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Items: 44

1.

TnI Structural Interface with the N-Terminal Lobe of TnC as a Determinant of Cardiac Contractility.

Vetter AD, Houang EM, Sell JJ, Thompson BR, Sham YY, Metzger JM.

Biophys J. 2018 Apr 10;114(7):1646-1656. doi: 10.1016/j.bpj.2018.02.015.

PMID:
29642034
2.

Can 5-methylcytosine analogues with extended alkyl side chains guide DNA methylation?

Kotandeniya D, Seiler CL, Fernandez J, Pujari SS, Curwick L, Murphy K, Wickramaratne S, Yan S, Murphy D, Sham YY, Tretyakova NY.

Chem Commun (Camb). 2018 Jan 25;54(9):1061-1064. doi: 10.1039/c7cc06867k.

PMID:
29323674
3.

All-Atom Molecular Dynamics-Based Analysis of Membrane-Stabilizing Copolymer Interactions with Lipid Bilayers Probed under Constant Surface Tensions.

Houang EM, Bates FS, Sham YY, Metzger JM.

J Phys Chem B. 2017 Nov 30;121(47):10657-10664. doi: 10.1021/acs.jpcb.7b08938. Epub 2017 Nov 20.

PMID:
29049887
4.

Chemical End Group Modified Diblock Copolymers Elucidate Anchor and Chain Mechanism of Membrane Stabilization.

Houang EM, Haman KJ, Kim M, Zhang W, Lowe DA, Sham YY, Lodge TP, Hackel BJ, Bates FS, Metzger JM.

Mol Pharm. 2017 Jul 3;14(7):2333-2339. doi: 10.1021/acs.molpharmaceut.7b00197. Epub 2017 Jun 12.

5.

Discovery of 1-Hydroxypyridine-2(1H)-thione-6-carboxylic Acid as a First-in-Class Low-Cytotoxic Nanomolar Metallo β-Lactamase Inhibitor.

Shin WS, Bergstrom A, Bonomo RA, Crowder MW, Muthyala R, Sham YY.

ChemMedChem. 2017 Jun 7;12(11):845-849. doi: 10.1002/cmdc.201700182. Epub 2017 May 22.

6.

The Stories Tryptophans Tell: Exploring Protein Dynamics of Heptosyltransferase I from Escherichia coli.

Cote JM, Ramirez-Mondragon CA, Siegel ZS, Czyzyk DJ, Gao J, Sham YY, Mukerji I, Taylor EA.

Biochemistry. 2017 Feb 14;56(6):886-895. doi: 10.1021/acs.biochem.6b00850. Epub 2017 Jan 30.

7.

Bypass of DNA-Protein Cross-links Conjugated to the 7-Deazaguanine Position of DNA by Translesion Synthesis Polymerases.

Wickramaratne S, Ji S, Mukherjee S, Su Y, Pence MG, Lior-Hoffmann L, Fu I, Broyde S, Guengerich FP, Distefano M, Schärer OD, Sham YY, Tretyakova N.

J Biol Chem. 2016 Nov 4;291(45):23589-23603. Epub 2016 Sep 12.

8.

Inhibition of Inflammatory and Neuropathic Pain by Targeting a Mu Opioid Receptor/Chemokine Receptor5 Heteromer (MOR-CCR5).

Akgün E, Javed MI, Lunzer MM, Powers MD, Sham YY, Watanabe Y, Portoghese PS.

J Med Chem. 2015 Nov 12;58(21):8647-57. doi: 10.1021/acs.jmedchem.5b01245. Epub 2015 Oct 20.

9.

Discovery of 1-hydroxypyridine-2-thiones as selective histone deacetylase inhibitors and their potential application for treating leukemia.

Muthyala R, Shin WS, Xie J, Sham YY.

Bioorg Med Chem Lett. 2015 Oct 1;25(19):4320-4. doi: 10.1016/j.bmcl.2015.07.065. Epub 2015 Jul 26.

PMID:
26264503
10.

A novel drug discovery strategy: mechanistic investigation of an enantiomeric antitumor agent targeting dual p53 and NF-κB pathways.

Zhuang C, Sheng C, Shin WS, Wu Y, Li J, Yao J, Dong G, Zhang W, Sham YY, Miao Z, Zhang W.

Oncotarget. 2014 Nov 15;5(21):10830-9.

11.

Molecular determinants of cardiac myocyte performance as conferred by isoform-specific TnI residues.

Thompson BR, Houang EM, Sham YY, Metzger JM.

Biophys J. 2014 May 20;106(10):2105-14. doi: 10.1016/j.bpj.2014.04.017.

12.

Cell permeable vanX inhibitors as vancomycin re-sensitizing agents.

Muthyala R, Rastogi N, Shin WS, Peterson ML, Sham YY.

