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Measuring antibiotic availability and use in 20 low- and middle-income countries.

Knowles R, Sharland M, Hsia Y, Magrini N, Moja L, Siyam A, Tayler E.

Bull World Health Organ. 2020 Mar 1;98(3):177-187C. doi: 10.2471/BLT.19.241349. Epub 2020 Jan 31.


Meropenem vs standard of care for treatment of neonatal late onset sepsis (NeoMero1): A randomised controlled trial.

Lutsar I, Chazallon C, Trafojer U, de Cabre VM, Auriti C, Bertaina C, Calo Carducci FI, Canpolat FE, Esposito S, Fournier I, Hallik M, Heath PT, Ilmoja ML, Iosifidis E, Kuznetsova J, Meyer L, Metsvaht T, Mitsiakos G, Pana ZD, Mosca F, Pugni L, Roilides E, Rossi P, Sarafidis K, Sanchez L, Sharland M, Usonis V, Warris A, Aboulker JP, Giaquinto C; NeoMero Consortium.

PLoS One. 2020 Mar 4;15(3):e0229380. doi: 10.1371/journal.pone.0229380. eCollection 2020.


2019 CAP Treatment Guidelines - The Need for a Change Towards a More Parsimonious Antibiotic Use?

Huttner B, Cappello B, Cooke G, Gandra S, Harbarth S, Imi M, Mendelson M, Moja L, Pulcini C, Sharland M, Zeng M, Magrini N; WHO EML Antibiotic Working Group.

Am J Respir Crit Care Med. 2020 Feb 18. doi: 10.1164/rccm.201911-2226LE. [Epub ahead of print] No abstract available.


Evaluation of the Coverage of 3 Antibiotic Regimens for Neonatal Sepsis in the Hospital Setting Across Asian Countries.

Bielicki JA, Sharland M, Heath PT, Walker AS, Agarwal R, Turner P, Cromwell DA.

JAMA Netw Open. 2020 Feb 5;3(2):e1921124. doi: 10.1001/jamanetworkopen.2019.21124.


Appropriateness of Antibiotic Prescribing in U.S. Children's Hospitals: A National Point Prevalence Survey.

Tribble AC, Lee BR, Flett KB, Handy LK, Gerber JS, Hersh AL, Kronman MP, Terrill CM, Sharland M, Newland JG.

Clin Infect Dis. 2020 Jan 16. pii: ciaa036. doi: 10.1093/cid/ciaa036. [Epub ahead of print]


Implementation and impact of pediatric antimicrobial stewardship programs: a systematic scoping review.

Donà D, Barbieri E, Daverio M, Lundin R, Giaquinto C, Zaoutis T, Sharland M.

Antimicrob Resist Infect Control. 2020 Jan 3;9:3. doi: 10.1186/s13756-019-0659-3. eCollection 2020. Review.


Bacterial pathogens and resistance causing community acquired paediatric bloodstream infections in low- and middle-income countries: a systematic review and meta-analysis.

Droz N, Hsia Y, Ellis S, Dramowski A, Sharland M, Basmaci R.

Antimicrob Resist Infect Control. 2019 Dec 30;8:207. doi: 10.1186/s13756-019-0673-5. eCollection 2019. Review.


Standardising neonatal and paediatric antibiotic clinical trial design and conduct: the PENTA-ID network view.

Folgori L, Lutsar I, Standing JF, Walker AS, Roilides E, Zaoutis TE, Jafri H, Giaquinto C, Turner MA, Sharland M.

BMJ Open. 2019 Dec 31;9(12):e032592. doi: 10.1136/bmjopen-2019-032592.


Mathematical modelling for antibiotic resistance control policy: do we know enough?

Knight GM, Davies NG, Colijn C, Coll F, Donker T, Gifford DR, Glover RE, Jit M, Klemm E, Lehtinen S, Lindsay JA, Lipsitch M, Llewelyn MJ, Mateus ALP, Robotham JV, Sharland M, Stekel D, Yakob L, Atkins KE.

BMC Infect Dis. 2019 Nov 29;19(1):1011. doi: 10.1186/s12879-019-4630-y.


Encouraging AWaRe-ness and discouraging inappropriate antibiotic use-the new 2019 Essential Medicines List becomes a global antibiotic stewardship tool.

Sharland M, Gandra S, Huttner B, Moja L, Pulcini C, Zeng M, Mendelson M, Cappello B, Cooke G, Magrini N; EML Expert Committee and Antibiotic Working Group.

