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Alcohol-Related Liver Disease: Areas of Consensus, Unmet Needs and Opportunities for Further Study.

Szabo G, Kamath PS, Shah VH, Thursz M, Mathurin P; EASL-AASLD Joint Meeting.

Hepatology. 2019 Jan 15. doi: 10.1002/hep.30369. [Epub ahead of print]


Response to Forrest et al.

Singal AK, Bataller R, Ahn J, Kamath PS, Shah VH.

Am J Gastroenterol. 2019 Jan;114(1):176. doi: 10.14309/ajg.0000000000000073. No abstract available.


Transforming growth factor β (TGFβ) crosstalk with the unfolded protein response is critical for hepatic stellate cell activation.

Liu Z, Li C, Kang N, Malhi H, Shah VH, Maiers JL.

J Biol Chem. 2019 Jan 4. pii: jbc.RA118.005761. doi: 10.1074/jbc.RA118.005761. [Epub ahead of print]


The role of 3D-MRE in the diagnosis of NASH in obese patients undergoing bariatric surgery.

Allen AM, Shah VH, Therneau TM, Venkatesh SK, Mounajjed T, Larson JJ, Mara KC, Schulte PJ, Kellogg TA, Kendrick ML, McKenzie TJ, Greiner SM, Li J, Glaser KJ, Wells ML, Chen J, Ehman RL, Yin M.

Hepatology. 2018 Dec 24. doi: 10.1002/hep.30483. [Epub ahead of print]


Enhancer of Zeste Homologue 2 Inhibition Attenuates TGF-β Dependent Hepatic Stellate Cell Activation and Liver Fibrosis.

Martin-Mateos R, De Assuncao TM, Arab JP, Jalan-Sakrikar N, Yaqoob U, Greuter T, Verma VK, Mathison AJ, Cao S, Lomberk G, Mathurin P, Urrutia R, Huebert RC, Shah VH.

Cell Mol Gastroenterol Hepatol. 2019;7(1):197-209. doi: 10.1016/j.jcmgh.2018.09.005. Epub 2018 Sep 15.


A Validated Score Predicts Acute Kidney Injury and Survival in Patients With Alcoholic Hepatitis.

Sujan R, Cruz-Lemini M, Altamirano J, Simonetto DA, Maiwall R, Axley P, Richardson T, Desai V, Cabezas J, Vargas V, Kamath PS, Shah VH, Sarin SK, Bataller R, Singal AK.

Liver Transpl. 2018 Dec;24(12):1655-1664. doi: 10.1002/lt.25328.


Comparison of Therapies for Primary Prevention of Esophageal Variceal Bleeding: A Systematic Review and Network Meta-analysis.

Sharma M, Singh S, Desai V, Shah VH, Kamath PS, Murad MH, Simonetto DA.

Hepatology. 2018 Aug 19. doi: 10.1002/hep.30220. [Epub ahead of print]


Posttraumatic Stress Disorder in Patients with Heavy Alcohol Consumption and Alcoholic Hepatitis.

Samala N, Lourens SG, Shah VH, Kamath PS, Sanyal AJ, Crabb DW, Tang Q, Radaeva S, Liangpunsakul S, Chalasani N.

Alcohol Clin Exp Res. 2018 Oct;42(10):1933-1938. doi: 10.1111/acer.13862. Epub 2018 Aug 26.


Too Stiff, Too Late . . . Timing Is Everything in Antiangiogenic Treatment of Liver Fibrosis.

Greuter T, Shah VH.

Hepatology. 2019 Jan;69(1):449-451. doi: 10.1002/hep.30124. Epub 2018 Dec 18. No abstract available.


Psoriasis: implication to disease and therapeutic strategies, with an emphasis on drug delivery approaches.

Todke P, Shah VH.

Int J Dermatol. 2018 Nov;57(11):1387-1402. doi: 10.1111/ijd.14047. Epub 2018 Jun 19.


Exploring new treatment paradigms for alcoholic hepatitis by extrapolating from NASH and cholestasis.

Peeraphatdit TB, Simonetto DA, Shah VH.

J Hepatol. 2018 Aug;69(2):275-277. doi: 10.1016/j.jhep.2018.05.012. Epub 2018 May 21. No abstract available.


Grand Rounds: Alcoholic Hepatitis.

Singal AK, Louvet A, Shah VH, Kamath PS.

J Hepatol. 2018 Aug;69(2):534-543. doi: 10.1016/j.jhep.2018.05.001. Epub 2018 Jun 13. Review.


P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-Promoting Myofibroblasts.

Dou C, Liu Z, Tu K, Zhang H, Chen C, Yaqoob U, Wang Y, Wen J, van Deursen J, Sicard D, Tschumperlin D, Zou H, Huang WC, Urrutia R, Shah VH, Kang N.

