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The CHK1 Inhibitor Prexasertib Exhibits Monotherapy Activity in High-Grade Serous Ovarian Cancer Models and Sensitizes to PARP inhibition.

Parmar K, Kochupurakkal BS, Lazaro JB, Wang ZC, Palakurthi S, Kirschmeier PT, Yang C, Sambel LA, Färkkilä A, Reznichenko E, Reavis HD, Dunn CE, Zou L, Do KT, Konstantinopoulos PA, Matulonis UA, Liu JF, D'Andrea AD, Shapiro GI.

Clin Cancer Res. 2019 Aug 13. pii: clincanres.0448.2019. doi: 10.1158/1078-0432.CCR-19-0448. [Epub ahead of print]


Comparison of the Causes of Death and Wounding Patterns in Urban Firearm-Related Violence and Civilian Public Mass Shooting Events.

Maghami S, Hendrix C, Matecki M, Mahendran K, Amdur R, Mitchell R, Diaz F, Estroff J, Smith ER, Shapiro G, Sarani B.

J Trauma Acute Care Surg. 2019 Aug 5. doi: 10.1097/TA.0000000000002470. [Epub ahead of print]


A mixed two-dose vaccination schedule: Not enough evidence to support a policy change in Quebec.

Rosberger Z, Steben M, Norris T, McFadyen A, Shapiro GK.

Vaccine. 2019 Jul 26;37(32):4421. doi: 10.1016/j.vaccine.2019.03.083. No abstract available.


Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss.

Fedoriw A, Rajapurkar SR, O'Brien S, Gerhart SV, Mitchell LH, Adams ND, Rioux N, Lingaraj T, Ribich SA, Pappalardi MB, Shah N, Laraio J, Liu Y, Butticello M, Carpenter CL, Creasy C, Korenchuk S, McCabe MT, McHugh CF, Nagarajan R, Wagner C, Zappacosta F, Annan R, Concha NO, Thomas RA, Hart TK, Smith JJ, Copeland RA, Moyer MP, Campbell J, Stickland K, Mills J, Jacques-O'Hagan S, Allain C, Johnston D, Raimondi A, Porter Scott M, Waters N, Swinger K, Boriack-Sjodin A, Riera T, Shapiro G, Chesworth R, Prinjha RK, Kruger RG, Barbash O, Mohammad HP.

Cancer Cell. 2019 Jul 8;36(1):100-114.e25. doi: 10.1016/j.ccell.2019.05.014. Epub 2019 Jun 27.


The Joint Counterterrorism Awareness Workshop Series (JCTAWS): Integrating disciplines for enhanced capabilities during a complex coordinated attack.

Shapiro GL, Armstrong JH, Roberts K, Gordon J, Smith ER, Afman J, Sasser SM.

J Emerg Manag. 2019 May/Jun;17(3):210-212. doi: 10.5055/jem.2019.0419.


First-in-Class, First-in-Human Study Evaluating LV305, a Dendritic-Cell Tropic Lentiviral Vector, in Sarcoma and Other Solid Tumors Expressing NY-ESO-1.

Somaiah N, Block MS, Kim JW, Shapiro GI, Do KT, Hwu P, Eder JP, Jones RL, Lu H, Ter Meulen JH, Bohac C, Chen M, Hsu FJ, Gnjatic S, Pollack SM.

Clin Cancer Res. 2019 Jun 21. doi: 10.1158/1078-0432.CCR-19-1025. [Epub ahead of print]


Mixed-methods study in England and Northern Ireland to understand young men who have sex with men's knowledge and attitudes towards human papillomavirus vaccination.

Kesten JM, Flannagan C, Ruane-McAteer E, Merriel SWD, Nadarzynski T, Shapiro G, Rosberger Z, Prue G.

BMJ Open. 2019 May 14;9(5):e025070. doi: 10.1136/bmjopen-2018-025070.


The Relationship of Level of Education to Social Reintegration after Burn Injury: A LIBRE Study.

Schulz JT, Shapiro GD, Acton A, Fidler P, Marino ME, Jette A, Schneider JE, Kazis LE, Ryan CM.

