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Items: 1 to 50 of 81

1.

THE EFFECT OF INDIVIDUALIZED FEEDBACK ON LEARNING CURVES IN EGD AND COLONOSCOPY: A CLUSTER RANDOMIZED CONTROLLED TRIAL.

Han S, Obuch JC, Keswani RN, Hall M, Patel SG, Menard-Katcher P, Simon V, Ezekwe E, Aagaard E, Ahmad A, Alghamdi S, Austin K, Brimhall B, Broy C, Carlin L, Cooley M, Di Palma JA, Duloy AM, Early DS, Ellert S, Gaumnitz EA, Goyal J, Kathpalia P, Day L, El-Nachef N, Kerman D, Lee RH, Lunsford T, Mittal M, Morigeau K, Pietrak S, Piper M, Shah AS, Shapiro AB, Shergill A, Sonnier W, Sorrell C, Vignesh S, Wani S.

Gastrointest Endosc. 2019 Nov 9. pii: S0016-5107(19)32401-0. doi: 10.1016/j.gie.2019.10.032. [Epub ahead of print]

PMID:
31715173
2.

5-Carboxytetramethylrhodamine-Ampicillin Fluorescence Anisotropy-Based Assay of Escherichia coli Penicillin-Binding Protein 2 Transpeptidase Inhibition.

Shapiro AB, Comita-Prevoir J, Sylvester M.

ACS Infect Dis. 2019 Jun 14;5(6):863-872. doi: 10.1021/acsinfecdis.8b00351. Epub 2019 Mar 19.

PMID:
30848883
3.

Frequency and Mechanism of Spontaneous Resistance to Sulbactam Combined with the Novel β-Lactamase Inhibitor ETX2514 in Clinical Isolates of Acinetobacter baumannii.

McLeod SM, Shapiro AB, Moussa SH, Johnstone M, McLaughlin RE, de Jonge BLM, Miller AA.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e01576-17. doi: 10.1128/AAC.01576-17. Print 2018 Feb.

4.

Kinetics of Sulbactam Hydrolysis by β-Lactamases, and Kinetics of β-Lactamase Inhibition by Sulbactam.

Shapiro AB.

Antimicrob Agents Chemother. 2017 Nov 22;61(12). pii: e01612-17. doi: 10.1128/AAC.01612-17. Print 2017 Dec.

5.

Reversibility of Covalent, Broad-Spectrum Serine β-Lactamase Inhibition by the Diazabicyclooctenone ETX2514.

Shapiro AB, Gao N, Jahić H, Carter NM, Chen A, Miller AA.

ACS Infect Dis. 2017 Nov 10;3(11):833-844. doi: 10.1021/acsinfecdis.7b00113. Epub 2017 Aug 28.

PMID:
28835096
6.

ETX2514 is a broad-spectrum β-lactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii.

Durand-Réville TF, Guler S, Comita-Prevoir J, Chen B, Bifulco N, Huynh H, Lahiri S, Shapiro AB, McLeod SM, Carter NM, Moussa SH, Velez-Vega C, Olivier NB, McLaughlin R, Gao N, Thresher J, Palmer T, Andrews B, Giacobbe RA, Newman JV, Ehmann DE, de Jonge B, O'Donnell J, Mueller JP, Tommasi RA, Miller AA.

Nat Microbiol. 2017 Jun 30;2:17104. doi: 10.1038/nmicrobiol.2017.104.

PMID:
28665414
7.

Antibacterial FabH Inhibitors with Mode of Action Validated in Haemophilus influenzae by in Vitro Resistance Mutation Mapping.

McKinney DC, Eyermann CJ, Gu RF, Hu J, Kazmirski SL, Lahiri SD, McKenzie AR, Shapiro AB, Breault G.

ACS Infect Dis. 2016 Jul 8;2(7):456-64. doi: 10.1021/acsinfecdis.6b00053. Epub 2016 May 9.

PMID:
27626097
8.

Ultrasound-guided airway blocks using a curvilinear probe.

Krause M, Khatibi B, Sztain JF, Rahman P, Shapiro AB, Sandhu NS.

