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Regulation of high glucose-induced apoptosis of brain pericytes by mitochondrial CA VA: A specific target for prevention of diabetic cerebrovascular pathology.

Price TO, Sheibani N, Shah GN.

Biochim Biophys Acta Mol Basis Dis. 2017 Apr;1863(4):929-935. doi: 10.1016/j.bbadis.2017.01.025. Epub 2017 Jan 26.


Blood-Brain Barrier Disruption and Neurovascular Unit Dysfunction in Diabetic Mice: Protection with the Mitochondrial Carbonic Anhydrase Inhibitor Topiramate.

Salameh TS, Shah GN, Price TO, Hayden MR, Banks WA.

J Pharmacol Exp Ther. 2016 Dec;359(3):452-459. Epub 2016 Oct 11.


Topiramate Protects Pericytes from Glucotoxicity: Role for Mitochondrial CA VA in Cerebromicrovascular Disease in Diabetes.

Patrick P, Price TO, Diogo AL, Sheibani N, Banks WA, Shah GN.

J Endocrinol Diabetes. 2015;2(2). pii:


Protective Effect of Topiramate on Hyperglycemia-Induced Cerebral Oxidative Stress, Pericyte Loss and Learning Behavior in Diabetic Mice.

Price TO, Farr SA, Niehoff ML, Ercal N, Morley JE, Shah GN.

Int Libr Diabetes Metab. 2015 Mar;1(1):6-12.


Antisense against Amyloid-β Protein Precursor Reverses Memory Deficits and Alters Gene Expression in Neurotropic and Insulin-Signaling Pathways in SAMP8 Mice.

Armbrecht HJ, Siddiqui AM, Green M, Farr SA, Kumar VB, Banks WA, Patrick P, Shah GN, Morley JE.

J Alzheimers Dis. 2015;46(2):535-48. doi: 10.3233/JAD-142760.


Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury.

Dohi K, Kraemer BC, Erickson MA, McMillan PJ, Kovac A, Flachbartova Z, Hansen KM, Shah GN, Sheibani N, Salameh T, Banks WA.

PLoS One. 2014 Sep 24;9(9):e108034. doi: 10.1371/journal.pone.0108034. eCollection 2014.


Active and passive case detection strategies for the control of leishmaniasis in Bangladesh.

Das AK, Harries AD, Hinderaker SG, Zachariah R, Ahmed B, Shah GN, Khogali MA, Das GI, Ahmed EM, Ritmeijer K.

Public Health Action. 2014 Mar 21;4(1):15-21. doi: 10.5588/pha.13.0084.


Identification of ATP8B1 as a blood-brain barrier-enriched protein.

Haas MJ, Shah GN, Onstead-Haas LM, Mooradian AD.

Cell Mol Neurobiol. 2014 May;34(4):473-8. doi: 10.1007/s10571-014-0045-x. Epub 2014 Mar 19.


Cardiorenal metabolic syndrome and diabetic cognopathy.

Hayden MR, Banks WA, Shah GN, Gu Z, Sowers JR.

Cardiorenal Med. 2013 Dec;3(4):265-82. doi: 10.1159/000357113. Epub 2013 Nov 29.


SAMP8 mice have altered hippocampal gene expression in long term potentiation, phosphatidylinositol signaling, and endocytosis pathways.

Armbrecht HJ, Siddiqui AM, Green M, Farr SA, Kumar VB, Banks WA, Patrick P, Shah GN, Morley JE.

Neurobiol Aging. 2014 Jan;35(1):159-68. doi: 10.1016/j.neurobiolaging.2013.07.018. Epub 2013 Aug 19.


Targeted mutagenesis of mitochondrial carbonic anhydrases VA and VB implicates both enzymes in ammonia detoxification and glucose metabolism.

Shah GN, Rubbelke TS, Hendin J, Nguyen H, Waheed A, Shoemaker JD, Sly WS.

Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7423-8. doi: 10.1073/pnas.1305805110. Epub 2013 Apr 15.


Pharmacological inhibition of mitochondrial carbonic anhydrases protects mouse cerebral pericytes from high glucose-induced oxidative stress and apoptosis.

Shah GN, Price TO, Banks WA, Morofuji Y, Kovac A, Ercal N, Sorenson CM, Shin ES, Sheibani N.

J Pharmacol Exp Ther. 2013 Mar;344(3):637-45. doi: 10.1124/jpet.112.201400. Epub 2012 Dec 17.


NMDA receptor-dependent afterdepolarizations are curtailed by carbonic anhydrase 14: regulation of a short-term postsynaptic potentiation.

Makani S, Chen HY, Esquenazi S, Shah GN, Waheed A, Sly WS, Chesler M.

J Neurosci. 2012 Nov 21;32(47):16754-62. doi: 10.1523/JNEUROSCI.1467-12.2012.


Topiramate treatment protects blood-brain barrier pericytes from hyperglycemia-induced oxidative damage in diabetic mice.

Price TO, Eranki V, Banks WA, Ercal N, Shah GN.

Endocrinology. 2012 Jan;153(1):362-72. doi: 10.1210/en.2011-1638. Epub 2011 Nov 22.


Progressive renal injury from transgenic expression of human carbonic anhydrase IV folding mutants is enhanced by deficiency of p58IPK.

Datta R, Shah GN, Rubbelke TS, Waheed A, Rauchman M, Goodman AG, Katze MG, Sly WS.

Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6448-52. doi: 10.1073/pnas.1001905107. Epub 2010 Mar 22.


Bicarbonate homeostasis in excitable tissues: role of AE3 Cl-/HCO3- exchanger and carbonic anhydrase XIV interaction.

Casey JR, Sly WS, Shah GN, Alvarez BV.

Am J Physiol Cell Physiol. 2009 Nov;297(5):C1091-102. doi: 10.1152/ajpcell.00177.2009. Epub 2009 Aug 19.


Nitric oxide activity and isoenzyme expression in the senescence-accelerated mouse p8 model of Alzheimer's disease: effects of anti-amyloid antibody and antisense treatments.

Ali AK, Banks WA, Kumar VB, Shah GN, Lynch JL, Farr SA, Fleegal-DeMotta MA, Morley JE.

J Gerontol A Biol Sci Med Sci. 2009 Oct;64(10):1025-30. doi: 10.1093/gerona/glp074. Epub 2009 Jun 16.


Lipopolysaccharide alters the blood-brain barrier transport of amyloid beta protein: a mechanism for inflammation in the progression of Alzheimer's disease.

Jaeger LB, Dohgu S, Sultana R, Lynch JL, Owen JB, Erickson MA, Shah GN, Price TO, Fleegal-Demotta MA, Butterfield DA, Banks WA.

Brain Behav Immun. 2009 May;23(4):507-17. doi: 10.1016/j.bbi.2009.01.017. Epub 2009 Feb 6. Erratum in: Brain Behav Immun. 2011 Nov;25(8):1737. Butterfiled, D Allan [corrected to Butterfield, D Allan].


Pathogenesis of retinitis pigmentosa associated with apoptosis-inducing mutations in carbonic anhydrase IV.

Datta R, Waheed A, Bonapace G, Shah GN, Sly WS.

Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3437-42. doi: 10.1073/pnas.0813178106. Epub 2009 Feb 11.


Infused Fc-tagged beta-glucuronidase crosses the placenta and produces clearance of storage in utero in mucopolysaccharidosis VII mice.

Grubb JH, Vogler C, Tan Y, Shah GN, MacRae AF, Sly WS.

Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8375-80. doi: 10.1073/pnas.0803715105. Epub 2008 Jun 10.


Signal sequence mutation in autosomal dominant form of hypoparathyroidism induces apoptosis that is corrected by a chemical chaperone.

