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Items: 1 to 50 of 111

1.

Medullary thymic epithelial NF-kB-inducing kinase (NIK)/IKKα pathway shapes autoimmunity and liver and lung homeostasis in mice.

Shen H, Ji Y, Xiong Y, Kim H, Zhong X, Jin MG, Shah YM, Omary MB, Liu Y, Qi L, Rui L.

Proc Natl Acad Sci U S A. 2019 Sep 17;116(38):19090-19097. doi: 10.1073/pnas.1901056116. Epub 2019 Sep 3.

PMID:
31481626
2.

Hypoxic Regulation of Neutrophils in Cancer.

Triner D, Shah YM.

Int J Mol Sci. 2019 Aug 27;20(17). pii: E4189. doi: 10.3390/ijms20174189. Review.

3.

A genetic mouse model of severe iron deficiency anemia reveals tissue-specific transcriptional stress responses and cardiac remodeling.

Schwartz AJ, Converso-Baran K, Michele DE, Shah YM.

J Biol Chem. 2019 Oct 11;294(41):14991-15002. doi: 10.1074/jbc.RA119.009578. Epub 2019 Aug 15.

PMID:
31416832
4.

A PHD in immunosuppression: oxygen-sensing pathways regulate immunosuppressive Tregs.

Zou W, Shah YM.

J Clin Invest. 2019 Jul 29;130:3524-3526. doi: 10.1172/JCI130009. eCollection 2019 Jul 29.

5.

Hypoxia inducible factor 1α in vascular smooth muscle cells promotes angiotensin II-induced vascular remodeling via activation of CCL7-mediated macrophage recruitment.

Qi D, Wei M, Jiao S, Song Y, Wang X, Xie G, Taranto J, Liu Y, Duan Y, Yu B, Li H, Shah YM, Xu Q, Du J, Gonzalez FJ, Qu A.

Cell Death Dis. 2019 Jul 18;10(8):544. doi: 10.1038/s41419-019-1757-0.

6.

Temporal induction of intestinal epithelial hypoxia-inducible factor-2α is sufficient to drive colitis.

Solanki S, Devenport SN, Ramakrishnan SK, Shah YM.

Am J Physiol Gastrointest Liver Physiol. 2019 Aug 1;317(2):G98-G107. doi: 10.1152/ajpgi.00081.2019. Epub 2019 Jun 26.

PMID:
31241981
7.

Adrenoceptor-related decrease in serum triglycerides is independent of PPARα activation.

Konstandi M, Kypreos KE, Matsubara T, Xepapadaki E, Shah YM, Krausz K, Andriopoulou CE, Kofinas A, Gonzalez FJ.

FEBS J. 2019 Jun 23. doi: 10.1111/febs.14966. [Epub ahead of print]

PMID:
31230416
8.

Notch and mTOR Signaling Pathways Promote Human Gastric Cancer Cell Proliferation.

Hibdon ES, Razumilava N, Keeley TM, Wong G, Solanki S, Shah YM, Samuelson LC.

Neoplasia. 2019 Jul;21(7):702-712. doi: 10.1016/j.neo.2019.05.002. Epub 2019 May 24.

9.

Genetic dissection of the different roles of hypothalamic kisspeptin neurons in regulating female reproduction.

Wang L, Vanacker C, Burger LL, Barnes T, Shah YM, Myers MG, Moenter SM.

Elife. 2019 Apr 4;8. pii: e43999. doi: 10.7554/eLife.43999.

10.

Enhancing career development of postdoctoral trainees: act locally and beyond.

Omary MB, Shah YM, Schnell S, Subramanian S, Swanson MS, O'Riordan MX.

J Physiol. 2019 May;597(9):2317-2322. doi: 10.1113/JP277684. Epub 2019 Mar 31. No abstract available.

PMID:
30929265
11.

Intestinal non-canonical NFκB signaling shapes the local and systemic immune response.

Ramakrishnan SK, Zhang H, Ma X, Jung I, Schwartz AJ, Triner D, Devenport SN, Das NK, Xue X, Zeng MY, Hu Y, Mortensen RM, Greenson JK, Cascalho M, Wobus CE, Colacino JA, Nunez G, Rui L, Shah YM.

