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Items: 39


Bufalin, a Traditional Chinese Medicine Compound, Prevents Tumor Formation in Two Murine Models of Colorectal Cancer.

Sun X, Ng TTH, Sham KWY, Zhang L, Chan MTV, Wu WKK, Cheng CHK.

Cancer Prev Res (Phila). 2019 Oct;12(10):653-666. doi: 10.1158/1940-6207.CAPR-19-0134. Epub 2019 Aug 20.


Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species.

Foti RS, Biswas K, Aral J, Be X, Berry L, Cheng Y, Conner K, Falsey JR, Glaus C, Herberich B, Hickman D, Ikotun T, Li H, Long J, Huang L, Miranda LP, Murray J, Moyer B, Netirojjanakul C, Nixey TE, Sham K, Soto M, Tegley CM, Tran L, Wu B, Yin L, Rock DA.

Drug Metab Dispos. 2019 Oct;47(10):1111-1121. doi: 10.1124/dmd.119.087742. Epub 2019 Aug 6.


Eukaryotic elongation factor-2 kinase expression is an independent prognostic factor in colorectal cancer.

Ng TH, Sham KWY, Xie CM, Ng SSM, To KF, Tong JHM, Liu WYZ, Zhang L, Chan MTV, Wu WKK, Cheng CHK.

BMC Cancer. 2019 Jul 2;19(1):649. doi: 10.1186/s12885-019-5873-0.


Activation of PTEN by inhibition of TRPV4 suppresses colon cancer development.

Liu X, Zhang P, Xie C, Sham KWY, Ng SSM, Chen Y, Cheng CHK.

Cell Death Dis. 2019 Jun 12;10(6):460. doi: 10.1038/s41419-019-1700-4.


Plasma and Liver Protein Binding of N-Acetylgalactosamine-Conjugated Small Interfering RNA.

Humphreys SC, Thayer MB, Lade JM, Wu B, Sham K, Basiri B, Hao Y, Huang X, Smith R, Rock BM.

Drug Metab Dispos. 2019 Oct;47(10):1174-1182. doi: 10.1124/dmd.119.086967. Epub 2019 May 16.


Engineering NaV1.7 Inhibitory JzTx-V Peptides with a Potency and Basicity Profile Suitable for Antibody Conjugation To Enhance Pharmacokinetics.

Murray JK, Wu B, Tegley CM, Nixey TE, Falsey JR, Herberich B, Yin L, Sham K, Long J, Aral J, Cheng Y, Netirojjanakul C, Doherty L, Glaus C, Ikotun T, Li H, Tran L, Soto M, Salimi-Moosavi H, Ligutti J, Amagasu S, Andrews KL, Be X, Lin MJ, Foti RS, Ilch CP, Youngblood B, Kornecook TJ, Karow M, Walker KW, Moyer BD, Biswas K, Miranda LP.

ACS Chem Biol. 2019 Apr 19;14(4):806-818. doi: 10.1021/acschembio.9b00183. Epub 2019 Mar 27.


Developmental protein kinase C hyper-activation results in microcephaly and behavioral abnormalities in zebrafish.

Liu T, Shi Y, Chan MTV, Peng G, Zhang Q, Sun X, Zhu Z, Xie Y, Sham KWY, Li J, Liu X, Ho IHT, Gin T, Lu Z, Wu WKK, Cheng CHK.

Transl Psychiatry. 2018 Oct 23;8(1):232. doi: 10.1038/s41398-018-0285-5.


Discovery of Tarantula Venom-Derived NaV1.7-Inhibitory JzTx-V Peptide 5-Br-Trp24 Analogue AM-6120 with Systemic Block of Histamine-Induced Pruritis.

Wu B, Murray JK, Andrews KL, Sham K, Long J, Aral J, Ligutti J, Amagasu S, Liu D, Zou A, Min X, Wang Z, Ilch CP, Kornecook TJ, Lin MJ, Be X, Miranda LP, Moyer BD, Biswas K.

J Med Chem. 2018 Nov 8;61(21):9500-9512. doi: 10.1021/acs.jmedchem.8b00736. Epub 2018 Oct 22.


Myelo-lymphoid lineage restriction occurs in the human haematopoietic stem cell compartment before lymphoid-primed multipotent progenitors.

Belluschi S, Calderbank EF, Ciaurro V, Pijuan-Sala B, Santoro A, Mende N, Diamanti E, Sham KYC, Wang X, Lau WWY, Jawaid W, Göttgens B, Laurenti E.

