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Effects of Sacubitril-Valsartan, versus Valsartan, in Women Compared to Men with Heart Failure and Preserved Ejection Fraction: Insights from PARAGON-HF.

McMurray JJV, Jackson AM, Lam CSP, Redfield MM, Anand IS, Ge J, Lefkowitz MP, Maggioni AP, Martinez F, Packer M, Pfeffer MA, Pieske B, Rizkala AR, Sabarwal SV, Shah AM, Shah SJ, Shi VC, van Veldhuisen DJ, Zannad F, Zile MR, Cikes M, Goncalvesova E, Katova T, Kosztin A, Lelonek M, Sweitzer NK, Vardeny O, Claggett B, Jhund PS, Solomon SD.

Circulation. 2019 Nov 17. doi: 10.1161/CIRCULATIONAHA.119.044491. [Epub ahead of print]


A histone deacetylase 7-derived peptide promotes vascular regeneration via facilitating 14-3-3γ phosphorylation.

Yang J, Moraga A, Xu J, Zhao Y, Luo P, Lao KH, Margariti A, Zhao Q, Ding W, Wang G, Zhang M, Zheng L, Zhang Z, Hu Y, Wang W, Shen L, Smith A, Shah AM, Wang Q, Zeng L.

Stem Cells. 2019 Nov 13. doi: 10.1002/stem.3122. [Epub ahead of print]


Impact of pulmonary disease on the prognosis in heart failure with preserved ejection fraction: the TOPCAT trial.

Ramalho SHR, Claggett BL, Sweitzer NK, Fang JC, Shah SJ, Anand IS, Pitt B, Lewis EF, Pfeffer MA, Solomon SD, Shah AM.

Eur J Heart Fail. 2019 Oct 31. doi: 10.1002/ejhf.1593. [Epub ahead of print] No abstract available.


A machine learning approach for the prediction of pulmonary hypertension.

Leha A, Hellenkamp K, Unsöld B, Mushemi-Blake S, Shah AM, Hasenfuß G, Seidler T.

PLoS One. 2019 Oct 25;14(10):e0224453. doi: 10.1371/journal.pone.0224453. eCollection 2019.


Prelamin A mediates myocardial inflammation in dilated and HIV-associated cardiomyopathies.

Brayson D, Frustaci A, Verardo R, Chimenti C, Russo MA, Hayward R, Ahmad S, Vizcay-Barrena G, Protti A, Zammit PS, dos Remedios CG, Ehler E, Shah AM, Shanahan CM.

JCI Insight. 2019 Nov 14;4(22). pii: 126315. doi: 10.1172/jci.insight.126315.


Effects of Nutritional Deprivation and Re-Alimentation on the Feed Efficiency, Blood Biochemistry, and Rumen Microflora in Yaks (Bos grunniens).

Zou H, Hu R, Wang Z, Shah AM, Zeng S, Peng Q, Xue B, Wang L, Zhang X, Wang X, Shi J, Li F, Zeng L.

Animals (Basel). 2019 Oct 15;9(10). pii: E807. doi: 10.3390/ani9100807.


Effects of Different Growth Stages of Amaranth Silage on the Rumen Degradation of Dairy Cows.

Ma J, Sun G, Shah AM, Fan X, Li S, Yu X.

Animals (Basel). 2019 Oct 12;9(10). pii: E793. doi: 10.3390/ani9100793.


Associations Between Left Ventricular Structure, Function, and Cerebral Amyloid: The ARIC-PET Study.

Johansen MC, Mosley TH, Knopman DS, Wong DF, Wagenknecht LE, Shah AM, Solomon SD, Gottesman RF.

Stroke. 2019 Oct 10:STROKEAHA119027220. doi: 10.1161/STROKEAHA.119.027220. [Epub ahead of print]


Response by Pfeffer et al to Letter Regarding Article, "Heart Failure With Preserved Ejection Fraction in Perspective".

Pfeffer MA, Shah AM, Borlaug BA.

Circ Res. 2019 Aug 2;125(4):e26. doi: 10.1161/CIRCRESAHA.119.315591. Epub 2019 Aug 1. No abstract available.


Association Between Circulating Troponin Concentrations, Left Ventricular Systolic and Diastolic Functions, and Incident Heart Failure in Older Adults.

Myhre PL, Claggett B, Ballantyne CM, Selvin E, Røsjø H, Omland T, Solomon SD, Skali H, Shah AM.

JAMA Cardiol. 2019 Sep 4. doi: 10.1001/jamacardio.2019.3113. [Epub ahead of print]


Exploring the impact of online information signals in leveraging the economic returns of physicians.