Lancet Infect Dis. 2019 Dec;19(12):1278-1280. doi: 10.1016/S1473-3099(19)30532-8. No abstract available.


Pediatric pharmacokinetics of the antibiotics in the access and watch groups of the 2019 WHO model list of essential medicines for children: a systematic review.

Rashed AN, Jackson C, Gastine S, Hsia Y, Bielicki J, Standing JF, Tomlin S, Sharland M.

Expert Rev Clin Pharmacol. 2019 Dec;12(12):1099-1106. doi: 10.1080/17512433.2019.1693257. Epub 2019 Nov 25.


GAPPS (Grading and Assessment of Pharmacokinetic-Pharmacodynamic Studies) a critical appraisal system for antimicrobial PKPD studies - development and application in pediatric antibiotic studies.

Gastine S, Rashed AN, Hsia Y, Jackson C, Barker CIS, Mathur S, Tomlin S, Lutsar I, Bielicki J, Standing JF, Sharland M.

Expert Rev Clin Pharmacol. 2019 Dec;12(12):1091-1098. doi: 10.1080/17512433.2019.1695600. Epub 2019 Nov 30. Review.


Systematic review of carbapenem-resistant Enterobacteriaceae causing neonatal sepsis in China.

Ding Y, Wang Y, Hsia Y, Sharland M, Heath PT.

Ann Clin Microbiol Antimicrob. 2019 Nov 14;18(1):36. doi: 10.1186/s12941-019-0334-9.


Antimicrobial Resistance Following Azithromycin Mass Drug Administration: Potential Surveillance Strategies to Assess Public Health Impact.

Mack I, Sharland M, Berkley JA, Klein N, Malhotra-Kumar S, Bielicki J.

Clin Infect Dis. 2020 Mar 17;70(7):1501-1508. doi: 10.1093/cid/ciz893.


Antibiotic prescriptions in Italian hospitalised children after serial point prevalence surveys (or pointless prevalence surveys): has anything actually changed over the years?

Tersigni C, Montagnani C, D'Argenio P, Duse M, Esposito S, Hsia Y, Sharland M, Galli L.

Ital J Pediatr. 2019 Oct 17;45(1):127. doi: 10.1186/s13052-019-0722-y.


Aetiology of invasive bacterial infection and antimicrobial resistance in neonates in sub-Saharan Africa: a systematic review and meta-analysis in line with the STROBE-NI reporting guidelines.

Okomo U, Akpalu ENK, Le Doare K, Roca A, Cousens S, Jarde A, Sharland M, Kampmann B, Lawn JE.

Lancet Infect Dis. 2019 Nov;19(11):1219-1234. doi: 10.1016/S1473-3099(19)30414-1. Epub 2019 Sep 12.


High rates of admission in lower middle-income countries' neonatal units suggest an enhanced focus on infection prevention and control measures is required.

Cook A, Lundin R, Bielicki J, Sharland M, Hsia Y.

Arch Dis Child. 2020 Feb;105(2):206-207. doi: 10.1136/archdischild-2019-317318. Epub 2019 Aug 28. No abstract available.


Towards understanding global patterns of antimicrobial use and resistance in neonatal sepsis: insights from the NeoAMR network.

Li G, Bielicki JA, Ahmed ASMNU, Islam MS, Berezin EN, Gallacci CB, Guinsburg R, da Silva Figueiredo CE, Santarone Vieira R, Silva AR, Teixeira C, Turner P, Nhan L, Orrego J, Pérez PM, Qi L, Papaevangelou V, Triantafyllidou P, Iosifidis E, Roilides E, Sarafidis K, Jinka DR, Nayakanti RR, Kumar P, Gautam V, Prakash V, Seeralar A, Murki S, Kandraju H, Singh S, Kumar A, Lewis L, Pukayastha J, Nangia S, K N Y, Chaurasia S, Chellani H, Obaro S, Dramowski A, Bekker A, Whitelaw A, Thomas R, Velaphi SC, Ballot DE, Nana T, Reubenson G, Fredericks J, Anugulruengkitt S, Sirisub A, Wong P, Lochindarat S, Boonkasidecha S, Preedisripipat K, Cressey TR, Paopongsawan P, Lumbiganon P, Pongpanut D, Sukrakanchana PO, Musoke P, Olson L, Larsson M, Heath PT, Sharland M.