Nat Commun. 2018 Oct 5;9(1):4100. doi: 10.1038/s41467-018-06442-4.


Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V.

Moyer BD, Murray JK, Ligutti J, Andrews K, Favreau P, Jordan JB, Lee JH, Liu D, Long J, Sham K, Shi L, Stöcklin R, Wu B, Yin R, Yu V, Zou A, Biswas K, Miranda LP.

PLoS One. 2018 May 3;13(5):e0196791. doi: 10.1371/journal.pone.0196791. eCollection 2018.


The highly overlapping actions of Lh signaling and Fsh signaling on zebrafish spermatogenesis.

Xie Y, Chu L, Liu Y, Sham KWY, Li J, Cheng CHK.

J Endocrinol. 2017 Sep;234(3):233-246. doi: 10.1530/JOE-17-0079. Epub 2017 Jun 13.


M8L12 cubic cages with all facial Δ or facial Λ configuration: effects of surface anions on the occupancy of the cage and anion exchange.

Yang J, Chang XY, Sham KC, Yiu SM, Kwong HL, Che CM.

Chem Commun (Camb). 2016 May 1;52(35):5981-4. doi: 10.1039/c6cc01635a. Epub 2016 Apr 11.


Evaluation of biocompatible alginate- and deferoxamine-coated ternary composites for magnetic resonance imaging and gene delivery into glioblastoma cells.

Leung KC, Sham KW, Chak CP, Lai JM, Lee SF, Wáng YX, Cheng CH.

Quant Imaging Med Surg. 2015 Jun;5(3):382-91. doi: 10.3978/j.issn.2223-4292.2015.03.12.


Silencing of EEF2K (eukaryotic elongation factor-2 kinase) reveals AMPK-ULK1-dependent autophagy in colon cancer cells.

Xie CM, Liu XY, Sham KW, Lai JM, Cheng CH.

Autophagy. 2014 Sep;10(9):1495-508. doi: 10.4161/auto.29164. Epub 2014 Jun 19.


Ternary hybrid nanocomposites for gene delivery and magnetic resonance imaging of hepatocellular carcinoma cells.

Leung KC, Wong CH, Zhu XM, Lee SF, Sham KW, Lai JM, Chak CP, Wang YX, Cheng CH.

Quant Imaging Med Surg. 2013 Dec;3(6):302-7. doi: 10.3978/j.issn.2223-4292.2013.12.05.


The optimization of aminooxadiazoles as orally active inhibitors of Cdc7.

Harrington PE, Bourbeau MP, Fotsch C, Frohn M, Pickrell AJ, Reichelt A, Sham K, Siegmund AC, Bailis JM, Bush T, Escobar S, Hickman D, Heller S, Hsieh F, Orf JN, Rong M, San Miguel T, Tan H, Zalameda L, Allen JG.

Bioorg Med Chem Lett. 2013 Dec 1;23(23):6396-400. doi: 10.1016/j.bmcl.2013.09.055. Epub 2013 Sep 25.


GPER mediates the inhibitory actions of estrogen on adipogenesis in 3T3-L1 cells through perturbation of mitotic clonal expansion.

Zhu P, Yuen JM, Sham KW, Cheng CH.

Gen Comp Endocrinol. 2013 Nov 1;193:19-26. doi: 10.1016/j.ygcen.2013.07.004. Epub 2013 Jul 18.


Nanoparticle-DNA-polymer composites for hepatocellular carcinoma cell labeling, sensing, and magnetic resonance imaging.

Leung KC, Lee SF, Wong CH, Chak CP, Lai JM, Zhu XM, Wang YX, Sham KW, Cheng CH.

Methods. 2013 Dec 15;64(3):315-21. doi: 10.1016/j.ymeth.2013.06.006. Epub 2013 Jun 27.


Increased efficacies in magnetofection and gene delivery to hepatocellular carcinoma cells with ternary organic-inorganic hybrid nanocomposites.

Leung KC, Chak CP, Lee SF, Lai JM, Zhu XM, Wang YX, Sham KW, Wong CH, Cheng CH.

Chem Asian J. 2013 Aug;8(8):1760-4. doi: 10.1002/asia.201300202. Epub 2013 May 31. No abstract available.


Regulation of the two kiss promoters in goldfish (Carassius auratus) by estrogen via different ERα pathways.

Wang Q, Sham KW, Ogawa S, Li S, Parhar IS, Cheng CH, Liu X, Lin H.

Mol Cell Endocrinol. 2013 Aug 15;375(1-2):130-9. doi: 10.1016/j.mce.2013.04.023. Epub 2013 May 20.


