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Items: 21

1.

Integrated design, execution, and analysis of arrayed and pooled CRISPR genome-editing experiments.

Canver MC, Haeussler M, Bauer DE, Orkin SH, Sanjana NE, Shalem O, Yuan GC, Zhang F, Concordet JP, Pinello L.

Nat Protoc. 2018 May;13(5):946-986. doi: 10.1038/nprot.2018.005. Epub 2018 Apr 12.

PMID:
29651054
2.

Identification of essential genes for cancer immunotherapy.

Patel SJ, Sanjana NE, Kishton RJ, Eidizadeh A, Vodnala SK, Cam M, Gartner JJ, Jia L, Steinberg SM, Yamamoto TN, Merchant AS, Mehta GU, Chichura A, Shalem O, Tran E, Eil R, Sukumar M, Guijarro EP, Day CP, Robbins P, Feldman S, Merlino G, Zhang F, Restifo NP.

Nature. 2017 Aug 31;548(7669):537-542. doi: 10.1038/nature23477. Epub 2017 Aug 7.

3.

CRISPRing the Regulatory Genome, the Challenge Ahead.

Sansbury SE, Sweeney KM, Shalem O.

Trends Genet. 2017 Sep;33(9):580-582. doi: 10.1016/j.tig.2017.07.001. Epub 2017 Jul 29.

PMID:
28764860
4.

Transcription control by the ENL YEATS domain in acute leukaemia.

Erb MA, Scott TG, Li BE, Xie H, Paulk J, Seo HS, Souza A, Roberts JM, Dastjerdi S, Buckley DL, Sanjana NE, Shalem O, Nabet B, Zeid R, Offei-Addo NK, Dhe-Paganon S, Zhang F, Orkin SH, Winter GE, Bradner JE.

Nature. 2017 Mar 9;543(7644):270-274. doi: 10.1038/nature21688. Epub 2017 Mar 1.

5.

High-resolution interrogation of functional elements in the noncoding genome.

Sanjana NE, Wright J, Zheng K, Shalem O, Fontanillas P, Joung J, Cheng C, Regev A, Zhang F.

Science. 2016 Sep 30;353(6307):1545-1549.

6.

Hypoxia as a therapy for mitochondrial disease.

Jain IH, Zazzeron L, Goli R, Alexa K, Schatzman-Bone S, Dhillon H, Goldberger O, Peng J, Shalem O, Sanjana NE, Zhang F, Goessling W, Zapol WM, Mootha VK.

Science. 2016 Apr 1;352(6281):54-61. doi: 10.1126/science.aad9642. Epub 2016 Feb 25.

7.

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis.

Canver MC, Smith EC, Sher F, Pinello L, Sanjana NE, Shalem O, Chen DD, Schupp PG, Vinjamur DS, Garcia SP, Luc S, Kurita R, Nakamura Y, Fujiwara Y, Maeda T, Yuan GC, Zhang F, Orkin SH, Bauer DE.

Nature. 2015 Nov 12;527(7577):192-7. doi: 10.1038/nature15521. Epub 2015 Sep 16.

8.

A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks.

Parnas O, Jovanovic M, Eisenhaure TM, Herbst RH, Dixit A, Ye CJ, Przybylski D, Platt RJ, Tirosh I, Sanjana NE, Shalem O, Satija R, Raychowdhury R, Mertins P, Carr SA, Zhang F, Hacohen N, Regev A.

Cell. 2015 Jul 30;162(3):675-86. doi: 10.1016/j.cell.2015.06.059. Epub 2015 Jul 16.

9.

Systematic dissection of the sequence determinants of gene 3' end mediated expression control.

Shalem O, Sharon E, Lubliner S, Regev I, Lotan-Pompan M, Yakhini Z, Segal E.

PLoS Genet. 2015 Apr 15;11(4):e1005147. doi: 10.1371/journal.pgen.1005147. eCollection 2015 Apr.

10.

High-throughput functional genomics using CRISPR-Cas9.

Shalem O, Sanjana NE, Zhang F.

Nat Rev Genet. 2015 May;16(5):299-311. doi: 10.1038/nrg3899. Epub 2015 Apr 9. Review.

11.

In vivo genome editing using Staphylococcus aureus Cas9.

