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Items: 1 to 50 of 107

1.

Concentration-response evaluation of ToxCast compounds for multivariate activity patterns of neural network function.

Kosnik MB, Strickland JD, Marvel SW, Wallis DJ, Wallace K, Richard AM, Reif DM, Shafer TJ.

Arch Toxicol. 2019 Dec 10. doi: 10.1007/s00204-019-02636-x. [Epub ahead of print]

PMID:
31822930
2.

Corrigendum to Recommendation on test readiness criteria for new approach methods in toxicology: exemplified for developmental neurotoxicity.

Bal-Price A, Hogberg HT, Crofton KM, Daneshian M, FitzGerald RE, Fritsche E, Heinonen T, Hougaard Bennekou S, Klima S, Piersma AH, Sachana M, Shafer TJ, Terron A, Monnet-Tschudi F, Viviani B, Waldmann T, Westerink RHS, Wilks MF, Witters H, Zurich MG, Leist M.

ALTEX. 2019;36(3):506. doi: 10.14573/altex.1904112.

3.

Application of Microelectrode Array Approaches to Neurotoxicity Testing and Screening.

Shafer TJ.

Adv Neurobiol. 2019;22:275-297. doi: 10.1007/978-3-030-11135-9_12. Review.

PMID:
31073941
4.

The Next Generation Blueprint of Computational Toxicology at the U.S. Environmental Protection Agency.

Thomas RS, Bahadori T, Buckley TJ, Cowden J, Deisenroth C, Dionisio KL, Frithsen JB, Grulke CM, Gwinn MR, Harrill JA, Higuchi M, Houck KA, Hughes MF, Hunter ES, Isaacs KK, Judson RS, Knudsen TB, Lambert JC, Linnenbrink M, Martin TM, Newton SR, Padilla S, Patlewicz G, Paul-Friedman K, Phillips KA, Richard AM, Sams R, Shafer TJ, Setzer RW, Shah I, Simmons JE, Simmons SO, Singh A, Sobus JR, Strynar M, Swank A, Tornero-Valez R, Ulrich EM, Villeneuve DL, Wambaugh JF, Wetmore BA, Williams AJ.

Toxicol Sci. 2019 Jun 1;169(2):317-332. doi: 10.1093/toxsci/kfz058.

PMID:
30835285
5.

Evaluation of Chemical Effects on Network Formation in Cortical Neurons Grown on Microelectrode Arrays.

Shafer TJ, Brown JP, Lynch B, Davila-Montero S, Wallace K, Friedman KP.

Toxicol Sci. 2019 Jun 1;169(2):436-455. doi: 10.1093/toxsci/kfz052.

PMID:
30816951
6.

International Regulatory and Scientific Effort for Improved Developmental Neurotoxicity Testing.

Sachana M, Bal-Price A, Crofton KM, Bennekou SH, Shafer TJ, Behl M, Terron A.

Toxicol Sci. 2019 Jan 1;167(1):45-57. doi: 10.1093/toxsci/kfy211.

PMID:
30476307
7.

From molecular mechanisms to functional impact: Developing integrated analyses in neurotoxicology - The 16th biennial meeting International Neurotoxicology Association and 8th meeting of the NeuroToxicity Society.

Westerink RHS, van Thriel C, Levin ED, Shafer TJ.

Neurotoxicology. 2019 May;72:125-126. doi: 10.1016/j.neuro.2018.11.002. Epub 2018 Nov 6. No abstract available.

PMID:
30412720
8.

Testing for developmental neurotoxicity using a battery of in vitro assays for key cellular events in neurodevelopment.

Harrill JA, Freudenrich T, Wallace K, Ball K, Shafer TJ, Mundy WR.

Toxicol Appl Pharmacol. 2018 Sep 1;354:24-39. doi: 10.1016/j.taap.2018.04.001. Epub 2018 Apr 5.

PMID:
29626487
9.

How Inaccurate Metrics Hide the True Potential for Organ Donation in the United States.

Siminoff LA, Gardiner HM, Wilson-Genderson M, Shafer TJ.

Prog Transplant. 2018 Mar;28(1):12-18. doi: 10.1177/1526924818757939.

PMID:
29592635
10.

Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity.

Bal-Price A, Hogberg HT, Crofton KM, Daneshian M, FitzGerald RE, Fritsche E, Heinonen T, Hougaard Bennekou S, Klima S, Piersma AH, Sachana M, Shafer TJ, Terron A, Monnet-Tschudi F, Viviani B, Waldmann T, Westerink RHS, Wilks MF, Witters H, Zurich MG, Leist M.