1,4-dihydroxy-2-naphthoic Acid Induces Apoptosis in Human Keratinocyte: Potential Application for Psoriasis Treatment.

Mok CF, Xie CM, Sham KW, Lin ZX, Cheng CH.

Evid Based Complement Alternat Med. 2013;2013:792840. doi: 10.1155/2013/792840. Epub 2013 Apr 11.


Dodecanuclear hexagonal-prismatic M12L18 coordination cages by subcomponent self-assembly.

Sham KC, Yiu SM, Kwong HL.

Inorg Chem. 2013 May 20;52(10):5648-50. doi: 10.1021/ic400665m. Epub 2013 May 7.


G-protein-coupled estrogen receptor 1 is involved in brain development during zebrafish (Danio rerio) embryogenesis.

Shi Y, Liu X, Zhu P, Li J, Sham KW, Cheng SH, Li S, Zhang Y, Cheng CH, Lin H.

Biochem Biophys Res Commun. 2013 May 24;435(1):21-7. doi: 10.1016/j.bbrc.2013.03.130. Epub 2013 Apr 11.


Enhanced cellular uptake and gene delivery of glioblastoma with deferoxamine-coated nanoparticle/plasmid DNA/branched polyethylenimine composites.

Leung KC, Chak CP, Lee SF, Lai JM, Zhu XM, Wang YX, Sham KW, Cheng CH.

Chem Commun (Camb). 2013 Jan 21;49(6):549-51. doi: 10.1039/c2cc36663k. Epub 2012 Nov 28.


Hollow superparamagnetic iron oxide nanoshells as a hydrophobic anticancer drug carrier: intracelluar pH-dependent drug release and enhanced cytotoxicity.

Zhu XM, Yuan J, Leung KC, Lee SF, Sham KW, Cheng CH, Au DW, Teng GJ, Ahuja AT, Wang YX.

Nanoscale. 2012 Sep 21;4(18):5744-54. doi: 10.1039/c2nr30960b. Epub 2012 Aug 16.


Photocytotoxicity and magnetic relaxivity responses of dual-porous γ-Fe2O3@meso-SiO2 microspheres.

Xuan SH, Lee SF, Lau JT, Zhu X, Wang YX, Wang F, Lai JM, Sham KW, Lo PC, Yu JC, Cheng CH, Leung KC.

ACS Appl Mater Interfaces. 2012 Apr;4(4):2033-40. doi: 10.1021/am300008x. Epub 2012 Mar 21.


Isoform-selective thiazolo[5,4-b]pyridine S1P1 agonists possessing acyclic amino carboxylate head-groups.

Reed AB, Lanman BA, Neira S, Harrington PE, Sham KK, Frohn M, Pickrell AJ, Tasker AS, Gore A, Fiorino M, Itano A, McElvain M, Middleton S, Morrison H, Xu H, Xu Y, Wong M, Cee VJ.

Bioorg Med Chem Lett. 2012 Feb 15;22(4):1779-83. doi: 10.1016/j.bmcl.2011.12.073. Epub 2011 Dec 21.


Optimization of a Potent, Orally Active S1P1 Agonist Containing a Quinolinone Core.

Harrington PE, Croghan MD, Fotsch C, Frohn M, Lanman BA, Pennington LD, Pickrell AJ, Reed AB, Sham KK, Tasker A, Arnett HA, Fiorino M, Lee MR, McElvain M, Morrison HG, Xu H, Xu Y, Zhang X, Wong M, Cee VJ.

ACS Med Chem Lett. 2011 Nov 23;3(1):74-8. doi: 10.1021/ml200252b. eCollection 2012 Jan 12.


Quinolinone-based agonists of S1P₁: use of a N-scan SAR strategy to optimize in vitro and in vivo activity.

Pennington LD, Croghan MD, Sham KK, Pickrell AJ, Harrington PE, Frohn MJ, Lanman BA, Reed AB, Lee MR, Xu H, McElvain M, Xu Y, Zhang X, Fiorino M, Horner M, Morrison HG, Arnett HA, Fotsch C, Tasker AS, Wong M, Cee VJ.

Bioorg Med Chem Lett. 2012 Jan 1;22(1):527-31. doi: 10.1016/j.bmcl.2011.10.085. Epub 2011 Nov 4.


Metallo-macrocycles with labile coordination sites through self assembly: binuclear phenyl bridged bisbipyridine manganese complexes.