Shah AM, Yan X, Shah SAA, Shah SJ, Mamirkulova G.

J Biomed Inform. 2019 Oct;98:103272. doi: 10.1016/j.jbi.2019.103272. Epub 2019 Aug 31.


Effect of Sacubitril-Valsartan vs Enalapril on Aortic Stiffness in Patients With Heart Failure and Reduced Ejection Fraction: A Randomized Clinical Trial.

Desai AS, Solomon SD, Shah AM, Claggett BL, Fang JC, Izzo J, McCague K, Abbas CA, Rocha R, Mitchell GF; EVALUATE-HF Investigators.

JAMA. 2019 Sep 2:1-10. doi: 10.1001/jama.2019.12843. [Epub ahead of print]


Association of Change in N-Terminal Pro-B-Type Natriuretic Peptide Following Initiation of Sacubitril-Valsartan Treatment With Cardiac Structure and Function in Patients With Heart Failure With Reduced Ejection Fraction.

Januzzi JL Jr, Prescott MF, Butler J, Felker GM, Maisel AS, McCague K, Camacho A, Piña IL, Rocha RA, Shah AM, Williamson KM, Solomon SD; PROVE-HF Investigators.

JAMA. 2019 Sep 2:1-11. doi: 10.1001/jama.2019.12821. [Epub ahead of print]


Mechanistic basis of neonatal heart regeneration revealed by transcriptome and histone modification profiling.

Wang Z, Cui M, Shah AM, Ye W, Tan W, Min YL, Botten GA, Shelton JM, Liu N, Bassel-Duby R, Olson EN.

Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18455-18465. doi: 10.1073/pnas.1905824116. Epub 2019 Aug 26.


Effects of Land Transport Stress on Variations in Ruminal Microbe Diversity and Immune Functions in Different Breeds of Cattle.

Li F, Shah AM, Wang Z, Peng Q, Hu R, Zou H, Tan C, Zhang X, Liao Y, Wang Y, Wang X, Zeng L, Xue B, Wang L.

Animals (Basel). 2019 Aug 23;9(9). pii: E599. doi: 10.3390/ani9090599.


Effects of Supplementation of Branches and Leaves Trimmed from Tea Plant on Growth Performance, Rumen Fermentation and Meat Composition of Nanjiang Yellow Goats.

Shah AM, Cai Y, Zou H, Zhang X, Wang L, Xue B; Peiqiang; Yu, Wang Z, Peng Q.

Animals (Basel). 2019 Aug 21;9(9). pii: E590. doi: 10.3390/ani9090590.


Reply: Mitochondrial Unfolded Protein Response (UPRmt) Activation in Cardiac Diseases: Opportunities and Challenges.

Smyrnias I, Gray SP, Díez J, Shah AM.

J Am Coll Cardiol. 2019 Aug 20;74(7):1012. doi: 10.1016/j.jacc.2019.06.026. No abstract available.


The association of retinal vessel calibres with heart failure and long-term alterations in cardiac structure and function: the Atherosclerosis Risk in Communities (ARIC) Study.

Chandra A, Seidelmann SB, Claggett BL, Klein BE, Klein R, Shah AM, Solomon SD.

Eur J Heart Fail. 2019 Oct;21(10):1207-1215. doi: 10.1002/ejhf.1564. Epub 2019 Aug 1.


Application of the H2 FPEF score to a global clinical trial of patients with heart failure with preserved ejection fraction: the TOPCAT trial.

Myhre PL, Vaduganathan M, Claggett BL, Lam CSP, Desai AS, Anand IS, Sweitzer NK, Fang JC, O'Meara E, Shah SJ, Shah AM, Lewis EF, Rouleau J, Pitt B, Solomon SD.

Eur J Heart Fail. 2019 Oct;21(10):1288-1291. doi: 10.1002/ejhf.1542. Epub 2019 Jul 22. No abstract available.


Assessing the role of extracellular signal-regulated kinases 1 and 2 in volume overload-induced cardiac remodelling.

Jochmann S, Elkenani M, Mohamed BA, Buchholz E, Lbik D, Binder L, Lorenz K, Shah AM, Hasenfuß G, Toischer K, Schnelle M.

ESC Heart Fail. 2019 Oct;6(5):1015-1026. doi: 10.1002/ehf2.12497. Epub 2019 Jul 19.


Impact of Malnutrition Using Geriatric Nutritional Risk Index in Heart Failure With Preserved Ejection Fraction.

Minamisawa M, Seidelmann SB, Claggett B, Hegde SM, Shah AM, Desai AS, Lewis EF, Shah SJ, Sweitzer NK, Fang JC, Anand IS, O'Meara E, Rouleau JL, Pitt B, Solomon SD.