J Clin Anesth. 2016 Sep;33:408-12. doi: 10.1016/j.jclinane.2016.04.058. Epub 2016 Jun 3.

PMID:
27555201
9.

Investigation of β-lactam antibacterial drugs, β-lactamases, and penicillin-binding proteins with fluorescence polarization and anisotropy: a review.

Shapiro AB.

Methods Appl Fluoresc. 2016 Apr 12;4(2):024002. doi: 10.1088/2050-6120/4/2/024002. Review.

PMID:
28809167
10.

Nuclear Targeting with an Auger Electron Emitter Potentiates the Action of a Widely Used Antineoplastic Drug.

Imstepf S, Pierroz V, Raposinho P, Bauwens M, Felber M, Fox T, Shapiro AB, Freudenberg R, Fernandes C, Gama S, Gasser G, Motthagy F, Santos IR, Alberto R.

Bioconjug Chem. 2015 Dec 16;26(12):2397-407. doi: 10.1021/acs.bioconjchem.5b00466. Epub 2015 Oct 29.

PMID:
26473388
11.

Inhibition of Neisseria gonorrhoeae Type II Topoisomerases by the Novel Spiropyrimidinetrione AZD0914.

Kern G, Palmer T, Ehmann DE, Shapiro AB, Andrews B, Basarab GS, Doig P, Fan J, Gao N, Mills SD, Mueller J, Sriram S, Thresher J, Walkup GK.

J Biol Chem. 2015 Aug 21;290(34):20984-94. doi: 10.1074/jbc.M115.663534. Epub 2015 Jul 6.

12.

Novel broad-spectrum inhibitors of bacterial methionine aminopeptidase.

Rose JA, Lahiri SD, McKinney DC, Albert R, Morningstar ML, Shapiro AB, Fisher SL, Fleming PR.

Bioorg Med Chem Lett. 2015 Aug 15;25(16):3301-6. doi: 10.1016/j.bmcl.2015.05.061. Epub 2015 May 30.

PMID:
26099541
13.

Discovery of efficacious Pseudomonas aeruginosa-targeted siderophore-conjugated monocarbams by application of a semi-mechanistic pharmacokinetic/pharmacodynamic model.

Murphy-Benenato KE, Bhagunde PR, Chen A, Davis HE, Durand-Réville TF, Ehmann DE, Galullo V, Harris JJ, Hatoum-Mokdad H, Jahić H, Kim A, Manjunatha MR, Manyak EL, Mueller J, Patey S, Quiroga O, Rooney M, Sha L, Shapiro AB, Sylvester M, Tan B, Tsai AS, Uria-Nickelsen M, Wu Y, Zambrowski M, Zhao SX.

J Med Chem. 2015 Mar 12;58(5):2195-205. doi: 10.1021/jm501506f. Epub 2015 Mar 3.

PMID:
25658376
14.

Molecular mechanisms of sulbactam antibacterial activity and resistance determinants in Acinetobacter baumannii.

Penwell WF, Shapiro AB, Giacobbe RA, Gu RF, Gao N, Thresher J, McLaughlin RE, Huband MD, DeJonge BL, Ehmann DE, Miller AA.

Antimicrob Agents Chemother. 2015 Mar;59(3):1680-9. doi: 10.1128/AAC.04808-14. Epub 2015 Jan 5.

15.

Quantitative investigation of the affinity of human respiratory syncytial virus phosphoprotein C-terminus binding to nucleocapsid protein.

Shapiro AB, Gao N, O'Connell N, Hu J, Thresher J, Gu RF, Overman R, Hardern IM, Sproat GG.

Virol J. 2014 Nov 19;11:191. doi: 10.1186/s12985-014-0191-2.

16.

Target-based resistance in Pseudomonas aeruginosa and Escherichia coli to NBTI 5463, a novel bacterial type II topoisomerase inhibitor.

Nayar AS, Dougherty TJ, Reck F, Thresher J, Gao N, Shapiro AB, Ehmann DE.

Antimicrob Agents Chemother. 2015 Jan;59(1):331-7. doi: 10.1128/AAC.04077-14. Epub 2014 Oct 27.