Sham KC, Zheng G, Li Y, Yiu SM, Kwong HL.

Dalton Trans. 2011 Dec 7;40(45):12060-2. doi: 10.1039/c1dt11589h. Epub 2011 Oct 13.


4-Methoxy-N-[2-(trifluoromethyl)biphenyl-4-ylcarbamoyl]nicotinamide: A Potent and Selective Agonist of S1P1.

Pennington LD, Sham KK, Pickrell AJ, Harrington PE, Frohn MJ, Lanman BA, Reed AB, Croghan MD, Lee MR, Xu H, McElvain M, Xu Y, Zhang X, Fiorino M, Horner M, Morrison HG, Arnett HA, Fotsch C, Wong M, Cee VJ.

ACS Med Chem Lett. 2011 Jul 29;2(10):752-7. doi: 10.1021/ml2001399. eCollection 2011 Oct 13.


Synthesis of biocompatible, mesoporous Fe(3)O(4) nano/microspheres with large surface area for magnetic resonance imaging and therapeutic applications.

Xuan S, Wang F, Lai JM, Sham KW, Wang YX, Lee SF, Yu JC, Cheng CH, Leung KC.

ACS Appl Mater Interfaces. 2011 Feb;3(2):237-44. doi: 10.1021/am1012358. Epub 2011 Jan 13.


New binuclear double-stranded manganese helicates as catalysts for alkene epoxidation.

Sham KC, Yeung HL, Yiu SM, Lau TC, Kwong HL.

Dalton Trans. 2010 Oct 28;39(40):9469-71. doi: 10.1039/c0dt00953a. Epub 2010 Sep 7.


Identification of a membrane estrogen receptor in zebrafish with homology to mammalian GPER and its high expression in early germ cells of the testis.

Liu X, Zhu P, Sham KW, Yuen JM, Xie C, Zhang Y, Liu Y, Li S, Huang X, Cheng CH, Lin H.

Biol Reprod. 2009 Jun;80(6):1253-61. doi: 10.1095/biolreprod.108.070250. Epub 2009 Feb 18.


Discovery of highly selective and potent p38 inhibitors based on a phthalazine scaffold.

Herberich B, Cao GQ, Chakrabarti PP, Falsey JR, Pettus L, Rzasa RM, Reed AB, Reichelt A, Sham K, Thaman M, Wurz RP, Xu S, Zhang D, Hsieh F, Lee MR, Syed R, Li V, Grosfeld D, Plant MH, Henkle B, Sherman L, Middleton S, Wong LM, Tasker AS.

J Med Chem. 2008 Oct 23;51(20):6271-9. doi: 10.1021/jm8005417. Epub 2008 Sep 26.


3-amino-7-phthalazinylbenzoisoxazoles as a novel class of potent, selective, and orally available inhibitors of p38alpha mitogen-activated protein kinase.

Pettus LH, Xu S, Cao GQ, Chakrabarti PP, Rzasa RM, Sham K, Wurz RP, Zhang D, Middleton S, Henkle B, Plant MH, Saris CJ, Sherman L, Wong LM, Powers DA, Tudor Y, Yu V, Lee MR, Syed R, Hsieh F, Tasker AS.

J Med Chem. 2008 Oct 23;51(20):6280-92. doi: 10.1021/jm8005405. Epub 2008 Sep 26.


A chiral iron-sexipyridine complex as a catalyst for alkene epoxidation with hydrogen peroxide.

Yeung HL, Sham KC, Tsang CS, Lau TC, Kwong HL.

Chem Commun (Camb). 2008 Aug 28;(32):3801-3. doi: 10.1039/b804281k. Epub 2008 Jul 2.


First X-ray cocrystal structure of a bacterial FabH condensing enzyme and a small molecule inhibitor achieved using rational design and homology modeling.

Daines RA, Pendrak I, Sham K, Van Aller GS, Konstantinidis AK, Lonsdale JT, Janson CA, Qiu X, Brandt M, Khandekar SS, Silverman C, Head MS.

J Med Chem. 2003 Jan 2;46(1):5-8.


(E)-3-[6-[[(2,6-dichlorophenyl)thio]methyl]-3-(2-phenylethoxy)-2- pyridinyl]-2-propenoic acid: a high-affinity leukotriene B4 receptor antagonist with oral antiinflammatory activity.

Daines RA, Chambers PA, Foley JJ, Griswold DE, Kingsbury WD, Martin LD, Schmidt DB, Sham KK, Sarau HM.

J Med Chem. 1996 Sep 13;39(19):3837-41.


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