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Items: 32


A Compound L1196M/G1202R ALK Mutation in a Patient with ALK-Positive Lung Cancer with Acquired Resistance to Brigatinib Also Confers Primary Resistance to Lorlatinib.

Sharma GG, Cortinovis D, Agustoni F, Arosio G, Villa M, Cordani N, Bidoli P, Bisson WH, Pagni F, Piazza R, Gambacorti-Passerini C, Mologni L.

J Thorac Oncol. 2019 Nov;14(11):e257-e259. doi: 10.1016/j.jtho.2019.06.028. No abstract available.


We shall overcome (drug resistance) some day.

Sharma GG, Mologni L.

Oncotarget. 2019 Jan 4;10(2):84-85. doi: 10.18632/oncotarget.26550. eCollection 2019 Jan 4. No abstract available.


Molecular and epigenetic regulatory mechanisms of normal stem cell radiosensitivity.

Fabbrizi MR, Warshowsky KE, Zobel CL, Hallahan DE, Sharma GG.

Cell Death Discov. 2018 Dec 18;4:117. doi: 10.1038/s41420-018-0132-8. eCollection 2018. Review.


Wiskott-Aldrich syndrome protein (WASP) is a tumor suppressor in T cell lymphoma.

Menotti M, Ambrogio C, Cheong TC, Pighi C, Mota I, Cassel SH, Compagno M, Wang Q, Dall'Olio R, Minero VG, Poggio T, Sharma GG, Patrucco E, Mastini C, Choudhari R, Pich A, Zamo A, Piva R, Giliani S, Mologni L, Collings CK, Kadoch C, Gambacorti-Passerini C, Notarangelo LD, Anton IM, Voena C, Chiarle R.

Nat Med. 2019 Jan;25(1):130-140. doi: 10.1038/s41591-018-0262-9. Epub 2018 Dec 3.


Lorlatinib Treatment Elicits Multiple On- and Off-Target Mechanisms of Resistance in ALK-Driven Cancer.

Redaelli S, Ceccon M, Zappa M, Sharma GG, Mastini C, Mauri M, Nigoghossian M, Massimino L, Cordani N, Farina F, Piazza R, Gambacorti-Passerini C, Mologni L.

Cancer Res. 2018 Dec 15;78(24):6866-6880. doi: 10.1158/0008-5472.CAN-18-1867. Epub 2018 Oct 15.


Transient PP2A inhibition alleviates normal tissue stem cell susceptibility to cell death during radiotherapy.

Fabbrizi MR, Meyer B, Misri S, Raj S, Zobel CL, Hallahan DE, Sharma GG.

Cell Death Dis. 2018 May 1;9(5):492. doi: 10.1038/s41419-018-0559-0.


Concomitant BCORL1 and BRAF Mutations in Vemurafenib-Resistant Melanoma Cells.

Mologni L, Costanza M, Sharma GG, Viltadi M, Massimino L, Citterio S, Purgante S, Raman H, Pirola A, Zucchetti M, Piazza R, Gambacorti-Passerini C.

Neoplasia. 2018 May;20(5):467-477. doi: 10.1016/j.neo.2018.02.009. Epub 2018 Mar 30.


Tumor Resistance against ALK Targeted Therapy-Where It Comes From and Where It Goes.

Sharma GG, Mota I, Mologni L, Patrucco E, Gambacorti-Passerini C, Chiarle R.

Cancers (Basel). 2018 Feb 28;10(3). pii: E62. doi: 10.3390/cancers10030062. Review.


Histone H3 Lysine 9 Acetylation Obstructs ATM Activation and Promotes Ionizing Radiation Sensitivity in Normal Stem Cells.

Meyer B, Fabbrizi MR, Raj S, Zobel CL, Hallahan DE, Sharma GG.

Stem Cell Reports. 2016 Dec 13;7(6):1013-1022. doi: 10.1016/j.stemcr.2016.11.004.


