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Items: 1 to 50 of 166

1.

VEROnA Protocol: A Pilot, Open-Label, Single-Arm, Phase 0, Window-of-Opportunity Study of Vandetanib-Eluting Radiopaque Embolic Beads (BTG-002814) in Patients With Resectable Liver Malignancies.

Beaton L, Tregidgo HFJ, Znati SA, Forsyth S, Clarkson MJ, Bandula S, Chouhan M, Lowe HL, Zaw Thin M, Hague J, Sharma D, Pollok JM, Davidson BR, Raja J, Munneke G, Stuckey DJ, Bascal ZA, Wilde PE, Cooper S, Ryan S, Czuczman P, Boucher E, Hartley JA, Lewis AL, Jansen M, Meyer T, Sharma RA.

JMIR Res Protoc. 2019 Oct 2;8(10):e13696. doi: 10.2196/13696.

2.

Identification of anticancer drugs to radiosensitise BRAF-wild-type and mutant colorectal cancer.

Carter R, Cheraghchi-Bashi A, Westhorpe A, Yu S, Shanneik Y, Seraia E, Ouaret D, Inoue Y, Koch C, Wilding J, Ebner D, Ryan AJ, Buffa FM, Sharma RA.

Cancer Biol Med. 2019 May;16(2):234-246. doi: 10.20892/j.issn.2095-3941.2018.0284.

3.

Hepatic Resection Following Selective Internal Radiation Therapy for Colorectal Cancer Metastases in the FOXFIRE Clinical Trial: Clinical Outcomes and Distribution of Microspheres.

Winter H, Rassam J, Virdee PS, Goldin R, Pitcheshwar P, Weaver K, Primrose J, Berry DP, Wasan HS, Sharma RA.

Cancers (Basel). 2019 Aug 12;11(8). pii: E1155. doi: 10.3390/cancers11081155.

4.

Yttrium-90 Transarterial Radioembolization for Chemotherapy-Refractory Intrahepatic Cholangiocarcinoma: A Prospective, Observational Study.

White J, Carolan-Rees G, Dale M, Patrick HE, See TC, Bell JK, Manas DM, Crellin A, Slevin NJ, Sharma RA.

J Vasc Interv Radiol. 2019 Aug;30(8):1185-1192. doi: 10.1016/j.jvir.2019.03.018. Epub 2019 Jun 27.

PMID:
31255499
5.

Rapid advances in auto-segmentation of organs at risk and target volumes in head and neck cancer.

Kosmin M, Ledsam J, Romera-Paredes B, Mendes R, Moinuddin S, de Souza D, Gunn L, Kelly C, Hughes CO, Karthikesalingam A, Nutting C, Sharma RA.

Radiother Oncol. 2019 Jun;135:130-140. doi: 10.1016/j.radonc.2019.03.004. Epub 2019 Mar 22. Review.

PMID:
31015159
6.

How rapid advances in imaging are defining the future of precision radiation oncology.

Beaton L, Bandula S, Gaze MN, Sharma RA.

Br J Cancer. 2019 Apr;120(8):779-790. doi: 10.1038/s41416-019-0412-y. Epub 2019 Mar 26. Review.

PMID:
30911090
7.

Obstructive sleep apnea and longitudinal Alzheimer's disease biomarker changes.

Bubu OM, Pirraglia E, Andrade AG, Sharma RA, Gimenez-Badia S, Umasabor-Bubu OQ, Hogan MM, Shim AM, Mukhtar F, Sharma N, Mbah AK, Seixas AA, Kam K, Zizi F, Borenstein AR, Mortimer JA, Kip KE, Morgan D, Rosenzweig I, Ayappa I, Rapoport DM, Jean-Louis G, Varga AW, Osorio RS; Alzheimer’s Disease Neuroimaging Initiative.

Sleep. 2019 Jun 11;42(6). pii: zsz048. doi: 10.1093/sleep/zsz048.

PMID:
30794315
8.

Sleep oscillation-specific associations with Alzheimer's disease CSF biomarkers: novel roles for sleep spindles and tau.

