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Behavioral adaptations in a relapsing mouse model of colitis.

Matisz CE, Vicentini FA, Hirota SA, Sharkey KA, Gruber AJ.

Physiol Behav. 2020 Mar 15;216:112802. doi: 10.1016/j.physbeh.2020.112802. Epub 2020 Jan 10.


Acute regulation of intestinal ion transport and permeability in response to luminal nutrients: the role of the enteric nervous system.

Cavin JB, Cuddihey H, MacNaughton WK, Sharkey KA.

Am J Physiol Gastrointest Liver Physiol. 2020 Feb 1;318(2):G254-G264. doi: 10.1152/ajpgi.00186.2019. Epub 2019 Nov 11.


Insights into the role of cannabis in the management of inflammatory bowel disease.

Picardo S, Kaplan GG, Sharkey KA, Seow CH.

Therap Adv Gastroenterol. 2019 Sep 3;12:1756284819870977. doi: 10.1177/1756284819870977. eCollection 2019. Review.


The Antidepressant Mirtazapine Inhibits Hepatic Innate Immune Networks to Attenuate Immune-Mediated Liver Injury in Mice.

Almishri W, Shaheen AA, Sharkey KA, Swain MG.

Front Immunol. 2019 Apr 12;10:803. doi: 10.3389/fimmu.2019.00803. eCollection 2019.


Antibiotic treatment affects the expression levels of copper transporters and the isotopic composition of copper in the colon of mice.

Miller KA, Vicentini FA, Hirota SA, Sharkey KA, Wieser ME.

Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):5955-5960. doi: 10.1073/pnas.1814047116. Epub 2019 Mar 8.


Reduced Microglial Activity and Enhanced Glutamate Transmission in the Basolateral Amygdala in Early CNS Autoimmunity.

Acharjee S, Verbeek M, Gomez CD, Bisht K, Lee B, Benoit L, Sharkey KA, Benediktsson A, Tremblay ME, Pittman QJ.

J Neurosci. 2018 Oct 17;38(42):9019-9033. doi: 10.1523/JNEUROSCI.0398-18.2018. Epub 2018 Sep 5. Erratum in: J Neurosci. 2019 May 6;:.


Modulation of the immune response by helminths: a role for serotonin?

Wang SJ, Sharkey KA, McKay DM.

Biosci Rep. 2018 Sep 20;38(5). pii: BSR20180027. doi: 10.1042/BSR20180027. Print 2018 Oct 31. Review.


Helminth Antigen-Conditioned Dendritic Cells Generate Anti-Inflammatory Cd4 T Cells Independent of Antigen Presentation via Major Histocompatibility Complex Class II.

Matisz CE, Geuking MB, Lopes F, Petri B, Wang A, Sharkey KA, McKay DM.

Am J Pathol. 2018 Nov;188(11):2589-2604. doi: 10.1016/j.ajpath.2018.07.008. Epub 2018 Aug 17.


Nausea-Induced 5-HT Release in the Interoceptive Insular Cortex and Regulation by Monoacylglycerol Lipase (MAGL) Inhibition and Cannabidiol.

Limebeer CL, Rock EM, Sharkey KA, Parker LA.

eNeuro. 2018 Jul 31;5(4). pii: ENEURO.0256-18.2018. doi: 10.1523/ENEURO.0256-18.2018. eCollection 2018 Jul-Aug.


Neuroimmunophysiology of the gut: advances and emerging concepts focusing on the epithelium.

Sharkey KA, Beck PL, McKay DM.

Nat Rev Gastroenterol Hepatol. 2018 Dec;15(12):765-784. doi: 10.1038/s41575-018-0051-4. Review.


Endocannabinoid regulation of homeostatic feeding and stress-induced alterations in food intake in male rats.

Sticht MA, Lau DJ, Keenan CM, Cavin JB, Morena M, Vemuri VK, Makriyannis A, Cravatt BF, Sharkey KA, Hill MN.

Br J Pharmacol. 2019 May;176(10):1524-1540. doi: 10.1111/bph.14453. Epub 2018 Aug 22.


Gut-derived serotonin contributes to bone deficits in colitis.

Lavoie B, Roberts JA, Haag MM, Spohn SN, Margolis KG, Sharkey KA, Lian JB, Mawe GM.

Pharmacol Res. 2019 Feb;140:75-84. doi: 10.1016/j.phrs.2018.07.018. Epub 2018 Jul 17.


Magnetic resonance imaging evidence of hippocampal structural changes in patients with primary biliary cholangitis.

Mosher VAL, Swain MG, Pang JXQ, Kaplan GG, Sharkey KA, MacQueen GM, Goodyear BG.