J Burn Care Res. 2019 Aug 14;40(5):696-702. doi: 10.1093/jbcr/irz074.


Incidence and Cause of Potentially Preventable Death after Civilian Public Mass Shooting in the US.

Smith ER, Sarani B, Shapiro G, Gondek S, Rivas L, Ju T, Robinson BR, Estroff JM, Fudenberg J, Amdur R, Mitchell R.

J Am Coll Surg. 2019 Sep;229(3):244-251. doi: 10.1016/j.jamcollsurg.2019.04.016. Epub 2019 Apr 25.


Phase Ib study of the MEK inhibitor cobimetinib (GDC-0973) in combination with the PI3K inhibitor pictilisib (GDC-0941) in patients with advanced solid tumors.

Shapiro GI, LoRusso P, Kwak E, Pandya S, Rudin CM, Kurkjian C, Cleary JM, Pilat MJ, Jones S, de Crespigny A, Fredrickson J, Musib L, Yan Y, Wongchenko M, Hsieh HJ, Gates MR, Chan IT, Bendell J.

Invest New Drugs. 2019 Apr 24. doi: 10.1007/s10637-019-00776-6. [Epub ahead of print]


PARP Inhibitor Efficacy Depends on CD8+ T-cell Recruitment via Intratumoral STING Pathway Activation in BRCA-Deficient Models of Triple-Negative Breast Cancer.

Pantelidou C, Sonzogni O, De Oliveria Taveira M, Mehta AK, Kothari A, Wang D, Visal T, Li MK, Pinto J, Castrillon JA, Cheney EM, Bouwman P, Jonkers J, Rottenberg S, Guerriero JL, Wulf GM, Shapiro GI.

Cancer Discov. 2019 Jun;9(6):722-737. doi: 10.1158/2159-8290.CD-18-1218. Epub 2019 Apr 23.


A phase 2, open-label study of brentuximab vedotin in patients with CD30-expressing solid tumors.

Sharman JP, Wheler JJ, Einhorn L, Dowlati A, Shapiro GI, Hilton J, Burke JM, Siddiqi T, Whiting N, Jalal SI.

Invest New Drugs. 2019 Aug;37(4):738-747. doi: 10.1007/s10637-019-00768-6. Epub 2019 Apr 16.


Crizotinib in ROS1-rearranged advanced non-small-cell lung cancer (NSCLC): updated results, including overall survival, from PROFILE 1001.

Shaw AT, Riely GJ, Bang YJ, Kim DW, Camidge DR, Solomon BJ, Varella-Garcia M, Iafrate AJ, Shapiro GI, Usari T, Wang SC, Wilner KD, Clark JW, Ou SI.

Ann Oncol. 2019 Apr 13. pii: mdz131. doi: 10.1093/annonc/mdz131. [Epub ahead of print]


Personalized chemotherapy in triple-negative breast cancer: are we ready for prime time?

Barroso-Sousa R, Shapiro GI, Tolaney SM.

Stem Cell Investig. 2019 Feb 22;6:4. doi: 10.21037/sci.2019.02.01. eCollection 2019. No abstract available.


Olaparib and α-specific PI3K inhibitor alpelisib for patients with epithelial ovarian cancer: a dose-escalation and dose-expansion phase 1b trial.

Konstantinopoulos PA, Barry WT, Birrer M, Westin SN, Cadoo KA, Shapiro GI, Mayer EL, O'Cearbhaill RE, Coleman RL, Kochupurakkal B, Whalen C, Curtis J, Farooq S, Luo W, Eismann J, Buss MK, Aghajanian C, Mills GB, Palakurthi S, Kirschmeier P, Liu J, Cantley LC, Kaufmann SH, Swisher EM, D'Andrea AD, Winer E, Wulf GM, Matulonis UA.

Lancet Oncol. 2019 Apr;20(4):570-580. doi: 10.1016/S1470-2045(18)30905-7. Epub 2019 Mar 14.


Burn survivors injured as children exhibit resilience in long-term community integration outcomes: A life impact burn recovery evaluation (LIBRE) study.

Cartwright S, Saret C, Shapiro GD, Ni P, Sheridan RL, Lee AF, Marino M, Acton A, Kazis LE, Schneider JC, Ryan CM.

