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Items: 1 to 50 of 91

1.

Cadmium exposure inhibits branching morphogenesis and causes alterations consistent with HIF-1α inhibition in human primary breast organoids.

Rocco SA, Koneva L, Middleton LYM, Thong T, Solanki S, Karram S, Nambunmee K, Harris C, Rozek LS, Sartor MA, Shah YM, Colacino JA.

Toxicol Sci. 2018 May 7. doi: 10.1093/toxsci/kfy112. [Epub ahead of print]

PMID:
29741670
2.

Adipocyte-derived Lysophosphatidylcholine Activates Adipocyte and Adipose Tissue Macrophage Nod-Like Receptor Protein 3 Inflammasomes Mediating Homocysteine-Induced Insulin Resistance.

Zhang SY, Dong YQ, Wang P, Zhang X, Yan Y, Sun L, Liu B, Zhang D, Zhang H, Liu H, Kong W, Hu G, Shah YM, Gonzalez FJ, Wang X, Jiang C.

EBioMedicine. 2018 May;31:202-216. doi: 10.1016/j.ebiom.2018.04.022. Epub 2018 Apr 27.

3.

Pancreatic HIF2α Stabilization Leads to Chronic Pancreatitis and Predisposes to Mucinous Cystic Neoplasm.

Schofield HK, Tandon M, Park MJ, Halbrook CJ, Ramakrishnan SK, Kim EC, Shi J, Omary MB, Shah YM, Esni F, Pasca di Magliano M.

Cell Mol Gastroenterol Hepatol. 2017 Nov 10;5(2):169-185.e2. doi: 10.1016/j.jcmgh.2017.10.008. eCollection 2018.

4.

Identification, isolation and characterization of human LGR5-positive colon adenoma cells.

Dame MK, Attili D, McClintock SD, Dedhia PH, Ouillette P, Hardt O, Chin AM, Xue X, Laliberte J, Katz EL, Newsome GM, Hill DR, Miller AJ, Tsai YH, Agorku D, Altheim CH, Bosio A, Simon B, Samuelson LC, Stoerker JA, Appelman HD, Varani J, Wicha MS, Brenner DE, Shah YM, Spence JR, Colacino JA.

Development. 2018 Mar 14;145(6). pii: dev153049. doi: 10.1242/dev.153049.

PMID:
29467240
5.

HIF1-alpha Regulates Acinar Cell Function and Response to Injury in Mouse Pancreas.

Park MJ, Iyer S, Xue X, Bragazzi Cunha J, Gu S, Moons D, Pipe SW, Williams JA, Simeone DM, Shah YM, Omary MB.

Gastroenterology. 2018 May;154(6):1630-1634.e3. doi: 10.1053/j.gastro.2018.01.037. Epub 2018 Feb 1.

PMID:
29409830
6.

An OLTAM system for analysis of brown/beige fat thermogenic activity.

Kim DI, Liao J, Emont MP, Park MJ, Jun H, Ramakrishnan SK, Lin JD, Shah YM, Omary MB, Wu J.

Int J Obes (Lond). 2018 Apr;42(4):939-945. doi: 10.1038/ijo.2017.308. Epub 2018 Jan 23.

PMID:
29359735
7.

A central role for hypoxia-inducible factor (HIF)-2α in hepatic glucose homeostasis.

Ramakrishnan SK, Shah YM.

Nutr Healthy Aging. 2017 Dec 7;4(3):207-216. doi: 10.3233/NHA-170022. Review.

8.

Indian Hedgehog Suppresses Intestinal Inflammation.

Razumilava N, Gumucio DL, Samuelson LC, Shah YM, Nusrat A, Merchant JL.

Cell Mol Gastroenterol Hepatol. 2017 Oct 31;5(1):63-64. doi: 10.1016/j.jcmgh.2017.10.003. eCollection 2018. No abstract available.

9.

Dual modulation of human hepatic zonation via canonical and non-canonical Wnt pathways.

