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Items: 1 to 50 of 142

1.

Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD⋅Yap Protein-Protein Interaction.

Bum-Erdene K, Zhou D, Gonzalez-Gutierrez G, Ghozayel MK, Si Y, Xu D, Shannon HE, Bailey BJ, Corson TW, Pollok KE, Wells CD, Meroueh SO.

Cell Chem Biol. 2019 Mar 21;26(3):378-389.e13. doi: 10.1016/j.chembiol.2018.11.010. Epub 2018 Dec 20.

PMID:
30581134
2.

Combination therapy in a xenograft model of glioblastoma: enhancement of the antitumor activity of temozolomide by an MDM2 antagonist.

Wang H, Cai S, Bailey BJ, Reza Saadatzadeh M, Ding J, Tonsing-Carter E, Georgiadis TM, Zachary Gunter T, Long EC, Minto RE, Gordon KR, Sen SE, Cai W, Eitel JA, Waning DL, Bringman LR, Wells CD, Murray ME, Sarkaria JN, Gelbert LM, Jones DR, Cohen-Gadol AA, Mayo LD, Shannon HE, Pollok KE.

J Neurosurg. 2017 Feb;126(2):446-459. doi: 10.3171/2016.1.JNS152513. Epub 2016 May 13.

3.

Potentiation of Carboplatin-Mediated DNA Damage by the Mdm2 Modulator Nutlin-3a in a Humanized Orthotopic Breast-to-Lung Metastatic Model.

Tonsing-Carter E, Bailey BJ, Saadatzadeh MR, Ding J, Wang H, Sinn AL, Peterman KM, Spragins TK, Silver JM, Sprouse AA, Georgiadis TM, Gunter TZ, Long EC, Minto RE, Marchal CC, Batuello CN, Safa AR, Hanenberg H, Territo PR, Sandusky GE, Mayo LD, Eischen CM, Shannon HE, Pollok KE.

Mol Cancer Ther. 2015 Dec;14(12):2850-63. doi: 10.1158/1535-7163.MCT-15-0237. Epub 2015 Oct 22.

4.

Brain Exposure of Two Selective Dual CDK4 and CDK6 Inhibitors and the Antitumor Activity of CDK4 and CDK6 Inhibition in Combination with Temozolomide in an Intracranial Glioblastoma Xenograft.

Raub TJ, Wishart GN, Kulanthaivel P, Staton BA, Ajamie RT, Sawada GA, Gelbert LM, Shannon HE, Sanchez-Martinez C, De Dios A.

Drug Metab Dispos. 2015 Sep;43(9):1360-71. doi: 10.1124/dmd.114.062745. Epub 2015 Jul 6.

PMID:
26149830
5.

Longitudinal Bioluminescence Imaging of Primary Versus Abdominal Metastatic Tumor Growth in Orthotopic Pancreatic Tumor Models in NSG Mice.

Shannon HE, Fishel ML, Xie J, Gu D, McCarthy BP, Riley AA, Sinn AL, Silver JM, Peterman K, Kelley MR, Hanenberg H, Korc M, Pollok KE, Territo PR.

Pancreas. 2015 Jan;44(1):64-75. doi: 10.1097/MPA.0000000000000238.

6.

Design, synthesis, and evaluation of curcumin-derived arylheptanoids for glioblastoma and neuroblastoma cytotoxicity.

Campos CA, Gianino JB, Bailey BJ, Baluyut ME, Wiek C, Hanenberg H, Shannon HE, Pollok KE, Ashfeld BL.

Bioorg Med Chem Lett. 2013 Dec 15;23(24):6874-8. doi: 10.1016/j.bmcl.2013.09.095. Epub 2013 Oct 11.

7.

GluK1 antagonists from 6-(tetrazolyl)phenyl decahydroisoquinoline derivatives: in vitro profile and in vivo analgesic efficacy.

Martinez-Perez JA, Iyengar S, Shannon HE, Bleakman D, Alt A, Clawson DK, Arnold BM, Bell MG, Bleisch TJ, Castaño AM, Del Prado M, Dominguez E, Escribano AM, Filla SA, Ho KH, Hudziak KJ, Jones CK, Mateo A, Mathes BM, Mattiuz EL, Ogden AM, Simmons RM, Stack DR, Stratford RE, Winter MA, Wu Z, Ornstein PL.

