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Long-term Host Immune Response Trajectories Among Hospitalized Patients With Sepsis.

Yende S, Kellum JA, Talisa VB, Peck Palmer OM, Chang CH, Filbin MR, Shapiro NI, Hou PC, Venkat A, LoVecchio F, Hawkins K, Crouser ED, Newman AB, Angus DC.

JAMA Netw Open. 2019 Aug 2;2(8):e198686. doi: 10.1001/jamanetworkopen.2019.8686.


Interleukin-6 improves infection identification when added to physician judgment during evaluation of potentially septic patients.

Henning DJ, Hall MK, Watsjold BK, Bhatraju PK, Kosamo S, Shapiro NI, Liles WC, Wurfel MM.

Am J Emerg Med. 2019 Jul 25:158361. doi: 10.1016/j.ajem.2019.158361. [Epub ahead of print]


Physician Judgment and Circulating Biomarkers Predict 28-Day Mortality in Emergency Department Patients.

Henning DJ, Bhatraju PK, Johnson NJ, Kosamo S, Shapiro NI, Zelnick LR, Liles WC, Wurfel MM.

Crit Care Med. 2019 Nov;47(11):1513-1521. doi: 10.1097/CCM.0000000000003899.


Validation of the Emergency Severity Index (Version 4) for the Triage of Adult Emergency Department Patients With Active Cancer.

Adler D, Abar B, Durham DD, Bastani A, Bernstein SL, Baugh CW, Bischof JJ, Coyne CJ, Grudzen CR, Henning DJ, Hudson MF, Klotz A, Lyman GH, Madsen TE, Pallin DJ, Reyes-Gibby CC, Rico JF, Ryan RJ, Shapiro NI, Swor R, Thomas CR Jr, Venkat A, Wilson J, Yeung SJ, Caterino JM.

J Emerg Med. 2019 Sep;57(3):354-361. doi: 10.1016/j.jemermed.2019.05.023. Epub 2019 Jul 26.


Intravenous fluid resuscitation is associated with septic endothelial glycocalyx degradation.

Hippensteel JA, Uchimido R, Tyler PD, Burke RC, Han X, Zhang F, McMurtry SA, Colbert JF, Lindsell CJ, Angus DC, Kellum JA, Yealy DM, Linhardt RJ, Shapiro NI, Schmidt EP.

Crit Care. 2019 Jul 23;23(1):259. doi: 10.1186/s13054-019-2534-2.


Plasma Peptidylarginine Deiminase IV Promotes VWF-Platelet String Formation and Accelerates Thrombosis After Vessel Injury.

Sorvillo N, Mizurini DM, Coxon C, Martinod K, Tilvawala R, Cherpokova D, Salinger AJ, Seward RJ, Staudinger C, Weerapana E, Shapiro NI, Costello CE, Thompson PR, Wagner DD.

Circ Res. 2019 Aug 16;125(5):507-519. doi: 10.1161/CIRCRESAHA.118.314571. Epub 2019 Jun 28.


Complement Deposition on the Surface of RBC After Trauma Serves A Biomarker of Moderate Trauma Severity: A Prospective Study.

Satyam A, Andreo K, Lapchak PH, Dalle Lucca JJ, Davis RB, Tsokos MG, Shapiro NI, Tsokos GC.

Shock. 2019 Apr 12. doi: 10.1097/SHK.0000000000001348. [Epub ahead of print]


Analysis of Diagnoses, Symptoms, Medications, and Admissions Among Patients With Cancer Presenting to Emergency Departments.

Caterino JM, Adler D, Durham DD, Yeung SJ, Hudson MF, Bastani A, Bernstein SL, Baugh CW, Coyne CJ, Grudzen CR, Henning DJ, Klotz A, Madsen TE, Pallin DJ, Reyes-Gibby CC, Rico JF, Ryan RJ, Shapiro NI, Swor R, Venkat A, Wilson J, Thomas CR Jr, Bischof JJ, Lyman GH.

JAMA Netw Open. 2019 Mar 1;2(3):e190979. doi: 10.1001/jamanetworkopen.2019.0979.


Using the Boston Syncope Observation Management Pathway to Reduce Hospital Admission and Adverse Outcomes.

Mechanic OJ, Pascheles CY, Lopez GJ, Winans AM, Shapiro NI, Tibbles C, Wolfe RE, Grossman SA.

