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Olaparib and α-specific PI3K inhibitor alpelisib for patients with epithelial ovarian cancer: a dose-escalation and dose-expansion phase 1b trial.

Konstantinopoulos PA, Barry WT, Birrer M, Westin SN, Cadoo KA, Shapiro GI, Mayer EL, O'Cearbhaill RE, Coleman RL, Kochupurakkal B, Whalen C, Curtis J, Farooq S, Luo W, Eismann J, Buss MK, Aghajanian C, Mills GB, Palakurthi S, Kirschmeier P, Liu J, Cantley LC, Kaufmann SH, Swisher EM, D'Andrea AD, Winer E, Wulf GM, Matulonis UA.

Lancet Oncol. 2019 Mar 14. pii: S1470-2045(18)30905-7. doi: 10.1016/S1470-2045(18)30905-7. [Epub ahead of print]


Burn survivors injured as children exhibit resilience in long-term community integration outcomes: A life impact burn recovery evaluation (LIBRE) study.

Cartwright S, Saret C, Shapiro GD, Ni P, Sheridan RL, Lee AF, Marino M, Acton A, Kazis LE, Schneider JC, Ryan CM.

Burns. 2019 Mar 5. pii: S0305-4179(18)30483-2. doi: 10.1016/j.burns.2019.02.008. [Epub ahead of print]


MicroRNA-Mediated Suppression of the TGF-β Pathway Confers Transmissible and Reversible CDK4/6 Inhibitor Resistance.

Cornell L, Wander SA, Visal T, Wagle N, Shapiro GI.

Cell Rep. 2019 Mar 5;26(10):2667-2680.e7. doi: 10.1016/j.celrep.2019.02.023.


Nonviral ultrasound-mediated gene delivery in small and large animal models.

Bez M, Foiret J, Shapiro G, Pelled G, Ferrara KW, Gazit D.

Nat Protoc. 2019 Feb 25. doi: 10.1038/s41596-019-0125-y. [Epub ahead of print]


Author Correction: HER kinase inhibition in patients with HER2- and HER3-mutant cancers.

Hyman DM, Piha-Paul SA, Won H, Rodon J, Saura C, Shapiro GI, Juric D, Quinn DI, Moreno V, Doger B, Mayer IA, Boni V, Calvo E, Loi S, Lockhart AC, Erinjeri JP, Scaltriti M, Ulaner GA, Patel J, Tang J, Beer H, Selcuklu SD, Hanrahan AJ, Bouvier N, Melcer M, Murali R, Schram AM, Smyth LM, Jhaveri K, Li BT, Drilon A, Harding JJ, Iyer G, Taylor BS, Berger MF, Cutler RE Jr, Xu F, Butturini A, Eli LD, Mann G, Farrell C, Lalani AS, Bryce RP, Arteaga CL, Meric-Bernstam F, Baselga J, Solit DB.

Nature. 2019 Feb;566(7745):E11-E12. doi: 10.1038/s41586-019-0974-0.


Using the precaution adoption process model to clarify human papillomavirus vaccine hesitancy in canadian parents of girls and parents of boys.

Tatar O, Shapiro GK, Perez S, Wade K, Rosberger Z.

Hum Vaccin Immunother. 2019 Feb 8. doi: 10.1080/21645515.2019.1575711. [Epub ahead of print]


Wounding Patterns Based on Firearm Type in Civilian Public Mass Shootings in the United States.

Sarani B, Hendrix C, Matecki M, Estroff J, Amdur RL, Robinson BRH, Shapiro G, Gondek S, Mitchell R, Smith ER.

J Am Coll Surg. 2019 Mar;228(3):228-234. doi: 10.1016/j.jamcollsurg.2018.11.014. Epub 2018 Dec 7.


Health Status in Adults With Chronic Conditions: Intervention Strategies for Improving Patient-Reported Outcomes.

Selim AJ, Qian SX, Rogers W, Arya D, Simmons K, Shapiro GD, Sonis LA, Kazis LE.

