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Clinical Development of Novel Drug-Radiotherapy Combinations.

Ahmad SS, Crittenden MR, Tran PT, Kluetz PG, Blumenthal GM, Bulbeck H, Baird RD, Williams KJ, Illidge T, Hahn S, Lawrence TS, Spears PA, Walker AJ, Sharma RA.

Clin Cancer Res. 2018 Nov 29. pii: clincanres.2466.2018. doi: 10.1158/1078-0432.CCR-18-2466. [Epub ahead of print]


New concepts on acute ocular ischemia.

Sharma RA, Newman NJ, Biousse V.

Curr Opin Neurol. 2018 Nov 15. doi: 10.1097/WCO.0000000000000634. [Epub ahead of print]


Prevalence of Sleep Disorders in Adults With Down Syndrome: A Comparative Study of Self-Reported, Actigraphic, and Polysomnographic Findings.

Giménez S, Videla L, Romero S, Benejam B, Clos S, Fernández S, Martínez M, Carmona-Iragui M, Antonijoan RM, Mayos M, Fortuna A, Peñacoba P, Plaza V, Osorio RS, Sharma RA, Bardés I, Rebillat AS, Lleó A, Blesa R, Videla S, Fortea J.

J Clin Sleep Med. 2018 Oct 15;14(10):1725-1733. doi: 10.5664/jcsm.7382.


Status of Canadian undergraduate medical education in ophthalmology.

Gostimir M, Sharma RA, Bhatti A.

Can J Ophthalmol. 2018 Oct;53(5):474-479. doi: 10.1016/j.jcjo.2017.11.015. Epub 2018 Feb 13.


Analysis of a National Programme for Selective Internal Radiation Therapy for Colorectal Cancer Liver Metastases.

White J, Carolan-Rees G, Dale M, Morgan HE, Patrick HE, See TC, Beeton EL, Swinson DEB, Bell JK, Manas DM, Crellin A, Slevin NJ, Sharma RA.

Clin Oncol (R Coll Radiol). 2018 Oct 5. pii: S0936-6555(18)30438-2. doi: 10.1016/j.clon.2018.09.002. [Epub ahead of print]


Long-term radiological and histological outcomes following selective internal radiation therapy to liver metastases from breast cancer.

Lyon PC, Winter H, Herbschleb K, Campo L, Carlisle R, Wu F, Goldin R, Coussios CC, Middleton MR, Gleeson FV, Boardman P, Sharma RA.

Radiol Case Rep. 2018 Sep 22;13(6):1259-1266. doi: 10.1016/j.radcr.2018.08.020. eCollection 2018 Dec.


Beyond the Knife: The Evolving Nonsurgical Management of Oligometastatic Colorectal Cancer.

Gill S, Liu DM, Green HM, Sharma RA.

Am Soc Clin Oncol Educ Book. 2018 May 23;(38):209-219. doi: 10.1200/EDBK_200941. Review.


Recommendations for clinical translation of nanoparticle-enhanced radiotherapy.

Ricketts K, Ahmad R, Beaton L, Cousins B, Critchley K, Davies M, Evans S, Fenuyi I, Gavriilidis A, Harmer QJ, Jayne D, Jefford M, Loizidou M, Macrobert A, Moorcroft S, Naasani I, Ong ZY, Prise KM, Rannard S, Richards T, Schettino G, Sharma RA, Tillement O, Wakefield G, Williams NR, Yaghini E, Royle G.

Br J Radiol. 2018 Dec;91(1092):20180325. doi: 10.1259/bjr.20180325. Epub 2018 Sep 17.


Functional Parameters Derived from Magnetic Resonance Imaging Reflect Vascular Morphology in Preclinical Tumors and in Human Liver Metastases.

Kannan P, Kretzschmar WW, Winter H, Warren D, Bates R, Allen PD, Syed N, Irving B, Papiez BW, Kaeppler J, Markelc B, Kinchesh P, Gilchrist S, Smart S, Schnabel JA, Maughan T, Harris AL, Muschel RJ, Partridge M, Sharma RA, Kersemans V.

Clin Cancer Res. 2018 Oct 1;24(19):4694-4704. doi: 10.1158/1078-0432.CCR-18-0033. Epub 2018 Jun 29.


Association between positive corneal rim cultures and microbiology screening protocols in Ontario.

