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Sustained perfusion of revascularized bioengineered livers heterotopically transplanted into immunosuppressed pigs.

Shaheen MF, Joo D, Ross JJ, Anderson BD, Chen HS, Huebert RC, Li Y, Amiot B, Young A, Zlochiver V, Nelson E, Mounajjed T, Dietz AB, Michalak G, Steiner BG, Davidow DS, Paradise CR, van Wijnen AJ, Shah VH, Liu M, Nyberg SL.

Nat Biomed Eng. 2019 Oct 14. doi: 10.1038/s41551-019-0460-x. [Epub ahead of print]


Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis.

Argemi J, Latasa MU, Atkinson SR, Blokhin IO, Massey V, Gue JP, Cabezas J, Lozano JJ, Van Booven D, Bell A, Cao S, Vernetti LA, Arab JP, Ventura-Cots M, Edmunds LR, Fondevilla C, Stärkel P, Dubuquoy L, Louvet A, Odena G, Gomez JL, Aragon T, Altamirano J, Caballeria J, Jurczak MJ, Taylor DL, Berasain C, Wahlestedt C, Monga SP, Morgan MY, Sancho-Bru P, Mathurin P, Furuya S, Lackner C, Rusyn I, Shah VH, Thursz MR, Mann J, Avila MA, Bataller R.

Nat Commun. 2019 Jul 16;10(1):3126. doi: 10.1038/s41467-019-11004-3.


Prevalence and Predictors of Third-Generation Cephalosporin Resistance in the Empirical Treatment of Spontaneous Bacterial Peritonitis.

Sunjaya DB, Lennon RJ, Shah VH, Kamath PS, Simonetto DA.

Mayo Clin Proc. 2019 Aug;94(8):1499-1508. doi: 10.1016/j.mayocp.2018.12.036. Epub 2019 Jul 11.


Assessing Surgical Risk in Idiopathic Portal Hypertension: Some Answers, an Extrapolation, and More Questions.

Simonetto DA, Kamath PS, Shah VH.

Hepatology. 2019 Sep;70(3):767-770. doi: 10.1002/hep.30847. Epub 2019 Aug 19. No abstract available.


New Prospects for Medical Management of Acute Alcoholic Hepatitis.

Liu M, Shah VH.

Clin Liver Dis (Hoboken). 2019 May 31;13(5):131-135. doi: 10.1002/cld.792. eCollection 2019 May. Review. No abstract available.


Alcohol Abstinence Does Not Fully Reverse Abnormalities of Mucosal-Associated Invariant T Cells in the Blood of Patients With Alcoholic Hepatitis.

Li W, Lin EL, Liangpunsakul S, Lan J, Chalasani S, Rane S, Puri P, Kamath PS, Sanyal AJ, Shah VH, Radaeva S, Crabb DW, Chalasani N, Yu Q.

Clin Transl Gastroenterol. 2019 Jun;10(6):e00052. doi: 10.14309/ctg.0000000000000052.


Blueberry Muffin Baby with Cytomegalovirus Hepatitis.

Shah VH, Rambhia KD, Mukhi JI, Singh RP.

Indian Dermatol Online J. 2019 May-Jun;10(3):327-329. doi: 10.4103/idoj.IDOJ_291_18. No abstract available.


How to Use Emotional Intelligence as a Career Catalyst- the X-Factor of Success for Trainees and Faculty in Gastroenterology and Hepatology.

Shah VH, Shah PP.

Gastroenterology. 2019 Aug;157(2):289-292. doi: 10.1053/j.gastro.2019.05.009. Epub 2019 May 11. No abstract available.


Proteasomal Degradation of Enhancer of Zeste Homologue 2 in Cholangiocytes Promotes Biliary Fibrosis.

Jalan-Sakrikar N, De Assuncao TM, Shi G, Aseem SO, Chi C, Shah VH, Huebert RC.

Hepatology. 2019 May 9. doi: 10.1002/hep.30706. [Epub ahead of print]


Neuropilin-1 aggravates liver cirrhosis by promoting angiogenesis via VEGFR2-dependent PI3K/Akt pathway in hepatic sinusoidal endothelial cells.