Arch Dis Child. 2020 Jan;105(1):26-31. doi: 10.1136/archdischild-2019-316816. Epub 2019 Aug 24. Erratum in: Arch Dis Child. 2020 Mar 27;:.


Global Divergence From World Health Organization Treatment Guidelines for Neonatal and Pediatric Sepsis.

Jackson C, Hsia Y, Basmaci R, Bielicki J, Heath PT, Versporten A, Goossens H, Sharland M.

Pediatr Infect Dis J. 2019 Nov;38(11):1104-1106. doi: 10.1097/INF.0000000000002433.


Adaptation of the WHO Essential Medicines List for national antibiotic stewardship policy in England: being AWaRe.

Budd E, Cramp E, Sharland M, Hand K, Howard P, Wilson P, Wilcox M, Muller-Pebody B, Hopkins S.

J Antimicrob Chemother. 2019 Nov 1;74(11):3384-3389. doi: 10.1093/jac/dkz321.


Implementation of a Highly Accurate Rapid Point-of-Care Test for Group a Streptococcus Detection at a Large Pediatric Emergency Department in South London.

Demirjian A, Bustinduy AL, Ladhani S, Iqbal Y, Sharland M.

Pediatr Infect Dis J. 2019 Aug;38(8):e183-e185. doi: 10.1097/INF.0000000000002284.


Antibiotic Review Kit for Hospitals (ARK-Hospital): study protocol for a stepped-wedge cluster-randomised controlled trial.

Walker AS, Budgell E, Laskawiec-Szkonter M, Sivyer K, Wordsworth S, Quaddy J, Santillo M, Krusche A, Roope LSJ, Bright N, Mowbray F, Jones N, Hand K, Rahman N, Dobson M, Hedley E, Crook D, Sharland M, Roseveare C, Hobbs FDR, Butler C, Vaughan L, Hopkins S, Yardley L, Peto TEA, Llewelyn MJ; ARK trial team.

Trials. 2019 Jul 11;20(1):421. doi: 10.1186/s13063-019-3497-y.


Strategic Trials to Define the Best Available Treatment for Neonatal and Pediatric Sepsis Caused by Carbapenem-resistant Organisms.

Donà D, Sharland M, Heath PT, Folgori L.

Pediatr Infect Dis J. 2019 Aug;38(8):825-827. doi: 10.1097/INF.0000000000002381.


Essential and forgotten antibiotics: An inventory in low- and middle-income countries.

Tebano G, Li G, Beovic B, Bielicki J, Brink A, Enani MA, Godman B, Hinrichsen SL, Kibuule D, Gabriel LH, Oduyebo O, Sharland M, Singh S, Wertheim HFL, Nathwani D, Pulcini C; European Society of Clinical Microbiology and Infectious Diseases Study Group for Antimicrobial Stewardship.

Int J Antimicrob Agents. 2019 Sep;54(3):273-282. doi: 10.1016/j.ijantimicag.2019.06.017. Epub 2019 Jun 28.


Management of Invasive Fungal Disease in Neonates and Children.

Ferreras-Antolín L, Sharland M, Warris A.

Pediatr Infect Dis J. 2019 Jun;38(6S Suppl 1):S2-S6. doi: 10.1097/INF.0000000000002317.


Use of the WHO Access, Watch, and Reserve classification to define patterns of hospital antibiotic use (AWaRe): an analysis of paediatric survey data from 56 countries.

Hsia Y, Lee BR, Versporten A, Yang Y, Bielicki J, Jackson C, Newland J, Goossens H, Magrini N, Sharland M; GARPEC and Global-PPS networks.

Lancet Glob Health. 2019 Jul;7(7):e861-e871. doi: 10.1016/S2214-109X(19)30071-3.


Safety and Efficacy of Tigecycline to Treat Multidrug-resistant Infections in Pediatrics: An Evidence Synthesis.

Sharland M, Rodvold KA, Tucker HR, Baillon-Plot N, Tawadrous M, Hickman MA, Raber S, Korth-Bradley JM, Díaz-Ponce H, Wible M.

Pediatr Infect Dis J. 2019 Jul;38(7):710-715. doi: 10.1097/INF.0000000000002339.


Efficacy, safety and impact on antimicrobial resistance of duration and dose of amoxicillin treatment for young children with Community-Acquired Pneumonia: a protocol for a randomIsed controlled Trial (CAP-IT).

