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Items: 22


Effect of Pregnenolone vs Placebo on Self-reported Chronic Low Back Pain Among US Military Veterans: A Randomized Clinical Trial.

Naylor JC, Kilts JD, Shampine LJ, Parke GJ, Wagner HR, Szabo ST, Smith KD, Allen TB, Telford-Marx EG, Dunn CE, Cuffe BT, O'Loughlin SH, Marx CE.

JAMA Netw Open. 2020 Mar 2;3(3):e200287. doi: 10.1001/jamanetworkopen.2020.0287.


Widespread Cortical Thickness Is Associated With Neuroactive Steroid Levels.

Morey RA, Davis SL, Haswell CC, Naylor JC, Kilts JD, Szabo ST, Shampine LJ, Parke GJ, Sun D, Swanson CA, Wagner HR; Mid-Atlantic MIRECC Workgroup, Marx CE.

Front Neurosci. 2019 Nov 12;13:1118. doi: 10.3389/fnins.2019.01118. eCollection 2019.


Neurosteroid Levels in the Orbital Frontal Cortex of Subjects with PTSD and Controls: A Preliminary Report.

Cruz DA, Glantz LA, McGaughey KD, Parke G, Shampine LJ, Kilts JD, Naylor JC, Marx CE, Williamson DE.

Chronic Stress (Thousand Oaks). 2019 Jan-Dec/;3. doi: 10.1177/2470547019838570. Epub 2019 Apr 18.


An exploratory pilot investigation of neurosteroids and self-reported pain in female Iraq/Afghanistan-era Veterans.

Naylor JC, Kilts JD, Strauss JL, Szabo ST, Dunn CE, Wagner HR, Hamer RM, Shampine LJ, Zanga JR, Marx CE; Department of Veterans Affairs Mid-Atlantic Mental Illness Research, Education, and Clinical Center Workgroup.

J Rehabil Res Dev. 2016;53(4):499-510. doi: 10.1682/JRRD.2014.11.0294.


Neurosteroids and Traumatic Brain Injury: Translating Biomarkers to Therapeutics; Overview and Pilot Investigations in Iraq and Afghanistan Era Veterans.

Marx CE, Naylor JC, Kilts JD, Dunn CE, Tupler LA, Szabo ST, Capehart BP, Morey RA, Shampine LJ, Acheson SK.

In: Laskowitz D, Grant G, editors. Translational Research in Traumatic Brain Injury. Boca Raton (FL): CRC Press/Taylor and Francis Group; 2016. Chapter 7.


Erratum to: DHEA metabolism to the neurosteroid androsterone: a possible mechanism of DHEA's antidepressant action.

Ben Dor R, Marx CE, Shampine LJ, Rubinow DR, Schmidt PJ.

Psychopharmacology (Berl). 2015 Oct;232(19):3683. doi: 10.1007/s00213-015-4046-3. No abstract available.


Allopregnanolone Levels Are Inversely Associated with Self-Reported Pain Symptoms in U.S. Iraq and Afghanistan-Era Veterans: Implications for Biomarkers and Therapeutics.

Naylor JC, Kilts JD, Szabo ST, Dunn CE, Keefe FJ, Tupler LA, Shampine LJ, Morey RA, Strauss JL, Hamer RM, Wagner HR; MIRECC Workgroup, Marx CE.

Pain Med. 2016 Jan;17(1):25-32.


DHEA metabolism to the neurosteroid androsterone: a possible mechanism of DHEA's antidepressant action.

Ben Dor R, Marx CE, Shampine LJ, Rubinow DR, Schmidt PJ.

Psychopharmacology (Berl). 2015 Sep;232(18):3375-83. doi: 10.1007/s00213-015-3991-1. Epub 2015 Jun 25. Erratum in: Psychopharmacology (Berl). 2015 Oct;232(19):3683.


Exploratory investigation of biomarker candidates for suicide in schizophrenia and bipolar disorder.

Youssef NA, Bradford DW, Kilts JD, Szabo ST, Naylor JC, Allen TB, Strauss JL, Hamer RM, Brancu M, Shampine LJ, Marx CE.

Crisis. 2015;36(1):46-54. doi: 10.1027/0227-5910/a000280. Erratum in: Crisis. 2016;37(1):77. Brunca, Mira [corrected to Brancu, Mira].


Neurosteroids and self-reported pain in veterans who served in the U.S. Military after September 11, 2001.

Kilts JD, Tupler LA, Keefe FJ, Payne VM, Hamer RM, Naylor JC, Calnaido RP, Morey RA, Strauss JL, Parke G, Massing MW, Youssef NA, Shampine LJ; tVeterans Affairs Mid-Atlantic Mental Illness, Research, Education and Clinical Center Workgroup, Marx CE.

Pain Med. 2010 Oct;11(10):1469-76. doi: 10.1111/j.1526-4637.2010.00927.x. Epub 2010 Aug 23.


