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Items: 33

1.

iRAPs curb antisense transcription in E. coli.

Magán A, Amman F, El-Isa F, Hartl N, Shamovsky I, Nudler E, Schroeder R, Sedlyarova N.

Nucleic Acids Res. 2019 Nov 18;47(20):10894-10905. doi: 10.1093/nar/gkz791.

2.

Transcription factor YcjW controls the emergency H2S production in E. coli.

Luhachack L, Rasouly A, Shamovsky I, Nudler E.

Nat Commun. 2019 Jun 28;10(1):2868. doi: 10.1038/s41467-019-10785-x.

3.

Paf1C regulates RNA polymerase II progression by modulating elongation rate.

Hou L, Wang Y, Liu Y, Zhang N, Shamovsky I, Nudler E, Tian B, Dynlacht BD.

Proc Natl Acad Sci U S A. 2019 Jul 16;116(29):14583-14592. doi: 10.1073/pnas.1904324116. Epub 2019 Jun 27.

4.

Discovery and Early Clinical Development of an Inhibitor of 5-Lipoxygenase Activating Protein (AZD5718) for Treatment of Coronary Artery Disease.

Pettersen D, Broddefalk J, Emtenäs H, Hayes MA, Lemurell M, Swanson M, Ulander J, Whatling C, Amilon C, Ericsson H, Westin Eriksson A, Granberg K, Plowright AT, Shamovsky I, Dellsèn A, Sundqvist M, Någård M, Lindstedt EL.

J Med Chem. 2019 May 9;62(9):4312-4324. doi: 10.1021/acs.jmedchem.8b02004. Epub 2019 Mar 26.

PMID:
30869888
5.

Identification and Pharmacological Profile of an Indane Based Series of Ghrelin Receptor Full Agonists.

Gardelli C, Wada H, Ray A, Caffrey M, Llinas A, Shamovsky I, Tholander J, Larsson J, Sivars U, Hultin L, Andersson U, Sanganee HJ, Stenvall K, Leidvik B, Gedda K, Jinton L, Rydén Landergren M, Karabelas K.

J Med Chem. 2018 Jul 26;61(14):5974-5987. doi: 10.1021/acs.jmedchem.8b00322. Epub 2018 Jul 6.

PMID:
29909635
6.

Theoretical studies of the second step of the nitric oxide synthase reaction: Electron tunneling prevents uncoupling.

Shamovsky I, Belfield G, Lewis R, Narjes F, Ripa L, Tyrchan C, Öberg L, Sjö P.

J Inorg Biochem. 2018 Apr;181:28-40. doi: 10.1016/j.jinorgbio.2018.01.009. Epub 2018 Jan 10.

PMID:
29407906
7.

Mechanism of biofilm-mediated stress resistance and lifespan extension in C. elegans.

Smolentseva O, Gusarov I, Gautier L, Shamovsky I, DeFrancesco AS, Losick R, Nudler E.

Sci Rep. 2017 Aug 2;7(1):7137. doi: 10.1038/s41598-017-07222-8.

8.

Glycogen controls Caenorhabditis elegans lifespan and resistance to oxidative stress.

Gusarov I, Pani B, Gautier L, Smolentseva O, Eremina S, Shamovsky I, Katkova-Zhukotskaya O, Mironov A, Nudler E.

Nat Commun. 2017 Jun 19;8:15868. doi: 10.1038/ncomms15868.

9.

sRNA-Mediated Control of Transcription Termination in E. coli.

Sedlyarova N, Shamovsky I, Bharati BK, Epshtein V, Chen J, Gottesman S, Schroeder R, Nudler E.

Cell. 2016 Sep 22;167(1):111-121.e13. doi: 10.1016/j.cell.2016.09.004.

10.

Rates and mechanisms of bacterial mutagenesis from maximum-depth sequencing.

Jee J, Rasouly A, Shamovsky I, Akivis Y, Steinman SR, Mishra B, Nudler E.

Nature. 2016 Jun 30;534(7609):693-6. Epub 2016 Jun 22.

11.

The discovery of a selective and potent A2a agonist with extended lung retention.

Åstrand AB, Lamm Bergström E, Zhang H, Börjesson L, Söderdahl T, Wingren C, Jansson AH, Smailagic A, Johansson C, Bladh H, Shamovsky I, Tunek A, Drmota T.

Pharmacol Res Perspect. 2015 Jun;3(3):e00134. doi: 10.1002/prp2.134. Epub 2015 May 4.

12.

Theoretical studies of the mechanism of N-hydroxylation of primary aromatic amines by cytochrome P450 1A2: radicaloid or anionic?

Ripa L, Mee C, Sjö P, Shamovsky I.

Chem Res Toxicol. 2014 Feb 17;27(2):265-78. doi: 10.1021/tx400376u. Epub 2014 Jan 24.

PMID:
24410629
13.

Bacterial nitric oxide extends the lifespan of C. elegans.

Gusarov I, Gautier L, Smolentseva O, Shamovsky I, Eremina S, Mironov A, Nudler E.

Cell. 2013 Feb 14;152(4):818-30. doi: 10.1016/j.cell.2012.12.043.

14.

Theoretical studies of chemical reactivity of metabolically activated forms of aromatic amines toward DNA.

Shamovsky I, Ripa L, Blomberg N, Eriksson LA, Hansen P, Mee C, Tyrchan C, O'Donovan M, Sjö P.