J Ambul Care Manage. 2019 Jan/Mar;42(1):2-20. doi: 10.1097/JAC.0000000000000262.


Molecular pain markers correlate with pH-sensitive MRI signal in a pig model of disc degeneration.

Bez M, Zhou Z, Sheyn D, Tawackoli W, Giaconi JC, Shapiro G, Ben David S, Gazit Z, Pelled G, Li D, Gazit D.

Sci Rep. 2018 Nov 26;8(1):17363. doi: 10.1038/s41598-018-34582-6.


Targeting MYC dependency in ovarian cancer through inhibition of CDK7 and CDK12/13.

Zeng M, Kwiatkowski NP, Zhang T, Nabet B, Xu M, Liang Y, Quan C, Wang J, Hao M, Palakurthi S, Zhou S, Zeng Q, Kirschmeier PT, Meghani K, Leggett AL, Qi J, Shapiro GI, Liu JF, Matulonis UA, Lin CY, Konstantinopoulos PA, Gray NS.

Elife. 2018 Nov 13;7. pii: e39030. doi: 10.7554/eLife.39030.


Association between maternal urinary speciated arsenic concentrations and gestational diabetes in a cohort of Canadian women.

Ashley-Martin J, Dodds L, Arbuckle TE, Bouchard MF, Shapiro GD, Fisher M, Monnier P, Morisset AS, Ettinger AS.

Environ Int. 2018 Dec;121(Pt 1):714-720. doi: 10.1016/j.envint.2018.10.008. Epub 2018 Oct 12.


Using an integrated conceptual framework to investigate parents' HPV vaccine decision for their daughters and sons.

Shapiro GK, Tatar O, Amsel R, Prue G, Zimet GD, Knauper B, Rosberger Z.

Prev Med. 2018 Nov;116:203-210. doi: 10.1016/j.ypmed.2018.09.017. Epub 2018 Sep 26.


Adverse birth outcomes and infant mortality according to registered First Nations status and First Nations community residence across Canada.

Shapiro GD, Sheppard AJ, Bushnik T, Kramer MS, Mashford-Pringle A, Kaufman JS, Yang S.

Can J Public Health. 2018 Dec;109(5-6):692-699. doi: 10.17269/s41997-018-0134-6. Epub 2018 Sep 21.


Prediction of DNA Repair Inhibitor Response in Short-Term Patient-Derived Ovarian Cancer Organoids.

Hill SJ, Decker B, Roberts EA, Horowitz NS, Muto MG, Worley MJ Jr, Feltmate CM, Nucci MR, Swisher EM, Nguyen H, Yang C, Morizane R, Kochupurakkal BS, Do KT, Konstantinopoulos PA, Liu JF, Bonventre JV, Matulonis UA, Shapiro GI, Berkowitz RS, Crum CP, D'Andrea AD.

Cancer Discov. 2018 Nov;8(11):1404-1421. doi: 10.1158/2159-8290.CD-18-0474. Epub 2018 Sep 13.


Factors associated with human papillomavirus (HPV) test acceptability in primary screening for cervical cancer: A mixed methods research synthesis.

Tatar O, Thompson E, Naz A, Perez S, Shapiro GK, Wade K, Zimet G, Gilca V, Janda M, Kahn J, Daley E, Rosberger Z.

Prev Med. 2018 Nov;116:40-50. doi: 10.1016/j.ypmed.2018.08.034. Epub 2018 Aug 31. Review.


Palbociclib resistance confers dependence on an FGFR-MAP kinase-mTOR-driven pathway in KRAS-mutant non-small cell lung cancer.

Haines E, Chen T, Kommajosyula N, Chen Z, Herter-Sprie GS, Cornell L, Wong KK, Shapiro GI.

Oncotarget. 2018 Aug 3;9(60):31572-31589. doi: 10.18632/oncotarget.25803. eCollection 2018 Aug 3.


Social Interactions and Social Activities After Burn Injury: A Life Impact Burn Recovery Evaluation (LIBRE) Study.