Datta R, Waheed A, Shah GN, Sly WS.

Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19989-94. Epub 2007 Dec 3.


Carbonic anhydrases IV and IX: subcellular localization and functional role in mouse skeletal muscle.

Scheibe RJ, Mundhenk K, Becker T, Hallerdei J, Waheed A, Shah GN, Sly WS, Gros G, Wetzel P.

Am J Physiol Cell Physiol. 2008 Feb;294(2):C402-12. Epub 2007 Nov 14.


Carbonic anhydrase XIV deficiency produces a functional defect in the retinal light response.

Ogilvie JM, Ohlemiller KK, Shah GN, Ulmasov B, Becker TA, Waheed A, Hennig AK, Lukasiewicz PD, Sly WS.

Proc Natl Acad Sci U S A. 2007 May 15;104(20):8514-9. Epub 2007 May 7.


Carbonic anhydrase XIV in skeletal muscle: subcellular localization and function from wild-type and knockout mice.

Wetzel P, Scheibe RJ, Hellmann B, Hallerdei J, Shah GN, Waheed A, Gros G, Sly WS.

Am J Physiol Cell Physiol. 2007 Jul;293(1):C358-66. Epub 2007 Apr 25.


Expression of membrane-bound carbonic anhydrases IV, IX, and XIV in the mouse heart.

Scheibe RJ, Gros G, Parkkila S, Waheed A, Grubb JH, Shah GN, Sly WS, Wetzel P.

J Histochem Cytochem. 2006 Dec;54(12):1379-91.


Carbonic anhydrase type II deficiency.

Bolt RJ, Wennink JM, Verbeke JI, Shah GN, Sly WS, Bökenkamp A.

Am J Kidney Dis. 2005 Nov;46(5):A50, e71-3. No abstract available.


Carbonic anhydrase IV and XIV knockout mice: roles of the respective carbonic anhydrases in buffering the extracellular space in brain.

Shah GN, Ulmasov B, Waheed A, Becker T, Makani S, Svichar N, Chesler M, Sly WS.

Proc Natl Acad Sci U S A. 2005 Nov 15;102(46):16771-6. Epub 2005 Oct 31.


Carbonic anhydrase XIV identified as the membrane CA in mouse retina: strong expression in Müller cells and the RPE.

Ochrietor JD, Clamp MF, Moroz TP, Grubb JH, Shah GN, Waheed A, Sly WS, Linser PJ.

Exp Eye Res. 2005 Oct;81(4):492-500.


Characterization of CA XV, a new GPI-anchored form of carbonic anhydrase.

Hilvo M, Tolvanen M, Clark A, Shen B, Shah GN, Waheed A, Halmi P, Hänninen M, Hämäläinen JM, Vihinen M, Sly WS, Parkkila S.

Biochem J. 2005 Nov 15;392(Pt 1):83-92.


Chemical chaperones protect from effects of apoptosis-inducing mutation in carbonic anhydrase IV identified in retinitis pigmentosa 17.

Bonapace G, Waheed A, Shah GN, Sly WS.

Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12300-5. Epub 2004 Aug 4.


Apoptosis-inducing signal sequence mutation in carbonic anhydrase IV identified in patients with the RP17 form of retinitis pigmentosa.

Rebello G, Ramesar R, Vorster A, Roberts L, Ehrenreich L, Oppon E, Gama D, Bardien S, Greenberg J, Bonapace G, Waheed A, Shah GN, Sly WS.

Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6617-22. Epub 2004 Apr 16.


Expression, assay, and structure of the extracellular domain of murine carbonic anhydrase XIV: implications for selective inhibition of membrane-associated isozymes.

Whittington DA, Grubb JH, Waheed A, Shah GN, Sly WS, Christianson DW.

J Biol Chem. 2004 Feb 20;279(8):7223-8. Epub 2003 Dec 3.


