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Items: 25

1.

Heat shock protein 90 inhibitors repurposed against Entamoeba histolytica.

Shahinas D, Debnath A, Benedict C, McKerrow JH, Pillai DR.

Front Microbiol. 2015 Apr 28;6:368. doi: 10.3389/fmicb.2015.00368. eCollection 2015.

2.

Characterization of an Enterococcus gallinarum Isolate Carrying a Dual vanA and vanB Cassette.

Eshaghi A, Shahinas D, Li A, Kariyawasam R, Banh P, Desjardins M, Melano RG, Patel SN.

J Clin Microbiol. 2015 Jul;53(7):2225-9. doi: 10.1128/JCM.03267-14. Epub 2015 May 6.

3.

First draft genome sequence of Aureimonas altamirensis, isolated from patient blood culture.

Eshaghi A, Shahinas D, Patel SN, Kus JV.

FEMS Microbiol Lett. 2015 Mar;362(6). pii: fnv016. doi: 10.1093/femsle/fnv016. Epub 2015 Feb 24.

PMID:
25714548
4.

Mutations in Plasmodium falciparum K13 propeller gene from Bangladesh (2009-2013).

Mohon AN, Alam MS, Bayih AG, Folefoc A, Shahinas D, Haque R, Pillai DR.

Malar J. 2014 Nov 18;13:431. doi: 10.1186/1475-2875-13-431.

5.

Hsp90 inhibitors as new leads to target parasitic diarrheal diseases.

Debnath A, Shahinas D, Bryant C, Hirata K, Miyamoto Y, Hwang G, Gut J, Renslo AR, Pillai DR, Eckmann L, Reed SL, McKerrow JH.

Antimicrob Agents Chemother. 2014 Jul;58(7):4138-44. doi: 10.1128/AAC.02576-14. Epub 2014 May 12.

6.

Vancomycin-variable Enterococcus faecium: in vivo emergence of vancomycin resistance in a vancomycin-susceptible isolate.

Coburn B, Low DE, Patel SN, Poutanen SM, Shahinas D, Eshaghi A, Willey BM, McGeer A.

J Clin Microbiol. 2014 May;52(5):1766-7. doi: 10.1128/JCM.03579-13. Epub 2014 Feb 12.

7.

Outbreak of vancomycin-susceptible Enterococcus faecium containing the wild-type vanA gene.

Szakacs TA, Kalan L, McConnell MJ, Eshaghi A, Shahinas D, McGeer A, Wright GD, Low DE, Patel SN.

J Clin Microbiol. 2014 May;52(5):1682-6. doi: 10.1128/JCM.03563-13. Epub 2014 Feb 12.

8.

A purine analog synergizes with chloroquine (CQ) by targeting Plasmodium falciparum Hsp90 (PfHsp90).

Shahinas D, Folefoc A, Taldone T, Chiosis G, Crandall I, Pillai DR.

PLoS One. 2013 Sep 30;8(9):e75446. doi: 10.1371/journal.pone.0075446. eCollection 2013.

9.

Linezolid resistance in Enterococcus faecium isolated in Ontario, Canada.

Patel SN, Memari N, Shahinas D, Toye B, Jamieson FB, Farrell DJ.

Diagn Microbiol Infect Dis. 2013 Dec;77(4):350-3. doi: 10.1016/j.diagmicrobio.2013.08.012. Epub 2013 Oct 2.

PMID:
24095643
10.

Comparative Genomic Analyses of Streptococcus pseudopneumoniae Provide Insight into Virulence and Commensalism Dynamics.

Shahinas D, Thornton CS, Tamber GS, Arya G, Wong A, Jamieson FB, Ma JH, Alexander DC, Low DE, Pillai DR.

PLoS One. 2013 Jun 19;8(6):e65670. doi: 10.1371/journal.pone.0065670. Print 2013.

11.

A suppressor screen of the chimeric AtCNGC11/12 reveals residues important for intersubunit interactions of cyclic nucleotide-gated ion channels.

Abdel-Hamid H, Chin K, Moeder W, Shahinas D, Gupta D, Yoshioka K.

Plant Physiol. 2013 Jul;162(3):1681-93. doi: 10.1104/pp.113.217539. Epub 2013 Jun 4.

12.

Targeting Plasmodium falciparum Hsp90: Towards Reversing Antimalarial Resistance.

Shahinas D, Folefoc A, Pillai DR.

Pathogens. 2013 Feb 4;2(1):33-54. doi: 10.3390/pathogens2010033. Review.

13.

Toward an understanding of changes in diversity associated with fecal microbiome transplantation based on 16S rRNA gene deep sequencing.

Shahinas D, Silverman M, Sittler T, Chiu C, Kim P, Allen-Vercoe E, Weese S, Wong A, Low DE, Pillai DR.