Gastroenterology. 2018 Jun;154(8):2209-2221.e14. doi: 10.1053/j.gastro.2018.02.015. Epub 2018 Feb 15.


Incidence and cost analysis of hospital admission and 30-day readmission among patients with cirrhosis.

Chirapongsathorn S, Krittanawong C, Enders FT, Pendegraft R, Mara KC, Borah BJ, Visscher SL, Loftus CG, Shah VH, Talwalkar JA, Kamath PS.

Hepatol Commun. 2018 Jan 18;2(2):188-198. doi: 10.1002/hep4.1137. eCollection 2018 Feb.


Interaction between the patatin-like phospholipase domain-containing protein 3 genotype and coffee drinking and the risk for acute alcoholic hepatitis.

Liangpunsakul S, Beaudoin JJ, Shah VH, Puri P, Sanyal AJ, Kamath PS, Lourens SG, Tang Q, Katz BP, Crabb DW, Chalasani NP.

Hepatol Commun. 2017 Nov 11;2(1):29-34. doi: 10.1002/hep4.1123. eCollection 2018 Jan.


Endothelial JAK2V617F does not enhance liver lesions in mice with Budd-Chiari syndrome.

Poisson J, Hilscher MB, Tanguy M, Hammoutene A, Boulanger CM, Villeval JL, Simonetto DA, Valla D, Shah VH, Rautou PE.

J Hepatol. 2018 May;68(5):1086-1087. doi: 10.1016/j.jhep.2018.01.010. Epub 2018 Jan 31. No abstract available.


Hepatic stellate cell-derived platelet-derived growth factor receptor-alpha-enriched extracellular vesicles promote liver fibrosis in mice through SHP2.

Kostallari E, Hirsova P, Prasnicka A, Verma VK, Yaqoob U, Wongjarupong N, Roberts LR, Shah VH.

Hepatology. 2018 Jul;68(1):333-348. doi: 10.1002/hep.29803. Epub 2018 May 10.


ACG Clinical Guideline: Alcoholic Liver Disease.

Singal AK, Bataller R, Ahn J, Kamath PS, Shah VH.

Am J Gastroenterol. 2018 Feb;113(2):175-194. doi: 10.1038/ajg.2017.469. Epub 2018 Jan 16.


Mechanosensing and fibrosis.

Tschumperlin DJ, Ligresti G, Hilscher MB, Shah VH.

J Clin Invest. 2018 Jan 2;128(1):74-84. doi: 10.1172/JCI93561. Epub 2018 Jan 2. Review.


Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms.

Drinane MC, Yaqoob U, Yu H, Luo F, Greuter T, Arab JP, Kostallari E, Verma VK, Maiers J, De Assuncao TM, Simons M, Mukhopadhyay D, Kisseleva T, Brenner DA, Urrutia R, Lomberk G, Gao Y, Ligresti G, Tschumperlin DJ, Revzin A, Cao S, Shah VH.

JCI Insight. 2017 Dec 21;2(24). pii: 92821. doi: 10.1172/jci.insight.92821. [Epub ahead of print]


Viral Hepatitis: Knowledge and Treatments for Hepatitis B and C Virus and Associated Transplantation and Neoplasia.

Sherman KE, Shah VH.

Gastroenterology. 2018 Feb;154(3):453-456. doi: 10.1053/j.gastro.2017.10.047. Epub 2017 Nov 14. No abstract available.


Improving survival in ACLF: growing evidence for use of G-CSF.

Simonetto DA, Shah VH, Kamath PS.

Hepatol Int. 2017 Nov;11(6):473-475. doi: 10.1007/s12072-017-9834-x. Epub 2017 Nov 9. No abstract available.


The circulating microbiome signature and inferred functional metagenomics in alcoholic hepatitis.

Puri P, Liangpunsakul S, Christensen JE, Shah VH, Kamath PS, Gores GJ, Walker S, Comerford M, Katz B, Borst A, Yu Q, Kumar DP, Mirshahi F, Radaeva S, Chalasani NP, Crabb DW, Sanyal AJ; TREAT Consortium.

Hepatology. 2018 Apr;67(4):1284-1302. doi: 10.1002/hep.29623. Epub 2018 Feb 22.


Challenges in Patient Enrollment and Retention in Clinical Studies for Alcoholic Hepatitis: Experience of the TREAT Consortium.

Comerford M, Lourens S, Liangpunsakul S, Chalasani NP, Sanyal AJ, Shah VH, Kamath PS, Puri P, Katz BP, Radaeva S, Crabb DW.

Alcohol Clin Exp Res. 2017 Dec;41(12):2000-2006. doi: 10.1111/acer.13515. Epub 2017 Oct 27. Review.


Therapeutic opportunities for alcoholic steatohepatitis and nonalcoholic steatohepatitis: exploiting similarities and differences in pathogenesis.

