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Items: 28


Mechanoresponsive stem cells acquire neural crest fate in jaw regeneration.

Ransom RC, Carter AC, Salhotra A, Leavitt T, Marecic O, Murphy MP, Lopez ML, Wei Y, Marshall CD, Shen EZ, Jones RE, Sharir A, Klein OD, Chan CKF, Wan DC, Chang HY, Longaker MT.

Nature. 2018 Oct 24. doi: 10.1038/s41586-018-0650-9. [Epub ahead of print]


Isl1 mediates mesenchymal expansion in the developing external genitalia via regulation of Bmp4, Fgf10 and Wnt5a.

Ching ST, Infante CR, Du W, Sharir A, Park S, Menke DB, Klein OD.

Hum Mol Genet. 2018 Jan 1;27(1):107-119. doi: 10.1093/hmg/ddx388.


Watching a deep dive: Live imaging provides lessons about tooth invagination.

Sharir A, Klein OD.

J Cell Biol. 2016 Sep 12;214(6):645-7. doi: 10.1083/jcb.201608088.


Human iPS Cell-Derived Neurons Uncover the Impact of Increased Ras Signaling in Costello Syndrome.

Rooney GE, Goodwin AF, Depeille P, Sharir A, Schofield CM, Yeh E, Roose JP, Klein OD, Rauen KA, Weiss LA, Ullian EM.

J Neurosci. 2016 Jan 6;36(1):142-52. doi: 10.1523/JNEUROSCI.1547-15.2016.


Isometric Scaling in Developing Long Bones Is Achieved by an Optimal Epiphyseal Growth Balance.

Stern T, Aviram R, Rot C, Galili T, Sharir A, Kalish Achrai N, Keller Y, Shahar R, Zelzer E.

PLoS Biol. 2015 Aug 4;13(8):e1002212. doi: 10.1371/journal.pbio.1002212. eCollection 2015 Aug.


Continuously growing rodent molars result from a predictable quantitative evolutionary change over 50 million years.

Tapaltsyan V, Eronen JT, Lawing AM, Sharir A, Janis C, Jernvall J, Klein OD.

Cell Rep. 2015 May 5;11(5):673-80. doi: 10.1016/j.celrep.2015.03.064. Epub 2015 Apr 23.


Loss of osteoblast Runx3 produces severe congenital osteopenia.

Bauer O, Sharir A, Kimura A, Hantisteanu S, Takeda S, Groner Y.

Mol Cell Biol. 2015 Apr;35(7):1097-109. doi: 10.1128/MCB.01106-14. Epub 2015 Jan 20.


Abnormal Ras signaling in Costello syndrome (CS) negatively regulates enamel formation.

Goodwin AF, Tidyman WE, Jheon AH, Sharir A, Zheng X, Charles C, Fagin JA, McMahon M, Diekwisch TG, Ganss B, Rauen KA, Klein OD.

Hum Mol Genet. 2014 Feb 1;23(3):682-92. doi: 10.1093/hmg/ddt455. Epub 2013 Sep 20.


Tendon-bone attachment unit is formed modularly by a distinct pool of Scx- and Sox9-positive progenitors.

Blitz E, Sharir A, Akiyama H, Zelzer E.

Development. 2013 Jul;140(13):2680-90. doi: 10.1242/dev.093906. Epub 2013 May 29.


A temporary decrease in mineral density in perinatal mouse long bones.

Sharir A, Milgram J, Dubnov-Raz G, Zelzer E, Shahar R.

Bone. 2013 Jan;52(1):197-205. doi: 10.1016/j.bone.2012.09.032. Epub 2012 Oct 6.


Muscle force regulates bone shaping for optimal load-bearing capacity during embryogenesis.

Sharir A, Stern T, Rot C, Shahar R, Zelzer E.

Development. 2011 Aug;138(15):3247-59. doi: 10.1242/dev.063768.


High resolution 3D imaging of ex-vivo biological samples by micro CT.

Sharir A, Ramniceanu G, Brumfeld V.

J Vis Exp. 2011 Jun 21;(52). pii: 2688. doi: 10.3791/2688.


The canine baculum: the structure and mechanical properties of an unusual bone.

Sharir A, Israeli D, Milgram J, Currey JD, Monsonego-Ornan E, Shahar R.

