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Items: 1 to 50 of 89

1.

Modeling Human Cancer-induced Cachexia.

Talbert EE, Cuitiño MC, Ladner KJ, Rajasekerea PV, Siebert M, Shakya R, Leone GW, Ostrowski MC, Paleo B, Weisleder N, Reiser PJ, Webb A, Timmers CD, Eiferman DS, Evans DC, Dillhoff ME, Schmidt CR, Guttridge DC.

Cell Rep. 2019 Aug 6;28(6):1612-1622.e4. doi: 10.1016/j.celrep.2019.07.016.

2.

Degree of MDM2 Amplification Affects Clinical Outcomes in Dedifferentiated Liposarcoma.

Bill KLJ, Seligson ND, Hays JL, Awasthi A, Demoret B, Stets CW, Duggan MC, Bupathi M, Brock GN, Millis SZ, Shakya R, Timmers CD, Wakely PE Jr, Pollock RE, Chen JL.

Oncologist. 2019 Jul;24(7):989-996. doi: 10.1634/theoncologist.2019-0047. Epub 2019 Apr 24.

PMID:
31019022
3.

Synergy from gene expression and network mining (SynGeNet) method predicts synergistic drug combinations for diverse melanoma genomic subtypes.

Regan-Fendt KE, Xu J, DiVincenzo M, Duggan MC, Shakya R, Na R, Carson WE 3rd, Payne PRO, Li F.

NPJ Syst Biol Appl. 2019 Feb 26;5:6. doi: 10.1038/s41540-019-0085-4. eCollection 2019.

4.

Differential Hepatotoxic Effects of Sodium Valproate at Different Doses in Albino Rats.

Shakya R, Hoque MK, Sapkota AS, Gupta PK.

Kathmandu Univ Med J (KUMJ). 2018 Jan.-Mar;16(61):78-82.

PMID:
30631023
5.

Loss of TXNIP enhances peritoneal metastasis and can be abrogated by dual TORC1/2 inhibition.

Spaeth-Cook D, Burch M, Belton R, Demoret B, Grosenbacher N, David J, Stets C, Cohen D, Shakya R, Hays JL, Chen JL.

Oncotarget. 2018 Nov 2;9(86):35676-35686. doi: 10.18632/oncotarget.26281. eCollection 2018 Nov 2.

6.

17β-Estradiol attenuates the influence of chronic activated microglia on SH-SY5Y cell proliferation via canonical WNT signaling pathway.

Shakya R, Chongthammakun S.

Neurosci Lett. 2019 Jan 23;692:174-180. doi: 10.1016/j.neulet.2018.10.063. Epub 2018 Nov 2.

PMID:
30391546
7.

Observation of current rectification by the new bimetallic iron(iii) hydrophobe [Fe(LN4O6)] on Au|LB-molecule|Au devices.

Weeraratne ADKI, Baydoun H, Shakya R, Niklas J, Xie L, Mao G, Stoian SA, Poluektov OG, Verani CN.

Dalton Trans. 2018 Oct 16;47(40):14352-14361. doi: 10.1039/c8dt03158d.

PMID:
30215065
8.

A simple in chemico method for testing skin sensitizing potential of chemicals using small endogenous molecules.

Nepal MR, Shakya R, Kang MJ, Jeong TC.

Toxicol Lett. 2018 Jun 1;289:75-85. doi: 10.1016/j.toxlet.2018.03.006. Epub 2018 Mar 12.

PMID:
29545173
9.

Catalytic upgrading of bio-oil produced from hydrothermal liquefaction of Nannochloropsis sp.

Shakya R, Adhikari S, Mahadevan R, Hassan EB, Dempster TA.

Bioresour Technol. 2018 Mar;252:28-36. doi: 10.1016/j.biortech.2017.12.067. Epub 2017 Dec 21.

PMID:
29306126
10.

Impact of gut microbiota on drug metabolism: an update for safe and effective use of drugs.

Noh K, Kang YR, Nepal MR, Shakya R, Kang MJ, Kang W, Lee S, Jeong HG, Jeong TC.

Arch Pharm Res. 2017 Dec;40(12):1345-1355. doi: 10.1007/s12272-017-0986-y. Epub 2017 Nov 27. Review.

PMID:
29181640
11.

Electroconvulsive Therapy in Functional Hallucination: Scope and Challenges.

Joshi S, Shakya R.

Case Rep Psychiatry. 2017;2017:9421973. doi: 10.1155/2017/9421973. Epub 2017 Oct 17.

12.

MAX Mutations in Endometrial Cancer: Clinicopathologic Associations and Recurrent MAX p.His28Arg Functional Characterization.