Clin Transl Gastroenterol. 2018 Jul 6;9(7):169. doi: 10.1038/s41424-018-0038-z.


The intestinal barrier in multiple sclerosis: implications for pathophysiology and therapeutics.

Camara-Lemarroy CR, Metz L, Meddings JB, Sharkey KA, Wee Yong V.

Brain. 2018 Jul 1;141(7):1900-1916. doi: 10.1093/brain/awy131. Review.


Altered Brain Excitability and Increased Anxiety in Mice With Experimental Colitis: Consideration of Hyperalgesia and Sex Differences.

Nyuyki KD, Cluny NL, Swain MG, Sharkey KA, Pittman QJ.

Front Behav Neurosci. 2018 Apr 3;12:58. doi: 10.3389/fnbeh.2018.00058. eCollection 2018.


Alterations in melatonin and 5-HT signalling in the colonic mucosa of mice with dextran-sodium sulfate-induced colitis.

MacEachern SJ, Keenan CM, Papakonstantinou E, Sharkey KA, Patel BA.

Br J Pharmacol. 2018 May;175(9):1535-1547. doi: 10.1111/bph.14163. Epub 2018 Mar 25.


Colonic immune cells in irritable bowel syndrome: A systematic review and meta-analysis.

Bashashati M, Moossavi S, Cremon C, Barbaro MR, Moraveji S, Talmon G, Rezaei N, Hughes PA, Bian ZX, Choi CH, Lee OY, Coëffier M, Chang L, Ohman L, Schmulson MJ, McCallum RW, Simren M, Sharkey KA, Barbara G.

Neurogastroenterol Motil. 2018 Jan;30(1). doi: 10.1111/nmo.13192. Epub 2017 Aug 29. Review.


The role of enteric neurons in the development and progression of colorectal cancer.

Rademakers G, Vaes N, Schonkeren S, Koch A, Sharkey KA, Melotte V.

Biochim Biophys Acta Rev Cancer. 2017 Dec;1868(2):420-434. doi: 10.1016/j.bbcan.2017.08.003. Epub 2017 Aug 25. Review.


Primary Biliary Cholangitis Alters Functional Connections of the Brain's Deep Gray Matter.

Mosher VAL, Swain MG, Pang JXQ, Kaplan GG, Sharkey KA, MacQueen GM, Goodyear BG.

Clin Transl Gastroenterol. 2017 Jul 27;8(7):e107. doi: 10.1038/ctg.2017.34.


Targeting the gut to treat obesity and its metabolic consequences: view from the Chair.

Sharkey KA.

Int J Obes Suppl. 2016 Dec;6(Suppl 1):S3-S5. doi: 10.1038/ijosup.2016.2. Epub 2016 Nov 16.


NDRG4, an early detection marker for colorectal cancer, is specifically expressed in enteric neurons.

Vaes N, Lentjes MHFM, Gijbels MJ, Rademakers G, Daenen KL, Boesmans W, Wouters KAD, Geuzens A, Qu X, Steinbusch HPJ, Rutten BPF, Baldwin SH, Sharkey KA, Hofstra RMW, van Engeland M, Vanden Berghe P, Melotte V.

Neurogastroenterol Motil. 2017 Sep;29(9). doi: 10.1111/nmo.13095. Epub 2017 May 19.


Suppression of colitis by adoptive transfer of helminth antigen-treated dendritic cells requires interleukin-4 receptor-α signaling.

Matisz CE, Faz-López B, Thomson E, Al Rajabi A, Lopes F, Terrazas LI, Wang A, Sharkey KA, McKay DM.

Sci Rep. 2017 Jan 17;7:40631. doi: 10.1038/srep40631.


Protective Actions of Epithelial 5-Hydroxytryptamine 4 Receptors in Normal and Inflamed Colon.

Spohn SN, Bianco F, Scott RB, Keenan CM, Linton AA, O'Neill CH, Bonora E, Dicay M, Lavoie B, Wilcox RL, MacNaughton WK, De Giorgio R, Sharkey KA, Mawe GM.

Gastroenterology. 2016 Nov;151(5):933-944.e3. doi: 10.1053/j.gastro.2016.07.032. Epub 2016 Jul 29.


Abnormal cannabidiol attenuates experimental colitis in mice, promotes wound healing and inhibits neutrophil recruitment.

Krohn RM, Parsons SA, Fichna J, Patel KD, Yates RM, Sharkey KA, Storr MA.

J Inflamm (Lond). 2016 Jul 14;13:21. doi: 10.1186/s12950-016-0129-0. eCollection 2016.


The Intrinsic Reflex Circuitry of the Inflamed Colon.

