Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 466


Coactivator condensation at super-enhancers links phase separation and gene control.

Sabari BR, Dall'Agnese A, Boija A, Klein IA, Coffey EL, Shrinivas K, Abraham BJ, Hannett NM, Zamudio AV, Manteiga JC, Li CH, Guo YE, Day DS, Schuijers J, Vasile E, Malik S, Hnisz D, Lee TI, Cisse II, Roeder RG, Sharp PA, Chakraborty AK, Young RA.

Science. 2018 Jul 27;361(6400). pii: eaar3958. doi: 10.1126/science.aar3958. Epub 2018 Jun 21.


DNA methylation of hepatic iron sensing genes and the regulation of hepcidin expression.

Sharp PA, Clarkson R, Hussain A, Weeks RJ, Morison IM.

PLoS One. 2018 May 17;13(5):e0197863. doi: 10.1371/journal.pone.0197863. eCollection 2018.


Deconvolution of seed and RNA-binding protein crosstalk in RNAi-based functional genomics.

Suzuki HI, Spengler RM, Grigelioniene G, Kobayashi T, Sharp PA.

Nat Genet. 2018 May;50(5):657-661. doi: 10.1038/s41588-018-0104-1. Epub 2018 Apr 16.


Mapping a functional cancer genome atlas of tumor suppressors in mouse liver using AAV-CRISPR-mediated direct in vivo screening.

Wang G, Chow RD, Ye L, Guzman CD, Dai X, Dong MB, Zhang F, Sharp PA, Platt RJ, Chen S.

Sci Adv. 2018 Feb 28;4(2):eaao5508. doi: 10.1126/sciadv.aao5508. eCollection 2018 Feb.


Transcriptional Pause Sites Delineate Stable Nucleosome-Associated Premature Polyadenylation Suppressed by U1 snRNP.

Chiu AC, Suzuki HI, Wu X, Mahat DB, Kriz AJ, Sharp PA.

Mol Cell. 2018 Feb 15;69(4):648-663.e7. doi: 10.1016/j.molcel.2018.01.006. Epub 2018 Feb 1.


Alternative RNA splicing in the endothelium mediated in part by Rbfox2 regulates the arterial response to low flow.

Murphy PA, Butty VL, Boutz PL, Begum S, Kimble AL, Sharp PA, Burge CB, Hynes RO.

Elife. 2018 Jan 2;7. pii: e29494. doi: 10.7554/eLife.29494.


Synthetic RNA-Based Immunomodulatory Gene Circuits for Cancer Immunotherapy.

Nissim L, Wu MR, Pery E, Binder-Nissim A, Suzuki HI, Stupp D, Wehrspaun C, Tabach Y, Sharp PA, Lu TK.

Cell. 2017 Nov 16;171(5):1138-1150.e15. doi: 10.1016/j.cell.2017.09.049. Epub 2017 Oct 19.


Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma.

Braun CJ, Stanciu M, Boutz PL, Patterson JC, Calligaris D, Higuchi F, Neupane R, Fenoglio S, Cahill DP, Wakimoto H, Agar NYR, Yaffe MB, Sharp PA, Hemann MT, Lees JA.

Cancer Cell. 2017 Oct 9;32(4):411-426.e11. doi: 10.1016/j.ccell.2017.08.018. Epub 2017 Sep 28.


AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma.

Chow RD, Guzman CD, Wang G, Schmidt F, Youngblood MW, Ye L, Errami Y, Dong MB, Martinez MA, Zhang S, Renauer P, Bilguvar K, Gunel M, Sharp PA, Zhang F, Platt RJ, Chen S.

Nat Neurosci. 2017 Oct;20(10):1329-1341. doi: 10.1038/nn.4620. Epub 2017 Aug 14.


Corrigendum: Dicer loss and recovery induce an oncogenic switch driven by transcriptional activation of the oncofetal Imp1-3 family.

JnBaptiste CK, Gurtan AM, Thai KK, Lu V, Bhutkar A, Su MJ, Rotem A, Jacks T, Sharp PA.

Genes Dev. 2017 May 15;31(10):1066. doi: 10.1101/gad.302513.117. No abstract available.