17.

Dimerization of isolated Pseudomonas aeruginosa lipopolysaccharide transporter component LptA.

Shapiro AB, Gu RF, Gao N.

Biochem Biophys Res Commun. 2014 Aug 8;450(4):1327-32. doi: 10.1016/j.bbrc.2014.06.138. Epub 2014 Jul 5.

PMID:
25003324
18.

Fluorescence anisotropy-based measurement of Pseudomonas aeruginosa penicillin-binding protein 2 transpeptidase inhibitor acylation rate constants.

Shapiro AB, Gao N, Gu RF, Thresher J.

Anal Biochem. 2014 Oct 15;463:15-22. doi: 10.1016/j.ab.2014.06.004. Epub 2014 Jun 16.

PMID:
24945954
19.

The role of a novel auxiliary pocket in bacterial phenylalanyl-tRNA synthetase druggability.

Abibi A, Ferguson AD, Fleming PR, Gao N, Hajec LI, Hu J, Laganas VA, McKinney DC, McLeod SM, Prince DB, Shapiro AB, Buurman ET.

J Biol Chem. 2014 Aug 1;289(31):21651-62. doi: 10.1074/jbc.M114.574061. Epub 2014 Jun 16.

21.

Discovery of ATP-Competitive Inhibitors of tRNAIle Lysidine Synthetase (TilS) by High-Throughput Screening.

Shapiro AB, Plant H, Walsh J, Sylvester M, Hu J, Gao N, Livchak S, Tentarelli S, Thresher J.

J Biomol Screen. 2014 Sep;19(8):1137-46. doi: 10.1177/1087057114534981. Epub 2014 May 12.

PMID:
24820111
22.

NBTI 5463 is a novel bacterial type II topoisomerase inhibitor with activity against gram-negative bacteria and in vivo efficacy.

Dougherty TJ, Nayar A, Newman JV, Hopkins S, Stone GG, Johnstone M, Shapiro AB, Cronin M, Reck F, Ehmann DE.

Antimicrob Agents Chemother. 2014 May;58(5):2657-64. doi: 10.1128/AAC.02778-13. Epub 2014 Feb 24. Erratum in: Antimicrob Agents Chemother. 2014 Jul;58(7):4250.

23.

Gastroesophageal reflux disease: the case for improving patient education in primary care.

Khan N, Bukhari S, Lakha A, Qaz B, Davis N, Shapiro AB, Kavin H.

J Fam Pract. 2013 Dec;62(12):719-25.

PMID:
24340333
24.

A high-throughput fluorescence anisotropy-based assay for human topoisomerase II β-catalyzed ATP-dependent supercoiled DNA relaxation.

Shapiro AB, Austin CA.

Anal Biochem. 2014 Mar 1;448:23-9. doi: 10.1016/j.ab.2013.11.029. Epub 2013 Dec 3.

25.

Improvement of the pharmacokinetics and in vivo antibacterial efficacy of a novel type IIa topoisomerase inhibitor by formulation in liposomes.

Shapiro AB, Newman J, Goteti K, Beaudoin ME, Harrison R, Hopkins S, Agrawal N, Rivin O.

Antimicrob Agents Chemother. 2013 Oct;57(10):4816-24. doi: 10.1128/AAC.00163-13. Epub 2013 Jul 22.

26.

Continuous fluorescence anisotropy-based assay of BOCILLIN FL penicillin reaction with penicillin binding protein 3.

Shapiro AB, Gu RF, Gao N, Livchak S, Thresher J.

Anal Biochem. 2013 Aug 1;439(1):37-43. doi: 10.1016/j.ab.2013.04.009. Epub 2013 Apr 16.

PMID:
23603065
27.

A high-throughput-compatible, fluorescence anisotropy-based assay for ATP-dependent supercoiled DNA relaxation by human topoisomerase IIα.

Shapiro AB.

Biochem Pharmacol. 2013 May 1;85(9):1269-77. doi: 10.1016/j.bcp.2013.02.006. Epub 2013 Feb 13.

PMID:
23415903
28.