Nat Commun. 2019 Feb 8;10(1):660. doi: 10.1038/s41467-019-08581-8.

12.

SMAD family member 3 (SMAD3) and SMAD4 repress HIF2α-dependent iron-regulatory genes.

Ma X, Das NK, Castillo C, Gourani A, Perekatt AO, Verzi MP, Shah YM.

J Biol Chem. 2019 Mar 15;294(11):3974-3986. doi: 10.1074/jbc.RA118.005549. Epub 2019 Jan 18.

PMID:
30659096
13.

Hypoxia-Inducible Factor (HIF)-1α Promotes Inflammation and Injury Following Aspiration-Induced Lung Injury in Mice.

Suresh MV, Balijepalli S, Zhang B, Singh VV, Swamy S, Panicker S, Dolgachev VA, Subramanian C, Ramakrishnan SK, Thomas B, Rao TC, Delano MJ, Machado-Aranda D, Shah YM, Raghavendran K.

Shock. 2018 Dec 24. doi: 10.1097/SHK.0000000000001312. [Epub ahead of print]

PMID:
30601332
14.

Neutrophils Restrict Tumor-Associated Microbiota to Reduce Growth and Invasion of Colon Tumors in Mice.

Triner D, Devenport SN, Ramakrishnan SK, Ma X, Frieler RA, Greenson JK, Inohara N, Nunez G, Colacino JA, Mortensen RM, Shah YM.

Gastroenterology. 2019 Apr;156(5):1467-1482. doi: 10.1053/j.gastro.2018.12.003. Epub 2018 Dec 11.

PMID:
30550822
15.

Clostridium difficile toxins induce VEGF-A and vascular permeability to promote disease pathogenesis.

Huang J, Kelly CP, Bakirtzi K, Villafuerte Gálvez JA, Lyras D, Mileto SJ, Larcombe S, Xu H, Yang X, Shields KS, Zhu W, Zhang Y, Goldsmith JD, Patel IJ, Hansen J, Huang M, Yla-Herttuala S, Moss AC, Paredes-Sabja D, Pothoulakis C, Shah YM, Wang J, Chen X.

Nat Microbiol. 2019 Feb;4(2):269-279. doi: 10.1038/s41564-018-0300-x. Epub 2018 Dec 3.

16.

Hepatic hepcidin/intestinal HIF-2α axis maintains iron absorption during iron deficiency and overload.

Schwartz AJ, Das NK, Ramakrishnan SK, Jain C, Jurkovic MT, Wu J, Nemeth E, Lakhal-Littleton S, Colacino JA, Shah YM.

J Clin Invest. 2019 Jan 2;129(1):336-348. doi: 10.1172/JCI122359. Epub 2018 Dec 10.

17.

Natural Secretory Immunoglobulins Promote Enteric Viral Infections.

Turula H, Bragazzi Cunha J, Mainou BA, Ramakrishnan SK, Wilke CA, Gonzalez-Hernandez MB, Pry A, Fava J, Bassis CM, Edelman J, Shah YM, Corthesy B, Moore BB, Wobus CE.

J Virol. 2018 Nov 12;92(23). pii: e00826-18. doi: 10.1128/JVI.00826-18. Print 2018 Dec 1.

18.

Myc-Associated Zinc Finger Protein Regulates the Proinflammatory Response in Colitis and Colon Cancer via STAT3 Signaling.

Triner D, Castillo C, Hakim JB, Xue X, Greenson JK, Nuñez G, Chen GY, Colacino JA, Shah YM.

Mol Cell Biol. 2018 Oct 29;38(22). pii: e00386-18. doi: 10.1128/MCB.00386-18. Print 2018 Nov 15.

19.

Hepatic NF-kB-inducing kinase (NIK) suppresses mouse liver regeneration in acute and chronic liver diseases.

Xiong Y, Torsoni AS, Wu F, Shen H, Liu Y, Zhong X, Canet MJ, Shah YM, Omary MB, Liu Y, Rui L.

Elife. 2018 Aug 2;7. pii: e34152. doi: 10.7554/eLife.34152.

20.

Insulin/Snail1 axis ameliorates fatty liver disease by epigenetically suppressing lipogenesis.

Liu Y, Jiang L, Sun C, Ireland N, Shah YM, Liu Y, Rui L.

