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Items: 1 to 50 of 112

1.

Tissue-specific differences in metabolites and transcripts contribute to the heterogeneity of ricinoleic acid accumulation in Ricinus communis L. (castor) seeds.

Sturtevant D, Romsdahl TB, Yu XH, Burks DJ, Azad RK, Shanklin J, Chapman KD.

Metabolomics. 2019 Jan 3;15(1):6. doi: 10.1007/s11306-018-1464-3.

PMID:
30830477
2.

Two clusters of residues contribute to the activity and substrate specificity of Fm1, a bifunctional oleate and linoleate desaturase of fungal origin.

Cai Y, Yu XH, Liu Q, Liu CJ, Shanklin J.

J Biol Chem. 2018 Dec 21;293(51):19844-19853. doi: 10.1074/jbc.RA118.005972. Epub 2018 Oct 22.

3.

Trehalose 6-Phosphate Positively Regulates Fatty Acid Synthesis by Stabilizing WRINKLED1.

Zhai Z, Keereetaweep J, Liu H, Feil R, Lunn JE, Shanklin J.

Plant Cell. 2018 Oct;30(10):2616-2627. doi: 10.1105/tpc.18.00521. Epub 2018 Sep 24.

4.

Biotin Attachment Domain-Containing Proteins Irreversibly Inhibit Acetyl CoA Carboxylase.

Keereetaweep J, Liu H, Zhai Z, Shanklin J.

Plant Physiol. 2018 May;177(1):208-215. doi: 10.1104/pp.18.00216. Epub 2018 Apr 6.

5.

Identification of bottlenecks in the accumulation of cyclic fatty acids in camelina seed oil.

Yu XH, Cahoon RE, Horn PJ, Shi H, Prakash RR, Cai Y, Hearney M, Chapman KD, Cahoon EB, Schwender J, Shanklin J.

Plant Biotechnol J. 2018 Apr;16(4):926-938. doi: 10.1111/pbi.12839. Epub 2018 Jan 18.

6.

Sugar Potentiation of Fatty Acid and Triacylglycerol Accumulation.

Zhai Z, Liu H, Xu C, Shanklin J.

Plant Physiol. 2017 Oct;175(2):696-707. doi: 10.1104/pp.17.00828. Epub 2017 Aug 25.

7.

Phosphorylation of WRINKLED1 by KIN10 Results in Its Proteasomal Degradation, Providing a Link between Energy Homeostasis and Lipid Biosynthesis.

Zhai Z, Liu H, Shanklin J.

Plant Cell. 2017 Apr;29(4):871-889. doi: 10.1105/tpc.17.00019. Epub 2017 Mar 17.

8.

A family of metal-dependent phosphatases implicated in metabolite damage-control.

Huang L, Khusnutdinova A, Nocek B, Brown G, Xu X, Cui H, Petit P, Flick R, Zallot R, Balmant K, Ziemak MJ, Shanklin J, de Crécy-Lagard V, Fiehn O, Gregory JF 3rd, Joachimiak A, Savchenko A, Yakunin AF, Hanson AD.

Nat Chem Biol. 2016 Aug;12(8):621-7. doi: 10.1038/nchembio.2108. Epub 2016 Jun 20.

PMID:
27322068
9.

Amino Acid Change in an Orchid Desaturase Enables Mimicry of the Pollinator's Sex Pheromone.

Sedeek KE, Whittle E, Guthörl D, Grossniklaus U, Shanklin J, Schlüter PM.

Curr Biol. 2016 Jun 6;26(11):1505-11. doi: 10.1016/j.cub.2016.04.018. Epub 2016 May 19.

10.

Cellular Organization of Triacylglycerol Biosynthesis in Microalgae.

Xu C, Andre C, Fan J, Shanklin J.

Subcell Biochem. 2016;86:207-21. doi: 10.1007/978-3-319-25979-6_9. Review.

PMID:
27023237
11.

Triacylglycerol Metabolism, Function, and Accumulation in Plant Vegetative Tissues.

Xu C, Shanklin J.