Chem Res Toxicol. 2012 Oct 15;25(10):2236-52. doi: 10.1021/tx300313b. Epub 2012 Sep 20.

PMID:
22946514
15.

Explanation for main features of structure-genotoxicity relationships of aromatic amines by theoretical studies of their activation pathways in CYP1A2.

Shamovsky I, Ripa L, Börjesson L, Mee C, Nordén B, Hansen P, Hasselgren C, O'Donovan M, Sjö P.

J Am Chem Soc. 2011 Oct 12;133(40):16168-85. doi: 10.1021/ja206427u. Epub 2011 Sep 21.

PMID:
21894985
16.

Increasing selectivity of CC chemokine receptor 8 antagonists by engineering nondesolvation related interactions with the intended and off-target binding sites.

Shamovsky I, de Graaf C, Alderin L, Bengtsson M, Bladh H, Börjesson L, Connolly S, Dyke HJ, van den Heuvel M, Johansson H, Josefsson BG, Kristoffersson A, Linnanen T, Lisius A, Männikkö R, Nordén B, Price S, Ripa L, Rognan D, Rosendahl A, Skrinjar M, Urbahns K.

J Med Chem. 2009 Dec 10;52(23):7706-23. doi: 10.1021/jm900713y.

PMID:
19954248
17.

Targeting eEF1A by a Legionella pneumophila effector leads to inhibition of protein synthesis and induction of host stress response.

Shen X, Banga S, Liu Y, Xu L, Gao P, Shamovsky I, Nudler E, Luo ZQ.

Cell Microbiol. 2009 Jun;11(6):911-26. doi: 10.1111/j.1462-5822.2009.01301.x. Epub 2009 Feb 27.

18.

Isolation and characterization of the heat shock RNA 1.

Shamovsky I, Nudler E.

Methods Mol Biol. 2009;540:265-79. doi: 10.1007/978-1-59745-558-9_19.

19.

Modular RNA heats up.

Shamovsky I, Nudler E.

Mol Cell. 2008 Feb 29;29(4):415-7. doi: 10.1016/j.molcel.2008.02.001.

20.

Overcoming undesirable HERG potency of chemokine receptor antagonists using baseline lipophilicity relationships.

Shamovsky I, Connolly S, David L, Ivanova S, Nordén B, Springthorpe B, Urbahns K.

J Med Chem. 2008 Mar 13;51(5):1162-78. doi: 10.1021/jm070543k. Epub 2008 Feb 8.

PMID:
18257512
21.

New insights into the mechanism of heat shock response activation.

Shamovsky I, Nudler E.

Cell Mol Life Sci. 2008 Mar;65(6):855-61. doi: 10.1007/s00018-008-7458-y. Review.

PMID:
18239856
22.

Gene control by large noncoding RNAs.

Shamovsky I, Nudler E.

Sci STKE. 2006 Oct 3;2006(355):pe40. Review.

PMID:
17018852
23.

RNA-mediated response to heat shock in mammalian cells.

Shamovsky I, Ivannikov M, Kandel ES, Gershon D, Nudler E.

Nature. 2006 Mar 23;440(7083):556-60.

PMID:
16554823
26.

The binding of zinc and copper ions to nerve growth factor is differentially affected by pH: implications for cerebral acidosis.

Ross GM, Shamovsky IL, Woo SB, Post JI, Vrkljan PN, Lawrance G, Solc M, Dostaler SM, Neet KE, Riopelle RJ.

J Neurochem. 2001 Aug;78(3):515-23.

27.

Zinc inhibits p75NTR-mediated apoptosis in chick neural retina.

Allington C, Shamovsky IL, Ross GM, Riopelle RJ.

Cell Death Differ. 2001 May;8(5):451-6.

28.

The interaction of neurotrophins with the p75NTR common neurotrophin receptor: a comprehensive molecular modeling study.

Shamovsky IL, Ross GM, Riopelle RJ, Weaver DF.

Protein Sci. 1999 Nov;8(11):2223-33. Erratum in: Protein Sci 2000 Mar;9(3):623.

29.

Reciprocal modulation of TrkA and p75NTR affinity states is mediated by direct receptor interactions.

Ross GM, Shamovsky IL, Lawrance G, Solc M, Dostaler SM, Weaver DF, Riopelle RJ.

Eur J Neurosci. 1998 Mar;10(3):890-8.

PMID:
9753156
30.

Zinc alters conformation and inhibits biological activities of nerve growth factor and related neurotrophins.

Ross GM, Shamovsky IL, Lawrance G, Solc M, Dostaler SM, Jimmo SL, Weaver DF, Riopelle RJ.

Nat Med. 1997 Aug;3(8):872-8.

PMID:
9256278
31.
32.

Electronic correlation effects in a fullerene molecule studied by the variational Monte Carlo method.

Krivnov VY, Shamovsky IL, Tornau EE, Rosengren A.

Phys Rev B Condens Matter. 1994 Oct 15;50(16):12144-12151. No abstract available.

PMID:
9975356
33.

Structural basis of steroid compounds interaction with "digitalis"-receptor sites of Na,K-dependent ATPase.

Kamernitzky AV, Reshetova IG, Ovchinnikov AA, Shamovsky IL, Massova IA, Mirsalikhova NM.

J Steroid Biochem. 1989 Jun;32(6):857-63.

PMID:
2547115

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