West J Emerg Med. 2019 Mar;20(2):250-255. doi: 10.5811/westjem.2018.11.39657. Epub 2019 Feb 4.


Lipopolysaccharide suppresses T cells by generating extracellular ATP that impairs their mitochondrial function via P2Y11 receptors.

Sueyoshi K, Ledderose C, Shen Y, Lee AH, Shapiro NI, Junger WG.

J Biol Chem. 2019 Apr 19;294(16):6283-6293. doi: 10.1074/jbc.RA118.007188. Epub 2019 Feb 20.


Chest computed tomography imaging utility for radiographically occult rib fractures in elderly fall-injured patients.

Singleton JM, Bilello LA, Canham LS, Levenson RB, Lopez GJ, Tadiri SP, Shapiro NI, Rosen CL.

J Trauma Acute Care Surg. 2019 May;86(5):838-843. doi: 10.1097/TA.0000000000002208.


The glycocalyx: a novel diagnostic and therapeutic target in sepsis.

Uchimido R, Schmidt EP, Shapiro NI.

Crit Care. 2019 Jan 17;23(1):16. doi: 10.1186/s13054-018-2292-6. Review.


Effect of Levocarnitine vs Placebo as an Adjunctive Treatment for Septic Shock: The Rapid Administration of Carnitine in Sepsis (RACE) Randomized Clinical Trial.

Jones AE, Puskarich MA, Shapiro NI, Guirgis FW, Runyon M, Adams JY, Sherwin R, Arnold R, Roberts BW, Kurz MC, Wang HE, Kline JA, Courtney DM, Trzeciak S, Sterling SA, Nandi U, Patki D, Viele K.

JAMA Netw Open. 2018 Dec 7;1(8):e186076. doi: 10.1001/jamanetworkopen.2018.6076.


The Potential Role of Ultrasound in the Work-up of Appendicitis in the Emergency Department.

Tyler PD, Carey J, Stashko E, Levenson RB, Shapiro NI, Rosen CL.

J Emerg Med. 2019 Feb;56(2):191-196. doi: 10.1016/j.jemermed.2018.10.034. Epub 2018 Dec 26.


Validation of the REGARDS Severe Sepsis Risk Score.

Wang HE, Donnelly JP, Yende S, Levitan EB, Shapiro NI, Dai Y, Zhao H, Heiss G, Odden M, Newman A, Safford M.

J Clin Med. 2018 Dec 11;7(12). pii: E536. doi: 10.3390/jcm7120536.


Microcirculatory perfusion disturbances in septic shock: results from the ProCESS trial.

Massey MJ, Hou PC, Filbin M, Wang H, Ngo L, Huang DT, Aird WC, Novack V, Trzeciak S, Yealy DM, Kellum JA, Angus DC, Shapiro NI; ProCESS investigators.

Crit Care. 2018 Nov 20;22(1):308. doi: 10.1186/s13054-018-2240-5.


Partial pressure of arterial carbon dioxide after resuscitation from cardiac arrest and neurological outcome: A prospective multi-center protocol-directed cohort study.

Hope Kilgannon J, Hunter BR, Puskarich MA, Shea L, Fuller BM, Jones C, Donnino M, Kline JA, Jones AE, Shapiro NI, Abella BS, Trzeciak S, Roberts BW.

Resuscitation. 2019 Feb;135:212-220. doi: 10.1016/j.resuscitation.2018.11.015. Epub 2018 Nov 16.


The 10 signs telling me that my cancer patient in the emergency department is at high risk of becoming critically ill.

Peyrony O, Shapiro NI.

Intensive Care Med. 2018 Dec;44(12):2315-2318. doi: 10.1007/s00134-018-5449-5. Epub 2018 Nov 12. No abstract available.


Charge Reductions Associated With Shorter Time to Recovery in Septic Shock.

Self WH, Liu D, Strayer N, Russ S, Ward MJ, Shapiro NI, Rice TW, Semler MW.

Chest. 2019 Feb;155(2):315-321. doi: 10.1016/j.chest.2018.10.034. Epub 2018 Nov 9.


Mean arterial pressure and mortality in patients with distributive shock: a retrospective analysis of the MIMIC-III database.

Vincent JL, Nielsen ND, Shapiro NI, Gerbasi ME, Grossman A, Doroff R, Zeng F, Young PJ, Russell JA.

Ann Intensive Care. 2018 Nov 8;8(1):107. doi: 10.1186/s13613-018-0448-9.


