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mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism.

Tang H, Inoki K, Brooks SV, Okazawa H, Lee M, Wang J, Kim M, Kennedy CL, Macpherson PCD, Ji X, Van Roekel S, Fraga DA, Wang K, Zhu J, Wang Y, Sharp ZD, Miller RA, Rando TA, Goldman D, Guan KL, Shrager JB.

Aging Cell. 2019 Jun;18(3):e12943. doi: 10.1111/acel.12943. Epub 2019 Mar 29.


Rapamycin Prevents Surgery-Induced Immune Dysfunction in Patients with Bladder Cancer.

Svatek RS, Ji N, de Leon E, Mukherjee NZ, Kabra A, Hurez V, Nicolas M, Michalek JE, Javors M, Wheeler K, Sharp ZD, Livi CB, Shu ZJ, Henkes D, Curiel TJ.

Cancer Immunol Res. 2019 Mar;7(3):466-475. doi: 10.1158/2326-6066.CIR-18-0336. Epub 2018 Dec 18.


Measurement of Adjuncts in Hard Ciders Obtainable in the United States Using Carbon Isotopes.

Singerling SA, Burkemper LK, Sharp ZD.

J Agric Food Chem. 2018 Oct 31;66(43):11422-11425. doi: 10.1021/acs.jafc.8b05415. Epub 2018 Oct 19.


mTOR inhibitors for treatment of low-risk prostate cancer.

Liss MA, Rickborn L, DiGiovanni J, Bacich D, DeGraffenried LA, Parihar M, Thompson IM, Sharp ZD.

Med Hypotheses. 2018 Aug;117:63-68. doi: 10.1016/j.mehy.2018.06.004. Epub 2018 Jun 5.


Nitrogen recycling at the Costa Rican subduction zone: The role of incoming plate structure.

Lee H, Fischer TP, de Moor JM, Sharp ZD, Takahata N, Sano Y.

Sci Rep. 2017 Oct 24;7(1):13933. doi: 10.1038/s41598-017-14287-y.


Do p53 stress responses impact organismal aging?

Hasty P, Campisi J, Sharp ZD.

Transl Cancer Res. 2016 Dec;5(6):685-691. doi: 10.21037/tcr.2016.12.02.


A Proof of Concept Study to Detect Urease Producing Bacteria in Lungs Using Aerosolized 13C-Urea.

Raissy HH, Timmins G, Davies L, Heynekamp T, Harkins M, Sharp ZD, Kelly HW.

Pediatr Allergy Immunol Pulmonol. 2016 Jun 1;29(2):68-73.


Adaptations to chronic rapamycin in mice.

Dodds SG, Livi CB, Parihar M, Hsu HK, Benavides AD, Morris J, Javors M, Strong R, Christy B, Hasty P, Sharp ZD.

Pathobiol Aging Age Relat Dis. 2016 May 27;6:31688. doi: 10.3402/pba.v6.31688. eCollection 2016.


Retrospective stable isotope analysis reveals ecosystem responses to river regulation over the last century.

Turner TF, Krabbenhoft TI, Collyer ML, Krabbenhoft CA, Edwards MS, Sharp ZD.

Ecology. 2015 Dec;96(12):3213-26.


Chronic mTOR inhibition in mice with rapamycin alters T, B, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune-deficient mice.

Hurez V, Dao V, Liu A, Pandeswara S, Gelfond J, Sun L, Bergman M, Orihuela CJ, Galvan V, Padrón Á, Drerup J, Liu Y, Hasty P, Sharp ZD, Curiel TJ.

Aging Cell. 2015 Dec;14(6):945-56. doi: 10.1111/acel.12380. Epub 2015 Aug 28.


Spatiotemporal control of estrogen-responsive transcription in ERα-positive breast cancer cells.

Hsu PY, Hsu HK, Hsiao TH, Ye Z, Wang E, Profit AL, Jatoi I, Chen Y, Kirma NB, Jin VX, Sharp ZD, Huang TH.

Oncogene. 2016 May 5;35(18):2379-89. doi: 10.1038/onc.2015.298. Epub 2015 Aug 24.


p53 and rapamycin are additive.