Wang L, Feng Y, Xie X, Wu H, Su XN, Qi J, Xin W, Gao L, Zhang Y, Shah VH, Zhu Q.

EBioMedicine. 2019 May;43:525-536. doi: 10.1016/j.ebiom.2019.04.050. Epub 2019 May 3.


Alcohol-related liver disease: Clinical practice guidelines by the Latin American Association for the Study of the Liver (ALEH).

Arab JP, Roblero JP, Altamirano J, Bessone F, Chaves Araujo R, Higuera-De la Tijera F, Restrepo JC, Torre A, Urzua A, Simonetto DA, Abraldes JG, Méndez-Sánchez N, Contreras F, Lucey MR, Shah VH, Cortez-Pinto H, Bataller R.

Ann Hepatol. 2019 May - Jun;18(3):518-535. doi: 10.1016/j.aohep.2019.04.005. Epub 2019 Apr 18. Review.


Alcohol Rehabilitation Within 30 Days of Hospital Discharge Is Associated With Reduced Readmission, Relapse, and Death in Patients With Alcoholic Hepatitis.

Peeraphatdit TB, Kamath PS, Karpyak VM, Davis B, Desai V, Liangpunsakul S, Sanyal A, Chalasani N, Shah VH, Simonetto DA.

Clin Gastroenterol Hepatol. 2019 Apr 28. pii: S1542-3565(19)30438-0. doi: 10.1016/j.cgh.2019.04.048. [Epub ahead of print]


p300 Acetyltransferase Is a Cytoplasm-to-Nucleus Shuttle for SMAD2/3 and TAZ Nuclear Transport in Transforming Growth Factor β-Stimulated Hepatic Stellate Cells.

Wang Y, Tu K, Liu D, Guo L, Chen Y, Li Q, Maiers JL, Liu Z, Shah VH, Dou C, Tschumperlin D, Voneschen L, Yang R, Kang N.

Hepatology. 2019 Oct;70(4):1409-1423. doi: 10.1002/hep.30668. Epub 2019 May 23.


Extracellular vesicles, the liquid biopsy of the future.

Eguchi A, Kostallari E, Feldstein AE, Shah VH.

J Hepatol. 2019 Jun;70(6):1292-1294. doi: 10.1016/j.jhep.2019.01.030. Epub 2019 Apr 12. No abstract available.


Incidence and Risk Factors Associated With 30-Day Readmission for Alcoholic Hepatitis.

Garg SK, Sarvepalli S, Singh D, Obaitan I, Peeraphatdit T, Jophlin L, Asrani SK, Shah VH, Leise MD.

J Clin Gastroenterol. 2019 Nov/Dec;53(10):759-764. doi: 10.1097/MCG.0000000000001202.


Pericytes in the Liver.

Kostallari E, Shah VH.

Adv Exp Med Biol. 2019;1122:153-167. doi: 10.1007/978-3-030-11093-2_9. Review.


Mechanical Stretch Increases Expression of CXCL1 in Liver Sinusoidal Endothelial Cells to Recruit Neutrophils, Generate Sinusoidal Microthombi, and Promote Portal Hypertension.

Hilscher MB, Sehrawat T, Arab JP, Zeng Z, Gao J, Liu M, Kostallari E, Gao Y, Simonetto DA, Yaqoob U, Cao S, Revzin A, Beyder A, Wang RA, Kamath PS, Kubes P, Shah VH.

Gastroenterology. 2019 Jul;157(1):193-209.e9. doi: 10.1053/j.gastro.2019.03.013. Epub 2019 Mar 11.


Current trials and novel therapeutic targets for alcoholic hepatitis.

Singal AK, Shah VH.

J Hepatol. 2019 Feb;70(2):305-313. doi: 10.1016/j.jhep.2018.10.026. Review.


Alcohol-related liver disease: Areas of consensus, unmet needs and opportunities for further study.

Thursz M, Kamath PS, Mathurin P, Szabo G, Shah VH.