Association Between Elevated Mean Arterial Blood Pressure and Neurologic Outcome After Resuscitation From Cardiac Arrest: Results From a Multicenter Prospective Cohort Study.

Roberts BW, Kilgannon JH, Hunter BR, Puskarich MA, Shea L, Donnino M, Jones C, Fuller BM, Kline JA, Jones AE, Shapiro NI, Abella BS, Trzeciak S.

Crit Care Med. 2019 Jan;47(1):93-100. doi: 10.1097/CCM.0000000000003474.


In vivo quantification of rolling and adhered leukocytes in human sepsis.

Fabian-Jessing BK, Massey MJ, Filbin MR, Hou PC, Wang HE, Kirkegaard H, Yealy DM, Aird WC, Kellum JA, Angus DC, Shapiro NI; ProCESS Investigators.

Crit Care. 2018 Sep 30;22(1):240. doi: 10.1186/s13054-018-2173-z.


Leukocyte Transcriptional Response in Sepsis.

Skibsted S, Bhasin MK, Henning DJ, Jaminet SC, Lewandowski J, Kirkegaard H, Aird WC, Shapiro NI.

Shock. 2019 Aug;52(2):166-173. doi: 10.1097/SHK.0000000000001258.


Liberal or restricted fluid resuscitation in critical illness: Shifting the needle back towards equipoise.

Macdonald SP, Shapiro NI.

Emerg Med Australas. 2018 Aug;30(4):446-447. doi: 10.1111/1742-6723.13130. No abstract available.


Challenges and Opportunities for Emergency Department Sepsis Screening at Triage.

Filbin MR, Thorsen JE, Lynch J, Gillingham TD, Pasakarnis CL, Capp R, Shapiro NI, Mooncai T, Hou PC, Heldt T, Reisner AT.

Sci Rep. 2018 Jul 23;8(1):11059. doi: 10.1038/s41598-018-29427-1.


Challenging Dogma: The Value of Bolus Fluids in the Early Resuscitation of Hyperdynamic Sepsis.

Hippensteel JA, Shapiro NI, Schmidt EP.

Am J Respir Crit Care Med. 2018 Oct 15;198(8):981-983. doi: 10.1164/rccm.201806-1071ED. No abstract available.


Sepsis-3 Septic Shock Criteria and Associated Mortality Among Infected Hospitalized Patients Assessed by a Rapid Response Team.

Fernando SM, Reardon PM, Rochwerg B, Shapiro NI, Yealy DM, Seely AJE, Perry JJ, Barnaby DP, Murphy K, Tanuseputro P, Kyeremanteng K.

Chest. 2018 Aug;154(2):309-316. doi: 10.1016/j.chest.2018.05.004. Epub 2018 May 17.


A prospective, multi-centre US clinical trial to determine accuracy of FebriDx point-of-care testing for acute upper respiratory infections with and without a confirmed fever.

Shapiro NI, Self WH, Rosen J, Sharp SC, Filbin MR, Hou PC, Parekh AD, Kurz MC, Sambursky R.

Ann Med. 2018 Aug;50(5):420-429. doi: 10.1080/07853890.2018.1474002. Epub 2018 May 18.


Liberal Versus Restrictive Intravenous Fluid Therapy for Early Septic Shock: Rationale for a Randomized Trial.

Self WH, Semler MW, Bellomo R, Brown SM, deBoisblanc BP, Exline MC, Ginde AA, Grissom CK, Janz DR, Jones AE, Liu KD, Macdonald SPJ, Miller CD, Park PK, Reineck LA, Rice TW, Steingrub JS, Talmor D, Yealy DM, Douglas IS, Shapiro NI; CLOVERS Protocol Committee and NHLBI Prevention and Early Treatment of Acute Lung Injury (PETAL) Network Investigators.

Ann Emerg Med. 2018 Oct;72(4):457-466. doi: 10.1016/j.annemergmed.2018.03.039. Epub 2018 May 10.


Comparison of Emergency Medicine Malpractice Cases Involving Residents to Nonresident Cases.

Gurley KL, Grossman SA, Janes M, Yu-Moe CW, Song E, Tibbles CD, Shapiro NI, Rosen CL.

Acad Emerg Med. 2018 Sep;25(9):980-986. doi: 10.1111/acem.13430.


Comparing Ran-Out Status of Inhaled Short-Acting Beta-Agonists in Emergency Department Patients with Acute Asthma: 1996-1998 versus 2015-2017.