J Struct Biol. 2011 Sep;175(3):451-6. doi: 10.1016/j.jsb.2011.06.006. Epub 2011 Jun 25.


Tendon homeostasis: the right pull.

Sharir A, Zelzer E.

Curr Biol. 2011 Jun 21;21(12):R472-4. doi: 10.1016/j.cub.2011.05.025.


Bone mineralization proceeds through intracellular calcium phosphate loaded vesicles: a cryo-electron microscopy study.

Mahamid J, Sharir A, Gur D, Zelzer E, Addadi L, Weiner S.

J Struct Biol. 2011 Jun;174(3):527-35. doi: 10.1016/j.jsb.2011.03.014. Epub 2011 Apr 2.


Mice lacking the orphan receptor ror1 have distinct skeletal abnormalities and are growth retarded.

Lyashenko N, Weissenböck M, Sharir A, Erben RG, Minami Y, Hartmann C.

Dev Dyn. 2010 Aug;239(8):2266-77. doi: 10.1002/dvdy.22362.


Bone vascularization and trabecular bone formation are mediated by PKB alpha/Akt1 in a gene-dosage-dependent manner: in vivo and ex vivo MRI.

Vandoorne K, Magland J, Plaks V, Sharir A, Zelzer E, Wehrli F, Hemmings BA, Harmelin A, Neeman M.

Magn Reson Med. 2010 Jul;64(1):54-64. doi: 10.1002/mrm.22395.


Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction.

Blitz E, Viukov S, Sharir A, Shwartz Y, Galloway JL, Pryce BA, Johnson RL, Tabin CJ, Schweitzer R, Zelzer E.

Dev Cell. 2009 Dec;17(6):861-73. doi: 10.1016/j.devcel.2009.10.010.


Muscle contraction is necessary to maintain joint progenitor cell fate.

Kahn J, Shwartz Y, Blitz E, Krief S, Sharir A, Breitel DA, Rattenbach R, Relaix F, Maire P, Rountree RB, Kingsley DM, Zelzer E.

Dev Cell. 2009 May;16(5):734-43. doi: 10.1016/j.devcel.2009.04.013.


The influence of severe prolonged exercise restriction on the mechanical and structural properties of bone in an avian model.

Shipov A, Sharir A, Zelzer E, Milgram J, Monsonego-Ornan E, Shahar R.

Vet J. 2010 Feb;183(2):153-60. doi: 10.1016/j.tvjl.2008.11.015. Epub 2009 Jan 8.


CD45 regulates retention, motility, and numbers of hematopoietic progenitors, and affects osteoclast remodeling of metaphyseal trabecules.

Shivtiel S, Kollet O, Lapid K, Schajnovitz A, Goichberg P, Kalinkovich A, Shezen E, Tesio M, Netzer N, Petit I, Sharir A, Lapidot T.

J Exp Med. 2008 Sep 29;205(10):2381-95. doi: 10.1084/jem.20080072. Epub 2008 Sep 8.


Amorphous calcium phosphate is a major component of the forming fin bones of zebrafish: Indications for an amorphous precursor phase.

Mahamid J, Sharir A, Addadi L, Weiner S.

Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12748-53. doi: 10.1073/pnas.0803354105. Epub 2008 Aug 27.


The effect of weight loading and subsequent release from loading on the postnatal skeleton.

Reich A, Sharir A, Zelzer E, Hacker L, Monsonego-Ornan E, Shahar R.

Bone. 2008 Oct;43(4):766-74. doi: 10.1016/j.bone.2008.06.004. Epub 2008 Jun 19.


Optical metrology methods for mechanical testing of whole bones.

Barak MM, Sharir A, Shahar R.

Vet J. 2009 Apr;180(1):7-14. doi: 10.1016/j.tvjl.2007.11.022. Epub 2008 Feb 21. Review.


Whole bone mechanics and mechanical testing.

Sharir A, Barak MM, Shahar R.

Vet J. 2008 Jul;177(1):8-17. Epub 2007 Nov 5. Review.


HIF1alpha regulation of Sox9 is necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis.

Amarilio R, Viukov SV, Sharir A, Eshkar-Oren I, Johnson RS, Zelzer E.

Development. 2007 Nov;134(21):3917-28. Epub 2007 Oct 3.


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