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A new screening method for ATP-independent kinase inhibitors identifies repurposed anti-cancer drugs.

Timaner M, Shaked Y.

EBioMedicine. 2018 Nov;37:21-22. doi: 10.1016/j.ebiom.2018.10.020. Epub 2018 Oct 24. No abstract available.


Correction: Dissecting the Autocrine and Paracrine Roles of the CCR2-CCL2 Axis in Tumor Survival and Angiogenesis.

Izhak L, Wildbaum G, Jung S, Stein A, Shaked Y, Karin N.

PLoS One. 2018 Apr 12;13(4):e0195170. doi: 10.1371/journal.pone.0195170. eCollection 2018.


Correction: Predominant Expression of CCL2 at the Tumor Site of Prostate Cancer Patients Directs a Selective Loss of Immunological Tolerance to CCL2 That Could Be Amplified in a Beneficial Manner.

Izhak L, Wildbaum G, Weinberg U, Shaked Y, Alami J, Dumont D, Friedman B, Stein A, Karin N.

J Immunol. 2018 Apr 1;200(7):2509-2510. doi: 10.4049/jimmunol.1800167. Epub 2018 Feb 23. No abstract available.


Copper oxide loaded PLGA nanospheres: towards a multifunctional nanoscale platform for ultrasound-based imaging and therapy.

Perlman O, Weitz IS, Sivan SS, Abu-Khalla H, Benguigui M, Shaked Y, Azhari H.

Nanotechnology. 2018 May 4;29(18):185102. doi: 10.1088/1361-6528/aab00c. Epub 2018 Feb 16.


Lifting the bandwidth limit of optical homodyne measurement with broadband parametric amplification.

Shaked Y, Michael Y, Vered RZ, Bello L, Rosenbluh M, Pe'er A.

Nat Commun. 2018 Feb 9;9(1):609. doi: 10.1038/s41467-018-03083-5.


Dose- and time-dependence of the host-mediated response to paclitaxel therapy: a mathematical modeling approach.

Benguigui M, Alishekevitz D, Timaner M, Shechter D, Raviv Z, Benzekry S, Shaked Y.

Oncotarget. 2017 Dec 20;9(2):2574-2590. doi: 10.18632/oncotarget.23514. eCollection 2018 Jan 5.


Therapy-Educated Mesenchymal Stem Cells Enrich for Tumor-Initiating Cells.

Timaner M, Letko-Khait N, Kotsofruk R, Benguigui M, Beyar-Katz O, Rachman-Tzemah C, Raviv Z, Bronshtein T, Machluf M, Shaked Y.

Cancer Res. 2018 Mar 1;78(5):1253-1265. doi: 10.1158/0008-5472.CAN-17-1547. Epub 2018 Jan 4.


CCR5 Directs the Mobilization of CD11b+Gr1+Ly6Clow Polymorphonuclear Myeloid Cells from the Bone Marrow to the Blood to Support Tumor Development.

Hawila E, Razon H, Wildbaum G, Blattner C, Sapir Y, Shaked Y, Umansky V, Karin N.

Cell Rep. 2017 Nov 21;21(8):2212-2222. doi: 10.1016/j.celrep.2017.10.104.


Blocking Surgically Induced Lysyl Oxidase Activity Reduces the Risk of Lung Metastases.

Rachman-Tzemah C, Zaffryar-Eilot S, Grossman M, Ribero D, Timaner M, Mäki JM, Myllyharju J, Bertolini F, Hershkovitz D, Sagi I, Hasson P, Shaked Y.

Cell Rep. 2017 Apr 25;19(4):774-784. doi: 10.1016/j.celrep.2017.04.005.


The potential clinical promise of 'multimodality' metronomic chemotherapy revealed by preclinical studies of metastatic disease.

Kerbel RS, Shaked Y.

Cancer Lett. 2017 Aug 1;400:293-304. doi: 10.1016/j.canlet.2017.02.005. Epub 2017 Feb 12. Review.


The antiangiogenic role of the pro-inflammatory cytokine interleukin-31.

Davidi S, Fremder E, Kan T, Raviv Z, Timaner M, Karin N, Hershkovitz D, Arohneim A, Shaked Y.

Oncotarget. 2017 Mar 7;8(10):16430-16444. doi: 10.18632/oncotarget.14857.


Next generation metronomic chemotherapy-report from the Fifth Biennial International Metronomic and Anti-angiogenic Therapy Meeting, 6-8 May 2016, Mumbai.

Pantziarka P, Hutchinson L, André N, Benzekry S, Bertolini F, Bhattacharjee A, Chiplunkar S, Duda DG, Gota V, Gupta S, Joshi A, Kannan S, Kerbel R, Kieran M, Palazzo A, Parikh A, Pasquier E, Patil V, Prabhash K, Shaked Y, Sholler GS, Sterba J, Waxman DJ, Banavali S.