Bioorg Med Chem Lett. 2014 Jun 1;24(11):2535-8. doi: 10.1016/j.bmcl.2014.03.097. Epub 2014 Apr 8.

PMID:
24751446
13.

Rapid identification of Keap1-Nrf2 small-molecule inhibitors through structure-based virtual screening and hit-based substructure search.

Zhuang C, Narayanapillai S, Zhang W, Sham YY, Xing C.

J Med Chem. 2014 Feb 13;57(3):1121-6. doi: 10.1021/jm4017174. Epub 2014 Jan 17.

PMID:
24417449
14.

Mutations in the amino terminus of herpes simplex virus type 1 gL can reduce cell-cell fusion without affecting gH/gL trafficking.

Zhou W, Chen F, Klyachkin Y, Sham YY, Geraghty RJ.

J Virol. 2014 Jan;88(1):739-44. doi: 10.1128/JVI.02383-13. Epub 2013 Oct 23.

15.

Structure and stability of human telomeric G-quadruplex with preclinical 9-amino acridines.

Ferreira R, Artali R, Benoit A, Gargallo R, Eritja R, Ferguson DM, Sham YY, Mazzini S.

PLoS One. 2013;8(3):e57701. doi: 10.1371/journal.pone.0057701. Epub 2013 Mar 15. Erratum in: PLoS One. 2013;8(12). doi:10.1371/annotation/e49600ba-2cfa-45c6-9984-2b337ad73add.

16.

5-Arylidenethioxothiazolidinones as inhibitors of tyrosyl-DNA phosphodiesterase I.

Sirivolu VR, Vernekar SK, Marchand C, Naumova A, Chergui A, Renaud A, Stephen AG, Chen F, Sham YY, Pommier Y, Wang Z.

J Med Chem. 2012 Oct 25;55(20):8671-84. doi: 10.1021/jm3008773. Epub 2012 Oct 8.

PMID:
23006064
17.

pH-responsive titratable inotropic performance of histidine-modified cardiac troponin I.

Palpant NJ, Houang EM, Sham YY, Metzger JM.

Biophys J. 2012 Apr 4;102(7):1570-9. doi: 10.1016/j.bpj.2012.01.024. Epub 2012 Apr 3.

18.

The design, synthesis and biological evaluations of C-6 or C-7 substituted 2-hydroxyisoquinoline-1,3-diones as inhibitors of hepatitis C virus.

Chen YL, Tang J, Kesler MJ, Sham YY, Vince R, Geraghty RJ, Wang Z.

Bioorg Med Chem. 2012 Jan 1;20(1):467-79. doi: 10.1016/j.bmc.2011.10.058. Epub 2011 Oct 24.

PMID:
22100256
19.

pH-Dependent transport of pemetrexed by breast cancer resistance protein.

Li L, Sham YY, Bikadi Z, Elmquist WF.

Drug Metab Dispos. 2011 Sep;39(9):1478-85. doi: 10.1124/dmd.111.039370. Epub 2011 May 31.

20.

A continuous fluorescence displacement assay for BioA: an enzyme involved in biotin biosynthesis.

Wilson DJ, Shi C, Duckworth BP, Muretta JM, Manjunatha U, Sham YY, Thomas DD, Aldrich CC.

Anal Biochem. 2011 Sep 1;416(1):27-38. doi: 10.1016/j.ab.2011.05.003. Epub 2011 May 8.

21.

N-3 Hydroxylation of Pyrimidine-2,4-diones Yields Dual Inhibitors of HIV Reverse Transcriptase and Integrase.

Tang J, Maddali K, Dreis CD, Sham YY, Vince R, Pommier Y, Wang Z.

ACS Med Chem Lett. 2011 Jan;2(1):63-67.

22.

6-Benzoyl-3-hydroxypyrimidine-2,4-diones as dual inhibitors of HIV reverse transcriptase and integrase.

Tang J, Maddali K, Dreis CD, Sham YY, Vince R, Pommier Y, Wang Z.

Bioorg Med Chem Lett. 2011 Apr 15;21(8):2400-2. doi: 10.1016/j.bmcl.2011.02.069. Epub 2011 Feb 18.

23.

3-Hydroxypyrimidine-2,4-diones as an inhibitor scaffold of HIV integrase.

Tang J, Maddali K, Metifiot M, Sham YY, Vince R, Pommier Y, Wang Z.

J Med Chem. 2011 Apr 14;54(7):2282-92. doi: 10.1021/jm1014378. Epub 2011 Mar 7.

24.

Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylase based on a cinnamic hydroxamic acid core structure.

Chen L, Petrelli R, Gao G, Wilson DJ, McLean GT, Jayaram HN, Sham YY, Pankiewicz KW.