J Hepatol. 2019 Mar;70(3):521-530. doi: 10.1016/j.jhep.2018.10.041. Epub 2019 Jan 15. Review.


Alcohol-Related Liver Disease: Areas of Consensus, Unmet Needs and Opportunities for Further Study.

Szabo G, Kamath PS, Shah VH, Thursz M, Mathurin P; EASL-AASLD Joint Meeting.

Hepatology. 2019 May;69(5):2271-2283. doi: 10.1002/hep.30369. Epub 2019 Jan 15. Review.


Response to Forrest et al.

Singal AK, Bataller R, Ahn J, Kamath PS, Shah VH.

Am J Gastroenterol. 2019 Jan;114(1):176. doi: 10.14309/ajg.0000000000000073. No abstract available.


Transforming growth factor β (TGFβ) cross-talk with the unfolded protein response is critical for hepatic stellate cell activation.

Liu Z, Li C, Kang N, Malhi H, Shah VH, Maiers JL.

J Biol Chem. 2019 Mar 1;294(9):3137-3151. doi: 10.1074/jbc.RA118.005761. Epub 2019 Jan 4.


The Role of Three-Dimensional Magnetic Resonance Elastography in the Diagnosis of Nonalcoholic Steatohepatitis in Obese Patients Undergoing Bariatric Surgery.

Allen AM, Shah VH, Therneau TM, Venkatesh SK, Mounajjed T, Larson JJ, Mara KC, Schulte PJ, Kellogg TA, Kendrick ML, McKenzie TJ, Greiner SM, Li J, Glaser KJ, Wells ML, Chen J, Ehman RL, Yin M.

Hepatology. 2018 Dec 24. doi: 10.1002/hep.30483. [Epub ahead of print]


Enhancer of Zeste Homologue 2 Inhibition Attenuates TGF-β Dependent Hepatic Stellate Cell Activation and Liver Fibrosis.

Martin-Mateos R, De Assuncao TM, Arab JP, Jalan-Sakrikar N, Yaqoob U, Greuter T, Verma VK, Mathison AJ, Cao S, Lomberk G, Mathurin P, Urrutia R, Huebert RC, Shah VH.

Cell Mol Gastroenterol Hepatol. 2019;7(1):197-209. doi: 10.1016/j.jcmgh.2018.09.005. Epub 2018 Sep 15.


Prioritization of Therapeutic Targets and Trial Design in Cirrhotic Portal Hypertension.

Abraldes JG, Trebicka J, Chalasani N, D'Amico G, Rockey DC, Shah VH, Bosch J, Garcia-Tsao G.

Hepatology. 2019 Mar;69(3):1287-1299. doi: 10.1002/hep.30314. Epub 2019 Feb 9.


A Validated Score Predicts Acute Kidney Injury and Survival in Patients With Alcoholic Hepatitis.

Sujan R, Cruz-Lemini M, Altamirano J, Simonetto DA, Maiwall R, Axley P, Richardson T, Desai V, Cabezas J, Vargas V, Kamath PS, Shah VH, Sarin SK, Bataller R, Singal AK.

Liver Transpl. 2018 Dec;24(12):1655-1664. doi: 10.1002/lt.25328.


Comparison of Therapies for Primary Prevention of Esophageal Variceal Bleeding: A Systematic Review and Network Meta-analysis.

Sharma M, Singh S, Desai V, Shah VH, Kamath PS, Murad MH, Simonetto DA.

Hepatology. 2019 Apr;69(4):1657-1675. doi: 10.1002/hep.30220. Epub 2019 Feb 20.


Posttraumatic Stress Disorder in Patients with Heavy Alcohol Consumption and Alcoholic Hepatitis.

Samala N, Lourens SG, Shah VH, Kamath PS, Sanyal AJ, Crabb DW, Tang Q, Radaeva S, Liangpunsakul S, Chalasani N.

Alcohol Clin Exp Res. 2018 Oct;42(10):1933-1938. doi: 10.1111/acer.13862. Epub 2018 Aug 26.


Too Stiff, Too Late . . . Timing Is Everything in Antiangiogenic Treatment of Liver Fibrosis.