Sharma RA, Park JSY, Wang Y, Zhang T, Sharpen L, Dixon W, Mather R.

Can J Ophthalmol. 2018 Jun;53(3):272-277. doi: 10.1016/j.jcjo.2017.09.009. Epub 2017 Dec 1.


Translational study identifies XPF and MUS81 as predictive biomarkers for oxaliplatin-based peri-operative chemotherapy in patients with esophageal adenocarcinoma.

MacGregor TP, Carter R, Gillies RS, Findlay JM, Kartsonaki C, Castro-Giner F, Sahgal N, Wang LM, Chetty R, Maynard ND, Cazier JB, Buffa F, McHugh PJ, Tomlinson I, Middleton MR, Sharma RA.

Sci Rep. 2018 May 8;8(1):7265. doi: 10.1038/s41598-018-24232-2.


Treatment of Nonarteritic Acute Central Retinal Artery Occlusion.

Sharma RA, Dattilo M, Newman NJ, Biousse V.

Asia Pac J Ophthalmol (Phila). 2018 Jul-Aug;7(4):235-241. doi: 10.22608/APO.201871. Epub 2018 May 2. Review.


Assessment of medical devices: the Emperor's new clothes: Author reply.

Sharma RA, Fumi L, Audisio RA, Denys A, Wood BJ, Pignatti F.

Br J Radiol. 2018 Jun;91(1086):20180310. doi: 10.1259/bjr.20180310. Epub 2018 May 11. No abstract available.


4D-PET reconstruction using a spline-residue model with spatial and temporal roughness penalties.

Ralli GP, Chappell MA, McGowan DR, Sharma RA, Higgins GS, Fenwick JD.

Phys Med Biol. 2018 May 4;63(9):095013. doi: 10.1088/1361-6560/aabb62.


Locoregional therapies in cholangiocarcinoma.

Labib PL, Davidson BR, Sharma RA, Pereira SP.

Hepat Oncol. 2017 Oct;4(4):99-109. doi: 10.2217/hep-2017-0014. Epub 2017 Nov 17.


Safety of selective internal radiation therapy (SIRT) with yttrium-90 microspheres combined with systemic anticancer agents: expert consensus.

Kennedy A, Brown DB, Feilchenfeldt J, Marshall J, Wasan H, Fakih M, Gibbs P, Knuth A, Sangro B, Soulen MC, Pittari G, Sharma RA.

J Gastrointest Oncol. 2017 Dec;8(6):1079-1099. doi: 10.21037/jgo.2017.09.10. Review.


Adequate SIRT activity dose is as important as adequate chemotherapy dose - Authors' reply.

Sharma RA, Gibbs P, Sharma NK, Ricke J, Taieb J, Moschandreas J, Virdee PS, Dutton P, van Hazel G, Wasan HS.

Lancet Oncol. 2017 Nov;18(11):e637. doi: 10.1016/S1470-2045(17)30801-X. Epub 2017 Oct 31. No abstract available.


Commentary: how will interventional oncology navigate the "valleys of death" for new medical devices?

Sharma RA, Fumi L, Audisio RA, Denys A, Wood BJ, Pignatti F.

Br J Radiol. 2018 Feb;91(1083):20170643. doi: 10.1259/bjr.20170643. Epub 2018 Jan 31.


Obstructive Sleep Apnea Severity Affects Amyloid Burden in Cognitively Normal Elderly. A Longitudinal Study.

Sharma RA, Varga AW, Bubu OM, Pirraglia E, Kam K, Parekh A, Wohlleber M, Miller MD, Andrade A, Lewis C, Tweardy S, Buj M, Yau PL, Sadda R, Mosconi L, Li Y, Butler T, Glodzik L, Fieremans E, Babb JS, Blennow K, Zetterberg H, Lu SE, Badia SG, Romero S, Rosenzweig I, Gosselin N, Jean-Louis G, Rapoport DM, de Leon MJ, Ayappa I, Osorio RS.

Am J Respir Crit Care Med. 2018 Apr 1;197(7):933-943. doi: 10.1164/rccm.201704-0704OC.


Barriers to electronic medical record implementation: a comparison between ophthalmology and other surgical specialties in Canada.

Park JSY, Sharma RA, Poulis B, Noble J.

Can J Ophthalmol. 2017 Oct;52(5):503-507. doi: 10.1016/j.jcjo.2017.02.018. Epub 2017 Apr 20.