Ecancermedicalscience. 2016 Nov 2;10:689. eCollection 2016.


The coach program - a "joint" approach to patient education and support.

Shaked Y, Dickson P, Workman K.

Healthc (Amst). 2016 Dec;4(4):259-263. doi: 10.1016/j.hjdsi.2016.07.002. Epub 2016 Dec 6.


Therapy-activated stromal cells can dictate tumor fate.

Kerbel RS, Shaked Y.

J Exp Med. 2016 Dec 12;213(13):2831-2833. Epub 2016 Nov 23. Review.


Heparanase is required for activation and function of macrophages.

Gutter-Kapon L, Alishekevitz D, Shaked Y, Li JP, Aronheim A, Ilan N, Vlodavsky I.

Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):E7808-E7817. Epub 2016 Nov 14.


Macrophage-Induced Lymphangiogenesis and Metastasis following Paclitaxel Chemotherapy Is Regulated by VEGFR3.

Alishekevitz D, Gingis-Velitski S, Kaidar-Person O, Gutter-Kapon L, Scherer SD, Raviv Z, Merquiol E, Ben-Nun Y, Miller V, Rachman-Tzemah C, Timaner M, Mumblat Y, Ilan N, Loven D, Hershkovitz D, Satchi-Fainaro R, Blum G, P Sleeman J, Vlodavsky I, Shaked Y.

Cell Rep. 2016 Oct 25;17(5):1344-1356. doi: 10.1016/j.celrep.2016.09.083.


Iron-Nutrient Interactions within Phytoplankton.

Schoffman H, Lis H, Shaked Y, Keren N.

Front Plant Sci. 2016 Aug 18;7:1223. doi: 10.3389/fpls.2016.01223. eCollection 2016. Review.


Evidence Implicating Immunological Host Effects in the Efficacy of Metronomic Low-Dose Chemotherapy.

Shaked Y, Pham E, Hariharan S, Magidey K, Beyar-Katz O, Xu P, Man S, Wu FT, Miller V, Andrews D, Kerbel RS.

Cancer Res. 2016 Oct 15;76(20):5983-5993. Epub 2016 Aug 28.


Enhanced ferrihydrite dissolution by a unicellular, planktonic cyanobacterium: a biological contribution to particulate iron bioavailability.

Kranzler C, Kessler N, Keren N, Shaked Y.

Environ Microbiol. 2016 Dec;18(12):5101-5111. doi: 10.1111/1462-2920.13496. Epub 2016 Aug 30.


Balancing efficacy of and host immune responses to cancer therapy: the yin and yang effects.

Shaked Y.

Nat Rev Clin Oncol. 2016 Oct;13(10):611-26. doi: 10.1038/nrclinonc.2016.57. Epub 2016 Apr 26. Review.


Bortezomib-induced pro-inflammatory macrophages as a potential factor limiting anti-tumour efficacy.

Beyar-Katz O, Magidey K, Ben-Tsedek N, Alishekevitz D, Timaner M, Miller V, Lindzen M, Yarden Y, Avivi I, Shaked Y.

J Pathol. 2016 Jul;239(3):262-73. doi: 10.1002/path.4723. Epub 2016 Apr 29.


Analysis of the Stromal Cellular Components of the Solid Tumor Microenvironment Using Flow Cytometry.

Timaner M, Beyar-Katz O, Shaked Y.

Curr Protoc Cell Biol. 2016 Mar 1;70:19.18.1-19.18.12. doi: 10.1002/0471143030.cb1918s70.


Rapid Hydrogen Peroxide release from the coral Stylophora pistillata during feeding and in response to chemical and physical stimuli.

Armoza-Zvuloni R, Schneider A, Sher D, Shaked Y.

Sci Rep. 2016 Feb 15;6:21000. doi: 10.1038/srep21000.


Offshore Evidence for an Undocumented Tsunami Event in the 'Low Risk' Gulf of Aqaba-Eilat, Northern Red Sea.

Goodman Tchernov B, Katz T, Shaked Y, Qupty N, Kanari M, Niemi T, Agnon A.

PLoS One. 2016 Jan 27;11(1):e0145802. doi: 10.1371/journal.pone.0145802. eCollection 2016.


Identification of Dormancy-Associated MicroRNAs for the Design of Osteosarcoma-Targeted Dendritic Polyglycerol Nanopolyplexes.

Tiram G, Segal E, Krivitsky A, Shreberk-Hassidim R, Ferber S, Ofek P, Udagawa T, Edry L, Shomron N, Roniger M, Kerem B, Shaked Y, Aviel-Ronen S, Barshack I, Calderón M, Haag R, Satchi-Fainaro R.

