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Items: 24


Immune Stimulation Using a Gut Microbe-Based Immunotherapy Reduces Disease Pathology and Improves Barrier Function in Ulcerative Colitis.

Sham HP, Bazett M, Bosiljcic M, Yang H, Luk B, Law HT, Morampudi V, Yu HB, Pankovich J, Sutcliffe S, Bressler B, Marshall JK, Fedorak RN, Chen J, Jones M, Gunn H, Kalyan S, Vallance BA.

Front Immunol. 2018 Sep 27;9:2211. doi: 10.3389/fimmu.2018.02211. eCollection 2018.


15-epi-Lipoxin A4, Resolvin D2, and Resolvin D3 Induce NF-κB Regulators in Bacterial Pneumonia.

Sham HP, Walker KH, Abdulnour RE, Krishnamoorthy N, Douda DN, Norris PC, Barkas I, Benito-Figueroa S, Colby JK, Serhan CN, Levy BD.

J Immunol. 2018 Apr 15;200(8):2757-2766. doi: 10.4049/jimmunol.1602090. Epub 2018 Mar 9.


Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Protective for Injured Epithelia.

Colby JK, Abdulnour RE, Sham HP, Dalli J, Colas RA, Winkler JW, Hellmann J, Wong B, Cui Y, El-Chemaly S, Petasis NA, Spite M, Serhan CN, Levy BD.

Am J Pathol. 2016 Jul;186(7):1801-1813. doi: 10.1016/j.ajpath.2016.03.011. Epub 2016 May 10.


The goblet cell-derived mediator RELM-β drives spontaneous colitis in Muc2-deficient mice by promoting commensal microbial dysbiosis.

Morampudi V, Dalwadi U, Bhinder G, Sham HP, Gill SK, Chan J, Bergstrom KS, Huang T, Ma C, Jacobson K, Gibson DL, Vallance BA.

Mucosal Immunol. 2016 Sep;9(5):1218-33. doi: 10.1038/mi.2015.140. Epub 2016 Jan 27.


Aspirin-triggered resolvin D1 is produced during self-resolving gram-negative bacterial pneumonia and regulates host immune responses for the resolution of lung inflammation.

Abdulnour RE, Sham HP, Douda DN, Colas RA, Dalli J, Bai Y, Ai X, Serhan CN, Levy BD.

Mucosal Immunol. 2016 Sep;9(5):1278-87. doi: 10.1038/mi.2015.129. Epub 2015 Dec 9.


Goblet Cell Derived RELM-β Recruits CD4+ T Cells during Infectious Colitis to Promote Protective Intestinal Epithelial Cell Proliferation.

Bergstrom KS, Morampudi V, Chan JM, Bhinder G, Lau J, Yang H, Ma C, Huang T, Ryz N, Sham HP, Zarepour M, Zaph C, Artis D, Nair M, Vallance BA.

PLoS Pathog. 2015 Aug 18;11(8):e1005108. doi: 10.1371/journal.ppat.1005108. eCollection 2015 Aug.


Metalloprotease NleC suppresses host NF-κB/inflammatory responses by cleaving p65 and interfering with the p65/RPS3 interaction.

Hodgson A, Wier EM, Fu K, Sun X, Yu H, Zheng W, Sham HP, Johnson K, Bailey S, Vallance BA, Wan F.

PLoS Pathog. 2015 Mar 10;11(3):e1004705. doi: 10.1371/journal.ppat.1004705. eCollection 2015 Mar.


Noncanonical inflammasome activation of caspase-4/caspase-11 mediates epithelial defenses against enteric bacterial pathogens.

Knodler LA, Crowley SM, Sham HP, Yang H, Wrande M, Ma C, Ernst RK, Steele-Mortimer O, Celli J, Vallance BA.

Cell Host Microbe. 2014 Aug 13;16(2):249-256. doi: 10.1016/j.chom.2014.07.002.


A novel mouse model of Campylobacter jejuni gastroenteritis reveals key pro-inflammatory and tissue protective roles for Toll-like receptor signaling during infection.

Stahl M, Ries J, Vermeulen J, Yang H, Sham HP, Crowley SM, Badayeva Y, Turvey SE, Gaynor EC, Li X, Vallance BA.

PLoS Pathog. 2014 Jul 17;10(7):e1004264. doi: 10.1371/journal.ppat.1004264. eCollection 2014 Jul.


Intestinal epithelium-specific MyD88 signaling impacts host susceptibility to infectious colitis by promoting protective goblet cell and antimicrobial responses.

Bhinder G, Stahl M, Sham HP, Crowley SM, Morampudi V, Dalwadi U, Ma C, Jacobson K, Vallance BA.

Infect Immun. 2014 Sep;82(9):3753-63. doi: 10.1128/IAI.02045-14. Epub 2014 Jun 23.


DNBS/TNBS colitis models: providing insights into inflammatory bowel disease and effects of dietary fat.

Morampudi V, Bhinder G, Wu X, Dai C, Sham HP, Vallance BA, Jacobson K.

J Vis Exp. 2014 Feb 27;(84):e51297. doi: 10.3791/51297.


CD4+ T cells drive goblet cell depletion during Citrobacter rodentium infection.