Kam K, Parekh A, Sharma RA, Andrade A, Lewin M, Castillo B, Bubu OM, Chua NJ, Miller MD, Mullins AE, Glodzik L, Mosconi L, Gosselin N, Prathamesh K, Chen Z, Blennow K, Zetterberg H, Bagchi N, Cavedoni B, Rapoport DM, Ayappa I, de Leon MJ, Petkova E, Varga AW, Osorio RS.

Mol Neurodegener. 2019 Feb 21;14(1):10. doi: 10.1186/s13024-019-0309-5.

9.

TheraSphere Yttrium-90 Glass Microspheres Combined With Chemotherapy Versus Chemotherapy Alone in Second-Line Treatment of Patients With Metastatic Colorectal Carcinoma of the Liver: Protocol for the EPOCH Phase 3 Randomized Clinical Trial.

Chauhan N, Mulcahy MF, Salem R, Benson Iii AB, Boucher E, Bukovcan J, Cosgrove D, Laframboise C, Lewandowski RJ, Master F, El-Rayes B, Strosberg JR, Sze DY, Sharma RA.

JMIR Res Protoc. 2019 Jan 17;8(1):e11545. doi: 10.2196/11545.

10.

Clinical Development of Novel Drug-Radiotherapy Combinations.

Ahmad SS, Crittenden MR, Tran PT, Kluetz PG, Blumenthal GM, Bulbeck H, Baird RD, Williams KJ, Illidge T, Hahn SM, Lawrence TS, Spears PA, Walker AJ, Sharma RA.

Clin Cancer Res. 2019 Mar 1;25(5):1455-1461. doi: 10.1158/1078-0432.CCR-18-2466. Epub 2018 Nov 29.

PMID:
30498095
11.

New concepts on acute ocular ischemia.

Sharma RA, Newman NJ, Biousse V.

Curr Opin Neurol. 2019 Feb;32(1):19-24. doi: 10.1097/WCO.0000000000000634. Review.

PMID:
30461463
12.

Prevalence of Sleep Disorders in Adults With Down Syndrome: A Comparative Study of Self-Reported, Actigraphic, and Polysomnographic Findings.

Giménez S, Videla L, Romero S, Benejam B, Clos S, Fernández S, Martínez M, Carmona-Iragui M, Antonijoan RM, Mayos M, Fortuna A, Peñacoba P, Plaza V, Osorio RS, Sharma RA, Bardés I, Rebillat AS, Lleó A, Blesa R, Videla S, Fortea J.

J Clin Sleep Med. 2018 Oct 15;14(10):1725-1733. doi: 10.5664/jcsm.7382.

13.

Status of Canadian undergraduate medical education in ophthalmology.

Gostimir M, Sharma RA, Bhatti A.

Can J Ophthalmol. 2018 Oct;53(5):474-479. doi: 10.1016/j.jcjo.2017.11.015. Epub 2018 Feb 13.

PMID:
30340714
14.

Analysis of a National Programme for Selective Internal Radiation Therapy for Colorectal Cancer Liver Metastases.

White J, Carolan-Rees G, Dale M, Morgan HE, Patrick HE, See TC, Beeton EL, Swinson DEB, Bell JK, Manas DM, Crellin A, Slevin NJ, Sharma RA.

Clin Oncol (R Coll Radiol). 2019 Jan;31(1):58-66. doi: 10.1016/j.clon.2018.09.002. Epub 2018 Oct 5.

PMID:
30297164
15.
16.

Long-term radiological and histological outcomes following selective internal radiation therapy to liver metastases from breast cancer.

Lyon PC, Winter H, Herbschleb K, Campo L, Carlisle R, Wu F, Goldin R, Coussios CC, Middleton MR, Gleeson FV, Boardman P, Sharma RA.

Radiol Case Rep. 2018 Sep 22;13(6):1259-1266. doi: 10.1016/j.radcr.2018.08.020. eCollection 2018 Dec.

17.

Beyond the Knife: The Evolving Nonsurgical Management of Oligometastatic Colorectal Cancer.

Gill S, Liu DM, Green HM, Sharma RA.

