai G.

Hum Mol Genet. 2018 Jul 1;27(13):2367-2382. doi: 10.1093/hmg/ddy149.

3.

Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia.

Mettananda S, Fisher CA, Hay D, Badat M, Quek L, Clark K, Hublitz P, Downes D, Kerry J, Gosden M, Telenius J, Sloane-Stanley JA, Faustino P, Coelho A, Doondeea J, Usukhbayar B, Sopp P, Sharpe JA, Hughes JR, Vyas P, Gibbons RJ, Higgs DR.

Nat Commun. 2017 Sep 4;8(1):424. doi: 10.1038/s41467-017-00479-7.

4.

Tissue-specific CTCF-cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo.

Hanssen LLP, Kassouf MT, Oudelaar AM, Biggs D, Preece C, Downes DJ, Gosden M, Sharpe JA, Sloane-Stanley JA, Hughes JR, Davies B, Higgs DR.

Nat Cell Biol. 2017 Aug;19(8):952-961. doi: 10.1038/ncb3573. Epub 2017 Jul 24.

5.

The chromatin remodelling factor ATRX suppresses R-loops in transcribed telomeric repeats.

Nguyen DT, Voon HPJ, Xella B, Scott C, Clynes D, Babbs C, Ayyub H, Kerry J, Sharpe JA, Sloane-Stanley JA, Butler S, Fisher CA, Gray NE, Jenuwein T, Higgs DR, Gibbons RJ.

EMBO Rep. 2017 Jun;18(6):914-928. doi: 10.15252/embr.201643078. Epub 2017 May 9.

6.

Enhancer deletion generates cellular phenotypic diversity due to bimodal gene expression.

De Gobbi M, Brazel AJ, Sharpe JA, Sloane-Stanley JA, Smith AJ, Wood WG, Vernimmen D.

Blood Cells Mol Dis. 2017 May;64:10-12. doi: 10.1016/j.bcmd.2017.02.006. Epub 2017 Mar 1. No abstract available.

7.

Pathological consequences of MICU1 mutations on mitochondrial calcium signalling and bioenergetics.

Bhosale G, Sharpe JA, Koh A, Kouli A, Szabadkai G, Duchen MR.

Biochim Biophys Acta Mol Cell Res. 2017 Jun;1864(6):1009-1017. doi: 10.1016/j.bbamcr.2017.01.015. Epub 2017 Jan 26.

8.

Ocular hypotensive effect of the novel EP3/FP agonist ONO-9054 versus Xalatan: results of a 28-day, double-masked, randomised study.

Miller Ellis E, Berlin MS, Ward CL, Sharpe JA, Jamil A, Harris A.

Br J Ophthalmol. 2017 Jun;101(6):796-800. doi: 10.1136/bjophthalmol-2016-309023. Epub 2016 Sep 20.

9.

Genetic dissection of the α-globin super-enhancer in vivo.

Hay D, Hughes JR, Babbs C, Davies JOJ, Graham BJ, Hanssen L, Kassouf MT, Marieke Oudelaar AM, Sharpe JA, Suciu MC, Telenius J, Williams R, Rode C, Li PS, Pennacchio LA, Sloane-Stanley JA, Ayyub H, Butler S, Sauka-Spengler T, Gibbons RJ, Smith AJH, Wood WG, Higgs DR.

Nat Genet. 2016 Aug;48(8):895-903. doi: 10.1038/ng.3605. Epub 2016 Jul 4.

10.

Calcium signaling as a mediator of cell energy demand and a trigger to cell death.

Bhosale G, Sharpe JA, Sundier SY, Duchen MR.

Ann N Y Acad Sci. 2015 Sep;1350:107-16. doi: 10.1111/nyas.12885. Review.

11.

Crystal structure of the antimicrobial peptidase lysostaphin from Staphylococcus simulans.

Sabala I, Jagielska E, Bardelang PT, Czapinska H, Dahms SO, Sharpe JA, James R, Than ME, Thomas NR, Bochtler M.

FEBS J. 2014 Sep;281(18):4112-22. doi: 10.1111/febs.12929. Epub 2014 Aug 1.

12.

Optic chiasm involvement on MRI with ethambutol-induced bitemporal hemianopia.

Osaguona VB, Sharpe JA, Awaji SA, Farb RI, Sundaram AN.