Walker CJ, Rush CM, Dama P, O'Hern MJ, Cosgrove CM, Gillespie JL, Zingarelli RA, Smith B, Stein ME, Mutch DG, Shakya R, Chang CW, Selvendiran K, Song JW, Cohn DE, Goodfellow PJ.

J Natl Cancer Inst. 2018 May 1;110(5):517-526. doi: 10.1093/jnci/djx238.

13.

Autoscopic Hallucination in Alcohol Dependence Syndrome: A Rare or Missed Phenomenon?

Joshi S, Thapa B, Shakya R.

Case Rep Psychiatry. 2017;2017:2598973. doi: 10.1155/2017/2598973. Epub 2017 Jul 24.

14.

Phase I and phase II metabolite identification of rutaecarpine in freshly isolated hepatocytes from male Sprague-Dawley rats.

Lee DW, Kang Y, Kang MJ, Noh K, Kim JH, Nepal MR, Shakya R, Lee YJ, Jahng Y, Lee S, Kim JA, Jeong TC.

Arch Pharm Res. 2017 Aug;40(8):972-979. doi: 10.1007/s12272-017-0937-7. Epub 2017 Aug 10.

PMID:
28799086
15.

Influence of biochemical composition during hydrothermal liquefaction of algae on product yields and fuel properties.

Shakya R, Adhikari S, Mahadevan R, Shanmugam SR, Nam H, Hassan EB, Dempster TA.

Bioresour Technol. 2017 Nov;243:1112-1120. doi: 10.1016/j.biortech.2017.07.046. Epub 2017 Jul 11.

PMID:
28764118
16.

Sex as a biological variable in response to temozolomide.

Russell L, Bolyard C, Banasavadi-Siddegowda Y, Weiss A, Zhang J, Shakya R, Powell K, Kaur B.

Neuro Oncol. 2017 Jun 1;19(6):873-874. doi: 10.1093/neuonc/nox040. No abstract available.

17.

Mutant p53 upregulates alpha-1 antitrypsin expression and promotes invasion in lung cancer.

Shakya R, Tarulli GA, Sheng L, Lokman NA, Ricciardelli C, Pishas KI, Selinger CI, Kohonen-Corish MRJ, Cooper WA, Turner AG, Neilsen PM, Callen DF.

Oncogene. 2017 Aug;36(31):4469-4480. doi: 10.1038/onc.2017.66. Epub 2017 Apr 3.

PMID:
28368395
18.

Bedside Ultrasound in the Emergency Department to Detect Hydronephrosis for the Evaluation of Suspected Ureteric Colic.

Shrestha R, Shakya RM, Khan A A.

Kathmandu Univ Med J (KUMJ). 2016 Apr-Jun;14(54):172-176.

PMID:
28166076
19.

Nutrient removal and energy production from aqueous phase of bio-oil generated via hydrothermal liquefaction of algae.

Shanmugam SR, Adhikari S, Shakya R.

Bioresour Technol. 2017 Apr;230:43-48. doi: 10.1016/j.biortech.2017.01.031. Epub 2017 Jan 19.

PMID:
28157563
20.

The Exportin-1 Inhibitor Selinexor Exerts Superior Antitumor Activity when Combined with T-Cell Checkpoint Inhibitors.

Farren MR, Hennessey RC, Shakya R, Elnaggar O, Young G, Kendra K, Landesman Y, Elloul S, Crochiere M, Klebanov B, Kashyap T, Burd CE, Lesinski GB.

Mol Cancer Ther. 2017 Mar;16(3):417-427. doi: 10.1158/1535-7163.MCT-16-0498. Epub 2017 Feb 1.

21.

Stromal Senescence By Prolonged CDK4/6 Inhibition Potentiates Tumor Growth.

Guan X, LaPak KM, Hennessey RC, Yu CY, Shakya R, Zhang J, Burd CE.

Mol Cancer Res. 2017 Mar;15(3):237-249. doi: 10.1158/1541-7786.MCR-16-0319. Epub 2016 Dec 30.

22.

IL-6 and PD-L1 antibody blockade combination therapy reduces tumour progression in murine models of pancreatic cancer.

Mace TA, Shakya R, Pitarresi JR, Swanson B, McQuinn CW, Loftus S, Nordquist E, Cruz-Monserrate Z, Yu L, Young G, Zhong X, Zimmers TA, Ostrowski MC, Ludwig T, Bloomston M, Bekaii-Saab T, Lesinski GB.

Gut. 2018 Feb;67(2):320-332. doi: 10.1136/gutjnl-2016-311585. Epub 2016 Oct 21.

23.

Treatment of aqueous phase of bio-oil by granular activated carbon and evaluation of biogas production.

Shanmugam SR, Adhikari S, Wang Z, Shakya R.