Chan JM, Bhinder G, Sham HP, Ryz N, Huang T, Bergstrom KS, Vallance BA.

Infect Immun. 2013 Dec;81(12):4649-58. doi: 10.1128/IAI.00655-13. Epub 2013 Oct 7.


SIGIRR, a negative regulator of TLR/IL-1R signalling promotes Microbiota dependent resistance to colonization by enteric bacterial pathogens.

Sham HP, Yu EY, Gulen MF, Bhinder G, Stahl M, Chan JM, Brewster L, Morampudi V, Gibson DL, Hughes MR, McNagny KM, Li X, Vallance BA.

PLoS Pathog. 2013;9(8):e1003539. doi: 10.1371/journal.ppat.1003539. Epub 2013 Aug 8.


The Citrobacter rodentium mouse model: studying pathogen and host contributions to infectious colitis.

Bhinder G, Sham HP, Chan JM, Morampudi V, Jacobson K, Vallance BA.

J Vis Exp. 2013 Feb 19;(72):e50222. doi: 10.3791/50222.


Active vitamin D (1,25-dihydroxyvitamin D3) increases host susceptibility to Citrobacter rodentium by suppressing mucosal Th17 responses.

Ryz NR, Patterson SJ, Zhang Y, Ma C, Huang T, Bhinder G, Wu X, Chan J, Glesby A, Sham HP, Dutz JP, Levings MK, Jacobson K, Vallance BA.

Am J Physiol Gastrointest Liver Physiol. 2012 Dec 15;303(12):G1299-311. doi: 10.1152/ajpgi.00320.2012. Epub 2012 Sep 27.


Regulated virulence controls the ability of a pathogen to compete with the gut microbiota.

Kamada N, Kim YG, Sham HP, Vallance BA, Puente JL, Martens EC, Núñez G.

Science. 2012 Jun 8;336(6086):1325-9. doi: 10.1126/science.1222195. Epub 2012 May 10.


Innate host responses to enteric bacterial pathogens: a balancing act between resistance and tolerance.

Bergstrom KS, Sham HP, Zarepour M, Vallance BA.

Cell Microbiol. 2012 Apr;14(4):475-84. doi: 10.1111/j.1462-5822.2012.01750.x. Epub 2012 Feb 15. Review.


Attaching and effacing bacterial effector NleC suppresses epithelial inflammatory responses by inhibiting NF-κB and p38 mitogen-activated protein kinase activation.

Sham HP, Shames SR, Croxen MA, Ma C, Chan JM, Khan MA, Wickham ME, Deng W, Finlay BB, Vallance BA.

Infect Immun. 2011 Sep;79(9):3552-62. doi: 10.1128/IAI.05033-11. Epub 2011 Jul 11.


Interleukin-11 reduces TLR4-induced colitis in TLR2-deficient mice and restores intestinal STAT3 signaling.

Gibson DL, Montero M, Ropeleski MJ, Bergstrom KS, Ma C, Ghosh S, Merkens H, Huang J, Månsson LE, Sham HP, McNagny KM, Vallance BA.

Gastroenterology. 2010 Oct;139(4):1277-88. doi: 10.1053/j.gastro.2010.06.057. Epub 2010 Jun 25.


Muc2 protects against lethal infectious colitis by disassociating pathogenic and commensal bacteria from the colonic mucosa.

Bergstrom KS, Kissoon-Singh V, Gibson DL, Ma C, Montero M, Sham HP, Ryz N, Huang T, Velcich A, Finlay BB, Chadee K, Vallance BA.

PLoS Pathog. 2010 May 13;6(5):e1000902. doi: 10.1371/journal.ppat.1000902.


Loss of single immunoglobulin interlukin-1 receptor-related molecule leads to enhanced colonic polyposis in Apc(min) mice.

Xiao H, Yin W, Khan MA, Gulen MF, Zhou H, Sham HP, Jacobson K, Vallance BA, Li X.

Gastroenterology. 2010 Aug;139(2):574-85. doi: 10.1053/j.gastro.2010.04.043. Epub 2010 Apr 21.


The pathogenic E. coli type III effector EspZ interacts with host CD98 and facilitates host cell prosurvival signalling.

Shames SR, Deng W, Guttman JA, de Hoog CL, Li Y, Hardwidge PR, Sham HP, Vallance BA, Foster LJ, Finlay BB.

Cell Microbiol. 2010 Sep 1;12(9):1322-39. doi: 10.1111/j.1462-5822.2010.01470.x. Epub 2010 Mar 31.


The single IgG IL-1-related receptor controls TLR responses in differentiated human intestinal epithelial cells.

Khan MA, Steiner TS, Sham HP, Bergstrom KS, Huang JT, Assi K, Salh B, Tai IT, Li X, Vallance BA.

J Immunol. 2010 Mar 1;184(5):2305-13. doi: 10.4049/jimmunol.0900021. Epub 2010 Feb 3.


Gut barrier disruption by an enteric bacterial pathogen accelerates insulitis in NOD mice.

Lee AS, Gibson DL, Zhang Y, Sham HP, Vallance BA, Dutz JP.

Diabetologia. 2010 Apr;53(4):741-8. doi: 10.1007/s00125-009-1626-y. Epub 2009 Dec 13.


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