JACC Heart Fail. 2019 Aug;7(8):664-675. doi: 10.1016/j.jchf.2019.04.020. Epub 2019 Jul 10.


ST2 in patients with severe aortic stenosis and heart failure.

Cai A, Miyazawa A, Sunderland N, Piper SE, Gibbs TGJ, Wang D, Redding S, Amin-Youseff G, Wendler O, Byrne J, MacCarthy PA, Shah AM, McDonagh TA, Dworakowski R.

Cardiol J. 2019 Jun 21. doi: 10.5603/CJ.a2019.0052. [Epub ahead of print]


Magnetic Resonance Perfusion or Fractional Flow Reserve in Coronary Disease.

Nagel E, Greenwood JP, McCann GP, Bettencourt N, Shah AM, Hussain ST, Perera D, Plein S, Bucciarelli-Ducci C, Paul M, Westwood MA, Marber M, Richter WS, Puntmann VO, Schwenke C, Schulz-Menger J, Das R, Wong J, Hausenloy DJ, Steen H, Berry C; MR-INFORM Investigators.

N Engl J Med. 2019 Jun 20;380(25):2418-2428. doi: 10.1056/NEJMoa1716734.


Association of Undifferentiated Dyspnea in Late Life With Cardiovascular and Noncardiovascular Dysfunction: A Cross-sectional Analysis From the ARIC Study.

Ramalho SHR, Santos M, Claggett B, Matsushita K, Kitzman DW, Loehr L, Solomon SD, Skali H, Shah AM.

JAMA Netw Open. 2019 Jun 5;2(6):e195321. doi: 10.1001/jamanetworkopen.2019.5321.


Oxidation of PKGIα mediates an endogenous adaptation to pulmonary hypertension.

Rudyk O, Rowan A, Prysyazhna O, Krasemann S, Hartmann K, Zhang M, Shah AM, Ruppert C, Weiss A, Schermuly RT, Ida T, Akaike T, Zhao L, Eaton P.

Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):13016-13025. doi: 10.1073/pnas.1904064116. Epub 2019 Jun 11.


Single-cell transcriptome analyses reveal novel targets modulating cardiac neovascularization by resident endothelial cells following myocardial infarction.

Li Z, Solomonidis EG, Meloni M, Taylor RS, Duffin R, Dobie R, Magalhaes MS, Henderson BEP, Louwe PA, D'Amico G, Hodivala-Dilke KM, Shah AM, Mills NL, Simons BD, Gray GA, Henderson NC, Baker AH, Brittan M.

Eur Heart J. 2019 Aug 7;40(30):2507-2520. doi: 10.1093/eurheartj/ehz305.


Heart Failure With Preserved Ejection Fraction In Perspective.

Pfeffer MA, Shah AM, Borlaug BA.

Circ Res. 2019 May 24;124(11):1598-1617. doi: 10.1161/CIRCRESAHA.119.313572.


Blood Pressure-Lowering by the Antioxidant Resveratrol Is Counterintuitively Mediated by Oxidation of cGMP-Dependent Protein Kinase.

Prysyazhna O, Wolhuter K, Switzer C, Santos C, Yang X, Lynham S, Shah AM, Eaton P, Burgoyne JR.

Circulation. 2019 Jul 9;140(2):126-137. doi: 10.1161/CIRCULATIONAHA.118.037398. Epub 2019 May 22.


Quality of life before and after total knee arthroplasty in clinical settings across Lahore, Pakistan.

Shah AMUD, Afzal F, Ans M, Ayaz S, Niazi SG, Asim M, Tahir IM, Akram M.

Pak J Pharm Sci. 2019 Mar;32(2 (Supplementary)):769-772.


Metabolically activated adipose tissue macrophages link obesity to triple-negative breast cancer.

Tiwari P, Blank A, Cui C, Schoenfelt KQ, Zhou G, Xu Y, Khramtsova G, Olopade F, Shah AM, Khan SA, Rosner MR, Becker L.

J Exp Med. 2019 Jun 3;216(6):1345-1358. doi: 10.1084/jem.20181616. Epub 2019 May 3.


Tolerizing CTL by Sustained Hepatic PD-L1 Expression Provides a New Therapy Approach in Mouse Sepsis.

von Knethen A, Schäfer A, Kuchler L, Knape T, Christen U, Hintermann E, Fißlthaler B, Schröder K, Brandes RP, Genz B, Abshagen K, Pützer BM, Sha LK, Weigert A, Syed SN, Schulz M, Shah AM, Ernst A, Putyrski M, Finkelmeier F, Pesic M, Greten F, Hogardt M, Kempf VAJ, Gunne S, Parnham MJ, Brüne B.