Inhibitors of the acetyltransferase domain of N-acetylglucosamine-1-phosphate-uridylyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU). Part 2: Optimization of physical properties leading to antibacterial aryl sulfonamides.

Stokes SS, Albert R, Buurman ET, Andrews B, Shapiro AB, Green OM, McKenzie AR, Otterbein LR.

Bioorg Med Chem Lett. 2012 Dec 1;22(23):7019-23. doi: 10.1016/j.bmcl.2012.10.003. Epub 2012 Oct 11.

PMID:
23099094
29.

A high-throughput-compatible fluorescence anisotropy-based assay for competitive inhibitors of Escherichia coli UDP-N-acetylglucosamine acyltransferase (LpxA).

Shapiro AB, Ross PL, Gao N, Livchak S, Kern G, Yang W, Andrews B, Thresher J.

J Biomol Screen. 2013 Mar;18(3):341-7. doi: 10.1177/1087057112462062. Epub 2012 Sep 26.

PMID:
23015018
30.

Time-dependent, reversible, oxaborole inhibition of Escherichia coli leucyl-tRNA synthetase measured with a continuous fluorescence assay.

Shapiro AB, Gao N, Hajec L, McKinney DC.

Anal Biochem. 2012 Dec 1;431(1):48-53. doi: 10.1016/j.ab.2012.08.024. Epub 2012 Sep 10.

PMID:
22975201
31.

Novel rapidly diversifiable antimicrobial RNA polymerase switch region inhibitors with confirmed mode of action in Haemophilus influenzae.

Buurman ET, Foulk MA, Gao N, Laganas VA, McKinney DC, Moustakas DT, Rose JA, Shapiro AB, Fleming PR.

J Bacteriol. 2012 Oct;194(20):5504-12. Epub 2012 Jul 27.

32.

Allosteric inhibition of the DNA-dependent ATPase activity of Escherichia coli DNA gyrase by a representative of a novel class of inhibitors.

Shapiro AB, Andrews B.

Biochem Pharmacol. 2012 Oct 1;84(7):900-4. doi: 10.1016/j.bcp.2012.07.007. Epub 2012 Jul 20.

PMID:
22820247
33.

An aminoquinazoline inhibitor of the essential bacterial cell wall synthetic enzyme GlmU has a unique non-protein-kinase-like binding mode.

Larsen NA, Nash TJ, Morningstar M, Shapiro AB, Joubran C, Blackett CJ, Patten AD, Boriack-Sjodin PA, Doig P.

Biochem J. 2012 Sep 15;446(3):405-13. doi: 10.1042/BJ20120596.

PMID:
22721802
34.

A high-throughput, homogeneous, fluorescence resonance energy transfer-based assay for phospho-N-acetylmuramoyl-pentapeptide translocase (MraY).

Shapiro AB, Jahić H, Gao N, Hajec L, Rivin O.

J Biomol Screen. 2012 Jun;17(5):662-72. doi: 10.1177/1087057112436885. Epub 2012 Feb 14.

PMID:
22337656
35.

Inhibitors of acetyltransferase domain of N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU). Part 1: Hit to lead evaluation of a novel arylsulfonamide series.

Green OM, McKenzie AR, Shapiro AB, Otterbein L, Ni H, Patten A, Stokes S, Albert R, Kawatkar S, Breed J.

Bioorg Med Chem Lett. 2012 Feb 15;22(4):1510-9. doi: 10.1016/j.bmcl.2012.01.016. Epub 2012 Jan 14.

PMID:
22297115
36.

A homogeneous, high-throughput-compatible, fluorescence intensity-based assay for UDP-N-acetylenolpyruvylglucosamine reductase (MurB) with nanomolar product detection.

Shapiro AB, Livchak S, Gao N, Whiteaker J, Thresher J, Jahić H, Huang J, Gu RF.

J Biomol Screen. 2012 Mar;17(3):327-38. doi: 10.1177/1087057111425188. Epub 2011 Nov 7.

PMID:
22068704
37.

In vitro validation of acetyltransferase activity of GlmU as an antibacterial target in Haemophilus influenzae.

Buurman ET, Andrews B, Gao N, Hu J, Keating TA, Lahiri S, Otterbein LR, Patten AD, Stokes SS, Shapiro AB.