Bioorg Med Chem Lett. 2013 Dec 1;23(23):6463-6. doi: 10.1016/j.bmcl.2013.09.045. Epub 2013 Sep 24.

PMID:
24140446
8.

GluK1 antagonists from 6-(carboxy)phenyl decahydroisoquinoline derivatives. SAR and evaluation of a prodrug strategy for oral efficacy in pain models.

Martinez-Perez JA, Iyengar S, Shannon HE, Bleakman D, Alt A, Arnold BM, Bell MG, Bleisch TJ, Castaño AM, Del Prado M, Dominguez E, Escribano AM, Filla SA, Ho KH, Hudziak KJ, Jones CK, Mateo A, Mathes BM, Mattiuz EL, Ogden AM, Simmons RM, Stack DR, Stratford RE, Winter MA, Wu Z, Ornstein PL.

Bioorg Med Chem Lett. 2013 Dec 1;23(23):6459-62. doi: 10.1016/j.bmcl.2013.09.046. Epub 2013 Sep 25.

PMID:
24119554
9.

Combining hedgehog signaling inhibition with focal irradiation on reduction of pancreatic cancer metastasis.

Gu D, Liu H, Su GH, Zhang X, Chin-Sinex H, Hanenberg H, Mendonca MS, Shannon HE, Chiorean EG, Xie J.

Mol Cancer Ther. 2013 Jun;12(6):1038-48. doi: 10.1158/1535-7163.MCT-12-1030. Epub 2013 Mar 6.

10.

Reproducibility of total choline/water ratios in mouse U87MG xenograft tumors by 1H-MRS.

Zhu M, Fischl AS, Trowbridge MA, Shannon HE.

J Magn Reson Imaging. 2012 Aug;36(2):459-67. doi: 10.1002/jmri.23664. Epub 2012 Apr 19.

PMID:
22517495
11.

Nonlinear mixed effects pharmacokinetic/pharmacodynamic analysis of the anticonvulsant ameltolide (LY201116) in a canine seizure model.

Territo PR, Shannon HE, Newhall K, Barnhart SD, Peters SC, Engleking DR, Bin T, Burnett TJ, Rodewald JM, Abdul-Karim B, Freise KJ.

J Vet Pharmacol Ther. 2008 Dec;31(6):562-70. doi: 10.1111/j.1365-2885.2008.00995.x.

PMID:
19000280
12.

Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas.

Perry KW, Falcone JF, Fell MJ, Ryder JW, Yu H, Love PL, Katner J, Gordon KD, Wade MR, Man T, Nomikos GG, Phebus LA, Cauvin AJ, Johnson KW, Jones CK, Hoffmann BJ, Sandusky GE, Walter MW, Porter WJ, Yang L, Merchant KM, Shannon HE, Svensson KA.

Neuropharmacology. 2008 Oct;55(5):743-54. doi: 10.1016/j.neuropharm.2008.06.016. Epub 2008 Jun 17.

PMID:
18602930
13.

Development and validation of the maximal electro-shock seizure model in dogs.

Territo PR, Freise KJ, Newhall K, Barnhart SD, Peters SC, Engleking DR, Burnett TJ, Abdul-Karim B, Shannon HE.

J Vet Pharmacol Ther. 2007 Dec;30(6):508-15.

PMID:
17991218
14.

Effects of kappa opioid receptor agonists on attention as assessed by a 5-choice serial reaction time task in rats.

Shannon HE, Eberle EL, Mitch CH, McKinzie DL, Statnick MA.

Neuropharmacology. 2007 Dec;53(8):930-41. Epub 2007 Sep 20.

PMID:
17959202
15.

Constitutive deletion of the serotonin-7 (5-HT(7)) receptor decreases electrical and chemical seizure thresholds.

Witkin JM, Baez M, Yu J, Barton ME, Shannon HE.

Epilepsy Res. 2007 Jun;75(1):39-45. Epub 2007 May 7.

PMID:
17485199
16.

A non-spatial, stimulus-comparison working memory task in rats and disruption by scopolamine.

Shannon HE, Yang L.

Neuroscience. 2007 Mar 30;145(3):955-62. Epub 2007 Feb 14.