MBio. 2012 Oct 23;3(5). pii: e00338-12. doi: 10.1128/mBio.00338-12.

14.

Harmine is a potent antimalarial targeting Hsp90 and synergizes with chloroquine and artemisinin.

Shahinas D, Macmullin G, Benedict C, Crandall I, Pillai DR.

Antimicrob Agents Chemother. 2012 Aug;56(8):4207-13. doi: 10.1128/AAC.00328-12. Epub 2012 May 21.

15.

Whole-genome sequence of Streptococcus pseudopneumoniae isolate IS7493.

Shahinas D, Tamber GS, Arya G, Wong A, Lau R, Jamieson F, Ma JH, Alexander DC, Low DE, Pillai DR.

J Bacteriol. 2011 Nov;193(21):6102-3. doi: 10.1128/JB.06075-11.

16.

Novel mutations in a patient isolate of Streptococcus agalactiae with reduced penicillin susceptibility emerging after long-term oral suppressive therapy.

Longtin J, Vermeiren C, Shahinas D, Tamber GS, McGeer A, Low DE, Katz K, Pillai DR.

Antimicrob Agents Chemother. 2011 Jun;55(6):2983-5. doi: 10.1128/AAC.01243-10. Epub 2011 Mar 7.

17.

Rapid pneumococcal evolution in response to clinical interventions.

Croucher NJ, Harris SR, Fraser C, Quail MA, Burton J, van der Linden M, McGee L, von Gottberg A, Song JH, Ko KS, Pichon B, Baker S, Parry CM, Lambertsen LM, Shahinas D, Pillai DR, Mitchell TJ, Dougan G, Tomasz A, Klugman KP, Parkhill J, Hanage WP, Bentley SD.

Science. 2011 Jan 28;331(6016):430-4. doi: 10.1126/science.1198545.

18.

Calmodulin binding to Arabidopsis cyclic nucleotide gated ion channels.

Abdel-Hamid H, Chin K, Shahinas D, Moeder W, Yoshioka K.

Plant Signal Behav. 2010 Sep;5(9):1147-9. Epub 2010 Sep 1.

19.

Artesunate misuse and Plasmodium falciparum malaria in traveler returning from Africa.

Shahinas D, Lau R, Khairnar K, Hancock D, Pillai DR.

Emerg Infect Dis. 2010 Oct;16(10):1608-10. doi: 10.3201/eid1610.100116.

20.

Importance of the alphaC-helix in the cyclic nucleotide binding domain for the stable channel regulation and function of cyclic nucleotide gated ion channels in Arabidopsis.

Chin K, Moeder W, Abdel-Hamid H, Shahinas D, Gupta D, Yoshioka K.

J Exp Bot. 2010 May;61(9):2383-93. doi: 10.1093/jxb/erq072. Epub 2010 Apr 8.

21.

A repurposing strategy identifies novel synergistic inhibitors of Plasmodium falciparum heat shock protein 90.

Shahinas D, Liang M, Datti A, Pillai DR.

J Med Chem. 2010 May 13;53(9):3552-7. doi: 10.1021/jm901796s.

PMID:
20349996
22.

Genome-wide dissection of globally emergent multi-drug resistant serotype 19A Streptococcus pneumoniae.

Pillai DR, Shahinas D, Buzina A, Pollock RA, Lau R, Khairnar K, Wong A, Farrell DJ, Green K, McGeer A, Low DE.

BMC Genomics. 2009 Dec 30;10:642. doi: 10.1186/1471-2164-10-642.

23.

The crystal structure of Aquifex aeolicus prephenate dehydrogenase reveals the mode of tyrosine inhibition.

Sun W, Shahinas D, Bonvin J, Hou W, Kimber MS, Turnbull J, Christendat D.

J Biol Chem. 2009 May 8;284(19):13223-32. doi: 10.1074/jbc.M806272200. Epub 2009 Mar 10.

24.

Identification of a functionally essential amino acid for Arabidopsis cyclic nucleotide gated ion channels using the chimeric AtCNGC11/12 gene.

Baxter J, Moeder W, Urquhart W, Shahinas D, Chin K, Christendat D, Kang HG, Angelova M, Kato N, Yoshioka K.

Plant J. 2008 Nov;56(3):457-69. doi: 10.1111/j.1365-313X.2008.03619.x. Epub 2008 Aug 14.

25.

Structural insight on the mechanism of regulation of the MarR family of proteins: high-resolution crystal structure of a transcriptional repressor from Methanobacterium thermoautotrophicum.

Saridakis V, Shahinas D, Xu X, Christendat D.

J Mol Biol. 2008 Mar 28;377(3):655-67. doi: 10.1016/j.jmb.2008.01.001. Epub 2008 Jan 11.

PMID:
18272181

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