Am Soc Clin Oncol Educ Book. 2018 May 23;38:209-219. doi: 10.1200/EDBK_200941. Review.

PMID:
30231355
18.

Recommendations for clinical translation of nanoparticle-enhanced radiotherapy.

Ricketts K, Ahmad R, Beaton L, Cousins B, Critchley K, Davies M, Evans S, Fenuyi I, Gavriilidis A, Harmer QJ, Jayne D, Jefford M, Loizidou M, Macrobert A, Moorcroft S, Naasani I, Ong ZY, Prise KM, Rannard S, Richards T, Schettino G, Sharma RA, Tillement O, Wakefield G, Williams NR, Yaghini E, Royle G.

Br J Radiol. 2018 Dec;91(1092):20180325. doi: 10.1259/bjr.20180325. Epub 2018 Sep 17.

19.

Functional Parameters Derived from Magnetic Resonance Imaging Reflect Vascular Morphology in Preclinical Tumors and in Human Liver Metastases.

Kannan P, Kretzschmar WW, Winter H, Warren D, Bates R, Allen PD, Syed N, Irving B, Papiez BW, Kaeppler J, Markelc B, Kinchesh P, Gilchrist S, Smart S, Schnabel JA, Maughan T, Harris AL, Muschel RJ, Partridge M, Sharma RA, Kersemans V.

Clin Cancer Res. 2018 Oct 1;24(19):4694-4704. doi: 10.1158/1078-0432.CCR-18-0033. Epub 2018 Jun 29.

20.

Association between positive corneal rim cultures and microbiology screening protocols in Ontario.

Sharma RA, Park JSY, Wang Y, Zhang T, Sharpen L, Dixon W, Mather R.

Can J Ophthalmol. 2018 Jun;53(3):272-277. doi: 10.1016/j.jcjo.2017.09.009. Epub 2017 Dec 1.

PMID:
29784165
21.

Translational study identifies XPF and MUS81 as predictive biomarkers for oxaliplatin-based peri-operative chemotherapy in patients with esophageal adenocarcinoma.

MacGregor TP, Carter R, Gillies RS, Findlay JM, Kartsonaki C, Castro-Giner F, Sahgal N, Wang LM, Chetty R, Maynard ND, Cazier JB, Buffa F, McHugh PJ, Tomlinson I, Middleton MR, Sharma RA.

Sci Rep. 2018 May 8;8(1):7265. doi: 10.1038/s41598-018-24232-2.

22.

Treatment of Nonarteritic Acute Central Retinal Artery Occlusion.

Sharma RA, Dattilo M, Newman NJ, Biousse V.

Asia Pac J Ophthalmol (Phila). 2018 Jul-Aug;7(4):235-241. doi: 10.22608/APO.201871. Epub 2018 May 2. Review.

PMID:
29717825
23.

Assessment of medical devices: the Emperor's new clothes: Author reply.

Sharma RA, Fumi L, Audisio RA, Denys A, Wood BJ, Pignatti F.

Br J Radiol. 2018 Jun;91(1086):20180310. doi: 10.1259/bjr.20180310. Epub 2018 May 11. No abstract available.

24.

4D-PET reconstruction using a spline-residue model with spatial and temporal roughness penalties.

Ralli GP, Chappell MA, McGowan DR, Sharma RA, Higgins GS, Fenwick JD.

Phys Med Biol. 2018 May 4;63(9):095013. doi: 10.1088/1361-6560/aabb62.

25.

Locoregional therapies in cholangiocarcinoma.

Labib PL, Davidson BR, Sharma RA, Pereira SP.

Hepat Oncol. 2017 Oct;4(4):99-109. doi: 10.2217/hep-2017-0014. Epub 2017 Nov 17.

26.

Safety of selective internal radiation therapy (SIRT) with yttrium-90 microspheres combined with systemic anticancer agents: expert consensus.

Kennedy A, Brown DB, Feilchenfeldt J, Marshall J, Wasan H, Fakih M, Gibbs P, Knuth A, Sangro B, Soulen MC, Pittari G, Sharma RA.