Greuter T, Shah VH.

Hepatology. 2019 Jan;69(1):449-451. doi: 10.1002/hep.30124. Epub 2018 Dec 18. No abstract available.


Psoriasis: implication to disease and therapeutic strategies, with an emphasis on drug delivery approaches.

Todke P, Shah VH.

Int J Dermatol. 2018 Nov;57(11):1387-1402. doi: 10.1111/ijd.14047. Epub 2018 Jun 19. Review.


Exploring new treatment paradigms for alcoholic hepatitis by extrapolating from NASH and cholestasis.

Peeraphatdit TB, Simonetto DA, Shah VH.

J Hepatol. 2018 Aug;69(2):275-277. doi: 10.1016/j.jhep.2018.05.012. Epub 2018 May 21. No abstract available.


Grand Rounds: Alcoholic Hepatitis.

Singal AK, Louvet A, Shah VH, Kamath PS.

J Hepatol. 2018 Aug;69(2):534-543. doi: 10.1016/j.jhep.2018.05.001. Epub 2018 Jun 13. Review.


P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-Promoting Myofibroblasts.

Dou C, Liu Z, Tu K, Zhang H, Chen C, Yaqoob U, Wang Y, Wen J, van Deursen J, Sicard D, Tschumperlin D, Zou H, Huang WC, Urrutia R, Shah VH, Kang N.

Gastroenterology. 2018 Jun;154(8):2209-2221.e14. doi: 10.1053/j.gastro.2018.02.015. Epub 2018 Feb 15.


Incidence and cost analysis of hospital admission and 30-day readmission among patients with cirrhosis.

Chirapongsathorn S, Krittanawong C, Enders FT, Pendegraft R, Mara KC, Borah BJ, Visscher SL, Loftus CG, Shah VH, Talwalkar JA, Kamath PS.

Hepatol Commun. 2018 Jan 18;2(2):188-198. doi: 10.1002/hep4.1137. eCollection 2018 Feb.


Interaction between the patatin-like phospholipase domain-containing protein 3 genotype and coffee drinking and the risk for acute alcoholic hepatitis.

Liangpunsakul S, Beaudoin JJ, Shah VH, Puri P, Sanyal AJ, Kamath PS, Lourens SG, Tang Q, Katz BP, Crabb DW, Chalasani NP.

Hepatol Commun. 2017 Nov 11;2(1):29-34. doi: 10.1002/hep4.1123. eCollection 2018 Jan.


Endothelial JAK2V617F does not enhance liver lesions in mice with Budd-Chiari syndrome.

Poisson J, Hilscher MB, Tanguy M, Hammoutene A, Boulanger CM, Villeval JL, Simonetto DA, Valla D, Shah VH, Rautou PE.

J Hepatol. 2018 May;68(5):1086-1087. doi: 10.1016/j.jhep.2018.01.010. Epub 2018 Jan 31. No abstract available.


Hepatic stellate cell-derived platelet-derived growth factor receptor-alpha-enriched extracellular vesicles promote liver fibrosis in mice through SHP2.

Kostallari E, Hirsova P, Prasnicka A, Verma VK, Yaqoob U, Wongjarupong N, Roberts LR, Shah VH.

Hepatology. 2018 Jul;68(1):333-348. doi: 10.1002/hep.29803. Epub 2018 May 10.


ACG Clinical Guideline: Alcoholic Liver Disease.

Singal AK, Bataller R, Ahn J, Kamath PS, Shah VH.

Am J Gastroenterol. 2018 Feb;113(2):175-194. doi: 10.1038/ajg.2017.469. Epub 2018 Jan 16.


Mechanosensing and fibrosis.

Tschumperlin DJ, Ligresti G, Hilscher MB, Shah VH.

J Clin Invest. 2018 Jan 2;128(1):74-84. doi: 10.1172/JCI93561. Epub 2018 Jan 2. Review.


Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms.