Dicer loss and recovery induce an oncogenic switch driven by transcriptional activation of the oncofetal Imp1-3 family.

JnBaptiste CK, Gurtan AM, Thai KK, Lu V, Bhutkar A, Su MJ, Rotem A, Jacks T, Sharp PA.

Genes Dev. 2017 Apr 1;31(7):674-687. doi: 10.1101/gad.296301.117. Erratum in: Genes Dev. 2017 May 15;31(10 ):1066.


A Phase Separation Model for Transcriptional Control.

Hnisz D, Shrinivas K, Young RA, Chakraborty AK, Sharp PA.

Cell. 2017 Mar 23;169(1):13-23. doi: 10.1016/j.cell.2017.02.007. Review.


Super-Enhancer-Mediated RNA Processing Revealed by Integrative MicroRNA Network Analysis.

Suzuki HI, Young RA, Sharp PA.

Cell. 2017 Mar 9;168(6):1000-1014.e15. doi: 10.1016/j.cell.2017.02.015.


In vitro assessment of iron availability from commercial Young Child Formulae supplemented with prebiotics.

Christides T, Ganis JC, Sharp PA.

Eur J Nutr. 2018 Mar;57(2):669-678. doi: 10.1007/s00394-016-1353-3. Epub 2016 Dec 9.


Conjugated Linoleic Acid Isomers Exert Differential Effects on an Adipocyte Model of HIV-associated Lipodystrophy.

Loonam CR, O'Dell SD, Sharp PA, Mullen A.

Curr HIV Res. 2017;15(1):46-55. doi: 10.2174/1570162X14666161207125948.


Leveraging Industry-Academia Collaborations in Adaptive Biomedical Innovation.

Stewart SR, Barone PW, Bellisario A, Cooney CL, Sharp PA, Sinskey AJ, Natesan S, Springs SL.

Clin Pharmacol Ther. 2016 Dec;100(6):647-653. doi: 10.1002/cpt.504. Epub 2016 Oct 22.


Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex.

Zhang X, Chen MH, Wu X, Kodani A, Fan J, Doan R, Ozawa M, Ma J, Yoshida N, Reiter JF, Black DL, Kharchenko PV, Sharp PA, Walsh CA.

Cell. 2016 Aug 25;166(5):1147-1162.e15. doi: 10.1016/j.cell.2016.07.025.


GENE EXPRESSION. Single-cell variability guided by microRNAs.

Garg S, Sharp PA.

Science. 2016 Jun 17;352(6292):1390-1. doi: 10.1126/science.aag1097. No abstract available.


Elucidating MicroRNA Regulatory Networks Using Transcriptional, Post-transcriptional, and Histone Modification Measurements.

Gosline SJ, Gurtan AM, JnBaptiste CK, Bosson A, Milani P, Dalin S, Matthews BJ, Yap YS, Sharp PA, Fraenkel E.

Cell Rep. 2016 Jan 12;14(2):310-9. doi: 10.1016/j.celrep.2015.12.031. Epub 2015 Dec 31.


Transcription factor trapping by RNA in gene regulatory elements.

Sigova AA, Abraham BJ, Ji X, Molinie B, Hannett NM, Guo YE, Jangi M, Giallourakis CC, Sharp PA, Young RA.

Science. 2015 Nov 20;350(6263):978-81. doi: 10.1126/science.aad3346. Epub 2015 Oct 29.


Development of a Best Evidence Statement for the Use of Pressure Therapy for Management of Hypertrophic Scarring.

Sharp PA, Pan B, Yakuboff KP, Rothchild D.

J Burn Care Res. 2016 Jul-Aug;37(4):255-64. doi: 10.1097/BCR.0000000000000253.


In vivo genome editing using Staphylococcus aureus Cas9.

Ran FA, Cong L, Yan WX, Scott DA, Gootenberg JS, Kriz AJ, Zetsche B, Shalem O, Wu X, Makarova KS, Koonin EV, Sharp PA, Zhang F.

Nature. 2015 Apr 9;520(7546):186-91. doi: 10.1038/nature14299. Epub 2015 Apr 1.


Harnessing RNA interference for therapy: the silent treatment.

Lieberman J, Sharp PA.