Christy B, Demaria M, Campisi J, Huang J, Jones D, Dodds SG, Williams C, Hubbard G, Livi CB, Gao X, Weintraub S, Curiel T, Sharp ZD, Hasty P.

Oncotarget. 2015 Jun 30;6(18):15802-13.


Prevention of carcinogen and inflammation-induced dermal cancer by oral rapamycin includes reducing genetic damage.

Dao V, Pandeswara S, Liu Y, Hurez V, Dodds S, Callaway D, Liu A, Hasty P, Sharp ZD, Curiel TJ.

Cancer Prev Res (Phila). 2015 May;8(5):400-9. doi: 10.1158/1940-6207.CAPR-14-0313-T. Epub 2015 Mar 3.


Senescent Cells Contribute to the Physiological Remodeling of Aged Lungs.

Calhoun C, Shivshankar P, Saker M, Sloane LB, Livi CB, Sharp ZD, Orihuela CJ, Adnot S, White ES, Richardson A, Le Saux CJ.

J Gerontol A Biol Sci Med Sci. 2016 Feb;71(2):153-60. doi: 10.1093/gerona/glu241. Epub 2015 Jan 7.


Divergent tissue and sex effects of rapamycin on the proteasome-chaperone network of old mice.

Rodriguez KA, Dodds SG, Strong R, Galvan V, Sharp ZD, Buffenstein R.

Front Mol Neurosci. 2014 Nov 4;7:83. doi: 10.3389/fnmol.2014.00083. eCollection 2014.


Rapid in vivo detection of isoniazid-sensitive Mycobacterium tuberculosis by breath test.

Choi SW, Maiga M, Maiga MC, Atudorei V, Sharp ZD, Bishai WR, Timmins GS.

Nat Commun. 2014 Sep 23;5:4989. doi: 10.1038/ncomms5989.


In vitro and in vivo studies of a rapid and selective breath test for tuberculosis based upon mycobacterial CO dehydrogenase.

Maiga M, Choi SW, Atudorei V, Maiga MC, Sharp ZD, Bishai WR, Timmins GS.

MBio. 2014 Apr 15;5(2):e00990. doi: 10.1128/mBio.00990-14.


Jasechko et al. reply.

Jasechko S, Sharp ZD, Gibson JJ, Birks SJ, Yi Y, Fawcett PJ.

Nature. 2014 Feb 13;506(7487):E2-3. doi: 10.1038/nature12926.


Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction.

Miller RA, Harrison DE, Astle CM, Fernandez E, Flurkey K, Han M, Javors MA, Li X, Nadon NL, Nelson JF, Pletcher S, Salmon AB, Sharp ZD, Van Roekel S, Winkleman L, Strong R.

Aging Cell. 2014 Jun;13(3):468-77. doi: 10.1111/acel.12194. Epub 2014 Feb 9.


eRapa restores a normal life span in a FAP mouse model.

Hasty P, Livi CB, Dodds SG, Jones D, Strong R, Javors M, Fischer KE, Sloane L, Murthy K, Hubbard G, Sun L, Hurez V, Curiel TJ, Sharp ZD.

Cancer Prev Res (Phila). 2014 Jan;7(1):169-78. doi: 10.1158/1940-6207.CAPR-13-0299. Epub 2013 Nov 26.


Amplification of distant estrogen response elements deregulates target genes associated with tamoxifen resistance in breast cancer.

Hsu PY, Hsu HK, Lan X, Juan L, Yan PS, Labanowska J, Heerema N, Hsiao TH, Chiu YC, Chen Y, Liu Y, Li L, Li R, Thompson IM, Nephew KP, Sharp ZD, Kirma NB, Jin VX, Huang TH.

Cancer Cell. 2013 Aug 12;24(2):197-212. doi: 10.1016/j.ccr.2013.07.007.


Terrestrial water fluxes dominated by transpiration.

Jasechko S, Sharp ZD, Gibson JJ, Birks SJ, Yi Y, Fawcett PJ.

Nature. 2013 Apr 18;496(7445):347-50. doi: 10.1038/nature11983. Epub 2013 Apr 3.


Chronic mechanistic target of rapamycin inhibition: preventing cancer to delay aging, or vice versa?.