McEnerney L, Duncan K, Bang BR, Elmasry S, Li M, Miki T, Ramakrishnan SK, Shah YM, Saito T.

Exp Mol Med. 2017 Dec 15;49(12):e413. doi: 10.1038/emm.2017.226.

10.

Quantitative proteomics identifies STEAP4 as a critical regulator of mitochondrial dysfunction linking inflammation and colon cancer.

Xue X, Bredell BX, Anderson ER, Martin A, Mays C, Nagao-Kitamoto H, Huang S, Győrffy B, Greenson JK, Hardiman K, Spence JR, Kamada N, Shah YM.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9608-E9617. doi: 10.1073/pnas.1712946114. Epub 2017 Oct 23.

11.

Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis.

Xie C, Yagai T, Luo Y, Liang X, Chen T, Wang Q, Sun D, Zhao J, Ramakrishnan SK, Sun L, Jiang C, Xue X, Tian Y, Krausz KW, Patterson AD, Shah YM, Wu Y, Jiang C, Gonzalez FJ.

Nat Med. 2017 Nov;23(11):1298-1308. doi: 10.1038/nm.4412. Epub 2017 Oct 9.

PMID:
29035368
12.

Genetic neutrophil deficiency ameliorates cerebral ischemia-reperfusion injury.

Frieler RA, Chung Y, Ahlers CG, Gheordunescu G, Song J, Vigil TM, Shah YM, Mortensen RM.

Exp Neurol. 2017 Dec;298(Pt A):104-111. doi: 10.1016/j.expneurol.2017.08.016. Epub 2017 Aug 31.

PMID:
28865993
13.

Hypoxia-inducible factor 2α (HIF-2α) promotes colon cancer growth by potentiating Yes-associated protein 1 (YAP1) activity.

Ma X, Zhang H, Xue X, Shah YM.

J Biol Chem. 2017 Oct 13;292(41):17046-17056. doi: 10.1074/jbc.M117.805655. Epub 2017 Aug 28.

PMID:
28848049
14.

Iron elevation and adipose tissue remodeling in the epididymal depot of a mouse model of polygenic obesity.

Ma X, Pham VT, Mori H, MacDougald OA, Shah YM, Bodary PF.

PLoS One. 2017 Jun 26;12(6):e0179889. doi: 10.1371/journal.pone.0179889. eCollection 2017.

15.

Epithelial Hypoxia-Inducible Factor 2α Facilitates the Progression of Colon Tumors through Recruiting Neutrophils.

Triner D, Xue X, Schwartz AJ, Jung I, Colacino JA, Shah YM.

Mol Cell Biol. 2017 Feb 15;37(5). pii: e00481-16. doi: 10.1128/MCB.00481-16. Print 2017 Mar 1.

16.

Regulation and function of bone morphogenetic protein signaling in colonic injury and inflammation.

Ji T, Takabayashi H, Mao M, Han X, Xue X, Brazil JC, Eaton KA, Shah YM, Todisco A.

Am J Physiol Gastrointest Liver Physiol. 2017 Jan 1;312(1):G24-G33. doi: 10.1152/ajpgi.00169.2016. Epub 2016 Nov 17.

17.

Molecular Characterization of Hypoxic Alveolar Epithelial Cells After Lung Contusion Indicates an Important Role for HIF-1α.

Sherman MA, Suresh MV, Dolgachev VA, McCandless LK, Xue X, Ziru L, Machado-Aranda D, Shah YM, Raghavendran K.

Ann Surg. 2018 Feb;267(2):382-391. doi: 10.1097/SLA.0000000000002070.

PMID:
27811509
18.

Transcription Factor ZBP-89 Drives a Feedforward Loop of β-Catenin Expression in Colorectal Cancer.

Essien BE, Sundaresan S, Ocadiz-Ruiz R, Chavis A, Tsao AC, Tessier AJ, Hayes MM, Photenhauer A, Saqui-Salces M, Kang AJ, Shah YM, Győrffy B, Merchant JL.