Lyttle MD, Bielicki JA, Barratt S, Dunn D, Finn A, Harper L, Jackson P, Powell CVE, Roland D, Stohr W, Sturgeon K, Wan M, Little P, Faust SN, Robotham J, Hay AD, Gibb DM, Sharland M; PERUKI, GAPRUKI and the CAP-IT trial team.

BMJ Open. 2019 May 22;9(5):e029875. doi: 10.1136/bmjopen-2019-029875.


Hard to study, hard to treat: putting children at the centre of antibiotic research and development.

Balasegaram M, Pécoul B, Gray G, Sharland M, Swaminathan S.

Lancet Infect Dis. 2019 Jun;19(6):573-574. doi: 10.1016/S1473-3099(19)30214-2. No abstract available.


Population pharmacokinetic meta-analysis of individual data to design the first randomized efficacy trial of vancomycin in neonates and young infants.

Jacqz-Aigrain E, Leroux S, Thomson AH, Allegaert K, Capparelli EV, Biran V, Simon N, Meibohm B, Lo YL, Marques R, Peris JE, Lutsar I, Saito J, Nakamura H, van den Anker JN, Sharland M, Zhao W.

J Antimicrob Chemother. 2019 Aug 1;74(8):2128-2138. doi: 10.1093/jac/dkz158.


Early origins of oral penicillin dosing for children.

Sharland E, Long P, Sharland M, Bielicki J, Saxena S, Wong ICK, Barker C.

Arch Dis Child. 2019 Apr 17. pii: archdischild-2018-316531. doi: 10.1136/archdischild-2018-316531. [Epub ahead of print] No abstract available.


The potential of fosfomycin for multi-drug resistant sepsis: an analysis of in vitro activity against invasive paediatric Gram-negative bacteria.

Williams PCM, Waichungo J, Gordon NC, Sharland M, Murunga S, Kamau A, Berkley JA.

J Med Microbiol. 2019 May;68(5):711-719. doi: 10.1099/jmm.0.000973. Epub 2019 Apr 17.


All-cause pneumonia in children after the introduction of pneumococcal vaccines in the United Kingdom: A population-based study.

Lau WCY, Bielicki J, Tersigni C, Saxena S, Wong ICK, Sharland M, Hsia Y.

Pharmacoepidemiol Drug Saf. 2019 Jun;28(6):821-829. doi: 10.1002/pds.4770. Epub 2019 Apr 16.


Estimating global trends in total and childhood antibiotic consumption, 2011-2015.

Jackson C, Hsia Y, Bielicki JA, Ellis S, Stephens P, Wong ICK, Sharland M.

BMJ Glob Health. 2019 Feb 27;4(1):e001241. doi: 10.1136/bmjgh-2018-001241. eCollection 2019.


Pattern of Antimicrobial Resistance in Bloodstream Isolates From Chinese Neonates.

Zhang J, Folgori L, Hsia Y, Sharland M, Yang Y.

Pediatr Infect Dis J. 2019 Jun;38(6):600-604. doi: 10.1097/INF.0000000000002246. No abstract available.


Neonatal sepsis in South Asia: huge burden and spiralling antimicrobial resistance.

Chaurasia S, Sivanandan S, Agarwal R, Ellis S, Sharland M, Sankar MJ.

BMJ. 2019 Jan 22;364:k5314. doi: 10.1136/bmj.k5314. Review. No abstract available.


The use of polymyxins to treat carbapenem resistant infections in neonates and children.

Thomas R, Velaphi S, Ellis S, Walker AS, Standing JF, Heath P, Sharland M, Dona' D.

Expert Opin Pharmacother. 2019 Mar;20(4):415-422. doi: 10.1080/14656566.2018.1559817. Epub 2018 Dec 21. Review.


Correction to: Pharmacokinetic-Pharmacodynamic Modeling in Pediatric Drug Development, and the Importance of Standardized Scaling of Clearance.

Germovsek E, Barker CIS, Sharland M, Standing JF.

Clin Pharmacokinet. 2019 Jan;58(1):139. doi: 10.1007/s40262-018-0723-9.


Consumption of oral antibiotic formulations for young children according to the WHO Access, Watch, Reserve (AWaRe) antibiotic groups: an analysis of sales data from 70 middle-income and high-income countries.

Hsia Y, Sharland M, Jackson C, Wong ICK, Magrini N, Bielicki JA.