J Neuroophthalmol. 2014 Jun;34(2):155-8. doi: 10.1097/WNO.0000000000000095.

PMID:
24647140
13.

Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling.

Logan CV, Szabadkai G, Sharpe JA, Parry DA, Torelli S, Childs AM, Kriek M, Phadke R, Johnson CA, Roberts NY, Bonthron DT, Pysden KA, Whyte T, Munteanu I, Foley AR, Wheway G, Szymanska K, Natarajan S, Abdelhamed ZA, Morgan JE, Roper H, Santen GW, Niks EH, van der Pol WL, Lindhout D, Raffaello A, De Stefani D, den Dunnen JT, Sun Y, Ginjaar I, Sewry CA, Hurles M, Rizzuto R; UK10K Consortium, Duchen MR, Muntoni F, Sheridan E.

Nat Genet. 2014 Feb;46(2):188-93. doi: 10.1038/ng.2851. Epub 2013 Dec 15.

PMID:
24336167
14.

Nprl3 is required for normal development of the cardiovascular system.

Kowalczyk MS, Hughes JR, Babbs C, Sanchez-Pulido L, Szumska D, Sharpe JA, Sloane-Stanley JA, Morriss-Kay GM, Smoot LB, Roberts AE, Watkins H, Bhattacharya S, Gibbons RJ, Ponting CP, Wood WG, Higgs DR.

Mamm Genome. 2012 Aug;23(7-8):404-15. doi: 10.1007/s00335-012-9398-y. Epub 2012 Apr 27.

PMID:
22538705
15.

Intragenic enhancers act as alternative promoters.

Kowalczyk MS, Hughes JR, Garrick D, Lynch MD, Sharpe JA, Sloane-Stanley JA, McGowan SJ, De Gobbi M, Hosseini M, Vernimmen D, Brown JM, Gray NE, Collavin L, Gibbons RJ, Flint J, Taylor S, Buckle VJ, Milne TA, Wood WG, Higgs DR.

Mol Cell. 2012 Feb 24;45(4):447-58. doi: 10.1016/j.molcel.2011.12.021. Epub 2012 Jan 19.

16.

An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment.

Lynch MD, Smith AJ, De Gobbi M, Flenley M, Hughes JR, Vernimmen D, Ayyub H, Sharpe JA, Sloane-Stanley JA, Sutherland L, Meek S, Burdon T, Gibbons RJ, Garrick D, Higgs DR.

EMBO J. 2012 Jan 18;31(2):317-29. doi: 10.1038/emboj.2011.399. Epub 2011 Nov 4.

17.

Antisaccade generation is impaired after parietal lobe lesions.

Sharpe JA, Cheng P, Eizenman M.

Ann N Y Acad Sci. 2011 Sep;1233:194-9. doi: 10.1111/j.1749-6632.2011.06178.x.

PMID:
21950993
18.

Polycomb eviction as a new distant enhancer function.

Vernimmen D, Lynch MD, De Gobbi M, Garrick D, Sharpe JA, Sloane-Stanley JA, Smith AJ, Higgs DR.

Genes Dev. 2011 Aug 1;25(15):1583-8. doi: 10.1101/gad.16985411.

19.

Static ocular counterroll reflex in skew deviation.

Chandrakumar M, Blakeman A, Goltz HC, Sharpe JA, Wong AM.

Neurology. 2011 Aug 16;77(7):638-44. doi: 10.1212/WNL.0b013e3182299f71. Epub 2011 Aug 3.

20.

Posterior reversible encephalopathy syndrome presenting as Balint syndrome.

Kumar S, Abhayambika A, Sundaram AN, Sharpe JA.

J Neuroophthalmol. 2011 Sep;31(3):224-7. doi: 10.1097/WNO.0b013e31821b5f92.

PMID:
21566529
21.

Codanin-1 mutations in congenital dyserythropoietic anemia type 1 affect HP1{alpha} localization in erythroblasts.

Renella R, Roberts NA, Brown JM, De Gobbi M, Bird LE, Hassanali T, Sharpe JA, Sloane-Stanley J, Ferguson DJ, Cordell J, Buckle VJ, Higgs DR, Wood WG.

Blood. 2011 Jun 23;117(25):6928-38. doi: 10.1182/blood-2010-09-308478. Epub 2011 Mar 1.

22.

Ocular torsion and vertical misalignment.