ACS Nano. 2016 Feb 23;10(2):2028-45. doi: 10.1021/acsnano.5b06189. Epub 2016 Feb 8.


Host JDP2 expression in the bone marrow contributes to metastatic spread.

Barbarov Y, Timaner M, Alishekevitz D, Hai T, Yokoyama KK, Shaked Y, Aronheim A.

Oncotarget. 2015 Nov 10;6(35):37737-49. doi: 10.18632/oncotarget.5648.


Response letter: "ATF3: A promoter or inhibitor of cardiac maladaptive remodeling".

Koren L, Shaked Y, Aronheim A.

Int J Cardiol. 2015 Dec 15;201:692. doi: 10.1016/j.ijcard.2015.08.169. Epub 2015 Aug 28. No abstract available.


Dequalinium blocks macrophage-induced metastasis following local radiation.

Timaner M, Bril R, Kaidar-Person O, Rachman-Tzemah C, Alishekevitz D, Kotsofruk R, Miller V, Nevelsky A, Daniel S, Raviv Z, Rotenberg SA, Shaked Y.

Oncotarget. 2015 Sep 29;6(29):27537-54. doi: 10.18632/oncotarget.4826.


ATF3-dependent cross-talk between cardiomyocytes and macrophages promotes cardiac maladaptive remodeling.

Koren L, Alishekevitz D, Elhanani O, Nevelsky A, Hai T, Kehat I, Shaked Y, Aronheim A.

Int J Cardiol. 2015 Nov 1;198:232-40. doi: 10.1016/j.ijcard.2015.06.099. Epub 2015 Jul 9.


Spectral Diversity and Regulation of Coral Fluorescence in a Mesophotic Reef Habitat in the Red Sea.

Eyal G, Wiedenmann J, Grinblat M, D'Angelo C, Kramarsky-Winter E, Treibitz T, Ben-Zvi O, Shaked Y, Smith TB, Harii S, Denis V, Noyes T, Tamir R, Loya Y.

PLoS One. 2015 Jun 24;10(6):e0128697. doi: 10.1371/journal.pone.0128697. eCollection 2015.


Blocking IL1β Pathway Following Paclitaxel Chemotherapy Slightly Inhibits Primary Tumor Growth but Promotes Spontaneous Metastasis.

Voloshin T, Alishekevitz D, Kaneti L, Miller V, Isakov E, Kaplanov I, Voronov E, Fremder E, Benhar M, Machluf M, Apte RN, Shaked Y.

Mol Cancer Ther. 2015 Jun;14(6):1385-94. doi: 10.1158/1535-7163.MCT-14-0969. Epub 2015 Apr 17.


A Comparative Study of Iron Uptake Rates and Mechanisms amongst Marine and Fresh Water Cyanobacteria: Prevalence of Reductive Iron Uptake.

Lis H, Kranzler C, Keren N, Shaked Y.

Life (Basel). 2015 Mar 11;5(1):841-60. doi: 10.3390/life5010841.


Classical-to-quantum transition with broadband four-wave mixing.

Vered RZ, Shaked Y, Ben-Or Y, Rosenbluh M, Pe'er A.

Phys Rev Lett. 2015 Feb 13;114(6):063902. Epub 2015 Feb 10.


Proteomics of microparticles with SILAC Quantification (PROMIS-Quan): a novel proteomic method for plasma biomarker quantification.

Harel M, Oren-Giladi P, Kaidar-Person O, Shaked Y, Geiger T.

Mol Cell Proteomics. 2015 Apr;14(4):1127-36. doi: 10.1074/mcp.M114.043364. Epub 2015 Jan 26.


Host effects contributing to cancer therapy resistance.

Katz OB, Shaked Y.

Drug Resist Updat. 2015 Mar;19:33-42. doi: 10.1016/j.drup.2014.12.002. Epub 2014 Dec 26. Review.


Problem Behaviors among Israeli Undergraduate Students: Applying Jessor's Problem Behavior Theory among Young Adult Students.

Korn L, Shaked Y, Fogel-Grinvald H.

Front Public Health. 2014 Dec 22;2:273. doi: 10.3389/fpubh.2014.00273. eCollection 2014.


Iron bioavailability to phytoplankton: an empirical approach.

Lis H, Shaked Y, Kranzler C, Keren N, Morel FM.

ISME J. 2015 Mar 17;9(4):1003-13. doi: 10.1038/ismej.2014.199.


Trace element profiles of the sea anemone Anemonia viridis living nearby a natural CO2 vent.

Horwitz R, Borell EM, Fine M, Shaked Y.

PeerJ. 2014 Sep 9;2:e538. doi: 10.7717/peerj.538. eCollection 2014.