J Gastrointest Oncol. 2017 Dec;8(6):1079-1099. doi: 10.21037/jgo.2017.09.10. Review.

27.

Adequate SIRT activity dose is as important as adequate chemotherapy dose - Authors' reply.

Sharma RA, Gibbs P, Sharma NK, Ricke J, Taieb J, Moschandreas J, Virdee PS, Dutton P, van Hazel G, Wasan HS.

Lancet Oncol. 2017 Nov;18(11):e637. doi: 10.1016/S1470-2045(17)30801-X. Epub 2017 Oct 31. No abstract available.

PMID:
29208391
28.

Commentary: how will interventional oncology navigate the "valleys of death" for new medical devices?

Sharma RA, Fumi L, Audisio RA, Denys A, Wood BJ, Pignatti F.

Br J Radiol. 2018 Feb;91(1083):20170643. doi: 10.1259/bjr.20170643. Epub 2018 Jan 31.

29.

Obstructive Sleep Apnea Severity Affects Amyloid Burden in Cognitively Normal Elderly. A Longitudinal Study.

Sharma RA, Varga AW, Bubu OM, Pirraglia E, Kam K, Parekh A, Wohlleber M, Miller MD, Andrade A, Lewis C, Tweardy S, Buj M, Yau PL, Sadda R, Mosconi L, Li Y, Butler T, Glodzik L, Fieremans E, Babb JS, Blennow K, Zetterberg H, Lu SE, Badia SG, Romero S, Rosenzweig I, Gosselin N, Jean-Louis G, Rapoport DM, de Leon MJ, Ayappa I, Osorio RS.

Am J Respir Crit Care Med. 2018 Apr 1;197(7):933-943. doi: 10.1164/rccm.201704-0704OC.

30.

Barriers to electronic medical record implementation: a comparison between ophthalmology and other surgical specialties in Canada.

Park JSY, Sharma RA, Poulis B, Noble J.

Can J Ophthalmol. 2017 Oct;52(5):503-507. doi: 10.1016/j.jcjo.2017.02.018. Epub 2017 Apr 20.

PMID:
28985812
31.

Effect of elicitors on the production of pyrroloquinazoline alkaloids by stimulating anthranilate synthase activity in Adhatoda vasica Nees cell cultures.

Singh B, Sahu PM, Sharma RA.

Planta. 2017 Dec;246(6):1125-1137. doi: 10.1007/s00425-017-2757-x. Epub 2017 Aug 17.

PMID:
28819874
32.

Introducing the Cancer Research UK Advanced Radiotherapy Technologies Network (ART-NET).

Harrington K, Hall E, Hawkins M, Henry A, MacKay R, Maughan T, McDonald A, Nutting C, Oelfke U, Sebag-Montefiore D, Sharma RA, van Herk M, Faivre-Finn C; ART-NET Steering Committee.

Clin Oncol (R Coll Radiol). 2017 Nov;29(11):707-710. doi: 10.1016/j.clon.2017.07.016. Epub 2017 Aug 12. No abstract available.

33.

First-line selective internal radiotherapy plus chemotherapy versus chemotherapy alone in patients with liver metastases from colorectal cancer (FOXFIRE, SIRFLOX, and FOXFIRE-Global): a combined analysis of three multicentre, randomised, phase 3 trials.

Wasan HS, Gibbs P, Sharma NK, Taieb J, Heinemann V, Ricke J, Peeters M, Findlay M, Weaver A, Mills J, Wilson C, Adams R, Francis A, Moschandreas J, Virdee PS, Dutton P, Love S, Gebski V, Gray A; FOXFIRE trial investigators; SIRFLOX trial investigators; FOXFIRE-Global trial investigators, van Hazel G, Sharma RA.

Lancet Oncol. 2017 Sep;18(9):1159-1171. doi: 10.1016/S1470-2045(17)30457-6. Epub 2017 Aug 3.

34.

Prevention and treatment of complications of selective internal radiation therapy: Expert guidance and systematic review.

Sangro B, Martínez-Urbistondo D, Bester L, Bilbao JI, Coldwell DM, Flamen P, Kennedy A, Ricke J, Sharma RA.