Nat Commun. 2018 Jul 16;9(1):2751. doi: 10.1038/s41467-018-05309-y.

21.

Cadmium Exposure Inhibits Branching Morphogenesis and Causes Alterations Consistent With HIF-1α Inhibition in Human Primary Breast Organoids.

Rocco SA, Koneva L, Middleton LYM, Thong T, Solanki S, Karram S, Nambunmee K, Harris C, Rozek LS, Sartor MA, Shah YM, Colacino JA.

Toxicol Sci. 2018 Aug 1;164(2):592-602. doi: 10.1093/toxsci/kfy112.

22.

Adipocyte-derived Lysophosphatidylcholine Activates Adipocyte and Adipose Tissue Macrophage Nod-Like Receptor Protein 3 Inflammasomes Mediating Homocysteine-Induced Insulin Resistance.

Zhang SY, Dong YQ, Wang P, Zhang X, Yan Y, Sun L, Liu B, Zhang D, Zhang H, Liu H, Kong W, Hu G, Shah YM, Gonzalez FJ, Wang X, Jiang C.

EBioMedicine. 2018 May;31:202-216. doi: 10.1016/j.ebiom.2018.04.022. Epub 2018 Apr 27.

23.

Pancreatic HIF2α Stabilization Leads to Chronic Pancreatitis and Predisposes to Mucinous Cystic Neoplasm.

Schofield HK, Tandon M, Park MJ, Halbrook CJ, Ramakrishnan SK, Kim EC, Shi J, Omary MB, Shah YM, Esni F, Pasca di Magliano M.

Cell Mol Gastroenterol Hepatol. 2017 Nov 10;5(2):169-185.e2. doi: 10.1016/j.jcmgh.2017.10.008. eCollection 2018.

24.

Identification, isolation and characterization of human LGR5-positive colon adenoma cells.

Dame MK, Attili D, McClintock SD, Dedhia PH, Ouillette P, Hardt O, Chin AM, Xue X, Laliberte J, Katz EL, Newsome GM, Hill DR, Miller AJ, Tsai YH, Agorku D, Altheim CH, Bosio A, Simon B, Samuelson LC, Stoerker JA, Appelman HD, Varani J, Wicha MS, Brenner DE, Shah YM, Spence JR, Colacino JA.

Development. 2018 Mar 14;145(6). pii: dev153049. doi: 10.1242/dev.153049.

25.

HIF1-alpha Regulates Acinar Cell Function and Response to Injury in Mouse Pancreas.

Park MJ, Iyer S, Xue X, Bragazzi Cunha J, Gu S, Moons D, Pipe SW, Williams JA, Simeone DM, Shah YM, Omary MB.

Gastroenterology. 2018 May;154(6):1630-1634.e3. doi: 10.1053/j.gastro.2018.01.037. Epub 2018 Feb 1.

26.

An OLTAM system for analysis of brown/beige fat thermogenic activity.

Kim DI, Liao J, Emont MP, Park MJ, Jun H, Ramakrishnan SK, Lin JD, Shah YM, Omary MB, Wu J.

Int J Obes (Lond). 2018 Apr;42(4):939-945. doi: 10.1038/ijo.2017.308. Epub 2018 Jan 23.

27.

A central role for hypoxia-inducible factor (HIF)-2α in hepatic glucose homeostasis.

Ramakrishnan SK, Shah YM.

Nutr Healthy Aging. 2017 Dec 7;4(3):207-216. doi: 10.3233/NHA-170022. Review.

28.

Indian Hedgehog Suppresses Intestinal Inflammation.

Razumilava N, Gumucio DL, Samuelson LC, Shah YM, Nusrat A, Merchant JL.

Cell Mol Gastroenterol Hepatol. 2017 Oct 31;5(1):63-64. doi: 10.1016/j.jcmgh.2017.10.003. eCollection 2018. No abstract available.

29.

Dual modulation of human hepatic zonation via canonical and non-canonical Wnt pathways.

McEnerney L, Duncan K, Bang BR, Elmasry S, Li M, Miki T, Ramakrishnan SK, Shah YM, Saito T.

Exp Mol Med. 2017 Dec 15;49(12):e413. doi: 10.1038/emm.2017.226.