Sharp ZD, Curiel TJ, Livi CB.

Interdiscip Top Gerontol. 2013;38:1-16. doi: 10.1159/000343625. Epub 2013 Jan 17. Review.


Rapamycin extends life span of Rb1+/- mice by inhibiting neuroendocrine tumors.

Livi CB, Hardman RL, Christy BA, Dodds SG, Jones D, Williams C, Strong R, Bokov A, Javors MA, Ikeno Y, Hubbard G, Hasty P, Sharp ZD.

Aging (Albany NY). 2013 Feb;5(2):100-10.


Unique meteorite from early Amazonian Mars: water-rich basaltic breccia Northwest Africa 7034.

Agee CB, Wilson NV, McCubbin FM, Ziegler K, Polyak VJ, Sharp ZD, Asmerom Y, Nunn MH, Shaheen R, Thiemens MH, Steele A, Fogel ML, Bowden R, Glamoclija M, Zhang Z, Elardo SM.

Science. 2013 Feb 15;339(6121):780-5. doi: 10.1126/science.1228858. Epub 2013 Jan 3.


mTORC1 and p53: clash of the gods?

Hasty P, Sharp ZD, Curiel TJ, Campisi J.

Cell Cycle. 2013 Jan 1;12(1):20-5.


Aging and cancer: can mTOR inhibitors kill two birds with one drug?

Sharp ZD, Richardson A.

Target Oncol. 2011 Mar;6(1):41-51. doi: 10.1007/s11523-011-0168-7. Epub 2011 Mar 11. Review.


Hydrogen isotope correction for laser instrument measurement bias at low water vapor concentration using conventional isotope analyses: application to measurements from Mauna Loa Observatory, Hawaii.

Johnson LR, Sharp ZD, Galewsky J, Strong M, Van Pelt AD, Dong F, Noone D.

Rapid Commun Mass Spectrom. 2011 Mar 15;25(5):608-16. doi: 10.1002/rcm.4894.


Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice.

Miller RA, Harrison DE, Astle CM, Baur JA, Boyd AR, de Cabo R, Fernandez E, Flurkey K, Javors MA, Nelson JF, Orihuela CJ, Pletcher S, Sharp ZD, Sinclair D, Starnes JW, Wilkinson JE, Nadon NL, Strong R.

J Gerontol A Biol Sci Med Sci. 2011 Feb;66(2):191-201. doi: 10.1093/gerona/glq178. Epub 2010 Oct 25.


Aging and TOR: interwoven in the fabric of life.

Sharp ZD.

Cell Mol Life Sci. 2011 Feb;68(4):587-97. doi: 10.1007/s00018-010-0542-0. Epub 2010 Oct 21. Review.


13[C]-urea breath test as a novel point-of-care biomarker for tuberculosis treatment and diagnosis.

Jassal MS, Nedeltchev GG, Lee JH, Choi SW, Atudorei V, Sharp ZD, Deretic V, Timmins GS, Bishai WR.

PLoS One. 2010 Aug 27;5(8):e12451. doi: 10.1371/journal.pone.0012451.


The chlorine isotope composition of the moon and implications for an anhydrous mantle.

Sharp ZD, Shearer CK, McKeegan KD, Barnes JD, Wang YQ.

Science. 2010 Aug 27;329(5995):1050-3. doi: 10.1126/science.1192606. Epub 2010 Aug 5.


Ligand-induced large-scale chromatin dynamics as a biosensor for the detection of estrogen receptor subtype selective ligands.

García-Becerra R, Berno V, Ordaz-Rosado D, Sharp ZD, Cooney AJ, Mancini MA, Larrea F.

Gene. 2010 Jun 15;458(1-2):37-44. doi: 10.1016/j.gene.2010.03.007. Epub 2010 Mar 24.


The role of mTOR signaling in controlling mammalian life span: what a fungicide teaches us about longevity.

Sharp ZD, Strong R.

J Gerontol A Biol Sci Med Sci. 2010 Jun;65(6):580-9. doi: 10.1093/gerona/glp212. Epub 2010 Jan 18. No abstract available.


Atmospheric CO2 concentrations during ancient greenhouse climates were similar to those predicted for A.D. 2100.

