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Pan-Cancer Analysis of Potential Synthetic Lethal Drug Targets Specific to Alterations in DNA Damage Response.

Das S, Camphausen K, Shankavaram U.

Front Oncol. 2019 Oct 25;9:1136. doi: 10.3389/fonc.2019.01136. eCollection 2019.


SL-BioDP: Multi-Cancer Interactive Tool for Prediction of Synthetic Lethality and Response to Cancer Treatment.

Deng X, Das S, Valdez K, Camphausen K, Shankavaram U.

Cancers (Basel). 2019 Oct 29;11(11). pii: E1682. doi: 10.3390/cancers11111682.


Comparison of Proteomic Biodosimetry Biomarkers Across Five Different Murine Strains.

Sproull M, Shankavaram U, Camphausen K.

Radiat Res. 2019 Dec;192(6):640-648. doi: 10.1667/RR15442.1. Epub 2019 Oct 16.


Radiation Drives the Evolution of Orthotopic Xenografts Initiated from Glioblastoma Stem-like Cells.

McAbee JH, Rath BH, Valdez K, Young DL, Wu X, Shankavaram UT, Camphausen K, Tofilon PJ.

Cancer Res. 2019 Dec 1;79(23):6032-6043. doi: 10.1158/0008-5472.CAN-19-2452. Epub 2019 Oct 15.


Long intergenic noncoding RNA profiles of pheochromocytoma and paraganglioma: A novel prognostic biomarker.

Ghosal S, Das S, Pang Y, Gonzales MK, Huynh TT, Yang Y, Taieb D, Crona J, Shankavaram UT, Pacak K.

Int J Cancer. 2020 Apr 15;146(8):2326-2335. doi: 10.1002/ijc.32654. Epub 2019 Oct 11.


DiscoverSL: an R package for multi-omic data driven prediction of synthetic lethality in cancers.

Das S, Deng X, Camphausen K, Shankavaram U.

Bioinformatics. 2019 Feb 15;35(4):701-702. doi: 10.1093/bioinformatics/bty673.


Microarray analysis of miRNA expression profiles following whole body irradiation in a mouse model.

Aryankalayil MJ, Chopra S, Makinde A, Eke I, Levin J, Shankavaram U, MacMillan L, Vanpouille-Box C, Demaria S, Coleman CN.

Biomarkers. 2018 Nov;23(7):689-703. doi: 10.1080/1354750X.2018.1479771. Epub 2018 Jun 19.


Radiation-induced alternative transcripts as detected in total and polysome-bound mRNA.

Wahba A, Ryan MC, Shankavaram UT, Camphausen K, Tofilon PJ.

Oncotarget. 2017 Oct 9;9(1):691-705. doi: 10.18632/oncotarget.21672. eCollection 2018 Jan 2.


Radiation-Induced Long Noncoding RNAs in a Mouse Model after Whole-Body Irradiation.

Aryankalayil MJ, Chopra S, Levin J, Eke I, Makinde A, Das S, Shankavaram U, Vanpouille-Box C, Demaria S, Coleman CN.

Radiat Res. 2018 Mar;189(3):251-263. doi: 10.1667/RR14891.1. Epub 2018 Jan 8.


Effect of Prostate Magnetic Resonance Imaging/Ultrasound Fusion-guided Biopsy on Radiation Treatment Recommendations.

Reed A, Valle LF, Shankavaram U, Krauze A, Kaushal A, Schott E, Cooley-Zgela T, Wood B, Pinto P, Choyke P, Turkbey B, Citrin DE.

Int J Radiat Oncol Biol Phys. 2017 Apr 1;97(5):947-951. doi: 10.1016/j.ijrobp.2016.12.016. Epub 2016 Dec 18.


Computational analysis of the mesenchymal signature landscape in gliomas.

Celiku O, Tandle A, Chung JY, Hewitt SM, Camphausen K, Shankavaram U.

BMC Med Genomics. 2017 Mar 9;10(1):13. doi: 10.1186/s12920-017-0252-7.