30.

Quantitative proteomics identifies STEAP4 as a critical regulator of mitochondrial dysfunction linking inflammation and colon cancer.

Xue X, Bredell BX, Anderson ER, Martin A, Mays C, Nagao-Kitamoto H, Huang S, Győrffy B, Greenson JK, Hardiman K, Spence JR, Kamada N, Shah YM.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9608-E9617. doi: 10.1073/pnas.1712946114. Epub 2017 Oct 23.

31.

Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis.

Xie C, Yagai T, Luo Y, Liang X, Chen T, Wang Q, Sun D, Zhao J, Ramakrishnan SK, Sun L, Jiang C, Xue X, Tian Y, Krausz KW, Patterson AD, Shah YM, Wu Y, Jiang C, Gonzalez FJ.

Nat Med. 2017 Nov;23(11):1298-1308. doi: 10.1038/nm.4412. Epub 2017 Oct 9.

32.

Genetic neutrophil deficiency ameliorates cerebral ischemia-reperfusion injury.

Frieler RA, Chung Y, Ahlers CG, Gheordunescu G, Song J, Vigil TM, Shah YM, Mortensen RM.

Exp Neurol. 2017 Dec;298(Pt A):104-111. doi: 10.1016/j.expneurol.2017.08.016. Epub 2017 Aug 31.

33.

Hypoxia-inducible factor 2α (HIF-2α) promotes colon cancer growth by potentiating Yes-associated protein 1 (YAP1) activity.

Ma X, Zhang H, Xue X, Shah YM.

J Biol Chem. 2017 Oct 13;292(41):17046-17056. doi: 10.1074/jbc.M117.805655. Epub 2017 Aug 28.

34.

Iron elevation and adipose tissue remodeling in the epididymal depot of a mouse model of polygenic obesity.

Ma X, Pham VT, Mori H, MacDougald OA, Shah YM, Bodary PF.

PLoS One. 2017 Jun 26;12(6):e0179889. doi: 10.1371/journal.pone.0179889. eCollection 2017.

35.

Epithelial Hypoxia-Inducible Factor 2α Facilitates the Progression of Colon Tumors through Recruiting Neutrophils.

Triner D, Xue X, Schwartz AJ, Jung I, Colacino JA, Shah YM.

Mol Cell Biol. 2017 Feb 15;37(5). pii: e00481-16. doi: 10.1128/MCB.00481-16. Print 2017 Mar 1.

36.

Regulation and function of bone morphogenetic protein signaling in colonic injury and inflammation.

Ji T, Takabayashi H, Mao M, Han X, Xue X, Brazil JC, Eaton KA, Shah YM, Todisco A.

Am J Physiol Gastrointest Liver Physiol. 2017 Jan 1;312(1):G24-G33. doi: 10.1152/ajpgi.00169.2016. Epub 2016 Nov 17.

37.

Molecular Characterization of Hypoxic Alveolar Epithelial Cells After Lung Contusion Indicates an Important Role for HIF-1α.

Sherman MA, Suresh MV, Dolgachev VA, McCandless LK, Xue X, Ziru L, Machado-Aranda D, Shah YM, Raghavendran K.

Ann Surg. 2018 Feb;267(2):382-391. doi: 10.1097/SLA.0000000000002070.

38.

Transcription Factor ZBP-89 Drives a Feedforward Loop of β-Catenin Expression in Colorectal Cancer.

Essien BE, Sundaresan S, Ocadiz-Ruiz R, Chavis A, Tsao AC, Tessier AJ, Hayes MM, Photenhauer A, Saqui-Salces M, Kang AJ, Shah YM, Győrffy B, Merchant JL.

Cancer Res. 2016 Dec 1;76(23):6877-6887. Epub 2016 Oct 10.

39.

Mitochondrial Amino Acid Metabolism Provides Vulnerabilities in Mutant KRAS-Driven Cancers.

Shah YM, Lyssiotis CA.

Gastroenterology. 2016 Nov;151(5):798-801. doi: 10.1053/j.gastro.2016.09.036. Epub 2016 Oct 3. No abstract available.

PMID:
27713037
40.

Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis.