Breecker DO, Sharp ZD, McFadden LD.

Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):576-80. doi: 10.1073/pnas.0902323106. Epub 2009 Dec 28.


Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.

Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE, Frenkel K, Carter CS, Pahor M, Javors MA, Fernandez E, Miller RA.

Nature. 2009 Jul 16;460(7253):392-5. doi: 10.1038/nature08221. Epub 2009 Jul 8.


Resistance to antiestrogen arzoxifene is mediated by overexpression of cyclin D1.

Zwart W, Rondaij M, Jalink K, Sharp ZD, Mancini MA, Neefjes J, Michalides R.

Mol Endocrinol. 2009 Sep;23(9):1335-45. doi: 10.1210/me.2008-0268. Epub 2009 May 28.


Design of aging intervention studies: the NIA interventions testing program.

Nadon NL, Strong R, Miller RA, Nelson J, Javors M, Sharp ZD, Peralba JM, Harrison DE.

Age (Dordr). 2008 Dec;30(4):187-99. doi: 10.1007/s11357-008-9048-1. Epub 2008 Apr 18.


Upper-mantle volatile chemistry at Oldoinyo Lengai volcano and the origin of carbonatites.

Fischer TP, Burnard P, Marty B, Hilton DR, Füri E, Palhol F, Sharp ZD, Mangasini F.

Nature. 2009 May 7;459(7243):77-80. doi: 10.1038/nature07977.


Activation of estrogen receptor-alpha by E2 or EGF induces temporally distinct patterns of large-scale chromatin modification and mRNA transcription.

Berno V, Amazit L, Hinojos C, Zhong J, Mancini MG, Sharp ZD, Mancini MA.

PLoS One. 2008 May 28;3(5):e2286. doi: 10.1371/journal.pone.0002286.


A field and laboratory method for monitoring the concentration and isotopic composition of soil CO2.

Breecker D, Sharp ZD.

Rapid Commun Mass Spectrom. 2008;22(4):449-54. doi: 10.1002/rcm.3382.


Chlorine isotope homogeneity of the mantle, crust and carbonaceous chondrites.

Sharp ZD, Barnes JD, Brearley AJ, Chaussidon M, Fischer TP, Kamenetsky VS.

Nature. 2007 Apr 26;446(7139):1062-5.


Estrogen-receptor-alpha exchange and chromatin dynamics are ligand- and domain-dependent.

Sharp ZD, Mancini MG, Hinojos CA, Dai F, Berno V, Szafran AT, Smith KP, Lele TP, Ingber DE, Mancini MA.

J Cell Sci. 2006 Oct 1;119(Pt 19):4101-16. Epub 2006 Sep 12. Erratum in: J Cell Sci. 2006 Oct 15;119(Pt 20):4365. Lele, Tanmay T [corrected to Lele, Tanmay P].


Molecular dynamics and nuclear receptor function.

Hinojos CA, Sharp ZD, Mancini MA.

Trends Endocrinol Metab. 2005 Jan-Feb;16(1):12-8. Review.


Inactivating Pit-1 mutations alter subnuclear dynamics suggesting a protein misfolding and nuclear stress response.

Sharp ZD, Stenoien DL, Mancini MG, Ouspenski II, Mancini MA.

J Cell Biochem. 2004 Jul 1;92(4):664-78.


Minimal effects of dietary restriction on neuroendocrine carcinogenesis in Rb+/- mice.

Sharp ZD, Lee WH, Nikitin AY, Flesken-Nikitin A, Ikeno Y, Reddick R, Richardson AG, Nelson JF.

Carcinogenesis. 2003 Feb;24(2):179-83.


Subduction and recycling of nitrogen along the Central American margin.

Fischer TP, Hilton DR, Zimmer MM, Shaw AM, Sharp ZD, Walker JA.

Science. 2002 Aug 16;297(5584):1154-7.


Insights into Wilson's Warbler migration from analyses of hydrogen stable-isotope ratios.

Kelly JF, Atudorei V, Sharp ZD, Finch DM.

Oecologia. 2002 Jan;130(2):216-221. doi: 10.1007/s004420100789. Epub 2002 Jan 1.


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