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Insights into the bioavailability of oceanic dissolved Fe from phytoplankton uptake kinetics.

Shaked Y, Buck KN, Mellett T, Maldonado MT.

ISME J. 2020 Feb 5. doi: 10.1038/s41396-020-0597-3. [Epub ahead of print]


Metronomic Maintenance Therapy for Rhabdomyosarcoma.

André N, Corradini N, Shaked Y.

Trends Cancer. 2019 Dec;5(12):756-759. doi: 10.1016/j.trecan.2019.10.004. Epub 2019 Nov 4.


Heparanase and Chemotherapy Synergize to Drive Macrophage Activation and Enhance Tumor Growth.

Bhattacharya U, Gutter-Kapon L, Kan T, Boyango I, Barash U, Yang SM, Liu J, Gross-Cohen M, Sanderson RD, Shaked Y, Ilan N, Vlodavsky I.

Cancer Res. 2020 Jan 1;80(1):57-68. doi: 10.1158/0008-5472.CAN-19-1676. Epub 2019 Nov 5.


The pro-tumorigenic host response to cancer therapies.

Shaked Y.

Nat Rev Cancer. 2019 Dec;19(12):667-685. doi: 10.1038/s41568-019-0209-6. Epub 2019 Oct 23. Review.


Elucidating the roles of ASPM isoforms reveals a novel prognostic marker for pancreatic cancer.

Timaner M, Shaked Y.

J Pathol. 2020 Feb;250(2):123-125. doi: 10.1002/path.5355. Epub 2019 Dec 2.


Selective collection of iron-rich dust particles by natural Trichodesmium colonies.

Kessler N, Armoza-Zvuloni R, Wang S, Basu S, Weber PK, Stuart RK, Shaked Y.

ISME J. 2020 Jan;14(1):91-103. doi: 10.1038/s41396-019-0505-x. Epub 2019 Sep 24.


Metallophores associated with Trichodesmium erythraeum colonies from the Gulf of Aqaba.

Gledhill M, Basu S, Shaked Y.

Metallomics. 2019 Sep 1;11(9):1547-1557. doi: 10.1039/c9mt00121b. Epub 2019 Sep 2.


Copper oxide nanoparticles inhibit pancreatic tumor growth primarily by targeting tumor initiating cells.

Benguigui M, Weitz IS, Timaner M, Kan T, Shechter D, Perlman O, Sivan S, Raviv Z, Azhari H, Shaked Y.

Sci Rep. 2019 Aug 30;9(1):12613. doi: 10.1038/s41598-019-48959-8.


Microparticles from tumors exposed to radiation promote immune evasion in part by PD-L1.

Timaner M, Kotsofruk R, Raviv Z, Magidey K, Shechter D, Kan T, Nevelsky A, Daniel S, de Vries EGE, Zhang T, Kaidar-Person O, Kerbel RS, Shaked Y.

Oncogene. 2020 Jan;39(1):187-203. doi: 10.1038/s41388-019-0971-7. Epub 2019 Aug 29.


Targeting the Interplay Between Cancer Fibroblasts, Mesenchymal Stem Cells, and Cancer Stem Cells in Desmoplastic Cancers.

Chan TS, Shaked Y, Tsai KK.

Front Oncol. 2019 Jul 31;9:688. doi: 10.3389/fonc.2019.00688. eCollection 2019. Review.


Proinflammatory Macrophages Promote Multiple Myeloma Resistance to Bortezomib Therapy.

Beyar-Katz O, Magidey K, Reiner-Benaim A, Barak N, Avivi I, Cohen Y, Timaner M, Avraham S, Hayun M, Lavi N, Bersudsky M, Voronov E, Apte RN, Shaked Y.

Mol Cancer Res. 2019 Nov;17(11):2331-2340. doi: 10.1158/1541-7786.MCR-19-0487. Epub 2019 Aug 13.


Colonies of marine cyanobacteria Trichodesmium interact with associated bacteria to acquire iron from dust.

Basu S, Gledhill M, de Beer D, Prabhu Matondkar SG, Shaked Y.

Commun Biol. 2019 Aug 2;2:284. doi: 10.1038/s42003-019-0534-z. eCollection 2019.


Hydrogen Dynamics in Trichodesmium Colonies and Their Potential Role in Mineral Iron Acquisition.

Eichner M, Basu S, Gledhill M, de Beer D, Shaked Y.

Front Microbiol. 2019 Jul 10;10:1565. doi: 10.3389/fmicb.2019.01565. eCollection 2019.


The multifaceted role of mesenchymal stem cells in cancer.

Timaner M, Tsai KK, Shaked Y.