Ohrtman EA, Shapiro GD, Simko LC, Dore E, Slavin MD, Saret C, Amaya F, Lomelin-Gascon J, Ni P, Acton A, Marino M, Kazis LE, Ryan CM, Schneider JC.

J Burn Care Res. 2018 Oct 23;39(6):1022-1028. doi: 10.1093/jbcr/iry038.


The Predictive Value of Head Circumference Growth during the First Year of Life on Early Child Traits.

Dupont C, Castellanos-Ryan N, Séguin JR, Muckle G, Simard MN, Shapiro GD, Herba CM, Fraser WD, Lippé S.

Sci Rep. 2018 Jun 29;8(1):9828. doi: 10.1038/s41598-018-28165-8.


Adverse birth outcomes in relation to maternal marital and cohabitation status in Canada.

Shapiro GD, Bushnik T, Wilkins R, Kramer MS, Kaufman JS, Sheppard AJ, Yang S.

Ann Epidemiol. 2018 Aug;28(8):503-509.e11. doi: 10.1016/j.annepidem.2018.05.001. Epub 2018 May 22.


The Development and Validity of the Adult Burn Outcome Questionnaire Short Form.

Chen L, Lee AF, Shapiro GD, Goverman J, Faoro N, Schneider JC, Kazis LE, Ryan CM.

J Burn Care Res. 2018 Aug 17;39(5):771-779. doi: 10.1093/jbcr/irx043.


Recent Advances and Future of Gene Therapy for Bone Regeneration.

Shapiro G, Lieber R, Gazit D, Pelled G.

Curr Osteoporos Rep. 2018 Aug;16(4):504-511. doi: 10.1007/s11914-018-0459-3. Review.


Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine.

Aguirre AJ, Nowak JA, Camarda ND, Moffitt RA, Ghazani AA, Hazar-Rethinam M, Raghavan S, Kim J, Brais LK, Ragon D, Welch MW, Reilly E, McCabe D, Marini L, Anderka K, Helvie K, Oliver N, Babic A, Da Silva A, Nadres B, Van Seventer EE, Shahzade HA, St Pierre JP, Burke KP, Clancy T, Cleary JM, Doyle LA, Jajoo K, McCleary NJ, Meyerhardt JA, Murphy JE, Ng K, Patel AK, Perez K, Rosenthal MH, Rubinson DA, Ryou M, Shapiro GI, Sicinska E, Silverman SG, Nagy RJ, Lanman RB, Knoerzer D, Welsch DJ, Yurgelun MB, Fuchs CS, Garraway LA, Getz G, Hornick JL, Johnson BE, Kulke MH, Mayer RJ, Miller JW, Shyn PB, Tuveson DA, Wagle N, Yeh JJ, Hahn WC, Corcoran RB, Carter SL, Wolpin BM.

Cancer Discov. 2018 Sep;8(9):1096-1111. doi: 10.1158/2159-8290.CD-18-0275. Epub 2018 Jun 14.


The Effect of Facial Burns on Long-Term Outcomes in Young Adults: A 5-Year Study.

Ryan CM, Lee A, Stoddard FJ Jr, Li NC, Schneider JC, Shapiro GD, Griggs CL, Wang C, Palmieri T, Meyer WJ 3rd, Pidcock FS, Reilly D, Sheridan RL, Kazis LE, Tompkins RG; Multi-Center Benchmarking Study Group.

J Burn Care Res. 2018 Jun 13;39(4):497-506. doi: 10.1093/jbcr/irx006.


An adaptive grid to improve the efficiency and accuracy of modelling underwater noise from shipping.

Trigg LE, Chen F, Shapiro GI, Ingram SN, Embling CB.

Mar Pollut Bull. 2018 Jun;131(Pt A):589-601. doi: 10.1016/j.marpolbul.2018.04.034. Epub 2018 May 3.


Maternal and cord blood manganese (Mn) levels and birth weight: The MIREC birth cohort study.

Ashley-Martin J, Dodds L, Arbuckle TE, Ettinger AS, Shapiro GD, Fisher M, Monnier P, Morisset AS, Fraser WD, Bouchard MF.

