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Items: 22


Identification of 4-(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2).

Rowbottom MW, Bain G, Calderon I, Lasof T, Lonergan D, Lai A, Huang F, Darlington J, Prodanovich P, Santini AM, King CD, Goulet L, Shannon KE, Ma GL, Nguyen K, MacKenna DA, Evans JF, Hutchinson JH.

J Med Chem. 2017 May 25;60(10):4403-4423. doi: 10.1021/acs.jmedchem.7b00345. Epub 2017 May 15.


Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis.

Bain G, Shannon KE, Huang F, Darlington J, Goulet L, Prodanovich P, Ma GL, Santini AM, Stein AJ, Lonergan D, King CD, Calderon I, Lai A, Hutchinson JH, Evans JF.

J Pharmacol Exp Ther. 2017 Jan;360(1):1-13. Epub 2016 Oct 17.


Neuroanatomical correlates of heterotypic comorbidity in externalizing male adolescents.

Sauder CL, Beauchaine TP, Gatzke-Kopp LM, Shannon KE, Aylward E.

J Clin Child Adolesc Psychol. 2012;41(3):346-52. doi: 10.1080/15374416.2012.658612. Epub 2012 Apr 4.


Effect of nitrate and glucose addition on denitrification and nitric oxide reductase (cnorB) gene abundance and mRNA levels in Pseudomonas mandelii inoculated into anoxic soil.

Shannon KE, Saleh-Lakha S, Burton DL, Zebarth BJ, Goyer C, Trevors JT.

Antonie Van Leeuwenhoek. 2011 Aug;100(2):183-95. doi: 10.1007/s10482-011-9577-y. Epub 2011 Mar 24.


Challenges in quantifying microbial gene expression in soil using quantitative reverse transcription real-time PCR.

Saleh-Lakha S, Shannon KE, Goyer C, Trevors JT.

J Microbiol Methods. 2011 Jun;85(3):239-43. doi: 10.1016/j.mimet.2011.03.007. Epub 2011 Mar 21.


Neurobiological adaptations to violence across development.

Mead HK, Beauchaine TP, Shannon KE.

Dev Psychopathol. 2010 Winter;22(1):1-22. doi: 10.1017/S0954579409990228. Review.


Effect of nitrate and acetylene on nirS, cnorB, and nosZ expression and denitrification activity in Pseudomonas mandelii.

Saleh-Lakha S, Shannon KE, Henderson SL, Zebarth BJ, Burton DL, Goyer C, Trevors JT.

Appl Environ Microbiol. 2009 Aug;75(15):5082-7. doi: 10.1128/AEM.00777-09. Epub 2009 Jun 12.


Effect of pH and temperature on denitrification gene expression and activity in Pseudomonas mandelii.

Saleh-Lakha S, Shannon KE, Henderson SL, Goyer C, Trevors JT, Zebarth BJ, Burton DL.

Appl Environ Microbiol. 2009 Jun;75(12):3903-11. doi: 10.1128/AEM.00080-09. Epub 2009 Apr 17.


Neurological correlates of reward responding in adolescents with and without externalizing behavior disorders.

Gatzke-Kopp LM, Beauchaine TP, Shannon KE, Chipman J, Fleming AP, Crowell SE, Liang O, Johnson LC, Aylward E.

J Abnorm Psychol. 2009 Feb;118(1):203-13. doi: 10.1037/a0014378.


Nitric oxide reductase gene expression and nitrous oxide production in nitrate-grown Pseudomonas mandelii.

Saleh-Lakha S, Shannon KE, Goyer C, Trevors JT, Zebarth BJ, Burton DL.

Appl Environ Microbiol. 2008 Nov;74(22):6876-9. doi: 10.1128/AEM.01533-08. Epub 2008 Sep 26.


Familial and temperamental predictors of resilience in children at risk for conduct disorder and depression.

Shannon KE, Beauchaine TP, Brenner SL, Neuhaus E, Gatzke-Kopp L.

Dev Psychopathol. 2007 Summer;19(3):701-27.


Application of real-time quantitative PCR for the detection of selected bacterial pathogens during municipal wastewater treatment.

Shannon KE, Lee DY, Trevors JT, Beaudette LA.

Sci Total Environ. 2007 Aug 15;382(1):121-9. Epub 2007 Apr 25.


R-isomers of Arg-Gly-Asp (RGD) mimics as potent alphavbeta3 inhibitors.