Theranostics. 2019 Mar 16;9(7):2003-2016. doi: 10.7150/thno.28057. eCollection 2019.


Blood and urine biomarkers in chronic kidney disease: An update.

Bidin MZ, Shah AM, Stanslas J, Seong CLT.

Clin Chim Acta. 2019 Aug;495:239-250. doi: 10.1016/j.cca.2019.04.069. Epub 2019 Apr 19. Review.


Cardioprotective Effect of the Mitochondrial Unfolded Protein Response During Chronic Pressure Overload.

Smyrnias I, Gray SP, Okonko DO, Sawyer G, Zoccarato A, Catibog N, López B, González A, Ravassa S, Díez J, Shah AM.

J Am Coll Cardiol. 2019 Apr 16;73(14):1795-1806. doi: 10.1016/j.jacc.2018.12.087.


Cardiac arrest after induction of anesthesia in a 2-month-old infant with undiagnosed Williams syndrome.

Dunlap JD, Green MC, Shah AM, Kibby BT, Billmire DF.

Ann Card Anaesth. 2019 Apr-Jun;22(2):210-212. doi: 10.4103/aca.ACA_38_18.


The continuous heart failure spectrum: moving beyond an ejection fraction classification.

Triposkiadis F, Butler J, Abboud FM, Armstrong PW, Adamopoulos S, Atherton JJ, Backs J, Bauersachs J, Burkhoff D, Bonow RO, Chopra VK, de Boer RA, de Windt L, Hamdani N, Hasenfuss G, Heymans S, Hulot JS, Konstam M, Lee RT, Linke WA, Lunde IG, Lyon AR, Maack C, Mann DL, Mebazaa A, Mentz RJ, Nihoyannopoulos P, Papp Z, Parissis J, Pedrazzini T, Rosano G, Rouleau J, Seferovic PM, Shah AM, Starling RC, Tocchetti CG, Trochu JN, Thum T, Zannad F, Brutsaert DL, Segers VF, De Keulenaer GW.

Eur Heart J. 2019 Jul 1;40(26):2155-2163. doi: 10.1093/eurheartj/ehz158.


Long-term Patterns of Age-Related Facial Bone Loss in Black Individuals.

Buziashvili D, Tower JI, Sangal NR, Shah AM, Paskhover B.

JAMA Facial Plast Surg. 2019 Jul 1;21(4):292-297. doi: 10.1001/jamafacial.2019.0028.


Alborixin clears amyloid-β by inducing autophagy through PTEN-mediated inhibition of the AKT pathway.

Wani A, Gupta M, Ahmad M, Shah AM, Ahsan AU, Qazi PH, Malik F, Singh G, Sharma PR, Kaddoumi A, Bharate SB, Vishwakarma RA, Kumar A.

Autophagy. 2019 Oct;15(10):1810-1828. doi: 10.1080/15548627.2019.1596476. Epub 2019 Apr 2.


Association of Patisiran, an RNA Interference Therapeutic, With Regional Left Ventricular Myocardial Strain in Hereditary Transthyretin Amyloidosis: The APOLLO Study.

Minamisawa M, Claggett B, Adams D, Kristen AV, Merlini G, Slama MS, Dispenzieri A, Shah AM, Falk RH, Karsten V, Sweetser MT, Chen J, Riese R, Vest J, Solomon SD.

JAMA Cardiol. 2019 May 1;4(5):466-472. doi: 10.1001/jamacardio.2019.0849.


Intra-aortic Balloon Counterpulsation for High-Risk Percutaneous Coronary Intervention: Defining Coronary Responders.

Briceno N, De Silva K, Ryan M, Patterson T, O'Gallagher K, Ellis H, Rivolo S, Lee J, Redwood S, Shah AM, Marber M, Perera D.

J Cardiovasc Transl Res. 2019 Aug;12(4):299-309. doi: 10.1007/s12265-019-09871-8. Epub 2019 Mar 15.


Continuous-Flow Left Ventricular Assist Device Survival Improves With Multidisciplinary Approach.

Jorde UP, Shah AM, Sims DB, Madan S, Siddiqi N, Luke A, Saeed O, Patel SR, Murthy S, Shin J, Oviedo J, Watts S, Jakobleff W, Forest S, Vukelic S, Belov D, Puius Y, Minamoto G, Muggia V, Carlese A, Leung S, Rahmanian M, Leff J, Goldstein D.