Int J Hyg Environ Health. 2018 Jul;221(6):876-882. doi: 10.1016/j.ijheh.2018.05.015. Epub 2018 Jun 7.


Pharmacokinetic Study of Rucaparib in Patients With Advanced Solid Tumors.

Shapiro GI, Kristeleit RS, Burris HA, LoRusso P, Patel MR, Drew Y, Giordano H, Maloney L, Watkins S, Goble S, Jaw-Tsai S, Xiao JJ.

Clin Pharmacol Drug Dev. 2019 Jan;8(1):107-118. doi: 10.1002/cpdd.575. Epub 2018 May 25.


Phase I study of the checkpoint kinase 1 inhibitor GDC-0575 in combination with gemcitabine in patients with refractory solid tumors.

Italiano A, Infante JR, Shapiro GI, Moore KN, LoRusso PM, Hamilton E, Cousin S, Toulmonde M, Postel-Vinay S, Tolaney S, Blackwood EM, Mahrus S, Peale FV, Lu X, Moein A, Epler J, DuPree K, Tagen M, Murray ER, Schutzman JL, Lauchle JO, Hollebecque A, Soria JC.

Ann Oncol. 2018 Feb 23. doi: 10.1093/annonc/mdy076. [Epub ahead of print]


Ultrasound-Mediated Gene Delivery Enhances Tendon Allograft Integration in Mini-Pig Ligament Reconstruction.

Bez M, Kremen TJ, Tawackoli W, Avalos P, Sheyn D, Shapiro G, Giaconi JC, Ben David S, Snedeker JG, Gazit Z, Ferrara KW, Gazit D, Pelled G.

Mol Ther. 2018 Jul 5;26(7):1746-1755. doi: 10.1016/j.ymthe.2018.04.020. Epub 2018 Apr 26.


The Associations of Gender With Social Participation of Burn Survivors: A Life Impact Burn Recovery Evaluation Profile Study.

Levi B, Kraft CT, Shapiro GD, Trinh NT, Dore EC, Jeng J, Lee AF, Acton A, Marino M, Jette A, Armstrong EA, Schneider JC, Kazis LE, Ryan CM.

J Burn Care Res. 2018 Oct 23;39(6):915-922. doi: 10.1093/jbcr/iry007.


Serum Obestatin: A Biomarker of Cardiovascular and All-Cause Mortality in Hemodialysis Patients.

Beberashvili I, Katkov A, Sinuani I, Azar A, Shapiro G, Feldman L, Gorelik O, Stav K, Efrati S.

Am J Nephrol. 2018;47(4):254-265. doi: 10.1159/000488285. Epub 2018 Apr 25.


Fatal Wounding Pattern and Causes of Potentially Preventable Death Following the Pulse Night Club Shooting Event.

Smith ER, Shapiro G, Sarani B.

Prehosp Emerg Care. 2018 Nov-Dec;22(6):662-668. doi: 10.1080/10903127.2018.1459980. Epub 2018 Apr 25.


RAS-MAPK Reactivation Facilitates Acquired Resistance in FGFR1-Amplified Lung Cancer and Underlies a Rationale for Upfront FGFR-MEK Blockade.

Bockorny B, Rusan M, Chen W, Liao RG, Li Y, Piccioni F, Wang J, Tan L, Thorner AR, Li T, Zhang Y, Miao C, Ovesen T, Shapiro GI, Kwiatkowski DJ, Gray NS, Meyerson M, Hammerman PS, Bass AJ.

Mol Cancer Ther. 2018 Jul;17(7):1526-1539. doi: 10.1158/1535-7163.MCT-17-0464. Epub 2018 Apr 13.


Phase I Trial of a Tablet Formulation of Pilaralisib, a Pan-Class I PI3K Inhibitor, in Patients with Advanced Solid Tumors.

Edelman G, Rodon J, Lager J, Castell C, Jiang J, Van Allen EM, Wagle N, Lindeman NI, Sholl LM, Shapiro GI.