Unique epigenetic influence of H2AX phosphorylation and H3K56 acetylation on normal stem cell radioresponses.

Jacobs KM, Misri S, Meyer B, Raj S, Zobel CL, Sleckman BP, Hallahan DE, Sharma GG.

Mol Biol Cell. 2016 Apr 15;27(8):1332-45. doi: 10.1091/mbc.E16-01-0017. Epub 2016 Mar 3.


Genome-wide distribution of histone H4 Lysine 16 acetylation sites and their relationship to gene expression.

Horikoshi N, Kumar P, Sharma GG, Chen M, Hunt CR, Westover K, Chowdhury S, Pandita TK.

Genome Integr. 2013 Apr 12;4(1):3. doi: 10.1186/2041-9414-4-3.


H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes.

Helmink BA, Tubbs AT, Dorsett Y, Bednarski JJ, Walker LM, Feng Z, Sharma GG, McKinnon PJ, Zhang J, Bassing CH, Sleckman BP.

Nature. 2011 Jan 13;469(7329):245-9. doi: 10.1038/nature09585. Epub 2010 Dec 15. Erratum in: Nature. 2011 Apr 14;472(7342):247.


Rad52 inactivation is synthetically lethal with BRCA2 deficiency.

Feng Z, Scott SP, Bussen W, Sharma GG, Guo G, Pandita TK, Powell SN.

Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):686-91. doi: 10.1073/pnas.1010959107. Epub 2010 Dec 8.


MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair.

Sharma GG, So S, Gupta A, Kumar R, Cayrou C, Avvakumov N, Bhadra U, Pandita RK, Porteus MH, Chen DJ, Cote J, Pandita TK.

Mol Cell Biol. 2010 Jul;30(14):3582-95. doi: 10.1128/MCB.01476-09. Epub 2010 May 17.


MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks.

Helmink BA, Bredemeyer AL, Lee BS, Huang CY, Sharma GG, Walker LM, Bednarski JJ, Lee WL, Pandita TK, Bassing CH, Sleckman BP.

J Exp Med. 2009 Mar 16;206(3):669-79. doi: 10.1084/jem.20081326. Epub 2009 Feb 16.


HP1-beta is required for development of the cerebral neocortex and neuromuscular junctions.

Aucott R, Bullwinkel J, Yu Y, Shi W, Billur M, Brown JP, Menzel U, Kioussis D, Wang G, Reisert I, Weimer J, Pandita RK, Sharma GG, Pandita TK, Fundele R, Singh PB.

J Cell Biol. 2008 Nov 17;183(4):597-606. doi: 10.1083/jcb.200804041.


Single-stranded DNA-binding protein hSSB1 is critical for genomic stability.

Richard DJ, Bolderson E, Cubeddu L, Wadsworth RI, Savage K, Sharma GG, Nicolette ML, Tsvetanov S, McIlwraith MJ, Pandita RK, Takeda S, Hay RT, Gautier J, West SC, Paull TT, Pandita TK, White MF, Khanna KK.

Nature. 2008 May 29;453(7195):677-81. doi: 10.1038/nature06883. Epub 2008 Apr 30.


The mammalian ortholog of Drosophila MOF that acetylates histone H4 lysine 16 is essential for embryogenesis and oncogenesis.

Gupta A, Guerin-Peyrou TG, Sharma GG, Park C, Agarwal M, Ganju RK, Pandita S, Choi K, Sukumar S, Pandita RK, Ludwig T, Pandita TK.

Mol Cell Biol. 2008 Jan;28(1):397-409. Epub 2007 Oct 29.


Defects in coding joint formation in vivo in developing ATM-deficient B and T lymphocytes.

Huang CY, Sharma GG, Walker LM, Bassing CH, Pandita TK, Sleckman BP.

J Exp Med. 2007 Jun 11;204(6):1371-81. Epub 2007 May 14.


A role for the HOXB7 homeodomain protein in DNA repair.