Sharpe JA, Kumar S, Sundaram AN.

Curr Opin Neurol. 2011 Feb;24(1):18-24. doi: 10.1097/WCO.0b013e328341e2b2. Review.

PMID:
21150599
23.

Involvement of the human ventrolateral thalamus in the control of visually guided saccades.

Kronenbuerger M, González EG, Liu LD, Moro E, Steinbach MJ, Lozano AM, Hodaie M, Dostrovsky JO, Sharpe JA, Hutchison WD.

Brain Stimul. 2010 Oct;3(4):226-9. doi: 10.1016/j.brs.2009.12.002. Epub 2009 Dec 30. No abstract available.

PMID:
20965452
24.

The cerebellar dysplasia of Chiari II malformation as revealed by eye movements.

Salman MS, Dennis M, Sharpe JA.

Can J Neurol Sci. 2009 Nov;36(6):713-24.

25.

Chromosome looping at the human alpha-globin locus is mediated via the major upstream regulatory element (HS -40).

Vernimmen D, Marques-Kranc F, Sharpe JA, Sloane-Stanley JA, Wood WG, Wallace HA, Smith AJ, Higgs DR.

Blood. 2009 Nov 5;114(19):4253-60. doi: 10.1182/blood-2009-03-213439. Epub 2009 Aug 20.

PMID:
19696202
26.

Visual fixation in Chiari type II malformation.

Salman MS, Sharpe JA, Lillakas L, Dennis M, Steinbach MJ.

J Child Neurol. 2009 Feb;24(2):161-5. doi: 10.1177/0883073808322326.

27.

Skeletal analysis of the Fgfr3(P244R) mouse, a genetic model for the Muenke craniosynostosis syndrome.

Twigg SR, Healy C, Babbs C, Sharpe JA, Wood WG, Sharpe PT, Morriss-Kay GM, Wilkie AO.

Dev Dyn. 2009 Feb;238(2):331-42. doi: 10.1002/dvdy.21790.

28.

Neurophysiology and neuroanatomy of smooth pursuit: lesion studies.

Sharpe JA.

Brain Cogn. 2008 Dec;68(3):241-54. doi: 10.1016/j.bandc.2008.08.015. Epub 2008 Nov 11. Review.

PMID:
19004537
29.

Resistance training and diastolic myocardial tissue velocities in obese children.

Naylor LH, Watts K, Sharpe JA, Jones TW, Davis EA, Thompson A, George K, Ramsay JM, O'Driscoll G, Green DJ.

Med Sci Sports Exerc. 2008 Dec;40(12):2027-32. doi: 10.1249/MSS.0b013e318182a9e0.

PMID:
18981948
30.

The vestibulo-ocular reflex during active head motion in Chiari II malformation.

Salman MS, Sharpe JA, Lillakas L, Dennis M, Steinbach MJ.

Can J Neurol Sci. 2008 Sep;35(4):495-500.

31.

Ocular motor nerve palsies: implications for diagnosis and mechanisms of repair.

Sharpe JA, Wong AM, Fouladvand M.

Prog Brain Res. 2008;171:59-66. doi: 10.1016/S0079-6123(08)00609-2.

32.

Dissociated palsy of vertical saccades: loss of voluntary and visually guided saccades with preservation of reflexive vestibular quick phases.

Kang JH, Sharpe JA.

J Neuroophthalmol. 2008 Jun;28(2):97-103. doi: 10.1097/WNO.0b013e3181772647.

PMID:
18562839
33.

Adaptive neural mechanism for Listing's law revealed in patients with skew deviation caused by brainstem or cerebellar lesion.

Fesharaki M, Karagiannis P, Tweed D, Sharpe JA, Wong AM.

Invest Ophthalmol Vis Sci. 2008 Jan;49(1):204-14. doi: 10.1167/iovs.07-0292.

34.

Square wave jerks in children and adolescents.

Salman MS, Sharpe JA, Lillakas L, Steinbach MJ.

Pediatr Neurol. 2008 Jan;38(1):16-9.

PMID:
18054687
35.

Tissue-specific histone modification and transcription factor binding in alpha globin gene expression.

De Gobbi M, Anguita E, Hughes J, Sloane-Stanley JA, Sharpe JA, Koch CM, Dunham I, Gibbons RJ, Wood WG, Higgs DR.

