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Items: 10

1.

Grking the Smoothened signal.

Sharpe HJ, de Sauvage FJ.

Sci Signal. 2018 Feb 6;11(516). pii: eaar6377. doi: 10.1126/scisignal.aar6377. Review.

PMID:
29438011
2.

Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma.

Bonilla X, Parmentier L, King B, Bezrukov F, Kaya G, Zoete V, Seplyarskiy VB, Sharpe HJ, McKee T, Letourneau A, Ribaux PG, Popadin K, Basset-Seguin N, Ben Chaabene R, Santoni FA, Andrianova MA, Guipponi M, Garieri M, Verdan C, Grosdemange K, Sumara O, Eilers M, Aifantis I, Michielin O, de Sauvage FJ, Antonarakis SE, Nikolaev SI.

Nat Genet. 2016 Apr;48(4):398-406. doi: 10.1038/ng.3525. Epub 2016 Mar 7.

PMID:
26950094
3.

Regulation of the oncoprotein Smoothened by small molecules.

Sharpe HJ, Wang W, Hannoush RN, de Sauvage FJ.

Nat Chem Biol. 2015 Apr;11(4):246-55. doi: 10.1038/nchembio.1776. Review.

PMID:
25785427
4.

Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma.

Sharpe HJ, Pau G, Dijkgraaf GJ, Basset-Seguin N, Modrusan Z, Januario T, Tsui V, Durham AB, Dlugosz AA, Haverty PM, Bourgon R, Tang JY, Sarin KY, Dirix L, Fisher DC, Rudin CM, Sofen H, Migden MR, Yauch RL, de Sauvage FJ.

Cancer Cell. 2015 Mar 9;27(3):327-41. doi: 10.1016/j.ccell.2015.02.001.

5.

Efficacy of Hedgehog pathway inhibitors in Basal cell carcinoma.

Basset-Seguin N, Sharpe HJ, de Sauvage FJ.

Mol Cancer Ther. 2015 Mar;14(3):633-41. doi: 10.1158/1535-7163.MCT-14-0703. Epub 2015 Jan 13. Review.

6.

A systematic approach to pair secretory cargo receptors with their cargo suggests a mechanism for cargo selection by Erv14.

Herzig Y, Sharpe HJ, Elbaz Y, Munro S, Schuldiner M.

PLoS Biol. 2012;10(5):e1001329. doi: 10.1371/journal.pbio.1001329. Epub 2012 May 22.

7.

Signaling: An oxysterol ligand for Smoothened.

Sharpe HJ, de Sauvage FJ.

Nat Chem Biol. 2012 Jan 18;8(2):139-40. doi: 10.1038/nchembio.774. No abstract available.

PMID:
22257852
8.

A comprehensive comparison of transmembrane domains reveals organelle-specific properties.

Sharpe HJ, Stevens TJ, Munro S.

Cell. 2010 Jul 9;142(1):158-69. doi: 10.1016/j.cell.2010.05.037.

9.

Sequence-specific intramembrane proteolysis: identification of a recognition motif in rhomboid substrates.

Strisovsky K, Sharpe HJ, Freeman M.

Mol Cell. 2009 Dec 25;36(6):1048-59. doi: 10.1016/j.molcel.2009.11.006.

10.

Membrane topology of the endoplasmic reticulum to Golgi transport factor Erv29p.

Foley DA, Sharpe HJ, Otte S.

Mol Membr Biol. 2007 Jul-Aug;24(4):259-68.

PMID:
17520482

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