Cancer Res. 2016 Dec 1;76(23):6877-6887. Epub 2016 Oct 10.

19.

Mitochondrial Amino Acid Metabolism Provides Vulnerabilities in Mutant KRAS-Driven Cancers.

Shah YM, Lyssiotis CA.

Gastroenterology. 2016 Nov;151(5):798-801. doi: 10.1053/j.gastro.2016.09.036. Epub 2016 Oct 3. No abstract available.

PMID:
27713037
20.

Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis.

Xue X, Ramakrishnan SK, Weisz K, Triner D, Xie L, Attili D, Pant A, Győrffy B, Zhan M, Carter-Su C, Hardiman KM, Wang TD, Dame MK, Varani J, Brenner D, Fearon ER, Shah YM.

Cell Metab. 2016 Sep 13;24(3):447-461. doi: 10.1016/j.cmet.2016.07.015. Epub 2016 Aug 18.

21.

Hypoxia-inducible factors: a central link between inflammation and cancer.

Triner D, Shah YM.

J Clin Invest. 2016 Oct 3;126(10):3689-3698. doi: 10.1172/JCI84430. Epub 2016 Aug 15.

22.

Minihepcidin peptides as disease modifiers in mice affected by β-thalassemia and polycythemia vera.

Casu C, Oikonomidou PR, Chen H, Nandi V, Ginzburg Y, Prasad P, Fleming RE, Shah YM, Valore EV, Nemeth E, Ganz T, MacDonald B, Rivella S.

Blood. 2016 Jul 14;128(2):265-76. doi: 10.1182/blood-2015-10-676742. Epub 2016 May 6.

23.

Neurotensin Promotes the Development of Colitis and Intestinal Angiogenesis via Hif-1α-miR-210 Signaling.

Bakirtzi K, Law IK, Xue X, Iliopoulos D, Shah YM, Pothoulakis C.

J Immunol. 2016 May 15;196(10):4311-21. doi: 10.4049/jimmunol.1501443. Epub 2016 Apr 13.

24.

Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis.

Ro SH, Xue X, Ramakrishnan SK, Cho CS, Namkoong S, Jang I, Semple IA, Ho A, Park HW, Shah YM, Lee JH.

Elife. 2016 Feb 25;5:e12204. doi: 10.7554/eLife.12204.

25.

Induction of WNT11 by hypoxia and hypoxia-inducible factor-1α regulates cell proliferation, migration and invasion.

Mori H, Yao Y, Learman BS, Kurozumi K, Ishida J, Ramakrishnan SK, Overmyer KA, Xue X, Cawthorn WP, Reid MA, Taylor M, Ning X, Shah YM, MacDougald OA.

Sci Rep. 2016 Feb 10;6:21520. doi: 10.1038/srep21520.

26.

HIF2α Is an Essential Molecular Brake for Postprandial Hepatic Glucagon Response Independent of Insulin Signaling.

Ramakrishnan SK, Zhang H, Takahashi S, Centofanti B, Periyasamy S, Weisz K, Chen Z, Uhler MD, Rui L, Gonzalez FJ, Shah YM.

Cell Metab. 2016 Mar 8;23(3):505-16. doi: 10.1016/j.cmet.2016.01.004. Epub 2016 Feb 4.

27.

PPARα (Peroxisome Proliferator-activated Receptor α) Activation Reduces Hepatic CEACAM1 Protein Expression to Regulate Fatty Acid Oxidation during Fasting-refeeding Transition.

Ramakrishnan SK, Khuder SS, Al-Share QY, Russo L, Abdallah SL, Patel PR, Heinrich G, Muturi HT, Mopidevi BR, Oyarce AM, Shah YM, Sanchez ER, Najjar SM.

J Biol Chem. 2016 Apr 8;291(15):8121-9. doi: 10.1074/jbc.M116.714014. Epub 2016 Feb 4.

28.

The role of hypoxia in intestinal inflammation.

Shah YM.

Mol Cell Pediatr. 2016 Dec;3(1):1. doi: 10.1186/s40348-016-0030-1. Epub 2016 Jan 26.

