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Items: 12


Polyethylene glycol functionalized carbon nanotubes/gelatin-chitosan nanocomposite: An approach for significant drug release.

Sharmeen S, Rahman AFMM, Lubna MM, Salem KS, Islam R, Khan MA.

Bioact Mater. 2018 Apr 4;3(3):236-244. doi: 10.1016/j.bioactmat.2018.03.001. eCollection 2018 Sep.


An Unusual Case of Systemic Lupus Erythematosus and Hemophagocytic Syndrome.

Sharmeen S, Hussain N.

Case Rep Rheumatol. 2016;2016:8957690. doi: 10.1155/2016/8957690. Epub 2016 Feb 14.


Granulomatous Interstitial Nephritis Presenting as Hypercalcemia and Nephrolithiasis.

Sharmeen S, Kalkan E, Yi C, Smith SD.

Case Rep Nephrol. 2016;2016:4186086. doi: 10.1155/2016/4186086. Epub 2016 Jan 19.


Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors.

Sukhai MA, Prabha S, Hurren R, Rutledge AC, Lee AY, Sriskanthadevan S, Sun H, Wang X, Skrtic M, Seneviratne A, Cusimano M, Jhas B, Gronda M, MacLean N, Cho EE, Spagnuolo PA, Sharmeen S, Gebbia M, Urbanus M, Eppert K, Dissanayake D, Jonet A, Dassonville-Klimpt A, Li X, Datti A, Ohashi PS, Wrana J, Rogers I, Sonnet P, Ellis WY, Corey SJ, Eaves C, Minden MD, Wang JC, Dick JE, Nislow C, Giaever G, Schimmer AD.

J Clin Invest. 2013 Jan;123(1):315-28. doi: 10.1172/JCI64180. Epub 2012 Dec 3.


Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain.

Page BD, Fletcher S, Yue P, Li Z, Zhang X, Sharmeen S, Datti A, Wrana JL, Trudel S, Schimmer AD, Turkson J, Gunning PT.

Bioorg Med Chem Lett. 2011 Sep 15;21(18):5605-9. doi: 10.1016/j.bmcl.2011.06.056. Epub 2011 Jun 30.


Antagonism of the Stat3-Stat3 protein dimer with salicylic acid based small molecules.

Fletcher S, Page BD, Zhang X, Yue P, Li ZH, Sharmeen S, Singh J, Zhao W, Schimmer AD, Trudel S, Turkson J, Gunning PT.

ChemMedChem. 2011 Aug 1;6(8):1459-70. doi: 10.1002/cmdc.201100194. Epub 2011 May 25.


Design, synthesis, and in vitro characterization of novel hybrid peptidomimetic inhibitors of STAT3 protein.

Shahani VM, Yue P, Fletcher S, Sharmeen S, Sukhai MA, Luu DP, Zhang X, Sun H, Zhao W, Schimmer AD, Turkson J, Gunning PT.

Bioorg Med Chem. 2011 Mar 1;19(5):1823-38. doi: 10.1016/j.bmc.2010.12.010. Epub 2010 Dec 9.


The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells.

Sharmeen S, Skrtic M, Sukhai MA, Hurren R, Gronda M, Wang X, Fonseca SB, Sun H, Wood TE, Ward R, Minden MD, Batey RA, Datti A, Wrana J, Kelley SO, Schimmer AD.

Blood. 2010 Nov 4;116(18):3593-603. doi: 10.1182/blood-2010-01-262675. Epub 2010 Jul 19.


The antihelmintic flubendazole inhibits microtubule function through a mechanism distinct from Vinca alkaloids and displays preclinical activity in leukemia and myeloma.

Spagnuolo PA, Hu J, Hurren R, Wang X, Gronda M, Sukhai MA, Di Meo A, Boss J, Ashali I, Beheshti Zavareh R, Fine N, Simpson CD, Sharmeen S, Rottapel R, Schimmer AD.

Blood. 2010 Jun 10;115(23):4824-33. doi: 10.1182/blood-2009-09-243055. Epub 2010 Mar 26.


Coordination complex SH2 domain proteomimetics: an alternative approach to disrupting oncogenic protein-protein interactions.

Drewry JA, Fletcher S, Yue P, Marushchak D, Zhao W, Sharmeen S, Zhang X, Schimmer AD, Gradinaru C, Turkson J, Gunning PT.

Chem Commun (Camb). 2010 Feb 14;46(6):892-4. doi: 10.1039/b919608k. Epub 2009 Dec 1.


Disruption of transcriptionally active Stat3 dimers with non-phosphorylated, salicylic acid-based small molecules: potent in vitro and tumor cell activities.

Fletcher S, Singh J, Zhang X, Yue P, Page BD, Sharmeen S, Shahani VM, Zhao W, Schimmer AD, Turkson J, Gunning PT.

Chembiochem. 2009 Aug 17;10(12):1959-64. doi: 10.1002/cbic.200900172. No abstract available.

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