Effect of elicitors on the production of pyrroloquinazoline alkaloids by stimulating anthranilate synthase activity in Adhatoda vasica Nees cell cultures.

Singh B, Sahu PM, Sharma RA.

Planta. 2017 Dec;246(6):1125-1137. doi: 10.1007/s00425-017-2757-x. Epub 2017 Aug 17.


Introducing the Cancer Research UK Advanced Radiotherapy Technologies Network (ART-NET).

Harrington K, Hall E, Hawkins M, Henry A, MacKay R, Maughan T, McDonald A, Nutting C, Oelfke U, Sebag-Montefiore D, Sharma RA, van Herk M, Faivre-Finn C; ART-NET Steering Committee.

Clin Oncol (R Coll Radiol). 2017 Nov;29(11):707-710. doi: 10.1016/j.clon.2017.07.016. Epub 2017 Aug 12. No abstract available.


First-line selective internal radiotherapy plus chemotherapy versus chemotherapy alone in patients with liver metastases from colorectal cancer (FOXFIRE, SIRFLOX, and FOXFIRE-Global): a combined analysis of three multicentre, randomised, phase 3 trials.

Wasan HS, Gibbs P, Sharma NK, Taieb J, Heinemann V, Ricke J, Peeters M, Findlay M, Weaver A, Mills J, Wilson C, Adams R, Francis A, Moschandreas J, Virdee PS, Dutton P, Love S, Gebski V, Gray A; FOXFIRE trial investigators; SIRFLOX trial investigators; FOXFIRE-Global trial investigators, van Hazel G, Sharma RA.

Lancet Oncol. 2017 Sep;18(9):1159-1171. doi: 10.1016/S1470-2045(17)30457-6. Epub 2017 Aug 3.


Prevention and treatment of complications of selective internal radiation therapy: Expert guidance and systematic review.

Sangro B, Martínez-Urbistondo D, Bester L, Bilbao JI, Coldwell DM, Flamen P, Kennedy A, Ricke J, Sharma RA.

Hepatology. 2017 Sep;66(3):969-982. doi: 10.1002/hep.29207. Epub 2017 Jul 27. Review.


Protocol for Combined Analysis of FOXFIRE, SIRFLOX, and FOXFIRE-Global Randomized Phase III Trials of Chemotherapy +/- Selective Internal Radiation Therapy as First-Line Treatment for Patients With Metastatic Colorectal Cancer.

Virdee PS, Moschandreas J, Gebski V, Love SB, Francis EA, Wasan HS, van Hazel G, Gibbs P, Sharma RA.

JMIR Res Protoc. 2017 Mar 28;6(3):e43. doi: 10.2196/resprot.7201.


Flavonoids from Heliotropium subulatum exudate and their evaluation for antioxidant, antineoplastic and cytotoxic activities II.

Singh B, Sahu PM, Sharma RA.

Cytotechnology. 2017 Feb;69(1):103-115. doi: 10.1007/s10616-016-0041-8. Epub 2016 Nov 30.


The need for multidisciplinarity in specialist training to optimize future patient care.

Tree AC, Harding V, Bhangu A, Krishnasamy V, Morton D, Stebbing J, Wood BJ, Sharma RA.

Nat Rev Clin Oncol. 2017 Aug;14(8):508-517. doi: 10.1038/nrclinonc.2016.185. Epub 2016 Nov 29. Review.


Imaging biomarker roadmap for cancer studies.

O'Connor JP, Aboagye EO, Adams JE, Aerts HJ, Barrington SF, Beer AJ, Boellaard R, Bohndiek SE, Brady M, Brown G, Buckley DL, Chenevert TL, Clarke LP, Collette S, Cook GJ, deSouza NM, Dickson JC, Dive C, Evelhoch JL, Faivre-Finn C, Gallagher FA, Gilbert FJ, Gillies RJ, Goh V, Griffiths JR, Groves AM, Halligan S, Harris AL, Hawkes DJ, Hoekstra OS, Huang EP, Hutton BF, Jackson EF, Jayson GC, Jones A, Koh DM, Lacombe D, Lambin P, Lassau N, Leach MO, Lee TY, Leen EL, Lewis JS, Liu Y, Lythgoe MF, Manoharan P, Maxwell RJ, Miles KA, Morgan B, Morris S, Ng T, Padhani AR, Parker GJ, Partridge M, Pathak AP, Peet AC, Punwani S, Reynolds AR, Robinson SP, Shankar LK, Sharma RA, Soloviev D, Stroobants S, Sullivan DC, Taylor SA, Tofts PS, Tozer GM, van Herk M, Walker-Samuel S, Wason J, Williams KJ, Workman P, Yankeelov TE, Brindle KM, McShane LM, Jackson A, Waterton JC.