Goto T, Camargo CA Jr, Gimenez-Zapiola C, Pallin DJ, Shapiro NI, Ferro TJ, Rainville C, Stoyanov S, Hasegawa K.

J Allergy Clin Immunol Pract. 2018 Nov - Dec;6(6):1999-2005.e3. doi: 10.1016/j.jaip.2018.04.001. Epub 2018 Apr 11.


A Novel Implementation of Magnetic Levitation to Quantify Leukocyte Size, Morphology, and Magnetic Properties to Identify Patients With Sepsis.

Andersen MS, Lu S, Lopez GJ, Lassen AT, Shapiro NI, Ghiran IC.

Shock. 2019 Feb;51(2):147-152. doi: 10.1097/SHK.0000000000001139.


Helpful Only When Elevated: Initial Serum Lactate in Stable Emergency Department Patients with Sepsis Is Specific, but Not Sensitive for Future Deterioration.

Fernando SM, Barnaby DP, Herry CL, Gallagher EJ, Shapiro NI, Seely AJE.

J Emerg Med. 2018 Jun;54(6):766-773. doi: 10.1016/j.jemermed.2018.01.040. Epub 2018 Mar 13.


Association Between Early Hyperoxia Exposure After Resuscitation From Cardiac Arrest and Neurological Disability: Prospective Multicenter Protocol-Directed Cohort Study.

Roberts BW, Kilgannon JH, Hunter BR, Puskarich MA, Pierce L, Donnino M, Leary M, Kline JA, Jones AE, Shapiro NI, Abella BS, Trzeciak S.

Circulation. 2018 May 15;137(20):2114-2124. doi: 10.1161/CIRCULATIONAHA.117.032054. Epub 2018 Feb 1.


Second consensus on the assessment of sublingual microcirculation in critically ill patients: results from a task force of the European Society of Intensive Care Medicine.

Ince C, Boerma EC, Cecconi M, De Backer D, Shapiro NI, Duranteau J, Pinsky MR, Artigas A, Teboul JL, Reiss IKM, Aldecoa C, Hutchings SD, Donati A, Maggiorini M, Taccone FS, Hernandez G, Payen D, Tibboel D, Martin DS, Zarbock A, Monnet X, Dubin A, Bakker J, Vincent JL, Scheeren TWL; Cardiovascular Dynamics Section of the ESICM.

Intensive Care Med. 2018 Mar;44(3):281-299. doi: 10.1007/s00134-018-5070-7. Epub 2018 Feb 6.


Tie2 protects the vasculature against thrombus formation in systemic inflammation.

Higgins SJ, De Ceunynck K, Kellum JA, Chen X, Gu X, Chaudhry SA, Schulman S, Libermann TA, Lu S, Shapiro NI, Christiani DC, Flaumenhaft R, Parikh SM.

J Clin Invest. 2018 Apr 2;128(4):1471-1484. doi: 10.1172/JCI97488. Epub 2018 Mar 5.


Preventing Hospitalization in Mild Acute Pancreatitis Using a Clinical Pathway in the Emergency Department.

Kothari D, Babineau M, Hall M, Freedman SD, Shapiro NI, Sheth SG.

J Clin Gastroenterol. 2018 Sep;52(8):734-741. doi: 10.1097/MCG.0000000000000954.


Mildly elevated lactate levels are associated with microcirculatory flow abnormalities and increased mortality: a microSOAP post hoc analysis.

Vellinga NAR, Boerma EC, Koopmans M, Donati A, Dubin A, Shapiro NI, Pearse RM, van der Voort PHJ, Dondorp AM, Bafi T, Fries M, Akarsu-Ayazoglu T, Pranskunas A, Hollenberg S, Balestra G, van Iterson M, Sadaka F, Minto G, Aypar U, Hurtado FJ, Martinelli G, Payen D, van Haren F, Holley A, Gomez H, Mehta RL, Rodriguez AH, Ruiz C, Canales HS, Duranteau J, Spronk PE, Jhanji S, Hubble S, Chierego M, Jung C, Martin D, Sorbara C, Bakker J, Ince C; microSOAP study group.

Crit Care. 2017 Oct 18;21(1):255. doi: 10.1186/s13054-017-1842-7.


Diagnostic Accuracy of FebriDx: A Rapid Test to Detect Immune Responses to Viral and Bacterial Upper Respiratory Infections.