Xue X, Ramakrishnan SK, Weisz K, Triner D, Xie L, Attili D, Pant A, Győrffy B, Zhan M, Carter-Su C, Hardiman KM, Wang TD, Dame MK, Varani J, Brenner D, Fearon ER, Shah YM.

Cell Metab. 2016 Sep 13;24(3):447-461. doi: 10.1016/j.cmet.2016.07.015. Epub 2016 Aug 18.

41.

Hypoxia-inducible factors: a central link between inflammation and cancer.

Triner D, Shah YM.

J Clin Invest. 2016 Oct 3;126(10):3689-3698. doi: 10.1172/JCI84430. Epub 2016 Aug 15.

42.

Minihepcidin peptides as disease modifiers in mice affected by β-thalassemia and polycythemia vera.

Casu C, Oikonomidou PR, Chen H, Nandi V, Ginzburg Y, Prasad P, Fleming RE, Shah YM, Valore EV, Nemeth E, Ganz T, MacDonald B, Rivella S.

Blood. 2016 Jul 14;128(2):265-76. doi: 10.1182/blood-2015-10-676742. Epub 2016 May 6.

43.

Neurotensin Promotes the Development of Colitis and Intestinal Angiogenesis via Hif-1α-miR-210 Signaling.

Bakirtzi K, Law IK, Xue X, Iliopoulos D, Shah YM, Pothoulakis C.

J Immunol. 2016 May 15;196(10):4311-21. doi: 10.4049/jimmunol.1501443. Epub 2016 Apr 13.

44.

Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis.

Ro SH, Xue X, Ramakrishnan SK, Cho CS, Namkoong S, Jang I, Semple IA, Ho A, Park HW, Shah YM, Lee JH.

Elife. 2016 Feb 25;5:e12204. doi: 10.7554/eLife.12204.

45.

Induction of WNT11 by hypoxia and hypoxia-inducible factor-1α regulates cell proliferation, migration and invasion.

Mori H, Yao Y, Learman BS, Kurozumi K, Ishida J, Ramakrishnan SK, Overmyer KA, Xue X, Cawthorn WP, Reid MA, Taylor M, Ning X, Shah YM, MacDougald OA.

Sci Rep. 2016 Feb 10;6:21520. doi: 10.1038/srep21520.

46.

HIF2α Is an Essential Molecular Brake for Postprandial Hepatic Glucagon Response Independent of Insulin Signaling.

Ramakrishnan SK, Zhang H, Takahashi S, Centofanti B, Periyasamy S, Weisz K, Chen Z, Uhler MD, Rui L, Gonzalez FJ, Shah YM.

Cell Metab. 2016 Mar 8;23(3):505-16. doi: 10.1016/j.cmet.2016.01.004. Epub 2016 Feb 4.

47.

PPARα (Peroxisome Proliferator-activated Receptor α) Activation Reduces Hepatic CEACAM1 Protein Expression to Regulate Fatty Acid Oxidation during Fasting-refeeding Transition.

Ramakrishnan SK, Khuder SS, Al-Share QY, Russo L, Abdallah SL, Patel PR, Heinrich G, Muturi HT, Mopidevi BR, Oyarce AM, Shah YM, Sanchez ER, Najjar SM.

J Biol Chem. 2016 Apr 8;291(15):8121-9. doi: 10.1074/jbc.M116.714014. Epub 2016 Feb 4.

48.

The role of hypoxia in intestinal inflammation.

Shah YM.

Mol Cell Pediatr. 2016 Dec;3(1):1. doi: 10.1186/s40348-016-0030-1. Epub 2016 Jan 26.

49.

Role of Intestinal HIF-2α in Health and Disease.

Ramakrishnan SK, Shah YM.

Annu Rev Physiol. 2016;78:301-25. doi: 10.1146/annurev-physiol-021115-105202. Epub 2015 Nov 19. Review.

50.

Tumor-selective proteotoxicity of verteporfin inhibits colon cancer progression independently of YAP1.

Zhang H, Ramakrishnan SK, Triner D, Centofanti B, Maitra D, Győrffy B, Sebolt-Leopold JS, Dame MK, Varani J, Brenner DE, Fearon ER, Omary MB, Shah YM.

Sci Signal. 2015 Oct 6;8(397):ra98. doi: 10.1126/scisignal.aac5418.

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