Semin Cancer Biol. 2019 Jun 15. pii: S1044-579X(19)30135-X. doi: 10.1016/j.semcancer.2019.06.003. [Epub ahead of print] Review.


Next Viable Routes to Targeting Pancreatic Cancer Stemness: Learning from Clinical Setbacks.

Tsai KK, Chan TS, Shaked Y.

J Clin Med. 2019 May 17;8(5). pii: E702. doi: 10.3390/jcm8050702. Review.


ATF3 and JDP2 deficiency in cancer associated fibroblasts promotes tumor growth via SDF-1 transcription.

Avraham S, Korin B, Aviram S, Shechter D, Shaked Y, Aronheim A.

Oncogene. 2019 May;38(20):3812-3823. doi: 10.1038/s41388-019-0692-y. Epub 2019 Jan 22.


A new screening method for ATP-independent kinase inhibitors identifies repurposed anti-cancer drugs.

Timaner M, Shaked Y.

EBioMedicine. 2018 Nov;37:21-22. doi: 10.1016/j.ebiom.2018.10.020. Epub 2018 Oct 24. No abstract available.


Correction: Dissecting the Autocrine and Paracrine Roles of the CCR2-CCL2 Axis in Tumor Survival and Angiogenesis.

Izhak L, Wildbaum G, Jung S, Stein A, Shaked Y, Karin N.

PLoS One. 2018 Apr 12;13(4):e0195170. doi: 10.1371/journal.pone.0195170. eCollection 2018.


Correction: Predominant Expression of CCL2 at the Tumor Site of Prostate Cancer Patients Directs a Selective Loss of Immunological Tolerance to CCL2 That Could Be Amplified in a Beneficial Manner.

Izhak L, Wildbaum G, Weinberg U, Shaked Y, Alami J, Dumont D, Friedman B, Stein A, Karin N.

J Immunol. 2018 Apr 1;200(7):2509-2510. doi: 10.4049/jimmunol.1800167. Epub 2018 Feb 23. No abstract available.


Copper oxide loaded PLGA nanospheres: towards a multifunctional nanoscale platform for ultrasound-based imaging and therapy.

Perlman O, Weitz IS, Sivan SS, Abu-Khalla H, Benguigui M, Shaked Y, Azhari H.

Nanotechnology. 2018 May 4;29(18):185102. doi: 10.1088/1361-6528/aab00c. Epub 2018 Feb 16.


Lifting the bandwidth limit of optical homodyne measurement with broadband parametric amplification.

Shaked Y, Michael Y, Vered RZ, Bello L, Rosenbluh M, Pe'er A.

Nat Commun. 2018 Feb 9;9(1):609. doi: 10.1038/s41467-018-03083-5.


Dose- and time-dependence of the host-mediated response to paclitaxel therapy: a mathematical modeling approach.

Benguigui M, Alishekevitz D, Timaner M, Shechter D, Raviv Z, Benzekry S, Shaked Y.

Oncotarget. 2017 Dec 20;9(2):2574-2590. doi: 10.18632/oncotarget.23514. eCollection 2018 Jan 5.


Therapy-Educated Mesenchymal Stem Cells Enrich for Tumor-Initiating Cells.

Timaner M, Letko-Khait N, Kotsofruk R, Benguigui M, Beyar-Katz O, Rachman-Tzemah C, Raviv Z, Bronshtein T, Machluf M, Shaked Y.

Cancer Res. 2018 Mar 1;78(5):1253-1265. doi: 10.1158/0008-5472.CAN-17-1547. Epub 2018 Jan 4.


CCR5 Directs the Mobilization of CD11b+Gr1+Ly6Clow Polymorphonuclear Myeloid Cells from the Bone Marrow to the Blood to Support Tumor Development.

Hawila E, Razon H, Wildbaum G, Blattner C, Sapir Y, Shaked Y, Umansky V, Karin N.

Cell Rep. 2017 Nov 21;21(8):2212-2222. doi: 10.1016/j.celrep.2017.10.104.


Blocking Surgically Induced Lysyl Oxidase Activity Reduces the Risk of Lung Metastases.

Rachman-Tzemah C, Zaffryar-Eilot S, Grossman M, Ribero D, Timaner M, Mäki JM, Myllyharju J, Bertolini F, Hershkovitz D, Sagi I, Hasson P, Shaked Y.

Cell Rep. 2017 Apr 25;19(4):774-784. doi: 10.1016/j.celrep.2017.04.005.


The potential clinical promise of 'multimodality' metronomic chemotherapy revealed by preclinical studies of metastatic disease.

Kerbel RS, Shaked Y.