Burns. 2019 Aug;45(5):1031-1040. doi: 10.1016/j.burns.2019.02.008. Epub 2019 Mar 6.


MicroRNA-Mediated Suppression of the TGF-β Pathway Confers Transmissible and Reversible CDK4/6 Inhibitor Resistance.

Cornell L, Wander SA, Visal T, Wagle N, Shapiro GI.

Cell Rep. 2019 Mar 5;26(10):2667-2680.e7. doi: 10.1016/j.celrep.2019.02.023.


Nonviral ultrasound-mediated gene delivery in small and large animal models.

Bez M, Foiret J, Shapiro G, Pelled G, Ferrara KW, Gazit D.

Nat Protoc. 2019 Apr;14(4):1015-1026. doi: 10.1038/s41596-019-0125-y. Epub 2019 Feb 25.


Author Correction: HER kinase inhibition in patients with HER2- and HER3-mutant cancers.

Hyman DM, Piha-Paul SA, Won H, Rodon J, Saura C, Shapiro GI, Juric D, Quinn DI, Moreno V, Doger B, Mayer IA, Boni V, Calvo E, Loi S, Lockhart AC, Erinjeri JP, Scaltriti M, Ulaner GA, Patel J, Tang J, Beer H, Selcuklu SD, Hanrahan AJ, Bouvier N, Melcer M, Murali R, Schram AM, Smyth LM, Jhaveri K, Li BT, Drilon A, Harding JJ, Iyer G, Taylor BS, Berger MF, Cutler RE Jr, Xu F, Butturini A, Eli LD, Mann G, Farrell C, Lalani AS, Bryce RP, Arteaga CL, Meric-Bernstam F, Baselga J, Solit DB.

Nature. 2019 Feb;566(7745):E11-E12. doi: 10.1038/s41586-019-0974-0.


Using the precaution adoption process model to clarify human papillomavirus vaccine hesitancy in canadian parents of girls and parents of boys.

Tatar O, Shapiro GK, Perez S, Wade K, Rosberger Z.

Hum Vaccin Immunother. 2019;15(7-8):1803-1814. doi: 10.1080/21645515.2019.1575711. Epub 2019 Apr 22.


Wounding Patterns Based on Firearm Type in Civilian Public Mass Shootings in the United States.

Sarani B, Hendrix C, Matecki M, Estroff J, Amdur RL, Robinson BRH, Shapiro G, Gondek S, Mitchell R, Smith ER.

J Am Coll Surg. 2019 Mar;228(3):228-234. doi: 10.1016/j.jamcollsurg.2018.11.014. Epub 2018 Dec 7.


Health Status in Adults With Chronic Conditions: Intervention Strategies for Improving Patient-Reported Outcomes.

Selim AJ, Qian SX, Rogers W, Arya D, Simmons K, Shapiro GD, Sonis LA, Kazis LE.

J Ambul Care Manage. 2019 Jan/Mar;42(1):2-20. doi: 10.1097/JAC.0000000000000262.


Molecular pain markers correlate with pH-sensitive MRI signal in a pig model of disc degeneration.

Bez M, Zhou Z, Sheyn D, Tawackoli W, Giaconi JC, Shapiro G, Ben David S, Gazit Z, Pelled G, Li D, Gazit D.

Sci Rep. 2018 Nov 26;8(1):17363. doi: 10.1038/s41598-018-34582-6.


Targeting MYC dependency in ovarian cancer through inhibition of CDK7 and CDK12/13.

Zeng M, Kwiatkowski NP, Zhang T, Nabet B, Xu M, Liang Y, Quan C, Wang J, Hao M, Palakurthi S, Zhou S, Zeng Q, Kirschmeier PT, Meghani K, Leggett AL, Qi J, Shapiro GI, Liu JF, Matulonis UA, Lin CY, Konstantinopoulos PA, Gray NS.

Elife. 2018 Nov 13;7. pii: e39030. doi: 10.7554/eLife.39030.


Association between maternal urinary speciated arsenic concentrations and gestational diabetes in a cohort of Canadian women.