Allopregnanolone levels are reduced in temporal cortex in patients with Alzheimer's disease compared to cognitively intact control subjects.

Naylor JC, Kilts JD, Hulette CM, Steffens DC, Blazer DG, Ervin JF, Strauss JL, Allen TB, Massing MW, Payne VM, Youssef NA, Shampine LJ, Marx CE.

Biochim Biophys Acta. 2010 Aug;1801(8):951-9. doi: 10.1016/j.bbalip.2010.05.006. Epub 2010 May 19.


Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia.

Marx CE, Keefe RS, Buchanan RW, Hamer RM, Kilts JD, Bradford DW, Strauss JL, Naylor JC, Payne VM, Lieberman JA, Savitz AJ, Leimone LA, Dunn L, Porcu P, Morrow AL, Shampine LJ.

Neuropsychopharmacology. 2009 Jul;34(8):1885-903. doi: 10.1038/npp.2009.26. Epub 2009 Apr 1.


Simultaneous quantification of GABAergic 3alpha,5alpha/3alpha,5beta neuroactive steroids in human and rat serum.

Porcu P, O'Buckley TK, Alward SE, Marx CE, Shampine LJ, Girdler SS, Morrow AL.

Steroids. 2009 Apr-May;74(4-5):463-73. doi: 10.1016/j.steroids.2008.12.015. Epub 2009 Jan 13.


Cerebrospinal fluid dehydroepiandrosterone levels are correlated with brain dehydroepiandrosterone levels, elevated in Alzheimer's disease, and related to neuropathological disease stage.

Naylor JC, Hulette CM, Steffens DC, Shampine LJ, Ervin JF, Payne VM, Massing MW, Kilts JD, Strauss JL, Calhoun PS, Calnaido RP, Blazer DG, Lieberman JA, Madison RD, Marx CE.

J Clin Endocrinol Metab. 2008 Aug;93(8):3173-8. doi: 10.1210/jc.2007-1229. Epub 2008 May 13.


Neuroactive steroids, mood stabilizers, and neuroplasticity: alterations following lithium and changes in Bcl-2 knockout mice.

Marx CE, Yuan P, Kilts JD, Madison RD, Shampine LJ, Manji HK.

Int J Neuropsychopharmacol. 2008 Jun;11(4):547-52. doi: 10.1017/S1461145708008444. Epub 2008 Feb 8.


The neurosteroid allopregnanolone is reduced in prefrontal cortex in Alzheimer's disease.

Marx CE, Trost WT, Shampine LJ, Stevens RD, Hulette CM, Steffens DC, Ervin JF, Butterfield MI, Blazer DG, Massing MW, Lieberman JA.

Biol Psychiatry. 2006 Dec 15;60(12):1287-94. Epub 2006 Sep 25.


Olanzapine and fluoxetine administration and coadministration increase rat hippocampal pregnenolone, allopregnanolone and peripheral deoxycorticosterone: implications for therapeutic actions.

Marx CE, Shampine LJ, Khisti RT, Trost WT, Bradford DW, Grobin AC, Massing MW, Madison RD, Butterfield MI, Lieberman JA, Morrow AL.

Pharmacol Biochem Behav. 2006 Aug;84(4):609-17. Epub 2006 Sep 20.


Clozapine markedly elevates pregnenolone in rat hippocampus, cerebral cortex, and serum: candidate mechanism for superior efficacy?

Marx CE, Shampine LJ, Duncan GE, VanDoren MJ, Grobin AC, Massing MW, Madison RD, Bradford DW, Butterfield MI, Lieberman JA, Morrow AL.

Pharmacol Biochem Behav. 2006 Aug;84(4):598-608. Epub 2006 Sep 8.


Subjective effects and changes in steroid hormone concentrations in humans following acute consumption of alcohol.

Pierucci-Lagha A, Covault J, Feinn R, Khisti RT, Morrow AL, Marx CE, Shampine LJ, Kranzler HR.

Psychopharmacology (Berl). 2006 Jun;186(3):451-61. Epub 2005 Dec 10.


Neuroactive steroids are altered in schizophrenia and bipolar disorder: relevance to pathophysiology and therapeutics.

Marx CE, Stevens RD, Shampine LJ, Uzunova V, Trost WT, Butterfield MI, Massing MW, Hamer RM, Morrow AL, Lieberman JA.

Neuropsychopharmacology. 2006 Jun;31(6):1249-63.


Steady-state brain concentrations of antihistamines in rats: interplay of membrane permeability, P-glycoprotein efflux and plasma protein binding.

Mahar Doan KM, Wring SA, Shampine LJ, Jordan KH, Bishop JP, Kratz J, Yang E, Serabjit-Singh CJ, Adkison KK, Polli JW.

Pharmacology. 2004 Oct;72(2):92-8.


Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs.

Mahar Doan KM, Humphreys JE, Webster LO, Wring SA, Shampine LJ, Serabjit-Singh CJ, Adkison KK, Polli JW.

J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37.


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