Disabled cell density sensing leads to dysregulated cholesterol synthesis in glioblastoma.

Kambach DM, Halim AS, Cauer AG, Sun Q, Tristan CA, Celiku O, Kesarwala AH, Shankavaram U, Batchelor E, Stommel JM.

Oncotarget. 2017 Feb 28;8(9):14860-14875. doi: 10.18632/oncotarget.14740.


Multivariate Analysis of Radiation Responsive Proteins to Predict Radiation Exposure in Total-Body Irradiation and Partial-Body Irradiation Models.

Sproull M, Kramp T, Tandle A, Shankavaram U, Camphausen K.

Radiat Res. 2017 Feb;187(2):251-258. doi: 10.1667/RR14558.1. Epub 2017 Jan 24.


FOXM1 and STAT3 interaction confers radioresistance in glioblastoma cells.

Maachani UB, Shankavaram U, Kramp T, Tofilon PJ, Camphausen K, Tandle AT.

Oncotarget. 2016 Nov 22;7(47):77365-77377. doi: 10.18632/oncotarget.12670.


Hypoxia-Inducible Factor 2α Mutation-Related Paragangliomas Classify as Discrete Pseudohypoxic Subcluster.

Fliedner SM, Shankavaram U, Marzouca G, Elkahloun A, Jochmanova I, Daerr R, Linehan WM, Timmers H, Tischler AS, Papaspyrou K, Brieger J, de Krijger R, Breza J, Eisenhofer G, Zhuang Z, Lehnert H, Pacak K.

Neoplasia. 2016 Sep;18(9):567-76. doi: 10.1016/j.neo.2016.07.008.


Molecular profiling of MPS1 gene silencing in U251 glioma cell line.

Shankavaram U, Maachani UB, Zhao S, Camphausen K, Tandle A.

Genom Data. 2015 Dec 1;6:36-39.


Radiation-Induced Alteration of the Brain Proteome: Understanding the Role of the Sirtuin 2 Deacetylase in a Murine Model.

Shukla S, Shankavaram UT, Nguyen P, Stanley BA, Smart DK.

J Proteome Res. 2015 Oct 2;14(10):4104-17. doi: 10.1021/acs.jproteome.5b00083. Epub 2015 Sep 16.


Serum Amyloid A as a Biomarker for Radiation Exposure.

Sproull M, Kramp T, Tandle A, Shankavaram U, Camphausen K.

Radiat Res. 2015 Jul;184(1):14-23. Epub 2015 Jun 26.


Modulation of miR-21 signaling by MPS1 in human glioblastoma.

Maachani UB, Tandle A, Shankavaram U, Kramp T, Camphausen K.

Oncotarget. 2016 Aug 16;7(33):52912-52927. doi: 10.18632/oncotarget.4143.


Targeting MPS1 Enhances Radiosensitization of Human Glioblastoma by Modulating DNA Repair Proteins.

Maachani UB, Kramp T, Hanson R, Zhao S, Celiku O, Shankavaram U, Colombo R, Caplen NJ, Camphausen K, Tandle A.

Mol Cancer Res. 2015 May;13(5):852-62. doi: 10.1158/1541-7786.MCR-14-0462-T. Epub 2015 Feb 26.


Germ-line PHD1 and PHD2 mutations detected in patients with pheochromocytoma/paraganglioma-polycythemia.

Yang C, Zhuang Z, Fliedner SM, Shankavaram U, Sun MG, Bullova P, Zhu R, Elkahloun AG, Kourlas PJ, Merino M, Kebebew E, Pacak K.

J Mol Med (Berl). 2015 Jan;93(1):93-104. doi: 10.1007/s00109-014-1205-7. Epub 2014 Sep 30.


Visualizing molecular profiles of glioblastoma with GBM-BioDP.

Celiku O, Johnson S, Zhao S, Camphausen K, Shankavaram U.

PLoS One. 2014 Jul 10;9(7):e101239. doi: 10.1371/journal.pone.0101239. eCollection 2014.


microRNA alterations driving acute and late stages of radiation-induced fibrosis in a murine skin model.