Ran FA, Cong L, Yan WX, Scott DA, Gootenberg JS, Kriz AJ, Zetsche B, Shalem O, Wu X, Makarova KS, Koonin EV, Sharp PA, Zhang F.

Nature. 2015 Apr 9;520(7546):186-91. doi: 10.1038/nature14299. Epub 2015 Apr 1.

12.

Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis.

Chen S, Sanjana NE, Zheng K, Shalem O, Lee K, Shi X, Scott DA, Song J, Pan JQ, Weissleder R, Lee H, Zhang F, Sharp PA.

Cell. 2015 Mar 12;160(6):1246-60. doi: 10.1016/j.cell.2015.02.038. Epub 2015 Mar 5.

13.

Improved vectors and genome-wide libraries for CRISPR screening.

Sanjana NE, Shalem O, Zhang F.

Nat Methods. 2014 Aug;11(8):783-784. doi: 10.1038/nmeth.3047. No abstract available.

14.

Genome-scale CRISPR-Cas9 knockout screening in human cells.

Shalem O, Sanjana NE, Hartenian E, Shi X, Scott DA, Mikkelson T, Heckl D, Ebert BL, Root DE, Doench JG, Zhang F.

Science. 2014 Jan 3;343(6166):84-87. doi: 10.1126/science.1247005. Epub 2013 Dec 12.

15.

DNA targeting specificity of RNA-guided Cas9 nucleases.

Hsu PD, Scott DA, Weinstein JA, Ran FA, Konermann S, Agarwala V, Li Y, Fine EJ, Wu X, Shalem O, Cradick TJ, Marraffini LA, Bao G, Zhang F.

Nat Biotechnol. 2013 Sep;31(9):827-32. doi: 10.1038/nbt.2647. Epub 2013 Jul 21.

16.

Measurements of the impact of 3' end sequences on gene expression reveal wide range and sequence dependent effects.

Shalem O, Carey L, Zeevi D, Sharon E, Keren L, Weinberger A, Dahan O, Pilpel Y, Segal E.

PLoS Comput Biol. 2013;9(3):e1002934. doi: 10.1371/journal.pcbi.1002934. Epub 2013 Mar 7.

17.

Widespread promoter-mediated coordination of transcription and mRNA degradation.

Dori-Bachash M, Shalem O, Manor YS, Pilpel Y, Tirosh I.

Genome Biol. 2012 Dec 13;13(12):R114. doi: 10.1186/gb-2012-13-12-r114.

18.

Axonal transcription factors signal retrogradely in lesioned peripheral nerve.

Ben-Yaakov K, Dagan SY, Segal-Ruder Y, Shalem O, Vuppalanchi D, Willis DE, Yudin D, Rishal I, Rother F, Bader M, Blesch A, Pilpel Y, Twiss JL, Fainzilber M.

EMBO J. 2012 Mar 21;31(6):1350-63. doi: 10.1038/emboj.2011.494. Epub 2012 Jan 13.

19.

Transcriptome kinetics is governed by a genome-wide coupling of mRNA production and degradation: a role for RNA Pol II.

Shalem O, Groisman B, Choder M, Dahan O, Pilpel Y.

PLoS Genet. 2011 Sep;7(9):e1002273. doi: 10.1371/journal.pgen.1002273. Epub 2011 Sep 8. Erratum in: PLoS Genet. 2011 Sep;7(9). doi: 10.1371/annotation/7919492c-3e4b-4363-96da-f75281c1340c.

20.

Signaling to transcription networks in the neuronal retrograde injury response.

Michaelevski I, Segal-Ruder Y, Rozenbaum M, Medzihradszky KF, Shalem O, Coppola G, Horn-Saban S, Ben-Yaakov K, Dagan SY, Rishal I, Geschwind DH, Pilpel Y, Burlingame AL, Fainzilber M.

Sci Signal. 2010 Jul 13;3(130):ra53. doi: 10.1126/scisignal.2000952.

21.

Transient transcriptional responses to stress are generated by opposing effects of mRNA production and degradation.

Shalem O, Dahan O, Levo M, Martinez MR, Furman I, Segal E, Pilpel Y.

Mol Syst Biol. 2008;4:223. doi: 10.1038/msb.2008.59. Epub 2008 Oct 14.

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