Ashley-Martin J, Dodds L, Arbuckle TE, Bouchard MF, Shapiro GD, Fisher M, Monnier P, Morisset AS, Ettinger AS.

Environ Int. 2018 Dec;121(Pt 1):714-720. doi: 10.1016/j.envint.2018.10.008. Epub 2018 Oct 12.


Using an integrated conceptual framework to investigate parents' HPV vaccine decision for their daughters and sons.

Shapiro GK, Tatar O, Amsel R, Prue G, Zimet GD, Knauper B, Rosberger Z.

Prev Med. 2018 Nov;116:203-210. doi: 10.1016/j.ypmed.2018.09.017. Epub 2018 Sep 26.


Adverse birth outcomes and infant mortality according to registered First Nations status and First Nations community residence across Canada.

Shapiro GD, Sheppard AJ, Bushnik T, Kramer MS, Mashford-Pringle A, Kaufman JS, Yang S.

Can J Public Health. 2018 Dec;109(5-6):692-699. doi: 10.17269/s41997-018-0134-6. Epub 2018 Sep 21.


Prediction of DNA Repair Inhibitor Response in Short-Term Patient-Derived Ovarian Cancer Organoids.

Hill SJ, Decker B, Roberts EA, Horowitz NS, Muto MG, Worley MJ Jr, Feltmate CM, Nucci MR, Swisher EM, Nguyen H, Yang C, Morizane R, Kochupurakkal BS, Do KT, Konstantinopoulos PA, Liu JF, Bonventre JV, Matulonis UA, Shapiro GI, Berkowitz RS, Crum CP, D'Andrea AD.

Cancer Discov. 2018 Nov;8(11):1404-1421. doi: 10.1158/2159-8290.CD-18-0474. Epub 2018 Sep 13.


Factors associated with human papillomavirus (HPV) test acceptability in primary screening for cervical cancer: A mixed methods research synthesis.

Tatar O, Thompson E, Naz A, Perez S, Shapiro GK, Wade K, Zimet G, Gilca V, Janda M, Kahn J, Daley E, Rosberger Z.

Prev Med. 2018 Nov;116:40-50. doi: 10.1016/j.ypmed.2018.08.034. Epub 2018 Aug 31.


Palbociclib resistance confers dependence on an FGFR-MAP kinase-mTOR-driven pathway in KRAS-mutant non-small cell lung cancer.

Haines E, Chen T, Kommajosyula N, Chen Z, Herter-Sprie GS, Cornell L, Wong KK, Shapiro GI.

Oncotarget. 2018 Aug 3;9(60):31572-31589. doi: 10.18632/oncotarget.25803. eCollection 2018 Aug 3.


Social Interactions and Social Activities After Burn Injury: A Life Impact Burn Recovery Evaluation (LIBRE) Study.

Ohrtman EA, Shapiro GD, Simko LC, Dore E, Slavin MD, Saret C, Amaya F, Lomelin-Gascon J, Ni P, Acton A, Marino M, Kazis LE, Ryan CM, Schneider JC.

J Burn Care Res. 2018 Oct 23;39(6):1022-1028. doi: 10.1093/jbcr/iry038.


The Predictive Value of Head Circumference Growth during the First Year of Life on Early Child Traits.

Dupont C, Castellanos-Ryan N, Séguin JR, Muckle G, Simard MN, Shapiro GD, Herba CM, Fraser WD, Lippé S.

Sci Rep. 2018 Jun 29;8(1):9828. doi: 10.1038/s41598-018-28165-8.


Adverse birth outcomes in relation to maternal marital and cohabitation status in Canada.

Shapiro GD, Bushnik T, Wilkins R, Kramer MS, Kaufman JS, Sheppard AJ, Yang S.

Ann Epidemiol. 2018 Aug;28(8):503-509.e11. doi: 10.1016/j.annepidem.2018.05.001. Epub 2018 May 22.


The Development and Validity of the Adult Burn Outcome Questionnaire Short Form.

Chen L, Lee AF, Shapiro GD, Goverman J, Faoro N, Schneider JC, Kazis LE, Ryan CM.