Nat Rev Clin Oncol. 2017 Mar;14(3):169-186. doi: 10.1038/nrclinonc.2016.162. Epub 2016 Oct 11. Review.


Imaging oligometastatic cancer before local treatment.

Franklin JM, Sharma RA, Harris AL, Gleeson FV.

Lancet Oncol. 2016 Sep;17(9):e406-14. doi: 10.1016/S1470-2045(16)30277-7. Epub 2016 Aug 30. Review.


Landmark study raises the bar for interventional oncology.

Shiao J, Winter H, Sharma RA.

Future Oncol. 2016 Aug;12(15):1747-9. doi: 10.2217/fon-2016-0212. Epub 2016 Jun 23. No abstract available.


Clinical development of new drug-radiotherapy combinations.

Sharma RA, Plummer R, Stock JK, Greenhalgh TA, Ataman O, Kelly S, Clay R, Adams RA, Baird RD, Billingham L, Brown SR, Buckland S, Bulbeck H, Chalmers AJ, Clack G, Cranston AN, Damstrup L, Ferraldeschi R, Forster MD, Golec J, Hagan RM, Hall E, Hanauske AR, Harrington KJ, Haswell T, Hawkins MA, Illidge T, Jones H, Kennedy AS, McDonald F, Melcher T, O'Connor JP, Pollard JR, Saunders MP, Sebag-Montefiore D, Smitt M, Staffurth J, Stratford IJ, Wedge SR; NCRI CTRad Academia-Pharma Joint Working Group.

Nat Rev Clin Oncol. 2016 Oct;13(10):627-42. doi: 10.1038/nrclinonc.2016.79. Epub 2016 Jun 1.


Isolated conjunctival mass presenting as acute myeloid leukemia in an infant.

Nair AG, Trivedi MG, Desai RJ, Potdar NA, Sharma RA, Manglani MV, Shinde CA.

Indian J Med Paediatr Oncol. 2016 Apr-Jun;37(2):124. doi: 10.4103/0971-5851.180146. No abstract available.


Pieces-of-parts for supervoxel segmentation with global context: Application to DCE-MRI tumour delineation.

Irving B, Franklin JM, Papież BW, Anderson EM, Sharma RA, Gleeson FV, Brady SM, Schnabel JA.

Med Image Anal. 2016 Aug;32:69-83. doi: 10.1016/ Epub 2016 Mar 21.


Differential clonal evolution in oesophageal cancers in response to neo-adjuvant chemotherapy.

Findlay JM, Castro-Giner F, Makino S, Rayner E, Kartsonaki C, Cross W, Kovac M, Ulahannan D, Palles C, Gillies RS, MacGregor TP, Church D, Maynard ND, Buffa F, Cazier JB, Graham TA, Wang LM, Sharma RA, Middleton M, Tomlinson I.

Nat Commun. 2016 Apr 5;7:11111. doi: 10.1038/ncomms11111.


Comparison of intraocular pressure post penetrating keratoplasty vs Descemet's stripping endothelial keratoplasty.

Sharma RA, Bursztyn LL, Golesic E, Mather R, Tingey DP.

Can J Ophthalmol. 2016 Feb;51(1):19-24. doi: 10.1016/j.jcjo.2015.09.014.


Radiosensitisation of human colorectal cancer cells by ruthenium(II) arene anticancer complexes.

Carter R, Westhorpe A, Romero MJ, Habtemariam A, Gallevo CR, Bark Y, Menezes N, Sadler PJ, Sharma RA.

Sci Rep. 2016 Feb 12;6:20596. doi: 10.1038/srep20596.


Clinical Trial of Oral Nelfinavir before and during Radiation Therapy for Advanced Rectal Cancer.