Blood. 2007 Dec 15;110(13):4503-10. Epub 2007 Aug 22. Erratum in: Blood. 2008 Feb 15;111(4):1773.

PMID:
17715390
36.

The vestibulo-ocular reflex during active head motion in children and adolescents.

Salman MS, Lillakas L, Dennis M, Steinbach MJ, Sharpe JA.

Childs Nerv Syst. 2007 Nov;23(11):1269-74. Epub 2007 Aug 21.

PMID:
17710419
37.

Defining the cause of skewed X-chromosome inactivation in X-linked mental retardation by use of a mouse model.

Muers MR, Sharpe JA, Garrick D, Sloane-Stanley J, Nolan PM, Hacker T, Wood WG, Higgs DR, Gibbons RJ.

Am J Hum Genet. 2007 Jun;80(6):1138-49. Epub 2007 Apr 25.

38.

Patterns of ocular oscillation in oculopalatal tremor: imaging correlations.

Kim JS, Moon SY, Choi KD, Kim JH, Sharpe JA.

Neurology. 2007 Apr 3;68(14):1128-35.

PMID:
17404195
39.

Smooth ocular pursuit in Chiari type II malformation.

Salman MS, Sharpe JA, Lillakas L, Steinbach MJ, Dennis M.

Dev Med Child Neurol. 2007 Apr;49(4):289-93.

40.

Manipulating the mouse genome to engineer precise functional syntenic replacements with human sequence.

Wallace HA, Marques-Kranc F, Richardson M, Luna-Crespo F, Sharpe JA, Hughes J, Wood WG, Higgs DR, Smith AJ.

Cell. 2007 Jan 12;128(1):197-209.

41.

Saccadic adaptation in Chiari type II malformation.

Salman MS, Sharpe JA, Eizenman M, Lillakas L, To T, Westall C, Steinbach MJ, Dennis M.

Can J Neurol Sci. 2006 Nov;33(4):372-8.

PMID:
17168162
42.

Saccadic adaptation in children.

Salman MS, Sharpe JA, Eizenman M, Lillakas L, To T, Westall C, Dennis M, Steinbach MJ.

J Child Neurol. 2006 Dec;21(12):1025-31.

PMID:
17156692
43.

Impact of obesity on diastolic function in subjects < or = 16 years of age.

Sharpe JA, Naylor LH, Jones TW, Davis EA, O'Driscoll G, Ramsay JM, Green DJ.

Am J Cardiol. 2006 Sep 1;98(5):691-3. Epub 2006 Jul 7.

PMID:
16923463
44.

Saccade dynamics in peripheral vs central sixth nerve palsies.

Wong AM, McReelis K, Sharpe JA.

Neurology. 2006 May 9;66(9):1390-8.

PMID:
16682672
45.

Loss of Atrx affects trophoblast development and the pattern of X-inactivation in extraembryonic tissues.

Garrick D, Sharpe JA, Arkell R, Dobbie L, Smith AJ, Wood WG, Higgs DR, Gibbons RJ.

PLoS Genet. 2006 Apr;2(4):e58. Epub 2006 Apr 21.

46.

Cerebellar vermis morphology in children with spina bifida and Chiari type II malformation.

Salman MS, Blaser SE, Sharpe JA, Dennis M.

Childs Nerv Syst. 2006 Apr;22(4):385-93. Epub 2005 Dec 22.

PMID:
16374591
47.

Smooth pursuit eye movements in children.

Salman MS, Sharpe JA, Lillakas L, Dennis M, Steinbach MJ.

Exp Brain Res. 2006 Feb;169(1):139-43. Epub 2005 Dec 16.

PMID:
16362363
48.

Cerebellar skew deviation and the torsional vestibuloocular reflex.

Wong AM, Sharpe JA.

Neurology. 2005 Aug 9;65(3):412-9.

PMID:
16087906
49.

Saccades in children.

Salman MS, Sharpe JA, Eizenman M, Lillakas L, Westall C, To T, Dennis M, Steinbach MJ.

Vision Res. 2006 Apr;46(8-9):1432-9. Epub 2005 Jul 26.

50.

Saccades in children with spina bifida and Chiari type II malformation.

Salman MS, Sharpe JA, Eizenman M, Lillakas L, To T, Westall C, Steinbach MJ, Dennis M.

Neurology. 2005 Jun 28;64(12):2098-101.

PMID:
15985580

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