Bioresour Technol. 2017 Jan;223:115-120. doi: 10.1016/j.biortech.2016.10.008. Epub 2016 Oct 13.

PMID:
27788424
24.

Stromal ETS2 Regulates Chemokine Production and Immune Cell Recruitment during Acinar-to-Ductal Metaplasia.

Pitarresi JR, Liu X, Sharma SM, Cuitiño MC, Kladney RD, Mace TA, Donohue S, Nayak SG, Qu C, Lee J, Woelke SA, Trela S, LaPak K, Yu L, McElroy J, Rosol TJ, Shakya R, Ludwig T, Lesinski GB, Fernandez SA, Konieczny SF, Leone G, Wu J, Ostrowski MC.

Neoplasia. 2016 Sep;18(9):541-52. doi: 10.1016/j.neo.2016.07.006.

25.

Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar-ductal metaplasia.

Liu X, Pitarresi JR, Cuitiño MC, Kladney RD, Woelke SA, Sizemore GM, Nayak SG, Egriboz O, Schweickert PG, Yu L, Trela S, Schilling DJ, Halloran SK, Li M, Dutta S, Fernandez SA, Rosol TJ, Lesinski GB, Shakya R, Ludwig T, Konieczny SF, Leone G, Wu J, Ostrowski MC.

Genes Dev. 2016 Sep 1;30(17):1943-55. doi: 10.1101/gad.283499.116. Epub 2016 Sep 15.

26.

The DNA resection protein CtIP promotes mammary tumorigenesis.

Reczek CR, Shakya R, Miteva Y, Szabolcs M, Ludwig T, Baer R.

Oncotarget. 2016 May 31;7(22):32172-83. doi: 10.18632/oncotarget.8605.

27.

Modeling flood reduction effects of low impact development at a watershed scale.

Ahiablame L, Shakya R.

J Environ Manage. 2016 Apr 15;171:81-91. doi: 10.1016/j.jenvman.2016.01.036. Epub 2016 Feb 13.

PMID:
26878221
28.

A staff support programme for rural hospitals in Nepal.

Zimmerman M, Shah S, Shakya R, Sundar Chansi B, Shah K, Munday D, Eyal N, Hayes B.

Bull World Health Organ. 2016 Jan 1;94(1):65-70. doi: 10.2471/BLT.15.153619. Epub 2015 Nov 2.

29.

Surgical mortality audit data validity.

Rey-Conde T, Shakya R, Allen J, Clarke E, North JB, Wysocki AP, Ware RS.

ANZ J Surg. 2016 Sep;86(9):644-7. doi: 10.1111/ans.13416. Epub 2015 Dec 21.

PMID:
26686874
30.

A Study on Nutritional Status of Rural School going Children in Kavre District.

Mansur DI, Haque MK, Sharma K, Mehta DK, Shakya R.

Kathmandu Univ Med J (KUMJ). 2015 Apr-Jun;13(50):146-51.

PMID:
26643832
31.

Single agent BMS-911543 Jak2 inhibitor has distinct inhibitory effects on STAT5 signaling in genetically engineered mice with pancreatic cancer.

Mace TA, Shakya R, Elnaggar O, Wilson K, Komar HM, Yang J, Pitarresi JR, Young GS, Ostrowski MC, Ludwig T, Bekaii-Saab T, Bloomston M, Lesinski GB.

Oncotarget. 2015 Dec 29;6(42):44509-22. doi: 10.18632/oncotarget.6332.

32.

Hormone-sensing mammary epithelial progenitors: emerging identity and hormonal regulation.

Tarulli GA, Laven-Law G, Shakya R, Tilley WD, Hickey TE.

J Mammary Gland Biol Neoplasia. 2015 Jun;20(1-2):75-91. doi: 10.1007/s10911-015-9344-1. Epub 2015 Sep 21. Review.

PMID:
26390871
33.

Implications of participatory methods to address mental health needs associated with climate change: 'photovoice' in Nepal.

MacFarlane EK, Shakya R, Berry HL, Kohrt BA.

BJPsych Int. 2015 May 1;12(2):33-35. eCollection 2015 May.

34.

Spectrum of bacterial pathogens and their antibiogram from cases of urinary tract infection among renal disorder patients.

Shakya R, Amatya R, Karki BM, Mandal PK, Shrestha KK.

Nepal Med Coll J. 2014 Sep;16(1):75-9.

PMID:
25799818
35.

Use of head circumference as a predictor of height of individual.

Mansur DI, Haque MK, Sharma K, Mehta DK, Shakya R.

Kathmandu Univ Med J (KUMJ). 2014 Apr-Jun;12(46):89-92.

PMID:
25552209
36.

Synthesis and regulation of chlorogenic acid in potato: Rerouting phenylpropanoid flux in HQT-silenced lines.