Simone BA, Ly D, Savage JE, Hewitt SM, Dan TD, Ylaya K, Shankavaram U, Lim M, Jin L, Camphausen K, Mitchell JB, Simone NL.

Int J Radiat Oncol Biol Phys. 2014 Sep 1;90(1):44-52. doi: 10.1016/j.ijrobp.2014.05.003. Epub 2014 Jun 28.


Anti-cancer potential of MAPK pathway inhibition in paragangliomas-effect of different statins on mouse pheochromocytoma cells.

Fliedner SM, Engel T, Lendvai NK, Shankavaram U, Nölting S, Wesley R, Elkahloun AG, Ungefroren H, Oldoerp A, Lampert G, Lehnert H, Timmers H, Pacak K.

PLoS One. 2014 May 20;9(5):e97712. doi: 10.1371/journal.pone.0097712. eCollection 2014.


High-throughput screening for the identification of new therapeutic options for metastatic pheochromocytoma and paraganglioma.

Giubellino A, Shankavaram U, Bullova P, Schovanek J, Zhang Y, Shen M, Patel N, Elkahloun A, Lee MJ, Trepel J, Ferrer M, Pacak K.

PLoS One. 2014 Apr 3;9(4):e90458. doi: 10.1371/journal.pone.0090458. eCollection 2014.


CD44 is prognostic for overall survival in the NCI randomized trial on breast conservation with 25 year follow-up.

Dan T, Hewitt SM, Ohri N, Ly D, Soule BP, Smith SL, Matsuda K, Council C, Shankavaram U, Lippman ME, Mitchell JB, Camphausen K, Simone NL.

Breast Cancer Res Treat. 2014 Jan;143(1):11-8. doi: 10.1007/s10549-013-2758-9. Epub 2013 Nov 26.


The ATP-competitive mTOR inhibitor INK128 enhances in vitro and in vivo radiosensitivity of pancreatic carcinoma cells.

Hayman TJ, Wahba A, Rath BH, Bae H, Kramp T, Shankavaram UT, Camphausen K, Tofilon PJ.

Clin Cancer Res. 2014 Jan 1;20(1):110-9. doi: 10.1158/1078-0432.CCR-13-2136. Epub 2013 Nov 6.


Role of type II pneumocyte senescence in radiation-induced lung fibrosis.

Citrin DE, Shankavaram U, Horton JA, Shield W 3rd, Zhao S, Asano H, White A, Sowers A, Thetford A, Chung EJ.

J Natl Cancer Inst. 2013 Oct 2;105(19):1474-84. doi: 10.1093/jnci/djt212. Epub 2013 Sep 19.


Chemoirradiation for glioblastoma multiforme: the national cancer institute experience.

Ho J, Ondos J, Ning H, Smith S, Kreisl T, Iwamoto F, Sul J, Kim L, McNeil K, Krauze A, Shankavaram U, Fine HA, Camphausen K.

PLoS One. 2013 Aug 5;8(8):e70745. doi: 10.1371/journal.pone.0070745. Print 2013.


Inhibition of polo-like kinase 1 in glioblastoma multiforme induces mitotic catastrophe and enhances radiosensitisation.

Tandle AT, Kramp T, Kil WJ, Halthore A, Gehlhaus K, Shankavaram U, Tofilon PJ, Caplen NJ, Camphausen K.

Eur J Cancer. 2013 Sep;49(14):3020-8. doi: 10.1016/j.ejca.2013.05.013. Epub 2013 Jun 18.


Genotype and tumor locus determine expression profile of pseudohypoxic pheochromocytomas and paragangliomas.

Shankavaram U, Fliedner SM, Elkahloun AG, Barb JJ, Munson PJ, Huynh TT, Matro JC, Turkova H, Linehan WM, Timmers HJ, Tischler AS, Powers JF, de Krijger R, Baysal BE, Takacova M, Pastorekova S, Gius D, Lehnert H, Camphausen K, Pacak K.