PMID:
17303343
17.

Effects of antiepileptic drugs on learning as assessed by a repeated acquisition of response sequences task in rats.

Shannon HE, Love PL.

Epilepsy Behav. 2007 Feb;10(1):16-25. Epub 2006 Dec 14.

PMID:
17174158
18.
19.

Antiallodynic and antihyperalgesic effects of selective competitive GLUK5 (GluR5) ionotropic glutamate receptor antagonists in the capsaicin and carrageenan models in rats.

Jones CK, Alt A, Ogden AM, Bleakman D, Simmons RM, Iyengar S, Dominguez E, Ornstein PL, Shannon HE.

J Pharmacol Exp Ther. 2006 Oct;319(1):396-404. Epub 2006 Jul 12.

PMID:
16837561
22.

Effects of antiepileptic drugs on attention as assessed by a five-choice serial reaction time task in rats.

Shannon HE, Love PL.

Epilepsy Behav. 2005 Dec;7(4):620-8. Epub 2005 Oct 25.

PMID:
16253568
23.

The seizure-related phenotype of brain-derived neurotrophic factor knockdown mice.

Barton ME, Shannon HE.

Neuroscience. 2005;136(2):563-9. Epub 2005 Sep 28.

PMID:
16198489
24.

The antihyperalgesic effects of the T-type calcium channel blockers ethosuximide, trimethadione, and mibefradil.

Barton ME, Eberle EL, Shannon HE.

Eur J Pharmacol. 2005 Oct 3;521(1-3):79-85. Epub 2005 Sep 19.

PMID:
16171802
25.

Anticonvulsant effects of LY456236, a selective mGlu1 receptor antagonist.

Shannon HE, Peters SC, Kingston AE.

Neuropharmacology. 2005;49 Suppl 1:188-95.

PMID:
16011839
27.

Two prodrugs of potent and selective GluR5 kainate receptor antagonists actives in three animal models of pain.

Dominguez E, Iyengar S, Shannon HE, Bleakman D, Alt A, Arnold BM, Bell MG, Bleisch TJ, Buckmaster JL, Castano AM, Del Prado M, Escribano A, Filla SA, Ho KH, Hudziak KJ, Jones CK, Martinez-Perez JA, Mateo A, Mathes BM, Mattiuz EL, Ogden AM, Simmons RM, Stack DR, Stratford RE, Winter MA, Wu Z, Ornstein PL.

J Med Chem. 2005 Jun 30;48(13):4200-3.

PMID:
15974569
28.

Comparison of the effects of anticonvulsant drugs with diverse mechanisms of action in the formalin test in rats.

Shannon HE, Eberle EL, Peters SC.

Neuropharmacology. 2005 Jun;48(7):1012-20.

PMID:
15857628
29.
30.
31.

Pharmacologic interactions between the muscarinic cholinergic and dopaminergic systems in the modulation of prepulse inhibition in rats.

Jones CK, Eberle EL, Shaw DB, McKinzie DL, Shannon HE.

J Pharmacol Exp Ther. 2005 Mar;312(3):1055-63. Epub 2004 Dec 1.

PMID:
15574685
32.

Efficacy of duloxetine, a potent and balanced serotonergic and noradrenergic reuptake inhibitor, in inflammatory and acute pain models in rodents.

Jones CK, Peters SC, Shannon HE.

J Pharmacol Exp Ther. 2005 Feb;312(2):726-32. Epub 2004 Oct 19.

PMID:
15494550
33.
34.

Within-session repeated acquisition behavior in rats as a potential model of executive function.

Shannon HE, Love PL.

Eur J Pharmacol. 2004 Sep 13;498(1-3):125-34.

PMID:
15363986
35.

Lesions of the laterodorsal tegmental nucleus disrupt prepulse inhibition of the acoustic startle reflex.

Jones CK, Shannon HE.

Pharmacol Biochem Behav. 2004 Jun;78(2):229-37.

PMID:
15219762
36.

Protection against cocaine toxicity in mice by the dopamine D3/D2 agonist R-(+)-trans-3,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol [(+)-PD 128,907].

Witkin JM, Dijkstra D, Levant B, Akunne HC, Zapata A, Peters S, Shannon HE, Gasior M.