29.

Role of Intestinal HIF-2α in Health and Disease.

Ramakrishnan SK, Shah YM.

Annu Rev Physiol. 2016;78:301-25. doi: 10.1146/annurev-physiol-021115-105202. Epub 2015 Nov 19. Review.

30.

Tumor-selective proteotoxicity of verteporfin inhibits colon cancer progression independently of YAP1.

Zhang H, Ramakrishnan SK, Triner D, Centofanti B, Maitra D, Győrffy B, Sebolt-Leopold JS, Dame MK, Varani J, Brenner DE, Fearon ER, Omary MB, Shah YM.

Sci Signal. 2015 Oct 6;8(397):ra98. doi: 10.1126/scisignal.aac5418.

31.

Intestine-specific Disruption of Hypoxia-inducible Factor (HIF)-2α Improves Anemia in Sickle Cell Disease.

Das N, Xie L, Ramakrishnan SK, Campbell A, Rivella S, Shah YM.

J Biol Chem. 2015 Sep 25;290(39):23523-7. doi: 10.1074/jbc.C115.681643. Epub 2015 Aug 19.

32.

c-Kit as a Novel Potential Therapeutic Target in Colorectal Cancer.

Shah YM, van den Brink GR.

Gastroenterology. 2015 Sep;149(3):534-7. doi: 10.1053/j.gastro.2015.07.027. Epub 2015 Jul 27. No abstract available.

PMID:
26226570
33.

Maternal intestinal HIF-2α is necessary for sensing iron demands of lactation in mice.

Ramakrishnan SK, Anderson ER, Martin A, Centofanti B, Shah YM.

Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):E3738-47. doi: 10.1073/pnas.1504891112. Epub 2015 Jun 29.

34.

Fatty acid binding protein-4 (FABP4) is a hypoxia inducible gene that sensitizes mice to liver ischemia/reperfusion injury.

Hu B, Guo Y, Garbacz WG, Jiang M, Xu M, Huang H, Tsung A, Billiar TR, Ramakrishnan SK, Shah YM, Lam KS, Huang M, Xie W.

J Hepatol. 2015 Oct;63(4):855-62. doi: 10.1016/j.jhep.2015.05.030. Epub 2015 Jun 10.

35.

Transgenic mouse models for alcohol metabolism, toxicity, and cancer.

Heit C, Dong H, Chen Y, Shah YM, Thompson DC, Vasiliou V.

Adv Exp Med Biol. 2015;815:375-87. doi: 10.1007/978-3-319-09614-8_22.

36.

PPARα-UGT axis activation represses intestinal FXR-FGF15 feedback signalling and exacerbates experimental colitis.

Zhou X, Cao L, Jiang C, Xie Y, Cheng X, Krausz KW, Qi Y, Sun L, Shah YM, Gonzalez FJ, Wang G, Hao H.

Nat Commun. 2014 Sep 3;5:4573. doi: 10.1038/ncomms5573.

37.

PPARα-dependent exacerbation of experimental colitis by the hypolipidemic drug fenofibrate.

Qi Y, Jiang C, Tanaka N, Krausz KW, Brocker CN, Fang ZZ, Bredell BX, Shah YM, Gonzalez FJ.

Am J Physiol Gastrointest Liver Physiol. 2014 Sep 1;307(5):G564-73. doi: 10.1152/ajpgi.00153.2014. Epub 2014 Jul 17.

38.

Bacterial siderophores that evade or overwhelm lipocalin 2 induce hypoxia inducible factor 1α and proinflammatory cytokine secretion in cultured respiratory epithelial cells.

Holden VI, Lenio S, Kuick R, Ramakrishnan SK, Shah YM, Bachman MA.

Infect Immun. 2014 Sep;82(9):3826-36. doi: 10.1128/IAI.01849-14. Epub 2014 Jun 30.

39.

Hypoxia-inducible factor/MAZ-dependent induction of caveolin-1 regulates colon permeability through suppression of occludin, leading to hypoxia-induced inflammation.