Hepatology. 2017 Sep;66(3):969-982. doi: 10.1002/hep.29207. Epub 2017 Jul 27. Review.

PMID:
28407278
35.

Protocol for Combined Analysis of FOXFIRE, SIRFLOX, and FOXFIRE-Global Randomized Phase III Trials of Chemotherapy +/- Selective Internal Radiation Therapy as First-Line Treatment for Patients With Metastatic Colorectal Cancer.

Virdee PS, Moschandreas J, Gebski V, Love SB, Francis EA, Wasan HS, van Hazel G, Gibbs P, Sharma RA.

JMIR Res Protoc. 2017 Mar 28;6(3):e43. doi: 10.2196/resprot.7201.

36.

Flavonoids from Heliotropium subulatum exudate and their evaluation for antioxidant, antineoplastic and cytotoxic activities II.

Singh B, Sahu PM, Sharma RA.

Cytotechnology. 2017 Feb;69(1):103-115. doi: 10.1007/s10616-016-0041-8. Epub 2016 Nov 30.

37.

The need for multidisciplinarity in specialist training to optimize future patient care.

Tree AC, Harding V, Bhangu A, Krishnasamy V, Morton D, Stebbing J, Wood BJ, Sharma RA.

Nat Rev Clin Oncol. 2017 Aug;14(8):508-517. doi: 10.1038/nrclinonc.2016.185. Epub 2016 Nov 29. Review.

PMID:
27898067
38.

Imaging biomarker roadmap for cancer studies.

O'Connor JP, Aboagye EO, Adams JE, Aerts HJ, Barrington SF, Beer AJ, Boellaard R, Bohndiek SE, Brady M, Brown G, Buckley DL, Chenevert TL, Clarke LP, Collette S, Cook GJ, deSouza NM, Dickson JC, Dive C, Evelhoch JL, Faivre-Finn C, Gallagher FA, Gilbert FJ, Gillies RJ, Goh V, Griffiths JR, Groves AM, Halligan S, Harris AL, Hawkes DJ, Hoekstra OS, Huang EP, Hutton BF, Jackson EF, Jayson GC, Jones A, Koh DM, Lacombe D, Lambin P, Lassau N, Leach MO, Lee TY, Leen EL, Lewis JS, Liu Y, Lythgoe MF, Manoharan P, Maxwell RJ, Miles KA, Morgan B, Morris S, Ng T, Padhani AR, Parker GJ, Partridge M, Pathak AP, Peet AC, Punwani S, Reynolds AR, Robinson SP, Shankar LK, Sharma RA, Soloviev D, Stroobants S, Sullivan DC, Taylor SA, Tofts PS, Tozer GM, van Herk M, Walker-Samuel S, Wason J, Williams KJ, Workman P, Yankeelov TE, Brindle KM, McShane LM, Jackson A, Waterton JC.

Nat Rev Clin Oncol. 2017 Mar;14(3):169-186. doi: 10.1038/nrclinonc.2016.162. Epub 2016 Oct 11. Review.

39.

Imaging oligometastatic cancer before local treatment.

Franklin JM, Sharma RA, Harris AL, Gleeson FV.

Lancet Oncol. 2016 Sep;17(9):e406-14. doi: 10.1016/S1470-2045(16)30277-7. Epub 2016 Aug 30. Review.

PMID:
27599145
40.

Landmark study raises the bar for interventional oncology.

Shiao J, Winter H, Sharma RA.

Future Oncol. 2016 Aug;12(15):1747-9. doi: 10.2217/fon-2016-0212. Epub 2016 Jun 23. No abstract available.

PMID:
27333807
41.

Clinical development of new drug-radiotherapy combinations.

Sharma RA, Plummer R, Stock JK, Greenhalgh TA, Ataman O, Kelly S, Clay R, Adams RA, Baird RD, Billingham L, Brown SR, Buckland S, Bulbeck H, Chalmers AJ, Clack G, Cranston AN, Damstrup L, Ferraldeschi R, Forster MD, Golec J, Hagan RM, Hall E, Hanauske AR, Harrington KJ, Haswell T, Hawkins MA, Illidge T, Jones H, Kennedy AS, McDonald F, Melcher T, O'Connor JP, Pollard JR, Saunders MP, Sebag-Montefiore D, Smitt M, Staffurth J, Stratford IJ, Wedge SR; NCRI CTRad Academia-Pharma Joint Working Group.