Drinane MC, Yaqoob U, Yu H, Luo F, Greuter T, Arab JP, Kostallari E, Verma VK, Maiers J, De Assuncao TM, Simons M, Mukhopadhyay D, Kisseleva T, Brenner DA, Urrutia R, Lomberk G, Gao Y, Ligresti G, Tschumperlin DJ, Revzin A, Cao S, Shah VH.

JCI Insight. 2017 Dec 21;2(24). pii: 92821. doi: 10.1172/jci.insight.92821.


Viral Hepatitis: Knowledge and Treatments for Hepatitis B and C Virus and Associated Transplantation and Neoplasia.

Sherman KE, Shah VH.

Gastroenterology. 2018 Feb;154(3):453-456. doi: 10.1053/j.gastro.2017.10.047. Epub 2017 Nov 14. No abstract available.


Improving survival in ACLF: growing evidence for use of G-CSF.

Simonetto DA, Shah VH, Kamath PS.

Hepatol Int. 2017 Nov;11(6):473-475. doi: 10.1007/s12072-017-9834-x. Epub 2017 Nov 9. No abstract available.


The circulating microbiome signature and inferred functional metagenomics in alcoholic hepatitis.

Puri P, Liangpunsakul S, Christensen JE, Shah VH, Kamath PS, Gores GJ, Walker S, Comerford M, Katz B, Borst A, Yu Q, Kumar DP, Mirshahi F, Radaeva S, Chalasani NP, Crabb DW, Sanyal AJ; TREAT Consortium.

Hepatology. 2018 Apr;67(4):1284-1302. doi: 10.1002/hep.29623. Epub 2018 Feb 22.


Challenges in Patient Enrollment and Retention in Clinical Studies for Alcoholic Hepatitis: Experience of the TREAT Consortium.

Comerford M, Lourens S, Liangpunsakul S, Chalasani NP, Sanyal AJ, Shah VH, Kamath PS, Puri P, Katz BP, Radaeva S, Crabb DW.

Alcohol Clin Exp Res. 2017 Dec;41(12):2000-2006. doi: 10.1111/acer.13515. Epub 2017 Oct 27. Review.


Therapeutic opportunities for alcoholic steatohepatitis and nonalcoholic steatohepatitis: exploiting similarities and differences in pathogenesis.

Greuter T, Malhi H, Gores GJ, Shah VH.

JCI Insight. 2017 Sep 7;2(17). pii: 95354. doi: 10.1172/jci.insight.95354. eCollection 2017 Sep 7. Review.


Use of Statins in Patients with Chronic Liver Disease and Cirrhosis: Current Views and Prospects.

Vargas JI, Arrese M, Shah VH, Arab JP.

Curr Gastroenterol Rep. 2017 Sep;19(9):43. doi: 10.1007/s11894-017-0584-7. Review.


Enhanced Ungual Permeation of Terbinafine HCl Delivered Through Liposome-Loaded Nail Lacquer Formulation Optimized by QbD Approach.

Shah VH, Jobanputra A.

AAPS PharmSciTech. 2018 Jan;19(1):213-224. doi: 10.1208/s12249-017-0831-0. Epub 2017 Jul 5.


Alcoholic hepatitis: Continued drinking and the mourning after.

Simonetto DA, Kamath PS, Shah VH.

Hepatology. 2017 Nov;66(5):1370-1372. doi: 10.1002/hep.29349. Epub 2017 Oct 11. No abstract available.


Lipopolysaccharide downregulates macrophage-derived IL-22 to modulate alcohol-induced hepatocyte cell death.

Liu Y, Verma VK, Malhi H, Gores GJ, Kamath PS, Sanyal A, Chalasani N, Gao B, Shah VH.

Am J Physiol Cell Physiol. 2017 Sep 1;313(3):C305-C313. doi: 10.1152/ajpcell.00005.2017. Epub 2017 Jun 21.


Gut-liver axis, cirrhosis and portal hypertension: the chicken and the egg.

Arab JP, Martin-Mateos RM, Shah VH.

Hepatol Int. 2018 Feb;12(Suppl 1):24-33. doi: 10.1007/s12072-017-9798-x. Epub 2017 May 26.


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