J Pharmacol Exp Ther. 2004 Mar;308(3):957-64. Epub 2004 Jan 7.

PMID:
14711932
37.

Comparison of the effect of glutamate receptor modulators in the 6 Hz and maximal electroshock seizure models.

Barton ME, Peters SC, Shannon HE.

Epilepsy Res. 2003 Sep;56(1):17-26.

PMID:
14529950
38.

Increased anxiety-related behavior in mice deficient for metabotropic glutamate 8 (mGlu8) receptor.

Linden AM, Johnson BG, Peters SC, Shannon HE, Tian M, Wang Y, Yu JL, Köster A, Baez M, Schoepp DD.

Neuropharmacology. 2002 Aug;43(2):251-9.

PMID:
12213279
39.

m-CPP hypolocomotion is selectively antagonized by compounds with high affinity for 5-HT(2C) receptors but not 5-HT(2A) or 5-HT(2B) receptors.

Gleason SD, Lucaites VL, Shannon HE, Nelson DL, Leander JD.

Behav Pharmacol. 2001 Dec;12(8):613-20.

PMID:
11856898
40.
41.

Antihyperalgesic effects of the muscarinic receptor ligand vedaclidine in models involving central sensitization in rats.

Shannon HE, Jones CK, Li DL, Peters SC, Simmons RM, Iyengar S.

Pain. 2001 Sep;93(3):221-7.

PMID:
11514081
42.

Investigations into the physiological role of muscarinic M2 and M4 muscarinic and M4 receptor subtypes using receptor knockout mice.

Bymaster FP, Carter PA, Zhang L, Falcone JF, Stengel PW, Cohen ML, Shannon HE, Gomeza J, Wess J, Felder CC.

Life Sci. 2001 Apr 27;68(22-23):2473-9.

PMID:
11392615
43.

The muscarinic receptor agonist BuTAC, a novel potential antipsychotic, does not impair learning and memory in mouse passive avoidance.

Rasmussen T, Fink-Jensen A, Sauerberg P, Swedberg MD, Thomsen C, Sheardown MJ, Jeppesen L, Calligaro DO, DeLapp NW, Whitesitt C, Ward JS, Shannon HE, Bymaster FP.

Schizophr Res. 2001 Apr 15;49(1-2):193-201.

PMID:
11343877
44.

The muscarinic agonist xanomeline increases monoamine release and immediate early gene expression in the rat prefrontal cortex.

Perry KW, Nisenbaum LK, George CA, Shannon HE, Felder CC, Bymaster FP.

Biol Psychiatry. 2001 Apr 15;49(8):716-25.

PMID:
11313039
45.

Communicating synergism in drug combination studies.

Brodkin J, Shannon HE.

Arzneimittelforschung. 2000 Aug;50(8):765-7.

PMID:
10994162
46.

Reversal of pertussis toxin-induced thermal allodynia by muscarinic cholinergic agonists in mice.

Womer DE, Shannon HE.

Neuropharmacology. 2000 Sep;39(12):2499-504.

PMID:
10974334
47.

Muscarinic receptor agonists decrease cocaine self-administration rates in drug-naive mice.

Rasmussen T, Sauerberg P, Nielsen EB, Swedberg MD, Thomsen C, Sheardown MJ, Jeppesen L, Calligaro DO, DeLapp NW, Whitesitt C, Ward JS, Shannon HE, Bymaster FP, Fink-Jensen A.

Eur J Pharmacol. 2000 Aug 25;402(3):241-6.

PMID:
10958890
48.

Muscarinic cholinergic modulation of prepulse inhibition of the acoustic startle reflex.

Jones CK, Shannon HE.

J Pharmacol Exp Ther. 2000 Sep;294(3):1017-23.

PMID:
10945854
49.

Pharmacologic reversal of pertussis toxin-induced thermal allodynia in mice.

Womer DE, Shannon HE.

Neuropharmacology. 2000 Jul 24;39(10):1732-9.

PMID:
10884555
50.

Yohimbine produces antinociception in the formalin test in rats: involvement of serotonin(1A) receptors.

Shannon HE, Lutz EA.

Psychopharmacology (Berl). 2000 Mar;149(1):93-7.

PMID:
10789888

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