JAMA. 2015 Mar 24-31;313(12):1207-8. doi: 10.1001/jama.2015.1241. No abstract available.


Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis.

Chen S, Sanjana NE, Zheng K, Shalem O, Lee K, Shi X, Scott DA, Song J, Pan JQ, Weissleder R, Lee H, Zhang F, Sharp PA.

Cell. 2015 Mar 12;160(6):1246-60. doi: 10.1016/j.cell.2015.02.038. Epub 2015 Mar 5.


Target specificity of the CRISPR-Cas9 system.

Wu X, Kriz AJ, Sharp PA.

Quant Biol. 2014 Jun;2(2):59-70.


Detained introns are a novel, widespread class of post-transcriptionally spliced introns.

Boutz PL, Bhutkar A, Sharp PA.

Genes Dev. 2015 Jan 1;29(1):63-80. doi: 10.1101/gad.247361.114.


Endogenous miRNA and target concentrations determine susceptibility to potential ceRNA competition.

Bosson AD, Zamudio JR, Sharp PA.

Mol Cell. 2014 Nov 6;56(3):347-59. doi: 10.1016/j.molcel.2014.09.018. Epub 2014 Oct 23.


Building robust transcriptomes with master splicing factors.

Jangi M, Sharp PA.

Cell. 2014 Oct 23;159(3):487-98. doi: 10.1016/j.cell.2014.09.054. Review.


Micromilling enhances iron bioaccessibility from wholegrain wheat.

Latunde-Dada GO, Li X, Parodi A, Edwards CH, Ellis PR, Sharp PA.

J Agric Food Chem. 2014 Nov 19;62(46):11222-7. doi: 10.1021/jf503474f. Epub 2014 Nov 7.


CRISPR-Cas9 knockin mice for genome editing and cancer modeling.

Platt RJ, Chen S, Zhou Y, Yim MJ, Swiech L, Kempton HR, Dahlman JE, Parnas O, Eisenhaure TM, Jovanovic M, Graham DB, Jhunjhunwala S, Heidenreich M, Xavier RJ, Langer R, Anderson DG, Hacohen N, Regev A, Feng G, Sharp PA, Zhang F.

Cell. 2014 Oct 9;159(2):440-55. doi: 10.1016/j.cell.2014.09.014. Epub 2014 Sep 25.


CRISPR-mediated direct mutation of cancer genes in the mouse liver.

Xue W, Chen S, Yin H, Tammela T, Papagiannakopoulos T, Joshi NS, Cai W, Yang G, Bronson R, Crowley DG, Zhang F, Anderson DG, Sharp PA, Jacks T.

Nature. 2014 Oct 16;514(7522):380-4. doi: 10.1038/nature13589. Epub 2014 Aug 6.


Practice guidelines for the application of nonsilicone or silicone gels and gel sheets after burn injury.

Nedelec B, Carter A, Forbes L, Hsu SC, McMahon M, Parry I, Ryan CM, Serghiou MA, Schneider JC, Sharp PA, de Oliveira A, Boruff J.

J Burn Care Res. 2015 May-Jun;36(3):345-74. doi: 10.1097/BCR.0000000000000124. Review.


Quercetin inhibits intestinal iron absorption and ferroportin transporter expression in vivo and in vitro.

Lesjak M, Hoque R, Balesaria S, Skinner V, Debnam ES, Srai SK, Sharp PA.

PLoS One. 2014 Jul 24;9(7):e102900. doi: 10.1371/journal.pone.0102900. eCollection 2014.


LincRNA-p21 activates p21 in cis to promote Polycomb target gene expression and to enforce the G1/S checkpoint.

Dimitrova N, Zamudio JR, Jong RM, Soukup D, Resnick R, Sarma K, Ward AJ, Raj A, Lee JT, Sharp PA, Jacks T.

Mol Cell. 2014 Jun 5;54(5):777-90. doi: 10.1016/j.molcel.2014.04.025. Epub 2014 May 22.


RNA Bind-n-Seq: quantitative assessment of the sequence and structural binding specificity of RNA binding proteins.

Lambert N, Robertson A, Jangi M, McGeary S, Sharp PA, Burge CB.

Mol Cell. 2014 Jun 5;54(5):887-900. doi: 10.1016/j.molcel.2014.04.016. Epub 2014 May 15.