J Burn Care Res. 2018 Aug 17;39(5):771-779. doi: 10.1093/jbcr/irx043.


Recent Advances and Future of Gene Therapy for Bone Regeneration.

Shapiro G, Lieber R, Gazit D, Pelled G.

Curr Osteoporos Rep. 2018 Aug;16(4):504-511. doi: 10.1007/s11914-018-0459-3. Review.


Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine.

Aguirre AJ, Nowak JA, Camarda ND, Moffitt RA, Ghazani AA, Hazar-Rethinam M, Raghavan S, Kim J, Brais LK, Ragon D, Welch MW, Reilly E, McCabe D, Marini L, Anderka K, Helvie K, Oliver N, Babic A, Da Silva A, Nadres B, Van Seventer EE, Shahzade HA, St Pierre JP, Burke KP, Clancy T, Cleary JM, Doyle LA, Jajoo K, McCleary NJ, Meyerhardt JA, Murphy JE, Ng K, Patel AK, Perez K, Rosenthal MH, Rubinson DA, Ryou M, Shapiro GI, Sicinska E, Silverman SG, Nagy RJ, Lanman RB, Knoerzer D, Welsch DJ, Yurgelun MB, Fuchs CS, Garraway LA, Getz G, Hornick JL, Johnson BE, Kulke MH, Mayer RJ, Miller JW, Shyn PB, Tuveson DA, Wagle N, Yeh JJ, Hahn WC, Corcoran RB, Carter SL, Wolpin BM.

Cancer Discov. 2018 Sep;8(9):1096-1111. doi: 10.1158/2159-8290.CD-18-0275. Epub 2018 Jun 14.


The Effect of Facial Burns on Long-Term Outcomes in Young Adults: A 5-Year Study.

Ryan CM, Lee A, Stoddard FJ Jr, Li NC, Schneider JC, Shapiro GD, Griggs CL, Wang C, Palmieri T, Meyer WJ 3rd, Pidcock FS, Reilly D, Sheridan RL, Kazis LE, Tompkins RG; Multi-Center Benchmarking Study Group.

J Burn Care Res. 2018 Jun 13;39(4):497-506. doi: 10.1093/jbcr/irx006.


An adaptive grid to improve the efficiency and accuracy of modelling underwater noise from shipping.

Trigg LE, Chen F, Shapiro GI, Ingram SN, Embling CB.

Mar Pollut Bull. 2018 Jun;131(Pt A):589-601. doi: 10.1016/j.marpolbul.2018.04.034. Epub 2018 May 3.


Maternal and cord blood manganese (Mn) levels and birth weight: The MIREC birth cohort study.

Ashley-Martin J, Dodds L, Arbuckle TE, Ettinger AS, Shapiro GD, Fisher M, Monnier P, Morisset AS, Fraser WD, Bouchard MF.

Int J Hyg Environ Health. 2018 Jul;221(6):876-882. doi: 10.1016/j.ijheh.2018.05.015. Epub 2018 Jun 7.


Pharmacokinetic Study of Rucaparib in Patients With Advanced Solid Tumors.

Shapiro GI, Kristeleit RS, Burris HA, LoRusso P, Patel MR, Drew Y, Giordano H, Maloney L, Watkins S, Goble S, Jaw-Tsai S, Xiao JJ.

Clin Pharmacol Drug Dev. 2019 Jan;8(1):107-118. doi: 10.1002/cpdd.575. Epub 2018 May 25.


Phase I study of the checkpoint kinase 1 inhibitor GDC-0575 in combination with gemcitabine in patients with refractory solid tumors.

Italiano A, Infante JR, Shapiro GI, Moore KN, LoRusso PM, Hamilton E, Cousin S, Toulmonde M, Postel-Vinay S, Tolaney S, Blackwood EM, Mahrus S, Peale FV, Lu X, Moein A, Epler J, DuPree K, Tagen M, Murray ER, Schutzman JL, Lauchle JO, Hollebecque A, Soria JC.

Ann Oncol. 2018 May 1;29(5):1304-1311. doi: 10.1093/annonc/mdy076.


Ultrasound-Mediated Gene Delivery Enhances Tendon Allograft Integration in Mini-Pig Ligament Reconstruction.