Greuter T, Malhi H, Gores GJ, Shah VH.

JCI Insight. 2017 Sep 7;2(17). pii: 95354. doi: 10.1172/jci.insight.95354. [Epub ahead of print] Review.


Use of Statins in Patients with Chronic Liver Disease and Cirrhosis: Current Views and Prospects.

Vargas JI, Arrese M, Shah VH, Arab JP.

Curr Gastroenterol Rep. 2017 Sep;19(9):43. doi: 10.1007/s11894-017-0584-7. Review.


Enhanced Ungual Permeation of Terbinafine HCl Delivered Through Liposome-Loaded Nail Lacquer Formulation Optimized by QbD Approach.

Shah VH, Jobanputra A.

AAPS PharmSciTech. 2018 Jan;19(1):213-224. doi: 10.1208/s12249-017-0831-0. Epub 2017 Jul 5.


Alcoholic hepatitis: Continued drinking and the mourning after.

Simonetto DA, Kamath PS, Shah VH.

Hepatology. 2017 Nov;66(5):1370-1372. doi: 10.1002/hep.29349. Epub 2017 Oct 11. No abstract available.


Lipopolysaccharide downregulates macrophage-derived IL-22 to modulate alcohol-induced hepatocyte cell death.

Liu Y, Verma VK, Malhi H, Gores GJ, Kamath PS, Sanyal A, Chalasani N, Gao B, Shah VH.

Am J Physiol Cell Physiol. 2017 Sep 1;313(3):C305-C313. doi: 10.1152/ajpcell.00005.2017. Epub 2017 Jun 21.


Gut-liver axis, cirrhosis and portal hypertension: the chicken and the egg.

Arab JP, Martin-Mateos RM, Shah VH.

Hepatol Int. 2018 Feb;12(Suppl 1):24-33. doi: 10.1007/s12072-017-9798-x. Epub 2017 May 26.


Alcohol abstinence ameliorates the dysregulated immune profiles in patients with alcoholic hepatitis: A prospective observational study.

Li W, Amet T, Xing Y, Yang D, Liangpunsakul S, Puri P, Kamath PS, Sanyal AJ, Shah VH, Katz BP, Radaeva S, Crabb DW, Chalasani N, Yu Q.

Hepatology. 2017 Aug;66(2):575-590. doi: 10.1002/hep.29242. Epub 2017 Jun 30.


Beta-blockers in patients with advanced cirrhosis: Red light, green light, yellow light….

Peeraphatdit TB, Kamath PS, Shah VH.

Liver Transpl. 2017 Jun;23(6):725-726. doi: 10.1002/lt.24780. No abstract available.


Acute Alcoholic Hepatitis: Natural History and Predictors of Mortality Using a Multicenter Prospective Study.

Lourens S, Sunjaya DB, Singal A, Liangpunsakul S, Puri P, Sanyal A, Ren X, Gores GJ, Radaeva S, Chalasani N, Crabb DW, Katz B, Kamath PS, Shah VH; TREAT Consortium.

Mayo Clin Proc Innov Qual Outcomes. 2017 Apr 28;1(1):37-48. doi: 10.1016/j.mayocpiqo.2017.04.004. eCollection 2017 Jul.


Infection in Severe Alcoholic Hepatitis: Yet Another Piece in the Puzzle.

Singal AK, Shah VH, Kamath PS.

Gastroenterology. 2017 Apr;152(5):938-940. doi: 10.1053/j.gastro.2017.02.030. Epub 2017 Mar 1. No abstract available.


Distinguishing between Hepatic Inflammation and Fibrosis with MR Elastography.

Yin M, Glaser KJ, Manduca A, Mounajjed T, Malhi H, Simonetto DA, Wang R, Yang L, Mao SA, Glorioso JM, Elgilani FM, Ward CJ, Harris PC, Nyberg SL, Shah VH, Ehman RL.

Radiology. 2017 Sep;284(3):694-705. doi: 10.1148/radiol.2017160622. Epub 2017 Jan 27.


The unfolded protein response mediates fibrogenesis and collagen I secretion through regulating TANGO1 in mice.

Maiers JL, Kostallari E, Mushref M, deAssuncao TM, Li H, Jalan-Sakrikar N, Huebert RC, Cao S, Malhi H, Shah VH.

Hepatology. 2017 Mar;65(3):983-998. doi: 10.1002/hep.28921. Epub 2016 Dec 31.


Inhibition of sphingosine 1-phosphate signaling ameliorates murine nonalcoholic steatohepatitis.

Mauer AS, Hirsova P, Maiers JL, Shah VH, Malhi H.

Am J Physiol Gastrointest Liver Physiol. 2017 Mar 1;312(3):G300-G313. doi: 10.1152/ajpgi.00222.2016. Epub 2016 Dec 30.


Reply to ''Alcohol and Liver Transplantation''.