Oncologist. 2018 Apr;23(4):401-e38. doi: 10.1634/theoncologist.2017-0691. Epub 2018 Mar 28.


Proceedings from the 2017 Mid-Year Meeting of the Committee for Tactical Emergency Casualty Care (C-TECC) and Committee Updates.

Hartford B, Shapiro G, Marino MJ, Smith R, Tang N.

J Spec Oper Med. 2018 Spring;18(1):160-161. No abstract available.


A First-in-Human Phase I Study of OPB-111077, a Small-Molecule STAT3 and Oxidative Phosphorylation Inhibitor, in Patients with Advanced Cancers.

Tolcher A, Flaherty K, Shapiro GI, Berlin J, Witzig T, Habermann T, Bullock A, Rock E, Elekes A, Lin C, Kostic D, Ohi N, Rasco D, Papadopoulos KP, Patnaik A, Smith L, Cote GM.

Oncologist. 2018 Jun;23(6):658-e72. doi: 10.1634/theoncologist.2017-0325. Epub 2018 Mar 6.


Cabozantinib in Patients with Advanced Merkel Cell Carcinoma.

Rabinowits G, Lezcano C, Catalano PJ, McHugh P, Becker H, Reilly MM, Huang J, Tyagi A, Thakuria M, Bresler SC, Sholl LM, Shapiro GI, Haddad R, DeCaprio JA.

Oncologist. 2018 Jul;23(7):814-821. doi: 10.1634/theoncologist.2017-0552. Epub 2018 Feb 14.


HER kinase inhibition in patients with HER2- and HER3-mutant cancers.

Hyman DM, Piha-Paul SA, Won H, Rodon J, Saura C, Shapiro GI, Juric D, Quinn DI, Moreno V, Doger B, Mayer IA, Boni V, Calvo E, Loi S, Lockhart AC, Erinjeri JP, Scaltriti M, Ulaner GA, Patel J, Tang J, Beer H, Selcuklu SD, Hanrahan AJ, Bouvier N, Melcer M, Murali R, Schram AM, Smyth LM, Jhaveri K, Li BT, Drilon A, Harding JJ, Iyer G, Taylor BS, Berger MF, Cutler RE Jr, Xu F, Butturini A, Eli LD, Mann G, Farrell C, Lalani AS, Bryce RP, Arteaga CL, Meric-Bernstam F, Baselga J, Solit DB.

Nature. 2018 Feb 8;554(7691):189-194. doi: 10.1038/nature25475. Epub 2018 Jan 31. Erratum in: Nature. 2019 Feb;566(7745):E11-E12.


Age modifies the association between serum obestatin, appetite and nutritional status in maintenance hemodialysis patients.

Katkov A, Sinuani I, Azar A, Shapiro G, Efrati S, Beberashvili I.

Eur J Clin Nutr. 2018 Jul;72(7):1007-1018. doi: 10.1038/s41430-018-0087-0. Epub 2018 Jan 23.


Knowledge and Attitudes of General Practitioners and Sexual Health Care Professionals Regarding Human Papillomavirus Vaccination for Young Men Who Have Sex with Men.

Merriel SWD, Flannagan C, Kesten JM, Shapiro GK, Nadarzynski T, Prue G.

Int J Environ Res Public Health. 2018 Jan 18;15(1). pii: E151. doi: 10.3390/ijerph15010151.


The vaccine hesitancy scale: Psychometric properties and validation.

Shapiro GK, Tatar O, Dube E, Amsel R, Knauper B, Naz A, Perez S, Rosberger Z.

Vaccine. 2018 Jan 29;36(5):660-667. doi: 10.1016/j.vaccine.2017.12.043. Epub 2017 Dec 27.


Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma.

Drew AE, Moradei O, Jacques SL, Rioux N, Boriack-Sjodin AP, Allain C, Scott MP, Jin L, Raimondi A, Handler JL, Ott HM, Kruger RG, McCabe MT, Sneeringer C, Riera T, Shapiro G, Waters NJ, Mitchell LH, Duncan KW, Moyer MP, Copeland RA, Smith J, Chesworth R, Ribich SA.