Hill EJ, Roberts C, Franklin JM, Enescu M, West N, MacGregor TP, Chu KY, Boyle L, Blesing C, Wang LM, Mukherjee S, Anderson EM, Brown G, Dutton S, Love SB, Schnabel JA, Quirke P, Muschel R, McKenna WG, Partridge M, Sharma RA.

Clin Cancer Res. 2016 Apr 15;22(8):1922-31. doi: 10.1158/1078-0432.CCR-15-1489. Epub 2016 Feb 9.


Anti-Inflammatory and Antimicrobial Properties of Flavonoids from Heliotropium subulatum Exudate.

Singh B, Sharma RA.

Inflamm Allergy Drug Targets. 2015;14(2):125-32.


Combination of Novel Agents with Radiotherapy to Treat Rectal Cancer.

Greenhalgh TA, Dearman C, Sharma RA.

Clin Oncol (R Coll Radiol). 2016 Feb;28(2):116-139. doi: 10.1016/j.clon.2015.11.002. Epub 2015 Dec 21. Review.


Management of a thyroid "incidentaloma" in a patient with cancer: a case report.

Dearman C, Hill EJ, Franklin JM, Sadler GP, Wang LM, Silva MA, Sharma RA.

Int Med Case Rep J. 2015 Oct 16;8:247-9. doi: 10.2147/IMCRJ.S92857. eCollection 2015.


Surgery versus SABR for resectable non-small-cell lung cancer.

Dearman C, van As N, Crellin A, Slevin N, Sharma RA.

Lancet Oncol. 2015 Aug;16(8):e373-4. doi: 10.1016/S1470-2045(15)00145-X. No abstract available.


Predictors of Compartment Syndrome After Tibial Fracture.

McQueen MM, Duckworth AD, Aitken SA, Sharma RA, Court-Brown CM.

J Orthop Trauma. 2015 Oct;29(10):451-5. doi: 10.1097/BOT.0000000000000347.


NEOSCOPE: a randomised Phase II study of induction chemotherapy followed by either oxaliplatin/capecitabine or paclitaxel/carboplatin based chemoradiation as pre-operative regimen for resectable oesophageal adenocarcinoma.

Mukherjee S, Hurt CN, Gwynne S, Bateman A, Gollins S, Radhakrishna G, Hawkins M, Canham J, Lewis W, Grabsch HI, Sharma RA, Wade W, Maggs R, Tranter B, Roberts A, Sebag-Montefiore D, Maughan T, Griffiths G, Crosby T.

BMC Cancer. 2015 Feb 12;15:48. doi: 10.1186/s12885-015-1062-y.


Immunoglobulin levels and CD4 / CD8 counts in β- thalassemia major.

Kadam PP, Manglani MV, Sharma SM, Sharma RA, Setia MS.

Indian Pediatr. 2014 Dec;51(12):1000-2.


Plant terpenes: defense responses, phylogenetic analysis, regulation and clinical applications.

Singh B, Sharma RA.

3 Biotech. 2015 Apr;5(2):129-151. doi: 10.1007/s13205-014-0220-2. Epub 2014 Apr 29.


Clinical trials of interventional oncology-moving from efficacy to outcomes.

Franklin JM, Gebski V, Poston GJ, Sharma RA.

Nat Rev Clin Oncol. 2015 Feb;12(2):93-104. doi: 10.1038/nrclinonc.2014.199. Epub 2014 Dec 9. Review.


Case histories in unresectable liver-dominant metastatic colorectal cancer.

Sharma RA, Peeters M, Taïeb J.

Future Oncol. 2014 Nov;10(15 Suppl):41-7. doi: 10.2217/fon.14.222. Review. No abstract available.


Glucose transporter isoform-1 receptor-positive infantile capillary hemangiomas: case report and literature review.

Brissette A, Sharma RA, Strube YN, Farmer J, Kratky V.

Can J Ophthalmol. 2014 Dec;49(6):e156-8. doi: 10.1016/j.jcjo.2014.09.007. Review. No abstract available. Erratum in: Can J Ophthalmol. 2017 Dec;52(6):630.


Selective internal radiotherapy of the liver: at the crossroads of interventional oncology research and national health service commissioning.

Sharma RA, Cummins C, Crellin A.

Clin Oncol (R Coll Radiol). 2014 Dec;26(12):733-5. doi: 10.1016/j.clon.2014.09.009. Epub 2014 Oct 2. No abstract available.


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