Xie L, Xue X, Taylor M, Ramakrishnan SK, Nagaoka K, Hao C, Gonzalez FJ, Shah YM.

Mol Cell Biol. 2014 Aug;34(16):3013-23. doi: 10.1128/MCB.00324-14. Epub 2014 Jun 2.

40.

Activation of HIF-1α does not increase intestinal tumorigenesis.

Xue X, Ramakrishnan SK, Shah YM.

Am J Physiol Gastrointest Liver Physiol. 2014 Jul 15;307(2):G187-95. doi: 10.1152/ajpgi.00112.2014. Epub 2014 May 29.

41.

Biomarkers of coordinate metabolic reprogramming in colorectal tumors in mice and humans.

Manna SK, Tanaka N, Krausz KW, Haznadar M, Xue X, Matsubara T, Bowman ED, Fearon ER, Harris CC, Shah YM, Gonzalez FJ.

Gastroenterology. 2014 May;146(5):1313-24. doi: 10.1053/j.gastro.2014.01.017. Epub 2014 Jan 15.

42.

Loss of von Hippel-Lindau protein (VHL) increases systemic cholesterol levels through targeting hypoxia-inducible factor 2α and regulation of bile acid homeostasis.

Ramakrishnan SK, Taylor M, Qu A, Ahn SH, Suresh MV, Raghavendran K, Gonzalez FJ, Shah YM.

Mol Cell Biol. 2014 Apr;34(7):1208-20. doi: 10.1128/MCB.01441-13. Epub 2014 Jan 13.

43.

Hypoxia-inducible factors link iron homeostasis and erythropoiesis.

Shah YM, Xie L.

Gastroenterology. 2014 Mar;146(3):630-42. doi: 10.1053/j.gastro.2013.12.031. Epub 2013 Dec 31. Review.

44.

Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia.

Anderson ER, Taylor M, Xue X, Ramakrishnan SK, Martin A, Xie L, Bredell BX, Gardenghi S, Rivella S, Shah YM.

Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):E4922-30. doi: 10.1073/pnas.1314197110. Epub 2013 Nov 26.

45.

Role of Myc in hepatocellular proliferation and hepatocarcinogenesis.

Qu A, Jiang C, Cai Y, Kim JH, Tanaka N, Ward JM, Shah YM, Gonzalez FJ.

J Hepatol. 2014 Feb;60(2):331-8. doi: 10.1016/j.jhep.2013.09.024. Epub 2013 Oct 2.

46.

Role of PPARα and HNF4α in stress-mediated alterations in lipid homeostasis.

Konstandi M, Shah YM, Matsubara T, Gonzalez FJ.

PLoS One. 2013 Aug 14;8(8):e70675. doi: 10.1371/journal.pone.0070675. eCollection 2013.

47.

Endothelial PAS domain protein 1 activates the inflammatory response in the intestinal epithelium to promote colitis in mice.

Xue X, Ramakrishnan S, Anderson E, Taylor M, Zimmermann EM, Spence JR, Huang S, Greenson JK, Shah YM.

Gastroenterology. 2013 Oct;145(4):831-41. doi: 10.1053/j.gastro.2013.07.010. Epub 2013 Jul 13.

48.

Cholestasis induces reversible accumulation of periplakin in mouse liver.

Ito S, Satoh J, Matsubara T, Shah YM, Ahn SH, Anderson CR, Shan W, Peters JM, Gonzalez FJ.

BMC Gastroenterol. 2013 Jul 13;13:116. doi: 10.1186/1471-230X-13-116.

49.

Intestinal iron homeostasis and colon tumorigenesis.

Xue X, Shah YM.

Nutrients. 2013 Jun 28;5(7):2333-51. doi: 10.3390/nu5072333. Review.

50.

Iron homeostasis in the liver.

Anderson ER, Shah YM.

Compr Physiol. 2013 Jan;3(1):315-30. doi: 10.1002/cphy.c120016. Review.

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