Annu Rev Plant Biol. 2016 Apr 29;67:179-206. doi: 10.1146/annurev-arplant-043015-111641. Epub 2016 Feb 3. Review.

PMID:
26845499
12.

50 years of Arabidopsis research: highlights and future directions.

Provart NJ, Alonso J, Assmann SM, Bergmann D, Brady SM, Brkljacic J, Browse J, Chapple C, Colot V, Cutler S, Dangl J, Ehrhardt D, Friesner JD, Frommer WB, Grotewold E, Meyerowitz E, Nemhauser J, Nordborg M, Pikaard C, Shanklin J, Somerville C, Stitt M, Torii KU, Waese J, Wagner D, McCourt P.

New Phytol. 2016 Feb;209(3):921-44. doi: 10.1111/nph.13687. Epub 2015 Oct 14. Review.

13.

Engineering a monolignol 4-O-methyltransferase with high selectivity for the condensed lignin precursor coniferyl alcohol.

Cai Y, Bhuiya MW, Shanklin J, Liu CJ.

J Biol Chem. 2015 Oct 30;290(44):26715-24. doi: 10.1074/jbc.M115.684217. Epub 2015 Sep 16.

14.

Half-of-the-Sites Reactivity of the Castor Δ9-18:0-Acyl Carrier Protein Desaturase.

Liu Q, Chai J, Moche M, Guy J, Lindqvist Y, Shanklin J.

Plant Physiol. 2015 Sep;169(1):432-41. doi: 10.1104/pp.15.00622. Epub 2015 Jul 29.

15.

Production of long chain alcohols and alkanes upon coexpression of an acyl-ACP reductase and aldehyde-deformylating oxygenase with a bacterial type-I fatty acid synthase in E. coli.

Coursolle D, Lian J, Shanklin J, Zhao H.

Mol Biosyst. 2015 Sep;11(9):2464-72. doi: 10.1039/c5mb00268k. Epub 2015 Jul 2.

PMID:
26135500
16.

Metabolic engineering of sugarcane to accumulate energy-dense triacylglycerols in vegetative biomass.

Zale J, Jung JH, Kim JY, Pathak B, Karan R, Liu H, Chen X, Wu H, Candreva J, Zhai Z, Shanklin J, Altpeter F.

Plant Biotechnol J. 2016 Feb;14(2):661-9. doi: 10.1111/pbi.12411. Epub 2015 Jun 8.

17.
18.

Redirection of metabolic flux for high levels of omega-7 monounsaturated fatty acid accumulation in camelina seeds.

Nguyen HT, Park H, Koster KL, Cahoon RE, Nguyen HT, Shanklin J, Clemente TE, Cahoon EB.

Plant Biotechnol J. 2015 Jan;13(1):38-50. doi: 10.1111/pbi.12233. Epub 2014 Jul 26.

19.

Efficient transformation and artificial miRNA gene silencing in Lemna minor.

Cantó-Pastor A, Mollá-Morales A, Ernst E, Dahl W, Zhai J, Yan Y, Meyers BC, Shanklin J, Martienssen R.

Plant Biol (Stuttg). 2015 Jan;17 Suppl 1:59-65. doi: 10.1111/plb.12215. Epub 2014 Jul 2.

20.

FAD2 and FAD3 desaturases form heterodimers that facilitate metabolic channeling in vivo.

Lou Y, Schwender J, Shanklin J.

J Biol Chem. 2014 Jun 27;289(26):17996-8007. doi: 10.1074/jbc.M114.572883. Epub 2014 May 8.

21.

The Spirodela polyrhiza genome reveals insights into its neotenous reduction fast growth and aquatic lifestyle.

Wang W, Haberer G, Gundlach H, Gläßer C, Nussbaumer T, Luo MC, Lomsadze A, Borodovsky M, Kerstetter RA, Shanklin J, Byrant DW, Mockler TC, Appenroth KJ, Grimwood J, Jenkins J, Chow J, Choi C, Adam C, Cao XH, Fuchs J, Schubert I, Rokhsar D, Schmutz J, Michael TP, Mayer KF, Messing J.