Neoplasia. 2013 Apr;15(4):435-47.


Correlation of plasma FL expression with bone marrow irradiation dose.

Sproull M, Avondoglio D, Kramp T, Shankavaram U, Camphausen K.

PLoS One. 2013;8(3):e58558. doi: 10.1371/journal.pone.0058558. Epub 2013 Mar 7.


StRAP: an integrated resource for profiling high-throughput cancer genomic data from stress response studies.

Johnson S, Issac B, Zhao S, Bisht M, Celiku O, Tofilon P, Camphausen K, Shankavaram U.

PLoS One. 2012;7(12):e51693. doi: 10.1371/journal.pone.0051693. Epub 2012 Dec 17.


Aryl hydrocarbon receptor-induced adrenomedullin mediates cigarette smoke carcinogenicity in humans and mice.

Portal-Nuñez S, Shankavaram UT, Rao M, Datrice N, Atay S, Aparicio M, Camphausen KA, Fernández-Salguero PM, Chang H, Lin P, Schrump DS, Garantziotis S, Cuttitta F, Zudaire E.

Cancer Res. 2012 Nov 15;72(22):5790-800. doi: 10.1158/0008-5472.CAN-12-0818. Epub 2012 Sep 19.


Translation initiation factor eIF4E is a target for tumor cell radiosensitization.

Hayman TJ, Williams ES, Jamal M, Shankavaram UT, Camphausen K, Tofilon PJ.

Cancer Res. 2012 May 1;72(9):2362-72. doi: 10.1158/0008-5472.CAN-12-0329. Epub 2012 Mar 7.


Molecular profiling indicates orthotopic xenograft of glioma cell lines simulate a subclass of human glioblastoma.

Shankavaram UT, Bredel M, Burgan WE, Carter D, Tofilon P, Camphausen K.

J Cell Mol Med. 2012 Mar;16(3):545-54. doi: 10.1111/j.1582-4934.2011.01345.x.


Parameters favorable to intraprostatic radiation dose escalation in men with localized prostate cancer.

Housri N, Ning H, Ondos J, Choyke P, Camphausen K, Citrin D, Arora B, Shankavaram U, Kaushal A.

Int J Radiat Oncol Biol Phys. 2011 Jun 1;80(2):614-20. doi: 10.1016/j.ijrobp.2010.06.050. Epub 2010 Oct 6.


Evaluation of the fullerene compound DF-1 as a radiation protector.

Brown AP, Chung EJ, Urick ME, Shield WP 3rd, Sowers AL, Thetford A, Shankavaram UT, Mitchell JB, Citrin DE.

Radiat Oncol. 2010 May 11;5:34. doi: 10.1186/1748-717X-5-34.


Dihydroartemisinin accelerates c-MYC oncoprotein degradation and induces apoptosis in c-MYC-overexpressing tumor cells.

Lu JJ, Meng LH, Shankavaram UT, Zhu CH, Tong LJ, Chen G, Lin LP, Weinstein JN, Ding J.

Biochem Pharmacol. 2010 Jul 1;80(1):22-30. doi: 10.1016/j.bcp.2010.02.016. Epub 2010 Mar 3.


Comparison of T2 and FLAIR imaging for target delineation in high grade gliomas.

Stall B, Zach L, Ning H, Ondos J, Arora B, Shankavaram U, Miller RW, Citrin D, Camphausen K.

Radiat Oncol. 2010 Jan 28;5:5. doi: 10.1186/1748-717X-5-5.


Multifactorial regulation of E-cadherin expression: an integrative study.

Reinhold WC, Reimers MA, Lorenzi P, Ho J, Shankavaram UT, Ziegler MS, Bussey KJ, Nishizuka S, Ikediobi O, Pommier YG, Weinstein JN.

Mol Cancer Ther. 2010 Jan;9(1):1-16. doi: 10.1158/1535-7163.MCT-09-0321. Epub 2010 Jan 6.


Urine analysis and protein networking identify met as a marker of metastatic prostate cancer.