Self WH, Rosen J, Sharp SC, Filbin MR, Hou PC, Parekh AD, Kurz MC, Shapiro NI.

J Clin Med. 2017 Oct 7;6(10). pii: E94. doi: 10.3390/jcm6100094.


In reply.

Henning DJ, Shapiro NI.

Ann Emerg Med. 2017 Oct;70(4):601. doi: 10.1016/j.annemergmed.2017.05.029. No abstract available.


The authors reply.

Schuetz P, Ebmeyer S, Johannes S, Wiemer JC, Schwabe A, Shapiro NI.

Crit Care Med. 2017 Oct;45(10):e1098-e1099. doi: 10.1097/CCM.0000000000002608. No abstract available.


Detection of membrane-bound and soluble antigens by magnetic levitation.

Andersen MS, Howard E, Lu S, Richard M, Gregory M, Ogembo G, Mazor O, Gorelik P, Shapiro NI, Sharda AV, Ghiran I.

Lab Chip. 2017 Oct 11;17(20):3462-3473. doi: 10.1039/c7lc00402h.


Quick Sequential Organ Failure Assessment and Systemic Inflammatory Response Syndrome Criteria as Predictors of Critical Care Intervention Among Patients With Suspected Infection.

Moskowitz A, Patel PV, Grossestreuer AV, Chase M, Shapiro NI, Berg K, Cocchi MN, Holmberg MJ, Donnino MW; Center for Resuscitation Science.

Crit Care Med. 2017 Nov;45(11):1813-1819. doi: 10.1097/CCM.0000000000002622.


Identification of Hypotensive Emergency Department Patients with Cardiogenic Etiologies.

Henning DJ, Kearney KE, Hall MK, Mahr C, Shapiro NI, Nichol G.

Shock. 2018 Feb;49(2):131-136. doi: 10.1097/SHK.0000000000000945.


Risk of Intracranial Hemorrhage in Ground-level Fall With Antiplatelet or Anticoagulant Agents.

Ganetsky M, Lopez G, Coreanu T, Novack V, Horng S, Shapiro NI, Bauer KA.

Acad Emerg Med. 2017 Oct;24(10):1258-1266. doi: 10.1111/acem.13217. Epub 2017 Jun 5.


Creating an automated trigger for sepsis clinical decision support at emergency department triage using machine learning.

Horng S, Sontag DA, Halpern Y, Jernite Y, Shapiro NI, Nathanson LA.

PLoS One. 2017 Apr 6;12(4):e0174708. doi: 10.1371/journal.pone.0174708. eCollection 2017.


The Absence of Fever Is Associated With Higher Mortality and Decreased Antibiotic and IV Fluid Administration in Emergency Department Patients With Suspected Septic Shock.

Henning DJ, Carey JR, Oedorf K, Day DE, Redfield CS, Huguenel CJ, Roberts JC, Sanchez LD, Wolfe RE, Shapiro NI.

Crit Care Med. 2017 Jun;45(6):e575-e582. doi: 10.1097/CCM.0000000000002311.


Application of the Third International Consensus Definitions for Sepsis (Sepsis-3) Classification: a retrospective population-based cohort study.

Donnelly JP, Safford MM, Shapiro NI, Baddley JW, Wang HE.

Lancet Infect Dis. 2017 Jun;17(6):661-670. doi: 10.1016/S1473-3099(17)30117-2. Epub 2017 Mar 4.


An Emergency Department Validation of the SEP-3 Sepsis and Septic Shock Definitions and Comparison With 1992 Consensus Definitions.

Henning DJ, Puskarich MA, Self WH, Howell MD, Donnino MW, Yealy DM, Jones AE, Shapiro NI.

Ann Emerg Med. 2017 Oct;70(4):544-552.e5. doi: 10.1016/j.annemergmed.2017.01.008. Epub 2017 Mar 3.


Serial Procalcitonin Predicts Mortality in Severe Sepsis Patients: Results From the Multicenter Procalcitonin MOnitoring SEpsis (MOSES) Study.

Schuetz P, Birkhahn R, Sherwin R, Jones AE, Singer A, Kline JA, Runyon MS, Self WH, Courtney DM, Nowak RM, Gaieski DF, Ebmeyer S, Johannes S, Wiemer JC, Schwabe A, Shapiro NI.

Crit Care Med. 2017 May;45(5):781-789. doi: 10.1097/CCM.0000000000002321.

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