Ann Thorac Surg. 2019 Aug;108(2):508-516. doi: 10.1016/j.athoracsur.2019.01.063. Epub 2019 Mar 7.


Paracrine Mechanisms of Redox Signalling for Postmitotic Cell and Tissue Regeneration.

Hervera A, Santos CX, De Virgiliis F, Shah AM, Di Giovanni S.

Trends Cell Biol. 2019 Jun;29(6):514-530. doi: 10.1016/j.tcb.2019.01.006. Epub 2019 Feb 19. Review.


Effect of Iron Isomaltoside on Skeletal Muscle Energetics in Patients With Chronic Heart Failure and Iron Deficiency.

Charles-Edwards G, Amaral N, Sleigh A, Ayis S, Catibog N, McDonagh T, Monaghan M, Amin-Youssef G, Kemp GJ, Shah AM, Okonko DO.

Circulation. 2019 May 21;139(21):2386-2398. doi: 10.1161/CIRCULATIONAHA.118.038516.


Arterial Vascular Pruning, Right Ventricular Size, and Clinical Outcomes in Chronic Obstructive Pulmonary Disease. A Longitudinal Observational Study.

Washko GR, Nardelli P, Ash SY, Vegas Sanchez-Ferrero G, Rahaghi FN, Come CE, Dransfield MT, Kalhan R, Han MK, Bhatt SP, Wells JM, Aaron CP, Diaz AA, Ross JC, Cuttica MJ, Labaki WW, Querejeta Roca G, Shah AM, Young K, Kinney GL, Hokanson JE, Agustí A, San José Estépar R.

Am J Respir Crit Care Med. 2019 Aug 15;200(4):454-461. doi: 10.1164/rccm.201811-2063OC.


Unanswered Questions Regarding Blood Pressure Management for HF Prevention.

Ramalho SHR, Shah AM.

Curr Hypertens Rep. 2019 Jan 18;21(1):7. doi: 10.1007/s11906-019-0908-0. Review.


Right Ventricular-Pulmonary Artery Coupling-Let's Not Lose the Forest for the Trees-Reply.

Nochioka K, Shah AM.

JAMA Cardiol. 2019 Feb 1;4(2):188-189. doi: 10.1001/jamacardio.2018.4485. No abstract available.


Hydrogen Sulfide Therapy Promotes Beneficial Systemic Effects in Experimental Heart Failure.

Nabeebaccus AA, Shah AM.

JACC Basic Transl Sci. 2018 Dec 31;3(6):810-812. doi: 10.1016/j.jacbts.2018.11.009. eCollection 2018 Dec. No abstract available.


Myocardial NADPH oxidase-4 regulates the physiological response to acute exercise.

Hancock M, Hafstad AD, Nabeebaccus AA, Catibog N, Logan A, Smyrnias I, Hansen SS, Lanner J, Schröder K, Murphy MP, Shah AM, Zhang M.

Elife. 2018 Dec 27;7. pii: e41044. doi: 10.7554/eLife.41044.


Refining Prediction of Atrial Fibrillation-Related Stroke Using the P2-CHA2DS2-VASc Score.

Maheshwari A, Norby FL, Roetker NS, Soliman EZ, Koene RJ, Rooney MR, O'Neal WT, Shah AM, Claggett BL, Solomon SD, Alonso A, Gottesman RF, Heckbert SR, Chen LY.

Circulation. 2019 Jan 8;139(2):180-191. doi: 10.1161/CIRCULATIONAHA.118.035411.


Effects of Patisiran, an RNA Interference Therapeutic, on Cardiac Parameters in Patients With Hereditary Transthyretin-Mediated Amyloidosis.

Solomon SD, Adams D, Kristen A, Grogan M, González-Duarte A, Maurer MS, Merlini G, Damy T, Slama MS, Brannagan TH 3rd, Dispenzieri A, Berk JL, Shah AM, Garg P, Vaishnaw A, Karsten V, Chen J, Gollob J, Vest J, Suhr O.

Circulation. 2019 Jan 22;139(4):431-443. doi: 10.1161/CIRCULATIONAHA.118.035831.


HFE H63D Polymorphism and the Risk for Systemic Hypertension, Myocardial Remodeling, and Adverse Cardiovascular Events in the ARIC Study.

Selvaraj S, Seidelmann S, Silvestre OM, Claggett B, Ndumele CE, Cheng S, Yu B, Fernandes-Silva MM, Grove ML, Boerwinkle E, Shah AM, Solomon SD.

Hypertension. 2019 Jan;73(1):68-74. doi: 10.1161/HYPERTENSIONAHA.118.11730.


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