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Items: 14


A TCR β-Chain Motif Biases toward Recognition of Human CD1 Proteins.

Reinink P, Shahine A, Gras S, Cheng TY, Farquhar R, Lopez K, Suliman SA, Reijneveld JF, Le Nours J, Tan LL, León SR, Jimenez J, Calderon R, Lecca L, Murray MB, Rossjohn J, Moody DB, Van Rhijn I.

J Immunol. 2019 Nov 6. pii: ji1900872. doi: 10.4049/jimmunol.1900872. [Epub ahead of print]


A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids.

Shahine A, Reinink P, Reijneveld JF, Gras S, Holzheimer M, Cheng TY, Minnaard AJ, Altman JD, Lenz S, Prandi J, Kubler-Kielb J, Moody DB, Rossjohn J, Van Rhijn I.

Nat Commun. 2019 Jan 4;10(1):56. doi: 10.1038/s41467-018-07898-0.


The intricacies of self-lipid antigen presentation by CD1b.

Shahine A.

Mol Immunol. 2018 Dec;104:27-36. doi: 10.1016/j.molimm.2018.09.022. Epub 2018 Nov 3. Review.


Lipids hide or step aside for CD1-autoreactive T cell receptors.

Cotton RN, Shahine A, Rossjohn J, Moody DB.

Curr Opin Immunol. 2018 Jun;52:93-99. doi: 10.1016/j.coi.2018.04.013. Epub 2018 May 5. Review.


Molecular recognition of microbial lipid-based antigens by T cells.

Gras S, Van Rhijn I, Shahine A, Le Nours J.

Cell Mol Life Sci. 2018 May;75(9):1623-1639. doi: 10.1007/s00018-018-2749-4. Epub 2018 Jan 16. Review.


Molecular features of lipid-based antigen presentation by group 1 CD1 molecules.

Le Nours J, Shahine A, Gras S.

Semin Cell Dev Biol. 2018 Dec;84:48-57. doi: 10.1016/j.semcdb.2017.11.002. Epub 2017 Nov 10. Review.


A molecular basis of human T cell receptor autoreactivity toward self-phospholipids.

Shahine A, Van Rhijn I, Cheng TY, Iwany S, Gras S, Moody DB, Rossjohn J.

Sci Immunol. 2017 Oct 20;2(16). pii: eaao1384. doi: 10.1126/sciimmunol.aao1384.


T cell receptor recognition of CD1b presenting a mycobacterial glycolipid.

Gras S, Van Rhijn I, Shahine A, Cheng TY, Bhati M, Tan LL, Halim H, Tuttle KD, Gapin L, Le Nours J, Moody DB, Rossjohn J.

Nat Commun. 2016 Oct 27;7:13257. doi: 10.1038/ncomms13257.


Cloning, expression, purification and crystallographic studies of galectin-11 from domestic sheep (Ovis aries).

Sakthivel D, Littler D, Shahine A, Troy S, Johnson M, Rossjohn J, Piedrafita D, Beddoe T.

Acta Crystallogr F Struct Biol Commun. 2015 Aug;71(Pt 8):993-7. doi: 10.1107/S2053230X15010195. Epub 2015 Jul 28.


A structural and functional investigation of a novel protein from Mycobacterium smegmatis implicated in mycobacterial macrophage survivability.

Shahine A, Littler D, Brammananath R, Chan PY, Crellin PK, Coppel RL, Rossjohn J, Beddoe T.

Acta Crystallogr D Biol Crystallogr. 2014 Sep;70(Pt 9):2264-76. doi: 10.1107/S139900471401092X. Epub 2014 Aug 23.


A structural characterization of the isoniazid Mycobacterium tuberculosis drug target, Rv2971, in its unliganded form.

Shahine A, Prasetyoputri A, Rossjohn J, Beddoe T.

Acta Crystallogr F Struct Biol Commun. 2014 May;70(Pt 5):572-7. doi: 10.1107/S2053230X14007158. Epub 2014 Apr 17.


Cloning, expression, purification and preliminary X-ray diffraction studies of a mycobacterial protein implicated in bacterial survival in macrophages.

Shahine AE, Chan PY, Littler D, Vivian J, Brammananth R, Crellin PK, Coppel RL, Rossjohn J, Beddoe T.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 May 1;69(Pt 5):566-9. doi: 10.1107/S1744309113010427. Epub 2013 Apr 30.


Tetrahydrolipstatin inhibition, functional analyses, and three-dimensional structure of a lipase essential for mycobacterial viability.

Crellin PK, Vivian JP, Scoble J, Chow FM, West NP, Brammananth R, Proellocks NI, Shahine A, Le Nours J, Wilce MC, Britton WJ, Coppel RL, Rossjohn J, Beddoe T.

J Biol Chem. 2010 Sep 24;285(39):30050-60. doi: 10.1074/jbc.M110.150094. Epub 2010 Jul 23.


Aggregation number-based degrees of counterion dissociation in sodium n-alkyl sulfate micelles.

Lebedeva NV, Shahine A, Bales BL.

J Phys Chem B. 2005 Oct 27;109(42):19806-16.


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