Mawe GM, Sharkey KA.

Adv Exp Med Biol. 2016;891:153-7. doi: 10.1007/978-3-319-27592-5_15. Review.


The Role of the Endocannabinoid System in the Brain-Gut Axis.

Sharkey KA, Wiley JW.

Gastroenterology. 2016 Aug;151(2):252-66. doi: 10.1053/j.gastro.2016.04.015. Epub 2016 Apr 29. Review.


The Endocannabinoid System and Its Role in Regulating the Intrinsic Neural Circuitry of the Gastrointestinal Tract.

Trautmann SM, Sharkey KA.

Int Rev Neurobiol. 2015;125:85-126. doi: 10.1016/bs.irn.2015.10.002. Epub 2015 Nov 6. Review.


Prevention of Diet-Induced Obesity Effects on Body Weight and Gut Microbiota in Mice Treated Chronically with Δ9-Tetrahydrocannabinol.

Cluny NL, Keenan CM, Reimer RA, Le Foll B, Sharkey KA.

PLoS One. 2015 Dec 3;10(12):e0144270. doi: 10.1371/journal.pone.0144270. eCollection 2015.


Endocannabinoid regulation of nausea is mediated by 2-arachidonoylglycerol (2-AG) in the rat visceral insular cortex.

Sticht MA, Limebeer CL, Rafla BR, Abdullah RA, Poklis JL, Ho W, Niphakis MJ, Cravatt BF, Sharkey KA, Lichtman AH, Parker LA.

Neuropharmacology. 2016 Mar;102:92-102. doi: 10.1016/j.neuropharm.2015.10.039. Epub 2015 Nov 2.


Adoptive transfer of helminth antigen-pulsed dendritic cells protects against the development of experimental colitis in mice.

Matisz CE, Leung G, Reyes JL, Wang A, Sharkey KA, McKay DM.

Eur J Immunol. 2015 Nov;45(11):3126-39. doi: 10.1002/eji.201545579. Epub 2015 Sep 25.


Transient receptor potential vanilloid 4 inhibits mouse colonic motility by activating NO-dependent enteric neurotransmission.

Fichna J, Poole DP, Veldhuis N, MacEachern SJ, Saur D, Zakrzewski PK, Cygankiewicz AI, Mokrowiecka A, Małecka-Panas E, Krajewska WM, Liedtke W, Steinhoff MS, Timmermans JP, Bunnett NW, Sharkey KA, Storr MA.

J Mol Med (Berl). 2015 Dec;93(12):1297-309. doi: 10.1007/s00109-015-1336-5. Epub 2015 Sep 2.


Involvement of Mast Cells in α7 Nicotinic Receptor Agonist Exacerbation of Freund's Complete Adjuvant-Induced Monoarthritis in Mice.

Lopes F, Graepel R, Reyes JL, Wang A, Petri B, McDougall JJ, Sharkey KA, McKay DM.

Arthritis Rheumatol. 2016 Feb;68(2):542-52. doi: 10.1002/art.39411.


Inhibiting Inducible Nitric Oxide Synthase in Enteric Glia Restores Electrogenic Ion Transport in Mice With Colitis.

MacEachern SJ, Patel BA, Keenan CM, Dicay M, Chapman K, McCafferty DM, Savidge TC, Beck PL, MacNaughton WK, Sharkey KA.

Gastroenterology. 2015 Aug;149(2):445-55.e3. doi: 10.1053/j.gastro.2015.04.007. Epub 2015 Apr 9.


Interactive effects of oligofructose and obesity predisposition on gut hormones and microbiota in diet-induced obese rats.

Cluny NL, Eller LK, Keenan CM, Reimer RA, Sharkey KA.

Obesity (Silver Spring). 2015 Apr;23(4):769-78. doi: 10.1002/oby.21017.


Microglia-dependent alteration of glutamatergic synaptic transmission and plasticity in the hippocampus during peripheral inflammation.

Riazi K, Galic MA, Kentner AC, Reid AY, Sharkey KA, Pittman QJ.

J Neurosci. 2015 Mar 25;35(12):4942-52. doi: 10.1523/JNEUROSCI.4485-14.2015.


Endocannabinoid signaling at the periphery: 50 years after THC.

Maccarrone M, Bab I, Bíró T, Cabral GA, Dey SK, Di Marzo V, Konje JC, Kunos G, Mechoulam R, Pacher P, Sharkey KA, Zimmer A.

Trends Pharmacol Sci. 2015 May;36(5):277-96. doi: 10.1016/ Epub 2015 Mar 18. Review.


Emerging roles for enteric glia in gastrointestinal disorders.

Sharkey KA.