Cancer Lett. 2017 Aug 1;400:293-304. doi: 10.1016/j.canlet.2017.02.005. Epub 2017 Feb 12. Review.


The antiangiogenic role of the pro-inflammatory cytokine interleukin-31.

Davidi S, Fremder E, Kan T, Raviv Z, Timaner M, Karin N, Hershkovitz D, Arohneim A, Shaked Y.

Oncotarget. 2017 Mar 7;8(10):16430-16444. doi: 10.18632/oncotarget.14857.


Next generation metronomic chemotherapy-report from the Fifth Biennial International Metronomic and Anti-angiogenic Therapy Meeting, 6-8 May 2016, Mumbai.

Pantziarka P, Hutchinson L, André N, Benzekry S, Bertolini F, Bhattacharjee A, Chiplunkar S, Duda DG, Gota V, Gupta S, Joshi A, Kannan S, Kerbel R, Kieran M, Palazzo A, Parikh A, Pasquier E, Patil V, Prabhash K, Shaked Y, Sholler GS, Sterba J, Waxman DJ, Banavali S.

Ecancermedicalscience. 2016 Nov 2;10:689. eCollection 2016.


The coach program - a "joint" approach to patient education and support.

Shaked Y, Dickson P, Workman K.

Healthc (Amst). 2016 Dec;4(4):259-263. doi: 10.1016/j.hjdsi.2016.07.002. Epub 2016 Dec 6.


Therapy-activated stromal cells can dictate tumor fate.

Kerbel RS, Shaked Y.

J Exp Med. 2016 Dec 12;213(13):2831-2833. Epub 2016 Nov 23. Review.


Heparanase is required for activation and function of macrophages.

Gutter-Kapon L, Alishekevitz D, Shaked Y, Li JP, Aronheim A, Ilan N, Vlodavsky I.

Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):E7808-E7817. Epub 2016 Nov 14.


Macrophage-Induced Lymphangiogenesis and Metastasis following Paclitaxel Chemotherapy Is Regulated by VEGFR3.

Alishekevitz D, Gingis-Velitski S, Kaidar-Person O, Gutter-Kapon L, Scherer SD, Raviv Z, Merquiol E, Ben-Nun Y, Miller V, Rachman-Tzemah C, Timaner M, Mumblat Y, Ilan N, Loven D, Hershkovitz D, Satchi-Fainaro R, Blum G, Sleeman JP, Vlodavsky I, Shaked Y.

Cell Rep. 2016 Oct 25;17(5):1344-1356. doi: 10.1016/j.celrep.2016.09.083.


Iron-Nutrient Interactions within Phytoplankton.

Schoffman H, Lis H, Shaked Y, Keren N.

Front Plant Sci. 2016 Aug 18;7:1223. doi: 10.3389/fpls.2016.01223. eCollection 2016. Review.


Evidence Implicating Immunological Host Effects in the Efficacy of Metronomic Low-Dose Chemotherapy.

Shaked Y, Pham E, Hariharan S, Magidey K, Beyar-Katz O, Xu P, Man S, Wu FT, Miller V, Andrews D, Kerbel RS.

Cancer Res. 2016 Oct 15;76(20):5983-5993. Epub 2016 Aug 28.


Enhanced ferrihydrite dissolution by a unicellular, planktonic cyanobacterium: a biological contribution to particulate iron bioavailability.

Kranzler C, Kessler N, Keren N, Shaked Y.

Environ Microbiol. 2016 Dec;18(12):5101-5111. doi: 10.1111/1462-2920.13496. Epub 2016 Aug 30.


Balancing efficacy of and host immune responses to cancer therapy: the yin and yang effects.

Shaked Y.

Nat Rev Clin Oncol. 2016 Oct;13(10):611-26. doi: 10.1038/nrclinonc.2016.57. Epub 2016 Apr 26. Review.


Bortezomib-induced pro-inflammatory macrophages as a potential factor limiting anti-tumour efficacy.

Beyar-Katz O, Magidey K, Ben-Tsedek N, Alishekevitz D, Timaner M, Miller V, Lindzen M, Yarden Y, Avivi I, Shaked Y.

J Pathol. 2016 Jul;239(3):262-73. doi: 10.1002/path.4723. Epub 2016 Apr 29.


Analysis of the Stromal Cellular Components of the Solid Tumor Microenvironment Using Flow Cytometry.

Timaner M, Beyar-Katz O, Shaked Y.

Curr Protoc Cell Biol. 2016 Mar 1;70:19.18.1-19.18.12. doi: 10.1002/0471143030.cb1918s70.


Rapid Hydrogen Peroxide release from the coral Stylophora pistillata during feeding and in response to chemical and physical stimuli.