J Biol Chem. 2011 Nov 25;286(47):40734-42. doi: 10.1074/jbc.M111.274068. Epub 2011 Oct 7.

38.

The white nipple sign: please do not disturb.

Khan NM, Shapiro AB.

Case Rep Gastroenterol. 2011 May;5(2):386-90. doi: 10.1159/000330292. Epub 2011 Jul 9.

39.

High-throughput, homogeneous, fluorescence intensity-based measurement of adenosine diphosphate and other ribonucleoside diphosphates with nanomolar sensitivity.

Shapiro AB, Hajec L, Gao N.

Anal Biochem. 2011 Aug 15;415(2):190-6. doi: 10.1016/j.ab.2011.04.027. Epub 2011 Apr 24.

PMID:
21570943
40.

A high-throughput absorbance-based assay for methionine produced by methionine aminopeptidase using S-adenosyl-L-methionine synthetase.

Shapiro AB, Gao N, Thresher J, Walkup GK, Whiteaker J.

J Biomol Screen. 2011 Jun;16(5):494-505. doi: 10.1177/1087057111398934. Epub 2011 Mar 14.

PMID:
21402755
41.

A high-throughput fluorescence resonance energy transfer-based assay for DNA ligase.

Shapiro AB, Eakin AE, Walkup GK, Rivin O.

J Biomol Screen. 2011 Jun;16(5):486-93. doi: 10.1177/1087057111398295. Epub 2011 Mar 11.

PMID:
21398623
42.

A story to create: stroke survivors' broken narratives.

Shapiro AB.

Top Stroke Rehabil. 2011 Jan-Feb;18(1):18-23. doi: 10.1310/tsr1801-18.

PMID:
21371975
43.

Novel bacterial NAD+-dependent DNA ligase inhibitors with broad-spectrum activity and antibacterial efficacy in vivo.

Mills SD, Eakin AE, Buurman ET, Newman JV, Gao N, Huynh H, Johnson KD, Lahiri S, Shapiro AB, Walkup GK, Yang W, Stokes SS.

Antimicrob Agents Chemother. 2011 Mar;55(3):1088-96. doi: 10.1128/AAC.01181-10. Epub 2010 Dec 28.

44.

[Interaction of fibrinogen with magnetite nanoparticles].

Bychkova AV, Sorokina ON, Kovarskiĭ AL, Shapiro AB, Leonova VB, Rozenfel'd MA.

Biofizika. 2010 Jul-Aug;55(4):605-11. Russian.

PMID:
20968070
45.

Correction for interference by test samples in high-throughput assays.

Shapiro AB, Walkup GK, Keating TA.

J Biomol Screen. 2009 Sep;14(8):1008-16. doi: 10.1177/1087057109341768. Epub 2009 Jul 30.

PMID:
19643982
46.

An integrated approach to fragment-based lead generation: philosophy, strategy and case studies from AstraZeneca's drug discovery programmes.

Albert JS, Blomberg N, Breeze AL, Brown AJ, Burrows JN, Edwards PD, Folmer RH, Geschwindner S, Griffen EJ, Kenny PW, Nowak T, Olsson LL, Sanganee H, Shapiro AB.

Curr Top Med Chem. 2007;7(16):1600-29. Review.

PMID:
17979771
47.

beta-Amyloid efflux mediated by p-glycoprotein.

Lam FC, Liu R, Lu P, Shapiro AB, Renoir JM, Sharom FJ, Reiner PB.

J Neurochem. 2001 Feb;76(4):1121-8.

48.

Ligand-mediated tertiary structure changes of reconstituted P-glycoprotein. A tryptophan fluorescence quenching analysis.

Sonveaux N, Vigano C, Shapiro AB, Ling V, Ruysschaert JM.

J Biol Chem. 1999 Jun 18;274(25):17649-54.

49.
50.

The mechanism of ATP-dependent multidrug transport by P-glycoprotein.

Shapiro AB, Ling V.

Acta Physiol Scand Suppl. 1998 Aug;643:227-34. Review.

PMID:
9789565

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