J Clin Invest. 2015 Mar 2;125(3):918-25. doi: 10.1172/JCI76303. Epub 2015 Feb 17. Review.


Inhibiting endocannabinoid biosynthesis: a novel approach to the treatment of constipation.

Bashashati M, Nasser Y, Keenan CM, Ho W, Piscitelli F, Nalli M, Mackie K, Storr MA, Di Marzo V, Sharkey KA.

Br J Pharmacol. 2015 Jun;172(12):3099-111. doi: 10.1111/bph.13114. Epub 2015 Apr 23.


Intestinal microbiota: a regulator of intestinal inflammation and cardiac ischemia?

Bashashati M, Habibi HR, Keshavarzian A, Schmulson M, Sharkey KA.

Curr Drug Targets. 2015;16(3):199-208. Review.


Orally administered indomethacin acutely reduces cellular prion protein in the small intestine and modestly increases survival of mice exposed to infectious prions.

Martin GR, Sharkey KA, Jirik FR.

Scand J Gastroenterol. 2015 May;50(5):542-9. doi: 10.3109/00365521.2014.1003400. Epub 2015 Jan 19.


AM841, a covalent cannabinoid ligand, powerfully slows gastrointestinal motility in normal and stressed mice in a peripherally restricted manner.

Keenan CM, Storr MA, Thakur GA, Wood JT, Wager-Miller J, Straiker A, Eno MR, Nikas SP, Bashashati M, Hu H, Mackie K, Makriyannis A, Sharkey KA.

Br J Pharmacol. 2015 May;172(9):2406-18. doi: 10.1111/bph.13069. Epub 2015 Feb 27.


Malabsorption plays a major role in the effects of the biliopancreatic diversion with duodenal switch on energy metabolism in rats.

Li W, Baraboi ED, Cluny NL, Roy MC, Samson P, Biertho L, Sharkey KA, Richard D.

Surg Obes Relat Dis. 2015 Mar-Apr;11(2):356-66. doi: 10.1016/j.soard.2014.07.020. Epub 2014 Aug 12.


The past 10 years of gastroenterology and hepatology-reflections and predictions.

Friedman SL, Quigley EM, Sharkey KA, Sung JJ, Whitcomb DC.

Nat Rev Gastroenterol Hepatol. 2014 Nov;11(11):692-700. doi: 10.1038/nrgastro.2014.167. Epub 2014 Oct 7. Review.


Cannabinoids alleviate experimentally induced intestinal inflammation by acting at central and peripheral receptors.

Fichna J, Bawa M, Thakur GA, Tichkule R, Makriyannis A, McCafferty DM, Sharkey KA, Storr M.

PLoS One. 2014 Oct 2;9(10):e109115. doi: 10.1371/journal.pone.0109115. eCollection 2014.


Neurohormonal signalling in the gastrointestinal tract: new frontiers.

Sharkey KA, Mawe GM.

J Physiol. 2014 Jul 15;592(14):2923-5. doi: 10.1113/jphysiol.2014.275487. Epub 2014 Jun 13. No abstract available.


Cytokine imbalance in irritable bowel syndrome: a systematic review and meta-analysis.

Bashashati M, Rezaei N, Shafieyoun A, McKernan DP, Chang L, Öhman L, Quigley EM, Schmulson M, Sharkey KA, Simrén M.

Neurogastroenterol Motil. 2014 Jul;26(7):1036-48. doi: 10.1111/nmo.12358. Epub 2014 May 5. Review.


Reprint of: Role of enteric neurotransmission in host defense and protection of the gastrointestinal tract.

Sharkey KA, Savidge TC.

Auton Neurosci. 2014 May;182:70-82. doi: 10.1016/j.autneu.2014.03.004. Epub 2014 Mar 15.


The subfornical organ: a novel site of action of cholecystokinin.

Ahmed AS, Dai L, Ho W, Ferguson AV, Sharkey KA.

Am J Physiol Regul Integr Comp Physiol. 2014 Mar 1;306(5):R363-73. doi: 10.1152/ajpregu.00462.2013. Epub 2014 Jan 15.


Role of enteric neurotransmission in host defense and protection of the gastrointestinal tract.

Sharkey KA, Savidge TC.

Auton Neurosci. 2014 Apr;181:94-106. doi: 10.1016/j.autneu.2013.12.006. Epub 2013 Dec 22. Review.


Regulation of nausea and vomiting by cannabinoids and the endocannabinoid system.

Sharkey KA, Darmani NA, Parker LA.

Eur J Pharmacol. 2014 Jan 5;722:134-46. doi: 10.1016/j.ejphar.2013.09.068. Epub 2013 Nov 1.

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