Rubin E, Wu X, Zhu T, Cheung JC, Chen H, Lorincz A, Pandita RK, Sharma GG, Ha HC, Gasson J, Hanakahi LA, Pandita TK, Sukumar S.

Cancer Res. 2007 Feb 15;67(4):1527-35.


Regulation of telomere movement by telomere chromatin structure.

Pandita TK, Hunt CR, Sharma GG, Yang Q.

Cell Mol Life Sci. 2007 Jan;64(2):131-8. Review.


ATM stabilizes DNA double-strand-break complexes during V(D)J recombination.

Bredemeyer AL, Sharma GG, Huang CY, Helmink BA, Walker LM, Khor KC, Nuskey B, Sullivan KE, Pandita TK, Bassing CH, Sleckman BP.

Nature. 2006 Jul 27;442(7101):466-70. Epub 2006 Jun 14.


Mammalian Rad9 plays a role in telomere stability, S- and G2-phase-specific cell survival, and homologous recombinational repair.

Pandita RK, Sharma GG, Laszlo A, Hopkins KM, Davey S, Chakhparonian M, Gupta A, Wellinger RJ, Zhang J, Powell SN, Roti Roti JL, Lieberman HB, Pandita TK.

Mol Cell Biol. 2006 Mar;26(5):1850-64.


Cdt1 transgenic mice develop lymphoblastic lymphoma in the absence of p53.

Seo J, Chung YS, Sharma GG, Moon E, Burack WR, Pandita TK, Choi K.

Oncogene. 2005 Dec 8;24(55):8176-86.


Impaired genomic stability and increased oxidative stress exacerbate different features of Ataxia-telangiectasia.

Ziv S, Brenner O, Amariglio N, Smorodinsky NI, Galron R, Carrion DV, Zhang W, Sharma GG, Pandita RK, Agarwal M, Elkon R, Katzin N, Bar-Am I, Pandita TK, Kucherlapati R, Rechavi G, Shiloh Y, Barzilai A.

Hum Mol Genet. 2005 Oct 1;14(19):2929-43. Epub 2005 Sep 8.


Involvement of human MOF in ATM function.

Gupta A, Sharma GG, Young CS, Agarwal M, Smith ER, Paull TT, Lucchesi JC, Khanna KK, Ludwig T, Pandita TK.

Mol Cell Biol. 2005 Jun;25(12):5292-305.


Genomic instability and enhanced radiosensitivity in Hsp70.1- and Hsp70.3-deficient mice.

Hunt CR, Dix DJ, Sharma GG, Pandita RK, Gupta A, Funk M, Pandita TK.

Mol Cell Biol. 2004 Jan;24(2):899-911.


Human heterochromatin protein 1 isoforms HP1(Hsalpha) and HP1(Hsbeta) interfere with hTERT-telomere interactions and correlate with changes in cell growth and response to ionizing radiation.

Sharma GG, Hwang KK, Pandita RK, Gupta A, Dhar S, Parenteau J, Agarwal M, Worman HJ, Wellinger RJ, Pandita TK.

Mol Cell Biol. 2003 Nov;23(22):8363-76.


Telomere stability correlates with longevity of human beings exposed to ionizing radiations.

Sharma GG, Hall EJ, Dhar S, Gupta A, Rao PH, Pandita TK.

Oncol Rep. 2003 Nov-Dec;10(6):1733-6.


hTERT associates with human telomeres and enhances genomic stability and DNA repair.

Sharma GG, Gupta A, Wang H, Scherthan H, Dhar S, Gandhi V, Iliakis G, Shay JW, Young CS, Pandita TK.

Oncogene. 2003 Jan 9;22(1):131-46.


Spontaneously immortalized cell lines obtained from adult Atm null mice retain sensitivity to ionizing radiation and exhibit a mutational pattern suggestive of oxidative stress.

Gage BM, Alroy D, Shin CY, Ponomareva ON, Dhar S, Sharma GG, Pandita TK, Thayer MJ, Turker MS.

Oncogene. 2001 Jul 19;20(32):4291-7.

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