Nat Commun. 2014;5:3311. doi: 10.1038/ncomms4311.

22.
23.

Coexpressing Escherichia coli cyclopropane synthase with Sterculia foetida Lysophosphatidic acid acyltransferase enhances cyclopropane fatty acid accumulation.

Yu XH, Prakash RR, Sweet M, Shanklin J.

Plant Physiol. 2014 Jan;164(1):455-65. doi: 10.1104/pp.113.230953. Epub 2013 Nov 7.

24.

Fusing catalase to an alkane-producing enzyme maintains enzymatic activity by converting the inhibitory byproduct H2O2 to the cosubstrate O2.

Andre C, Kim SW, Yu XH, Shanklin J.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3191-6. doi: 10.1073/pnas.1218769110. Epub 2013 Feb 7.

25.

Parallel and competitive pathways for substrate desaturation, hydroxylation, and radical rearrangement by the non-heme diiron hydroxylase AlkB.

Cooper HL, Mishra G, Huang X, Pender-Cudlip M, Austin RN, Shanklin J, Groves JT.

J Am Chem Soc. 2012 Dec 19;134(50):20365-75. doi: 10.1021/ja3059149. Epub 2012 Dec 10.

26.

Feedback regulation of plastidic acetyl-CoA carboxylase by 18:1-acyl carrier protein in Brassica napus.

Andre C, Haslam RP, Shanklin J.

Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):10107-12. doi: 10.1073/pnas.1204604109. Epub 2012 Jun 4.

27.

Oil accumulation is controlled by carbon precursor supply for fatty acid synthesis in Chlamydomonas reinhardtii.

Fan J, Yan C, Andre C, Shanklin J, Schwender J, Xu C.

Plant Cell Physiol. 2012 Aug;53(8):1380-90. doi: 10.1093/pcp/pcs082. Epub 2012 May 28.

PMID:
22642988
28.

Conjugated fatty acid synthesis: residues 111 and 115 influence product partitioning of Momordica charantia conjugase.

Rawat R, Yu XH, Sweet M, Shanklin J.

J Biol Chem. 2012 May 11;287(20):16230-7. doi: 10.1074/jbc.M111.325316. Epub 2012 Mar 26.

29.

Remote control of regioselectivity in acyl-acyl carrier protein-desaturases.

Guy JE, Whittle E, Moche M, Lengqvist J, Lindqvist Y, Shanklin J.

Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16594-9. doi: 10.1073/pnas.1110221108. Epub 2011 Sep 19.

30.

Male Sterile2 encodes a plastid-localized fatty acyl carrier protein reductase required for pollen exine development in Arabidopsis.

Chen W, Yu XH, Zhang K, Shi J, De Oliveira S, Schreiber L, Shanklin J, Zhang D.

Plant Physiol. 2011 Oct;157(2):842-53. doi: 10.1104/pp.111.181693. Epub 2011 Aug 3.

31.

Defective pollen wall is required for anther and microspore development in rice and encodes a fatty acyl carrier protein reductase.

Shi J, Tan H, Yu XH, Liu Y, Liang W, Ranathunge K, Franke RB, Schreiber L, Wang Y, Kai G, Shanklin J, Ma H, Zhang D.

Plant Cell. 2011 Jun;23(6):2225-46. doi: 10.1105/tpc.111.087528. Epub 2011 Jun 24.

32.
33.

Stearoyl-acyl carrier protein desaturases are associated with floral isolation in sexually deceptive orchids.

Schlüter PM, Xu S, Gagliardini V, Whittle E, Shanklin J, Grossniklaus U, Schiestl FP.

Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5696-701. doi: 10.1073/pnas.1013313108. Epub 2011 Mar 21.

34.

Metabolic engineering of seeds can achieve levels of omega-7 fatty acids comparable with the highest levels found in natural plant sources.

Nguyen HT, Mishra G, Whittle E, Pidkowich MS, Bevan SA, Merlo AO, Walsh TA, Shanklin J.