Sci Rep. 2017 Dec 21;7(1):17993. doi: 10.1038/s41598-017-18446-z.


Ketamine in the Prehospital Environment: A National Survey of Paramedics in the United States.

Buckland DM, Crowe RP, Cash RE, Gondek S, Maluso P, Sirajuddin S, Smith ER, Dangerfield P, Shapiro G, Wanka C, Panchal AR, Sarani B.

Prehosp Disaster Med. 2018 Feb;33(1):23-28. doi: 10.1017/S1049023X17007142. Epub 2017 Dec 21.


First-in-Class ERK1/2 Inhibitor Ulixertinib (BVD-523) in Patients with MAPK Mutant Advanced Solid Tumors: Results of a Phase I Dose-Escalation and Expansion Study.

Sullivan RJ, Infante JR, Janku F, Wong DJL, Sosman JA, Keedy V, Patel MR, Shapiro GI, Mier JW, Tolcher AW, Wang-Gillam A, Sznol M, Flaherty K, Buchbinder E, Carvajal RD, Varghese AM, Lacouture ME, Ribas A, Patel SP, DeCrescenzo GA, Emery CM, Groover AL, Saha S, Varterasian M, Welsch DJ, Hyman DM, Li BT.

Cancer Discov. 2018 Feb;8(2):184-195. doi: 10.1158/2159-8290.CD-17-1119. Epub 2017 Dec 15.


Associations between maternal triclosan concentrations in early pregnancy and gestational diabetes mellitus, impaired glucose tolerance, gestational weight gain and fetal markers of metabolic function.

Shapiro GD, Arbuckle TE, Ashley-Martin J, Fraser WD, Fisher M, Bouchard MF, Monnier P, Morisset AS, Ettinger AS, Dodds L.

Environ Res. 2018 Feb;161:554-561. doi: 10.1016/j.envres.2017.12.001.


Genomic Biomarkers Predicting Response to Selective CDK4/6 Inhibition: Progress in an Elusive Search.

Shapiro GI.

Cancer Cell. 2017 Dec 11;32(6):721-723. doi: 10.1016/j.ccell.2017.11.013.


Correlates of Tinder Use and Risky Sexual Behaviors in Young Adults.

Shapiro GK, Tatar O, Sutton A, Fisher W, Naz A, Perez S, Rosberger Z.

Cyberpsychol Behav Soc Netw. 2017 Dec;20(12):727-734. doi: 10.1089/cyber.2017.0279. Epub 2017 Dec 6.


Sensitizing HR-proficient cancers to PARP inhibitors.

Lim E, Johnson SF, Geyer M, Serra V, Shapiro GI.

Mol Cell Oncol. 2017 Mar 3;4(6):e1299272. doi: 10.1080/23723556.2017.1299272. eCollection 2017. No abstract available.


Parents' involvement in the human papillomavirus vaccination decision for their sons.

Perez S, Restle H, Naz A, Tatar O, Shapiro GK, Rosberger Z.

Sex Reprod Healthc. 2017 Dec;14:33-39. doi: 10.1016/j.srhc.2017.08.005. Epub 2017 Aug 24.


Impact of Work-Related Burn Injury on Social Reintegration Outcomes: A Life Impact Burn Recovery Evaluation (LIBRE) Study.

Schneider JC, Shie VL, Espinoza LF, Shapiro GD, Lee A, Acton A, Marino M, Jette A, Kazis LE, Ryan CM; LIBRE Advisory Board.

Arch Phys Med Rehabil. 2017 Nov 26. pii: S0003-9993(17)31383-7. doi: 10.1016/j.apmr.2017.10.022. [Epub ahead of print]


Psychosocial correlates of HPV vaccine acceptability in college males: A cross-sectional exploratory study.

Tatar O, Perez S, Naz A, Shapiro GK, Rosberger Z.

Papillomavirus Res. 2017 Dec;4:99-107. doi: 10.1016/j.pvr.2017.11.001. Epub 2017 Nov 8.

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