Bioorg Med Chem. 2010 Aug 15;18(16):5950-64. doi: 10.1016/j.bmc.2010.06.081. Epub 2010 Jul 1.

PMID:
20650640
25.

Triazole-linked inhibitors of inosine monophosphate dehydrogenase from human and Mycobacterium tuberculosis.

Chen L, Wilson DJ, Xu Y, Aldrich CC, Felczak K, Sham YY, Pankiewicz KW.

J Med Chem. 2010 Jun 24;53(12):4768-78. doi: 10.1021/jm100424m.

26.

Scaffold rearrangement of dihydroxypyrimidine inhibitors of HIV integrase: Docking model revisited.

Tang J, Maddali K, Pommier Y, Sham YY, Wang Z.

Bioorg Med Chem Lett. 2010 Jun 1;20(11):3275-9. doi: 10.1016/j.bmcl.2010.04.048. Epub 2010 Apr 21.

PMID:
20457521
27.

Pathogenic peptide deviations support a model of adaptive evolution of chordate cardiac performance by troponin mutations.

Palpant NJ, Houang EM, Delport W, Hastings KE, Onufriev AV, Sham YY, Metzger JM.

Physiol Genomics. 2010 Jul 7;42(2):287-99. doi: 10.1152/physiolgenomics.00033.2010. Epub 2010 Apr 27.

28.

Design, asymmetric synthesis, and evaluation of pseudosymmetric sulfoximine inhibitors against HIV-1 protease.

Lu D, Sham YY, Vince R.

Bioorg Med Chem. 2010 Mar 1;18(5):2037-48. doi: 10.1016/j.bmc.2010.01.020. Epub 2010 Jan 21.

PMID:
20138769
29.

Selective inhibition of nicotinamide adenine dinucleotide kinases by dinucleoside disulfide mimics of nicotinamide adenine dinucleotide analogues.

Petrelli R, Sham YY, Chen L, Felczak K, Bennett E, Wilson D, Aldrich C, Yu JS, Cappellacci L, Franchetti P, Grifantini M, Mazzola F, Di Stefano M, Magni G, Pankiewicz KW.

Bioorg Med Chem. 2009 Aug 1;17(15):5656-64. doi: 10.1016/j.bmc.2009.06.013. Epub 2009 Jun 13.

PMID:
19596199
30.

Shared catalysis in virus entry and bacterial cell wall depolymerization.

Cohen DN, Sham YY, Haugstad GD, Xiang Y, Rossmann MG, Anderson DL, Popham DL.

J Mol Biol. 2009 Apr 3;387(3):607-18. doi: 10.1016/j.jmb.2009.02.001. Epub 2009 Feb 9.

31.

Design and synthesis of sulfoximine based inhibitors for HIV-1 protease.

Raza A, Sham YY, Vince R.

Bioorg Med Chem Lett. 2008 Oct 15;18(20):5406-10. doi: 10.1016/j.bmcl.2008.09.044. Epub 2008 Sep 13.

PMID:
18829317
32.

Impact of the C-terminal loop of histidine triad nucleotide binding protein1 (Hint1) on substrate specificity.

Chou TF, Sham YY, Wagner CR.

Biochemistry. 2007 Nov 13;46(45):13074-9. Epub 2007 Oct 16.

PMID:
17939685
33.

Development of selective inhibitors for anti-apoptotic Bcl-2 proteins from BHI-1.

Xing C, Wang L, Tang X, Sham YY.

Bioorg Med Chem. 2007 Mar 1;15(5):2167-76. Epub 2006 Dec 14.

34.
35.

Amiodarone analog-dependent effects on CYP2C9-mediated metabolism and kinetic profiles.

Kumar V, Locuson CW, Sham YY, Tracy TS.

Drug Metab Dispos. 2006 Oct;34(10):1688-96. Epub 2006 Jun 30.

36.

Homology modeling and molecular dynamics simulations of the mu opioid receptor in a membrane-aqueous system.

Zhang Y, Sham YY, Rajamani R, Gao J, Portoghese PS.

Chembiochem. 2005 May;6(5):853-9.

PMID:
15776407
38.

Structured disorder and conformational selection.

Tsai CJ, Ma B, Sham YY, Kumar S, Nussinov R.

Proteins. 2001 Sep 1;44(4):418-27. Review.

PMID:
11484219
39.

Protein folding and function: the N-terminal fragment in adenylate kinase.

Kumar S, Sham YY, Tsai CJ, Nussinov R.

Biophys J. 2001 May;80(5):2439-54.

41.

How important are entropic contributions to enzyme catalysis?

Villa J, Strajbl M, Glennon TM, Sham YY, Chu ZT, Warshel A.

Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):11899-904.

43.
44.

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