Bez M, Kremen TJ, Tawackoli W, Avalos P, Sheyn D, Shapiro G, Giaconi JC, Ben David S, Snedeker JG, Gazit Z, Ferrara KW, Gazit D, Pelled G.

Mol Ther. 2018 Jul 5;26(7):1746-1755. doi: 10.1016/j.ymthe.2018.04.020. Epub 2018 Apr 26.


The Associations of Gender With Social Participation of Burn Survivors: A Life Impact Burn Recovery Evaluation Profile Study.

Levi B, Kraft CT, Shapiro GD, Trinh NT, Dore EC, Jeng J, Lee AF, Acton A, Marino M, Jette A, Armstrong EA, Schneider JC, Kazis LE, Ryan CM.

J Burn Care Res. 2018 Oct 23;39(6):915-922. doi: 10.1093/jbcr/iry007.


Serum Obestatin: A Biomarker of Cardiovascular and All-Cause Mortality in Hemodialysis Patients.

Beberashvili I, Katkov A, Sinuani I, Azar A, Shapiro G, Feldman L, Gorelik O, Stav K, Efrati S.

Am J Nephrol. 2018;47(4):254-265. doi: 10.1159/000488285. Epub 2018 Apr 25.


Fatal Wounding Pattern and Causes of Potentially Preventable Death Following the Pulse Night Club Shooting Event.

Smith ER, Shapiro G, Sarani B.

Prehosp Emerg Care. 2018 Nov-Dec;22(6):662-668. doi: 10.1080/10903127.2018.1459980. Epub 2018 Apr 25.


RAS-MAPK Reactivation Facilitates Acquired Resistance in FGFR1-Amplified Lung Cancer and Underlies a Rationale for Upfront FGFR-MEK Blockade.

Bockorny B, Rusan M, Chen W, Liao RG, Li Y, Piccioni F, Wang J, Tan L, Thorner AR, Li T, Zhang Y, Miao C, Ovesen T, Shapiro GI, Kwiatkowski DJ, Gray NS, Meyerson M, Hammerman PS, Bass AJ.

Mol Cancer Ther. 2018 Jul;17(7):1526-1539. doi: 10.1158/1535-7163.MCT-17-0464. Epub 2018 Apr 13.


Phase I Trial of a Tablet Formulation of Pilaralisib, a Pan-Class I PI3K Inhibitor, in Patients with Advanced Solid Tumors.

Edelman G, Rodon J, Lager J, Castell C, Jiang J, Van Allen EM, Wagle N, Lindeman NI, Sholl LM, Shapiro GI.

Oncologist. 2018 Apr;23(4):401-e38. doi: 10.1634/theoncologist.2017-0691. Epub 2018 Mar 28.


Proceedings from the 2017 Mid-Year Meeting of the Committee for Tactical Emergency Casualty Care (C-TECC) and Committee Updates.

Hartford B, Shapiro G, Marino MJ, Smith R, Tang N.

J Spec Oper Med. 2018 Spring;18(1):160-161. No abstract available.


A First-in-Human Phase I Study of OPB-111077, a Small-Molecule STAT3 and Oxidative Phosphorylation Inhibitor, in Patients with Advanced Cancers.

Tolcher A, Flaherty K, Shapiro GI, Berlin J, Witzig T, Habermann T, Bullock A, Rock E, Elekes A, Lin C, Kostic D, Ohi N, Rasco D, Papadopoulos KP, Patnaik A, Smith L, Cote GM.

Oncologist. 2018 Jun;23(6):658-e72. doi: 10.1634/theoncologist.2017-0325. Epub 2018 Mar 6.


Cabozantinib in Patients with Advanced Merkel Cell Carcinoma.

Rabinowits G, Lezcano C, Catalano PJ, McHugh P, Becker H, Reilly MM, Huang J, Tyagi A, Thakuria M, Bresler SC, Sholl LM, Shapiro GI, Haddad R, DeCaprio JA.

Oncologist. 2018 Jul;23(7):814-821. doi: 10.1634/theoncologist.2017-0552. Epub 2018 Feb 14.

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