Lessons from the Fourth Metronomic and Anti-angiogenic Therapy Meeting, 24-25 June 2014, Milan.

Bouche G, André N, Banavali S, Berthold F, Berruti A, Bocci G, Brandi G, Cavallaro U, Cinieri S, Colleoni M, Curigliano G, Di Desidero T, Eniu A, Fazio N, Kerbel R, Hutchinson L, Ledzewicz U, Munzone E, Pasquier E, Graciela Scharovsky O, Shaked Y, Stěrba J, Villalba M, Bertolini F.

Ecancermedicalscience. 2014 Sep 9;8:463. doi: 10.3332/ecancer.2014.463. eCollection 2014.


Anti-Bv8 antibody and metronomic gemcitabine improve pancreatic adenocarcinoma treatment outcome following weekly gemcitabine therapy.

Hasnis E, Alishekevitz D, Gingis-Veltski S, Bril R, Fremder E, Voloshin T, Raviv Z, Karban A, Shaked Y.

Neoplasia. 2014 Jun;16(6):501-10. doi: 10.1016/j.neo.2014.05.011. Epub 2014 Jun 20.


Lenalidomide and metronomic melphalan for CMML and higher risk MDS: a phase 2 clinical study with biomarkers of angiogenesis.

Buckstein R, Kerbel R, Cheung M, Shaked Y, Chodirker L, Lee CR, Lenis M, Davidson C, Cussen MA, Reis M, Chesney A, Zhang L, Mamedov A, Wells RA.

Leuk Res. 2014 Jul;38(7):756-63. doi: 10.1016/j.leukres.2014.03.022. Epub 2014 Apr 5.


Anti-VEGF-A affects the angiogenic properties of tumor-derived microparticles.

Munster M, Fremder E, Miller V, Ben-Tsedek N, Davidi S, Scherer SJ, Shaked Y.

PLoS One. 2014 Apr 21;9(4):e95983. doi: 10.1371/journal.pone.0095983. eCollection 2014.


Small but mighty: microparticles as mediators of tumor progression.

Voloshin T, Fremder E, Shaked Y.

Cancer Microenviron. 2014 Aug;7(1-2):11-21. doi: 10.1007/s12307-014-0144-8. Epub 2014 Apr 6.


Remission from Depression among Adults with Arthritis: A 12-Year Followup of a Population-Based Study.

Fuller-Thomson E, Battiston M, Gadalla TM, Shaked Y, Raza F.

Depress Res Treat. 2014;2014:828965. doi: 10.1155/2014/828965. Epub 2014 Jan 27.


Tumor-derived microparticles induce bone marrow-derived cell mobilization and tumor homing: a process regulated by osteopontin.

Fremder E, Munster M, Aharon A, Miller V, Gingis-Velitski S, Voloshin T, Alishekevitz D, Bril R, Scherer SJ, Loven D, Brenner B, Shaked Y.

Int J Cancer. 2014 Jul 15;135(2):270-81. doi: 10.1002/ijc.28678. Epub 2014 Jan 13.


Tumor dormancy and the angiogenic switch: possible implications of bone marrow- derived cells.

Shaked Y, McAllister S, Fainaru O, Almog N.

Curr Pharm Des. 2014;20(30):4920-33. Review.


Sulfur isotope homogeneity of oceanic DMSP and DMS.

Amrani A, Said-Ahmad W, Shaked Y, Kiene RP.

Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18413-8. doi: 10.1073/pnas.1312956110. Epub 2013 Oct 28.


Differential therapeutic effects of anti-VEGF-A antibody in different tumor models: implications for choosing appropriate tumor models for drug testing.

Alishekevitz D, Bril R, Loven D, Miller V, Voloshin T, Gingis-Velistki S, Fremder E, Scherer SJ, Shaked Y.

Mol Cancer Ther. 2014 Jan;13(1):202-13. doi: 10.1158/1535-7163.MCT-13-0356. Epub 2013 Oct 22.


Coordinated transporter activity shapes high-affinity iron acquisition in cyanobacteria.

Kranzler C, Lis H, Finkel OM, Schmetterer G, Shaked Y, Keren N.

ISME J. 2014 Feb;8(2):409-17. doi: 10.1038/ismej.2013.161. Epub 2013 Oct 3.


Lysyl oxidase-like-2 promotes tumour angiogenesis and is a potential therapeutic target in angiogenic tumours.

Zaffryar-Eilot S, Marshall D, Voloshin T, Bar-Zion A, Spangler R, Kessler O, Ghermazien H, Brekhman V, Suss-Toby E, Adam D, Shaked Y, Smith V, Neufeld G.

Carcinogenesis. 2013 Oct;34(10):2370-9. doi: 10.1093/carcin/bgt241. Epub 2013 Jul 4.


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