Plant Physiol. 2010 Dec;154(4):1897-904. doi: 10.1104/pp.110.165340. Epub 2010 Oct 13. Erratum in: Plant Physiol. 2011 Mar;155(3):1473. Pidkowich, Mark S [added].

35.

Reflections on the ozone hole.

Shanklin J.

Nature. 2010 May 6;465(7294):34-5. doi: 10.1038/465034a. No abstract available.

PMID:
20445611
36.

Evidence that the yeast desaturase Ole1p exists as a dimer in vivo.

Lou Y, Shanklin J.

J Biol Chem. 2010 Jun 18;285(25):19384-90. doi: 10.1074/jbc.M110.125377. Epub 2010 Apr 20.

37.

Stereochemistry of 10-sulfoxidation catalyzed by a soluble Delta9 desaturase.

Tremblay AE, Tan N, Whittle E, Hodgson DJ, Dawson B, Buist PH, Shanklin J.

Org Biomol Chem. 2010 Mar 21;8(6):1322-8. doi: 10.1039/b921753c. Epub 2010 Jan 7.

PMID:
20204203
38.

Desaturases: emerging models for understanding functional diversification of diiron-containing enzymes.

Shanklin J, Guy JE, Mishra G, Lindqvist Y.

J Biol Chem. 2009 Jul 10;284(28):18559-63. doi: 10.1074/jbc.R900009200. Epub 2009 Apr 10. Review.

39.

Revealing the catalytic potential of an acyl-ACP desaturase: tandem selective oxidation of saturated fatty acids.

Whittle EJ, Tremblay AE, Buist PH, Shanklin J.

Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14738-43. doi: 10.1073/pnas.0805645105. Epub 2008 Sep 16.

40.

The crystal structure of the ivy Delta4-16:0-ACP desaturase reveals structural details of the oxidized active site and potential determinants of regioselectivity.

Guy JE, Whittle E, Kumaran D, Lindqvist Y, Shanklin J.

J Biol Chem. 2007 Jul 6;282(27):19863-71. Epub 2007 Apr 26.

41.

Stereochemistry of Delta4 dehydrogenation catalyzed by an ivy (Hedera helix) Delta9 desaturase homolog.

Tremblay AE, Whittle E, Buist PH, Shanklin J.

Org Biomol Chem. 2007 Apr 21;5(8):1270-5. Epub 2007 Mar 19.

PMID:
17406726
42.

Modulating seed beta-ketoacyl-acyl carrier protein synthase II level converts the composition of a temperate seed oil to that of a palm-like tropical oil.

Pidkowich MS, Nguyen HT, Heilmann I, Ischebeck T, Shanklin J.

Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4742-7. Epub 2007 Mar 5.

44.

A single mutation in the castor Delta9-18:0-desaturase changes reaction partitioning from desaturation to oxidase chemistry.

Guy JE, Abreu IA, Moche M, Lindqvist Y, Whittle E, Shanklin J.

Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17220-4. Epub 2006 Nov 6.

45.

The Arabidopsis stearoyl-acyl carrier protein-desaturase family and the contribution of leaf isoforms to oleic acid synthesis.

Kachroo A, Shanklin J, Whittle E, Lapchyk L, Hildebrand D, Kachroo P.

Plant Mol Biol. 2007 Jan;63(2):257-71. Epub 2006 Oct 28.

PMID:
17072561
46.

In vitro enzymatic oxidation of a fluorine-tagged sulfido substrate analogue: a 19F NMR investigation.

Tremblay AE, Buist PH, Hodgson D, Dawson B, Whittle E, Shanklin J.

Magn Reson Chem. 2006 Jun;44(6):629-32.

PMID:
16534835
48.

A multifunctional acyl-acyl carrier protein desaturase from Hedera helix L. (English ivy) can synthesize 16- and 18-carbon monoene and diene products.

Whittle E, Cahoon EB, Subrahmanyam S, Shanklin J.

J Biol Chem. 2005 Aug 5;280(31):28169-76. Epub 2005 Jun 6.

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