Nat Rev Clin Oncol. 2016 Oct;13(10):627-42. doi: 10.1038/nrclinonc.2016.79. Epub 2016 Jun 1.

42.

Isolated conjunctival mass presenting as acute myeloid leukemia in an infant.

Nair AG, Trivedi MG, Desai RJ, Potdar NA, Sharma RA, Manglani MV, Shinde CA.

Indian J Med Paediatr Oncol. 2016 Apr-Jun;37(2):124. doi: 10.4103/0971-5851.180146. No abstract available.

43.

Pieces-of-parts for supervoxel segmentation with global context: Application to DCE-MRI tumour delineation.

Irving B, Franklin JM, Papież BW, Anderson EM, Sharma RA, Gleeson FV, Brady SM, Schnabel JA.

Med Image Anal. 2016 Aug;32:69-83. doi: 10.1016/j.media.2016.03.002. Epub 2016 Mar 21.

44.

Differential clonal evolution in oesophageal cancers in response to neo-adjuvant chemotherapy.

Findlay JM, Castro-Giner F, Makino S, Rayner E, Kartsonaki C, Cross W, Kovac M, Ulahannan D, Palles C, Gillies RS, MacGregor TP, Church D, Maynard ND, Buffa F, Cazier JB, Graham TA, Wang LM, Sharma RA, Middleton M, Tomlinson I.

Nat Commun. 2016 Apr 5;7:11111. doi: 10.1038/ncomms11111.

45.

Comparison of intraocular pressure post penetrating keratoplasty vs Descemet's stripping endothelial keratoplasty.

Sharma RA, Bursztyn LL, Golesic E, Mather R, Tingey DP.

Can J Ophthalmol. 2016 Feb;51(1):19-24. doi: 10.1016/j.jcjo.2015.09.014.

PMID:
26874154
46.

Radiosensitisation of human colorectal cancer cells by ruthenium(II) arene anticancer complexes.

Carter R, Westhorpe A, Romero MJ, Habtemariam A, Gallevo CR, Bark Y, Menezes N, Sadler PJ, Sharma RA.

Sci Rep. 2016 Feb 12;6:20596. doi: 10.1038/srep20596.

47.

Clinical Trial of Oral Nelfinavir before and during Radiation Therapy for Advanced Rectal Cancer.

Hill EJ, Roberts C, Franklin JM, Enescu M, West N, MacGregor TP, Chu KY, Boyle L, Blesing C, Wang LM, Mukherjee S, Anderson EM, Brown G, Dutton S, Love SB, Schnabel JA, Quirke P, Muschel R, McKenna WG, Partridge M, Sharma RA.

Clin Cancer Res. 2016 Apr 15;22(8):1922-31. doi: 10.1158/1078-0432.CCR-15-1489. Epub 2016 Feb 9.

48.

Anti-Inflammatory and Antimicrobial Properties of Flavonoids from Heliotropium subulatum Exudate.

Singh B, Sharma RA.

Inflamm Allergy Drug Targets. 2015;14(2):125-32.

PMID:
26728771
49.

Combination of Novel Agents with Radiotherapy to Treat Rectal Cancer.

Greenhalgh TA, Dearman C, Sharma RA.

Clin Oncol (R Coll Radiol). 2016 Feb;28(2):116-139. doi: 10.1016/j.clon.2015.11.002. Epub 2015 Dec 21. Review.

PMID:
26719097
50.

Management of a thyroid "incidentaloma" in a patient with cancer: a case report.

Dearman C, Hill EJ, Franklin JM, Sadler GP, Wang LM, Silva MA, Sharma RA.

Int Med Case Rep J. 2015 Oct 16;8:247-9. doi: 10.2147/IMCRJ.S92857. eCollection 2015.

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