Russo AL, Jedlicka K, Wernick M, McNally D, Kirk M, Sproull M, Smith S, Shankavaram U, Kaushal A, Figg WD, Dahut W, Citrin D, Bottaro DP, Albert PS, Tofilon PJ, Camphausen K.

Clin Cancer Res. 2009 Jul 1;15(13):4292-8. doi: 10.1158/1078-0432.CCR-09-0599. Epub 2009 Jun 23.


CellMiner: a relational database and query tool for the NCI-60 cancer cell lines.

Shankavaram UT, Varma S, Kane D, Sunshine M, Chary KK, Reinhold WC, Pommier Y, Weinstein JN.

BMC Genomics. 2009 Jun 23;10:277. doi: 10.1186/1471-2164-10-277.


Physiologic oxygen concentration enhances the stem-like properties of CD133+ human glioblastoma cells in vitro.

McCord AM, Jamal M, Shankavaram UT, Lang FF, Camphausen K, Tofilon PJ.

Mol Cancer Res. 2009 Apr;7(4):489-97. doi: 10.1158/1541-7786.MCR-08-0360. Erratum in: Mol Cancer Res. 2009 Jun;7(6):987. Shankavarum, Uma T [corrected to Shankavaram, Uma T].


Radiation-induced gene translation profiles reveal tumor type and cancer-specific components.

Kumaraswamy S, Chinnaiyan P, Shankavaram UT, Lü X, Camphausen K, Tofilon PJ.

Cancer Res. 2008 May 15;68(10):3819-26. doi: 10.1158/0008-5472.CAN-08-0016.


Nonclassic functions of human topoisomerase I: genome-wide and pharmacologic analyses.

Miao ZH, Player A, Shankavaram U, Wang YH, Zimonjic DB, Lorenzi PL, Liao ZY, Liu H, Shimura T, Zhang HL, Meng LH, Zhang YW, Kawasaki ES, Popescu NC, Aladjem MI, Goldstein DJ, Weinstein JN, Pommier Y.

Cancer Res. 2007 Sep 15;67(18):8752-61.


Transcript and protein expression profiles of the NCI-60 cancer cell panel: an integromic microarray study.

Shankavaram UT, Reinhold WC, Nishizuka S, Major S, Morita D, Chary KK, Reimers MA, Scherf U, Kahn A, Dolginow D, Cossman J, Kaldjian EP, Scudiero DA, Petricoin E, Liotta L, Lee JK, Weinstein JN.

Mol Cancer Ther. 2007 Mar;6(3):820-32. Epub 2007 Mar 5.


Detailed DNA methylation profiles of the E-cadherin promoter in the NCI-60 cancer cells.

Reinhold WC, Reimers MA, Maunakea AK, Kim S, Lababidi S, Scherf U, Shankavaram UT, Ziegler MS, Stewart C, Kouros-Mehr H, Cui H, Dolginow D, Scudiero DA, Pommier YG, Munroe DJ, Feinberg AP, Weinstein JN.

Mol Cancer Ther. 2007 Feb;6(2):391-403. Epub 2007 Feb 1.


Asparagine synthetase as a causal, predictive biomarker for L-asparaginase activity in ovarian cancer cells.

Lorenzi PL, Reinhold WC, Rudelius M, Gunsior M, Shankavaram U, Bussey KJ, Scherf U, Eichler GS, Martin SE, Chin K, Gray JW, Kohn EC, Horak ID, Von Hoff DD, Raffeld M, Goldsmith PK, Caplen NJ, Weinstein JN.

Mol Cancer Ther. 2006 Nov;5(11):2613-23. Epub 2006 Nov 6.


Activation of aminoflavone (NSC 686288) by a sulfotransferase is required for the antiproliferative effect of the drug and for induction of histone gamma-H2AX.

Meng LH, Shankavaram U, Chen C, Agama K, Fu HQ, Gonzalez FJ, Weinstein J, Pommier Y.

Cancer Res. 2006 Oct 1;66(19):9656-64.

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