Nagarajan SR, Devadas B, Malecha JW, Lu HF, Ruminski PG, Rico JG, Rogers TE, Marrufo LD, Collins JT, Kleine HP, Lantz MK, Zhu J, Green NF, Russell MA, Landis BH, Miller LM, Meyer DM, Duffin TD, Engleman VW, Finn MB, Freeman SK, Griggs DW, Williams ML, Nickols MA, Pegg JA, Shannon KE, Steininger C, Westlin MM, Nickols GA, Keene JL.

Bioorg Med Chem. 2007 Jun 1;15(11):3783-800. Epub 2007 Mar 15.


Discovery of +(2-{4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}-cyclopropyl)acetic acid as potent and selective alphavbeta3 inhibitor: design, synthesis, and optimization.

Nagarajan SR, Lu HF, Gasiecki AF, Khanna IK, Parikh MD, Desai BN, Rogers TE, Clare M, Chen BB, Russell MA, Keene JL, Duffin T, Engleman VW, Finn MB, Freeman SK, Klover JA, Nickols GA, Nickols MA, Shannon KE, Steininger CA, Westlin WF, Westlin MM, Williams ML.

Bioorg Med Chem. 2007 May 15;15(10):3390-412. Epub 2007 Mar 13.


Synthesis of pyrazoles and isoxazoles as potent alpha(v)beta3 receptor antagonists.

Penning TD, Khilevich A, Chen BB, Russell MA, Boys ML, Wang Y, Duffin T, Engleman VW, Finn MB, Freeman SK, Hanneke ML, Keene JL, Klover JA, Nickols GA, Nickols MA, Rader RK, Settle SL, Shannon KE, Steininger CN, Westlin MM, Westlin WF.

Bioorg Med Chem Lett. 2006 Jun 15;16(12):3156-61. Epub 2006 Apr 18.


Synthesis of 2,5-thiazole butanoic acids as potent and selective alpha(v)beta3 integrin receptor antagonists with improved oral pharmacokinetic properties.

Wendt JA, Wu H, Stenmark HG, Boys ML, Downs VL, Penning TD, Chen BB, Wang Y, Duffin T, Finn MB, Keene JL, Engleman VW, Freeman SK, Hanneke ML, Shannon KE, Nickols MA, Steininger CN, Westlin M, Klover JA, Westlin W, Nickols GA, Russell MA.

Bioorg Med Chem Lett. 2006 Feb 15;16(4):845-9. Epub 2005 Nov 21.


Anti-metastatic properties of RGD-peptidomimetic agents S137 and S247.

Shannon KE, Keene JL, Settle SL, Duffin TD, Nickols MA, Westlin M, Schroeter S, Ruminski PG, Griggs DW.

Clin Exp Metastasis. 2004;21(2):129-38.


Synthesis of cinnamic acids and related isosteres as potent and selective alpha v beta 3 receptor antagonists.

Penning TD, Russell MA, Chen BB, Chen HY, Desai BN, Docter SH, Edwards DJ, Gesicki GJ, Liang CD, Malecha JW, Yu SS, Engleman VW, Freeman SK, Hanneke ML, Shannon KE, Westlin MM, Nickols GA.

Bioorg Med Chem Lett. 2004 Mar 22;14(6):1471-6.


Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome.

Bell DW, Varley JM, Szydlo TE, Kang DH, Wahrer DC, Shannon KE, Lubratovich M, Verselis SJ, Isselbacher KJ, Fraumeni JF, Birch JM, Li FP, Garber JE, Haber DA.

Science. 1999 Dec 24;286(5449):2528-31.


Heterozygous germline ATM mutations do not contribute to radiation-associated malignancies after Hodgkin's disease.

Nichols KE, Levitz S, Shannon KE, Wahrer DC, Bell DW, Chang G, Hegde S, Neuberg D, Shafman T, Tarbell NJ, Mauch P, Ishioka C, Haber DA, Diller L.

J Clin Oncol. 1999 Apr;17(4):1259.


Ovarian cancer: an update on genetics and therapy.

Penson RT, Shannon KE, Sharpless NE, Seiden MV.

Compr Ther. 1998 Oct;24(10):477-87. Review.


Germline mutations in PTEN are an infrequent cause of genetic predisposition to breast cancer.

FitzGerald MG, Marsh DJ, Wahrer D, Bell D, Caron S, Shannon KE, Ishioka C, Isselbacher KJ, Garber JE, Eng C, Haber DA.

Oncogene. 1998 Aug 13;17(6):727-31.

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