Global microRNA depletion suppresses tumor angiogenesis.

Chen S, Xue Y, Wu X, Le C, Bhutkar A, Bell EL, Zhang F, Langer R, Sharp PA.

Genes Dev. 2014 May 15;28(10):1054-67. doi: 10.1101/gad.239681.114. Epub 2014 May 1.


Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells.

Wu X, Scott DA, Kriz AJ, Chiu AC, Hsu PD, Dadon DB, Cheng AW, Trevino AE, Konermann S, Chen S, Jaenisch R, Zhang F, Sharp PA.

Nat Biotechnol. 2014 Jul;32(7):670-6. doi: 10.1038/nbt.2889. Epub 2014 Apr 20.


Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype.

Yin H, Xue W, Chen S, Bogorad RL, Benedetti E, Grompe M, Koteliansky V, Sharp PA, Jacks T, Anderson DG.

Nat Biotechnol. 2014 Jun;32(6):551-3. doi: 10.1038/nbt.2884. Epub 2014 Mar 30. Erratum in: Nat Biotechnol. 2014 Sep;32(9):952.


Rbfox2 controls autoregulation in RNA-binding protein networks.

Jangi M, Boutz PL, Paul P, Sharp PA.

Genes Dev. 2014 Mar 15;28(6):637-51. doi: 10.1101/gad.235770.113.


Argonaute-bound small RNAs from promoter-proximal RNA polymerase II.

Zamudio JR, Kelly TJ, Sharp PA.

Cell. 2014 Feb 27;156(5):920-34. doi: 10.1016/j.cell.2014.01.041.


Meeting global challenges.

Sharp PA, Leshner AI.

Science. 2014 Feb 7;343(6171):579. doi: 10.1126/science.1250725. No abstract available.


Divergent transcription: a driving force for new gene origination?

Wu X, Sharp PA.

Cell. 2013 Nov 21;155(5):990-6. doi: 10.1016/j.cell.2013.10.048.


Regulation of glucose transporter expression in human intestinal Caco-2 cells following exposure to an anthocyanin-rich berry extract.

Alzaid F, Cheung HM, Preedy VR, Sharp PA.

PLoS One. 2013 Nov 13;8(11):e78932. doi: 10.1371/journal.pone.0078932. eCollection 2013.


Promoter directionality is controlled by U1 snRNP and polyadenylation signals.

Almada AE, Wu X, Kriz AJ, Burge CB, Sharp PA.

Nature. 2013 Jul 18;499(7458):360-3. doi: 10.1038/nature12349. Epub 2013 Jun 23.


Let-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts.

Gurtan AM, Ravi A, Rahl PB, Bosson AD, JnBaptiste CK, Bhutkar A, Whittaker CA, Young RA, Sharp PA.

Genes Dev. 2013 Apr 15;27(8):941-54. doi: 10.1101/gad.215376.113.


Molecular biology. A circuitous route to noncoding RNA.

Wilusz JE, Sharp PA.

Science. 2013 Apr 26;340(6131):440-1. doi: 10.1126/science.1238522. No abstract available.


Copper deficiency leads to anemia, duodenal hypoxia, upregulation of HIF-2α and altered expression of iron absorption genes in mice.

Matak P, Zumerle S, Mastrogiannaki M, El Balkhi S, Delga S, Mathieu JR, Canonne-Hergaux F, Poupon J, Sharp PA, Vaulont S, Peyssonnaux C.

PLoS One. 2013;8(3):e59538. doi: 10.1371/journal.pone.0059538. Epub 2013 Mar 28.


The role of miRNAs in regulating gene expression networks.

Gurtan AM, Sharp PA.

J Mol Biol. 2013 Oct 9;425(19):3582-600. doi: 10.1016/j.jmb.2013.03.007. Epub 2013 Mar 13. Review.


Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells.

Sigova AA, Mullen AC, Molinie B, Gupta S, Orlando DA, Guenther MG, Almada AE, Lin C, Sharp PA, Giallourakis CC, Young RA.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2876-81. doi: 10.1073/pnas.1221904110. Epub 2013 Feb 4.

Supplemental Content

Loading ...
Support Center