Lancet Infect Dis. 2019 Jan;19(1):67-75. doi: 10.1016/S1473-3099(18)30547-4. Epub 2018 Dec 3.


Enterovirus and parechovirus meningitis in infants younger than 90 days old in the UK and Republic of Ireland: a British Paediatric Surveillance Unit study.

Kadambari S, Braccio S, Ribeiro S, Allen DJ, Pebody R, Brown D, Cunney R, Sharland M, Ladhani S.

Arch Dis Child. 2019 Jun;104(6):552-557. doi: 10.1136/archdischild-2018-315643. Epub 2018 Dec 8.


Antibiotics and Cure Rates in Childhood Febrile Urinary Tract Infections in Clinical Trials: A Systematic Review and Meta-analysis.

Vazouras K, Basmaci R, Bielicki J, Folgori L, Zaoutis T, Sharland M, Hsia Y.

Drugs. 2018 Oct;78(15):1593-1604. doi: 10.1007/s40265-018-0988-1.


World Society for Pediatric Infectious Diseases declaration on combating antimicrobial resistance in children.

Buttery J, Yang Y, Sharland M; World Society for Pediatric Infectious Diseases.

World J Pediatr. 2018 Dec;14(6):523-524. doi: 10.1007/s12519-018-0195-x. Epub 2018 Oct 5. No abstract available.


Priority Needs for Conducting Pandemic-relevant Clinical Research With Children in Europe: A Consensus Study With Pediatric Clinician-researchers.

Gal M, Gobat N, Francis NA, Hood K, Butler CC, Bielicki J, Fraaij PL, Sharland M, Jarvis J, van Rossum AMC, Heikkinen T, Martinon-Torres F, Herberg J, Watkins A, Webb SAR, Moore R, Sukumar P, Nichol A.

Pediatr Infect Dis J. 2019 May;38(5):e82-e86. doi: 10.1097/INF.0000000000002204.


Scaling beta-lactam antimicrobial pharmacokinetics from early life to old age.

Lonsdale DO, Baker EH, Kipper K, Barker C, Philips B, Rhodes A, Sharland M, Standing JF.

Br J Clin Pharmacol. 2019 Feb;85(2):316-346. doi: 10.1111/bcp.13756. Epub 2018 Nov 26.


Management of children with multidrug-resistant sepsis in low-income and middle-income countries.

Basmaci R, Bielicki J, Daniels R, Kissoon N, Ellis S, Balasegaram M, Sharland M.

Lancet Child Adolesc Health. 2018 Jan;2(1):8-10. doi: 10.1016/S2352-4642(17)30153-0. Epub 2017 Nov 28. No abstract available.


Interventions to prevent urinary catheter-associated infections in children and neonates: a systematic review.

Araujo da Silva AR, Marques AF, Biscaia di Biase C, Zingg W, Dramowski A, Sharland M.

J Pediatr Urol. 2018 Dec;14(6):556.e1-556.e9. doi: 10.1016/j.jpurol.2018.07.011. Epub 2018 Jul 21.


Clinical Photography: A Self Help Guide.

Sharland M.

Prim Dent J. Summer 2018;7(2):36-9. No abstract available.


Antibiotic usage in Chinese children: a point prevalence survey.

Zhang JS, Liu G, Zhang WS, Shi HY, Lu G, Zhao CA, Li CC, Li YQ, Shao YN, Tian DY, Ding MJ, Li CY, Luo LJ, Dong XY, Jin P, Wang P, Zhu CM, Wang CQ, Zheng YJ, Deng JK, Sharland M, Hsia YF, Shen KL, Yang YH.

World J Pediatr. 2018 Aug;14(4):335-343. doi: 10.1007/s12519-018-0176-0. Epub 2018 Jul 30.


Using risk adjustment to improve the interpretation of global inpatient pediatric antibiotic prescribing.

Bielicki JA, Sharland M, Versporten A, Goossens H, Cromwell DA.

PLoS One. 2018 Jul 6;13(7):e0199878. doi: 10.1371/journal.pone.0199878. eCollection 2018.


Antibiotic use for community-acquired pneumonia in neonates and children: WHO evidence review.

Mathur S, Fuchs A, Bielicki J, Van Den Anker J, Sharland M.

Paediatr Int Child Health. 2018 Nov;38(sup1):S66-S75. doi: 10.1080/20469047.2017.1409455.

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