Russ KB, Chen NW, Kamath PS, Shah VH, Kuo YF, Singal AK.

Alcohol Alcohol. 2017 Jan;52(1):127. doi: 10.1093/alcalc/agw057. Epub 2016 Sep 5. No abstract available.


Transcriptional Induction of Periostin by a Sulfatase 2-TGFβ1-SMAD Signaling Axis Mediates Tumor Angiogenesis in Hepatocellular Carcinoma.

Chen G, Nakamura I, Dhanasekaran R, Iguchi E, Tolosa EJ, Romecin PA, Vera RE, Almada LL, Miamen AG, Chaiteerakij R, Zhou M, Asiedu MK, Moser CD, Han S, Hu C, Banini BA, Oseini AM, Chen Y, Fang Y, Yang D, Shaleh HM, Wang S, Wu D, Song T, Lee JS, Thorgeirsson SS, Chevet E, Shah VH, Fernandez-Zapico ME, Roberts LR.

Cancer Res. 2017 Feb 1;77(3):632-645. doi: 10.1158/0008-5472.CAN-15-2556. Epub 2016 Nov 21.


Hepatic Stellate Cell Selective Disruption of Dynamin-2 GTPase Increases Murine Fibrogenesis through Up-Regulation of Sphingosine-1 Phosphate-Induced Cell Migration.

Wang R, Ding Q, De Assuncao TM, Mounajjed T, Maiers JL, Dou C, Cao S, Yaqoob U, Huebert RC, Shah VH.

Am J Pathol. 2017 Jan;187(1):134-145. doi: 10.1016/j.ajpath.2016.09.001. Epub 2016 Nov 10.


Alcohol Use after Liver Transplantation is Independent of Liver Disease Etiology.

Russ KB, Chen NW, Kamath PS, Shah VH, Kuo YF, Singal AK.

Alcohol Alcohol. 2016 Nov;51(6):698-701. Epub 2016 Jun 6.


Extracellular vesicles in liver pathobiology: Small particles with big impact.

Hirsova P, Ibrahim SH, Verma VK, Morton LA, Shah VH, LaRusso NF, Gores GJ, Malhi H.

Hepatology. 2016 Dec;64(6):2219-2233. doi: 10.1002/hep.28814. Epub 2016 Oct 20. Review.


How to Succeed in Academic Gastroenterology.

Allen JI, Wang TC, Cohen WS, Shah VH.

Gastroenterology. 2016 Oct;151(4):578-581.e6. doi: 10.1053/j.gastro.2016.08.034. Epub 2016 Aug 27. No abstract available.


Pathogenesis of Alcoholic Liver Disease.

Dunn W, Shah VH.

Clin Liver Dis. 2016 Aug;20(3):445-56. doi: 10.1016/j.cld.2016.02.004. Epub 2016 Mar 28. Review.


Endothelial notch signaling is essential to prevent hepatic vascular malformations in mice.

Cuervo H, Nielsen CM, Simonetto DA, Ferrell L, Shah VH, Wang RA.

Hepatology. 2016 Oct;64(4):1302-1316. doi: 10.1002/hep.28713. Epub 2016 Aug 4.


Effects of Age, Sex, Body Weight, and Quantity of Alcohol Consumption on Occurrence and Severity of Alcoholic Hepatitis.

Liangpunsakul S, Puri P, Shah VH, Kamath P, Sanyal A, Urban T, Ren X, Katz B, Radaeva S, Chalasani N, Crabb DW; Translational Research and Evolving Alcoholic Hepatitis Treatment Consortium.

Clin Gastroenterol Hepatol. 2016 Dec;14(12):1831-1838.e3. doi: 10.1016/j.cgh.2016.05.041. Epub 2016 Jun 15.


Angiocrine signaling in the hepatic sinusoids in health and disease.

Kostallari E, Shah VH.

Am J Physiol Gastrointest Liver Physiol. 2016 Aug 1;311(2):G246-51. doi: 10.1152/ajpgi.00118.2016. Epub 2016 Jun 10. Review.


Sinusoidal communication in liver fibrosis and regeneration.

Marrone G, Shah VH, Gracia-Sancho J.

J Hepatol. 2016 Sep;65(3):608-17. doi: 10.1016/j.jhep.2016.04.018. Epub 2016 May 2. Review.


Non-canonical role of matrix metalloprotease (MMP) in activation and migration of hepatic stellate cells (HSCs).

Baig MS, Yaqoob U, Cao S, Saqib U, Shah VH.

Life Sci. 2016 Jun 15;155:155-60. doi: 10.1016/j.lfs.2016.04.031. Epub 2016 Apr 29.


Statins and portal hypertension: A tale of two models.

Arab JP, Shah VH.

Hepatology. 2016 Jun;63(6):2044-7. doi: 10.1002/hep.28567. Review. No abstract available.


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