Payyavula RS, Shakya R, Sengoda VG, Munyaneza JE, Swamy P, Navarre DA.

Plant Biotechnol J. 2015 May;13(4):551-64. doi: 10.1111/pbi.12280. Epub 2014 Nov 25.

37.

Xanthogranulomatous inflammation of gallbladder and bile duct causing obstructive jaundice masquerades gallbladder cancer: a formidable diagnostic challenge continues.

Garg PK, Pandey D, Mridha AR, Shakya R, Sharma J.

J Gastrointest Cancer. 2014 Dec;45 Suppl 1:178-81. doi: 10.1007/s12029-014-9620-0. No abstract available.

PMID:
24802227
38.
39.

The transcriptional regulatory network of proneural glioma determines the genetic alterations selected during tumor progression.

Sonabend AM, Bansal M, Guarnieri P, Lei L, Amendolara B, Soderquist C, Leung R, Yun J, Kennedy B, Sisti J, Bruce S, Bruce R, Shakya R, Ludwig T, Rosenfeld S, Sims PA, Bruce JN, Califano A, Canoll P.

Cancer Res. 2014 Mar 1;74(5):1440-1451. doi: 10.1158/0008-5472.CAN-13-2150. Epub 2014 Jan 3.

40.

High prevalence of BRCA1 and BRCA2 germline mutations with loss of heterozygosity in a series of resected pancreatic adenocarcinoma and other neoplastic lesions.

Lucas AL, Shakya R, Lipsyc MD, Mitchel EB, Kumar S, Hwang C, Deng L, Devoe C, Chabot JA, Szabolcs M, Ludwig T, Chung WK, Frucht H.

Clin Cancer Res. 2013 Jul 1;19(13):3396-403. doi: 10.1158/1078-0432.CCR-12-3020. Epub 2013 May 8.

41.

Mixed capillary venous retroperitoneal hemangioma.

Godar M, Yuan Q, Shakya R, Xia Y, Zhang P.

Case Rep Radiol. 2013;2013:258352. doi: 10.1155/2013/258352. Epub 2013 Feb 28.

42.

Changes in potato phenylpropanoid metabolism during tuber development.

Navarre DA, Payyavula RS, Shakya R, Knowles NR, Pillai SS.

Plant Physiol Biochem. 2013 Apr;65:89-101. doi: 10.1016/j.plaphy.2013.01.007. Epub 2013 Jan 28.

PMID:
23434926
43.

Career choices and what influences Nepali medical students and young doctors: a cross-sectional study.

Hayes BW, Shakya R.

Hum Resour Health. 2013 Feb 8;11:5. doi: 10.1186/1478-4491-11-5.

44.

Hypomethylating therapy in an aggressive stroma-rich model of pancreatic carcinoma.

Shakya R, Gonda T, Quante M, Salas M, Kim S, Brooks J, Hirsch S, Davies J, Cullo A, Olive K, Wang TC, Szabolcs M, Tycko B, Ludwig T.

Cancer Res. 2013 Jan 15;73(2):885-96. doi: 10.1158/0008-5472.CAN-12-1880. Epub 2012 Nov 29.

45.

Acute appendicitis in elderly patients: a challenge for surgeons.

Pokharel N, Sapkota P, Kc B, Rimal S, Thapa S, Shakya R.

Nepal Med Coll J. 2011 Dec;13(4):285-8.

PMID:
23016482
46.

Altered leaf colour is associated with increased superoxide-scavenging activity in aureusidin-producing transgenic plants.

Shakya R, Ye J, Rommens CM.

Plant Biotechnol J. 2012 Dec;10(9):1046-55. doi: 10.1111/j.1467-7652.2012.00732.x. Epub 2012 Aug 24.

47.

Medical students' characteristics as predictors of career practice location: retrospective cohort study tracking graduates of Nepal's first medical college.

Zimmerman M, Shakya R, Pokhrel BM, Eyal N, Rijal BP, Shrestha RN, Sayami A.

BMJ. 2012 Aug 13;345:e4826. doi: 10.1136/bmj.e4826.

48.

Tuber-specific silencing of asparagine synthetase-1 reduces the acrylamide-forming potential of potatoes grown in the field without affecting tuber shape and yield.

Chawla R, Shakya R, Rommens CM.

Plant Biotechnol J. 2012 Oct;10(8):913-24. doi: 10.1111/j.1467-7652.2012.00720.x. Epub 2012 Jun 22.

49.

Morphometric analysis of clavicle in nepalese population.

Haque MK, Mansur ID, Krishnamurthy A, Karki R, Sharma K, Shakya R.

Kathmandu Univ Med J (KUMJ). 2011 Jul-Sep;9(35):193-7.

PMID:
22609506
50.

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