Localization of carbonic anhydrase XII to the basolateral membrane of H+-secreting cells of mouse and rat kidney.

Kyllönen MS, Parkkila S, Rajaniemi H, Waheed A, Grubb JH, Shah GN, Sly WS, Kaunisto K.

J Histochem Cytochem. 2003 Sep;51(9):1217-24.


Mucopolysaccharidosis VII: clinical, biochemical and molecular investigation of a Brazilian family.

Schwartz I, Silva LR, Leistner S, Todeschini LA, Burin MG, Pina-Neto JM, Islam RM, Shah GN, Sly WS, Giugliani R.

Clin Genet. 2003 Aug;64(2):172-5. No abstract available.


A phenocopy of CAII deficiency: a novel genetic explanation for inherited infantile osteopetrosis with distal renal tubular acidosis.

Borthwick KJ, Kandemir N, Topaloglu R, Kornak U, Bakkaloglu A, Yordam N, Ozen S, Mocan H, Shah GN, Sly WS, Karet FE.

J Med Genet. 2003 Feb;40(2):115-21.


Methylation patterns of the human beta-glucuronidase gene locus: boundaries of methylation and general implications for frequent point mutations at CpG dinucleotides.

Tomatsu S, Orii KO, Islam MR, Shah GN, Grubb JH, Sukegawa K, Suzuki Y, Orii T, Kondo N, Sly WS.

Genomics. 2002 Mar;79(3):363-75.


Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells.

Whittington DA, Waheed A, Ulmasov B, Shah GN, Grubb JH, Sly WS, Christianson DW.

Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9545-50. Epub 2001 Aug 7.


Bone marrow transplantation corrects osteopetrosis in the carbonic anhydrase II deficiency syndrome.

McMahon C, Will A, Hu P, Shah GN, Sly WS, Smith OP.

Blood. 2001 Apr 1;97(7):1947-50.


Expression of membrane-associated carbonic anhydrase XIV on neurons and axons in mouse and human brain.

Parkkila S, Parkkila AK, Rajaniemi H, Shah GN, Grubb JH, Waheed A, Sly WS.

Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1918-23.


Purification and kinetic analysis of recombinant CA XII, a membrane carbonic anhydrase overexpressed in certain cancers.

Ulmasov B, Waheed A, Shah GN, Grubb JH, Sly WS, Tu C, Silverman DN.

Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14212-7.


Mitochondrial carbonic anhydrase CA VB: differences in tissue distribution and pattern of evolution from those of CA VA suggest distinct physiological roles.

Shah GN, Hewett-Emmett D, Grubb JH, Migas MC, Fleming RE, Waheed A, Sly WS.

Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1677-82.


Active site residues of human beta-glucuronidase. Evidence for Glu(540) as the nucleophile and Glu(451) as the acid-base residue.

Islam MR, Tomatsu S, Shah GN, Grubb JH, Jain S, Sly WS.

J Biol Chem. 1999 Aug 13;274(33):23451-5.


Novel translational repressor (NAT-1) expression is modified by thyroid state and age in brain and liver.

Shah GN, Li J, Mooradian AD.

Eur J Endocrinol. 1998 Dec;139(6):649-53.


Human carbonic anhydrase XII: cDNA cloning, expression, and chromosomal localization of a carbonic anhydrase gene that is overexpressed in some renal cell cancers.

Türeci O, Sahin U, Vollmar E, Siemer S, Göttert E, Seitz G, Parkkila AK, Shah GN, Grubb JH, Pfreundschuh M, Sly WS.

Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7608-13.


Age-related changes in thyroid hormone responsive protein (THRP) expression in cerebral tissue of rats.

Mooradian AD, Li J, Shah GN.

Brain Res. 1998 May 18;793(1-2):302-4.


Age-related changes in glucose transporter-one mRNA structure and function.

Mooradian AD, Shah GN.

Proc Soc Exp Biol Med. 1997 Dec;216(3):380-5.


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