Armoza-Zvuloni R, Schneider A, Sher D, Shaked Y.

Sci Rep. 2016 Feb 15;6:21000. doi: 10.1038/srep21000.


Offshore Evidence for an Undocumented Tsunami Event in the 'Low Risk' Gulf of Aqaba-Eilat, Northern Red Sea.

Goodman Tchernov B, Katz T, Shaked Y, Qupty N, Kanari M, Niemi T, Agnon A.

PLoS One. 2016 Jan 27;11(1):e0145802. doi: 10.1371/journal.pone.0145802. eCollection 2016.


Identification of Dormancy-Associated MicroRNAs for the Design of Osteosarcoma-Targeted Dendritic Polyglycerol Nanopolyplexes.

Tiram G, Segal E, Krivitsky A, Shreberk-Hassidim R, Ferber S, Ofek P, Udagawa T, Edry L, Shomron N, Roniger M, Kerem B, Shaked Y, Aviel-Ronen S, Barshack I, Calderón M, Haag R, Satchi-Fainaro R.

ACS Nano. 2016 Feb 23;10(2):2028-45. doi: 10.1021/acsnano.5b06189. Epub 2016 Feb 8.


Host JDP2 expression in the bone marrow contributes to metastatic spread.

Barbarov Y, Timaner M, Alishekevitz D, Hai T, Yokoyama KK, Shaked Y, Aronheim A.

Oncotarget. 2015 Nov 10;6(35):37737-49. doi: 10.18632/oncotarget.5648.


Response letter: "ATF3: A promoter or inhibitor of cardiac maladaptive remodeling".

Koren L, Shaked Y, Aronheim A.

Int J Cardiol. 2015 Dec 15;201:692. doi: 10.1016/j.ijcard.2015.08.169. Epub 2015 Aug 28. No abstract available.


Dequalinium blocks macrophage-induced metastasis following local radiation.

Timaner M, Bril R, Kaidar-Person O, Rachman-Tzemah C, Alishekevitz D, Kotsofruk R, Miller V, Nevelsky A, Daniel S, Raviv Z, Rotenberg SA, Shaked Y.

Oncotarget. 2015 Sep 29;6(29):27537-54. doi: 10.18632/oncotarget.4826.


ATF3-dependent cross-talk between cardiomyocytes and macrophages promotes cardiac maladaptive remodeling.

Koren L, Alishekevitz D, Elhanani O, Nevelsky A, Hai T, Kehat I, Shaked Y, Aronheim A.

Int J Cardiol. 2015 Nov 1;198:232-40. doi: 10.1016/j.ijcard.2015.06.099. Epub 2015 Jul 9.


Spectral Diversity and Regulation of Coral Fluorescence in a Mesophotic Reef Habitat in the Red Sea.

Eyal G, Wiedenmann J, Grinblat M, D'Angelo C, Kramarsky-Winter E, Treibitz T, Ben-Zvi O, Shaked Y, Smith TB, Harii S, Denis V, Noyes T, Tamir R, Loya Y.

PLoS One. 2015 Jun 24;10(6):e0128697. doi: 10.1371/journal.pone.0128697. eCollection 2015.


Blocking IL1β Pathway Following Paclitaxel Chemotherapy Slightly Inhibits Primary Tumor Growth but Promotes Spontaneous Metastasis.

Voloshin T, Alishekevitz D, Kaneti L, Miller V, Isakov E, Kaplanov I, Voronov E, Fremder E, Benhar M, Machluf M, Apte RN, Shaked Y.

Mol Cancer Ther. 2015 Jun;14(6):1385-94. doi: 10.1158/1535-7163.MCT-14-0969. Epub 2015 Apr 17.


A Comparative Study of Iron Uptake Rates and Mechanisms amongst Marine and Fresh Water Cyanobacteria: Prevalence of Reductive Iron Uptake.

Lis H, Kranzler C, Keren N, Shaked Y.

Life (Basel). 2015 Mar 11;5(1):841-60. doi: 10.3390/life5010841.


Classical-to-quantum transition with broadband four-wave mixing.

Vered RZ, Shaked Y, Ben-Or Y, Rosenbluh M, Pe'er A.

Phys Rev Lett. 2015 Feb 13;114(6):063902. Epub 2015 Feb 10.


Proteomics of microparticles with SILAC Quantification (PROMIS-Quan): a novel proteomic method for plasma biomarker quantification.

Harel M, Oren-Giladi P, Kaidar-Person O, Shaked Y, Geiger T.

Mol Cell Proteomics. 2015 Apr;14(4):1127-36. doi: 10.1074/mcp.M114.043364. Epub 2015 Jan 26.

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