ALTEX. 2018;35(3):306-352. doi: 10.14573/altex.1712081. Epub 2018 Feb 23. Erratum in: ALTEX. 2019;36(3):506.

11.

Defining toxicological tipping points in neuronal network development.

Frank CL, Brown JP, Wallace K, Wambaugh JF, Shah I, Shafer TJ.

Toxicol Appl Pharmacol. 2018 Sep 1;354:81-93. doi: 10.1016/j.taap.2018.01.017. Epub 2018 Feb 3.

PMID:
29397954
12.

From the Cover: Developmental Neurotoxicants Disrupt Activity in Cortical Networks on Microelectrode Arrays: Results of Screening 86 Compounds During Neural Network Formation.

Frank CL, Brown JP, Wallace K, Mundy WR, Shafer TJ.

Toxicol Sci. 2017 Nov 1;160(1):121-135. doi: 10.1093/toxsci/kfx169.

PMID:
28973552
13.

A multivariate extension of mutual information for growing neural networks.

Ball KR, Grant C, Mundy WR, Shafer TJ.

Neural Netw. 2017 Nov;95:29-43. doi: 10.1016/j.neunet.2017.07.009. Epub 2017 Jul 24.

PMID:
28850900
14.

Screening the ToxCast phase II libraries for alterations in network function using cortical neurons grown on multi-well microelectrode array (mwMEA) plates.

Strickland JD, Martin MT, Richard AM, Houck KA, Shafer TJ.

Arch Toxicol. 2018 Jan;92(1):487-500. doi: 10.1007/s00204-017-2035-5. Epub 2017 Aug 2.

15.

Assaying Spontaneous Network Activity and Cellular Viability Using Multi-well Microelectrode Arrays.

Brown JP, Lynch BS, Curry-Chisolm IM, Shafer TJ, Strickland JD.

Methods Mol Biol. 2017;1601:153-170. doi: 10.1007/978-1-4939-6960-9_13.

PMID:
28470525
16.

Editor's Highlight: Evaluation of a Microelectrode Array-Based Assay for Neural Network Ontogeny Using Training Set Chemicals.

Brown JP, Hall D, Frank CL, Wallace K, Mundy WR, Shafer TJ.

Toxicol Sci. 2016 Nov;154(1):126-139. Epub 2016 Aug 4.

PMID:
27492221
17.

In vitro screening of silver nanoparticles and ionic silver using neural networks yields differential effects on spontaneous activity and pharmacological responses.

Strickland JD, LeFew WR, Crooks J, Hall D, Ortenzio JN, Dreher K, Shafer TJ.

Toxicology. 2016 Apr 29;355-356:1-8. doi: 10.1016/j.tox.2016.05.009. Epub 2016 May 11.

PMID:
27179409
18.

Effects of an environmentally-relevant mixture of pyrethroid insecticides on spontaneous activity in primary cortical networks on microelectrode arrays.

Johnstone AFM, Strickland JD, Crofton KM, Gennings C, Shafer TJ.

Neurotoxicology. 2017 May;60:234-239. doi: 10.1016/j.neuro.2016.05.005. Epub 2016 May 10.

19.

A multi-laboratory evaluation of microelectrode array-based measurements of neural network activity for acute neurotoxicity testing.

Vassallo A, Chiappalone M, De Camargos Lopes R, Scelfo B, Novellino A, Defranchi E, Palosaari T, Weisschu T, Ramirez T, Martinoia S, Johnstone AFM, Mack CM, Landsiedel R, Whelan M, Bal-Price A, Shafer TJ.

Neurotoxicology. 2017 May;60:280-292. doi: 10.1016/j.neuro.2016.03.019. Epub 2016 Mar 29.

PMID:
27036093
20.

Characterization of Early Cortical Neural Network Development in Multiwell Microelectrode Array Plates.

Cotterill E, Hall D, Wallace K, Mundy WR, Eglen SJ, Shafer TJ.

J Biomol Screen. 2016 Jun;21(5):510-9. doi: 10.1177/1087057116640520. Epub 2016 Mar 29.

21.

In vitro screening of metal oxide nanoparticles for effects on neural function using cortical networks on microelectrode arrays.

Strickland JD, Lefew WR, Crooks J, Hall D, Ortenzio JN, Dreher K, Shafer TJ.

Nanotoxicology. 2016;10(5):619-28. doi: 10.3109/17435390.2015.1107142. Epub 2015 Nov 23.

PMID:
26593696
22.

Expanding the test set: Chemicals with potential to disrupt mammalian brain development.

Mundy WR, Padilla S, Breier JM, Crofton KM, Gilbert ME, Herr DW, Jensen KF, Radio NM, Raffaele KC, Schumacher K, Shafer TJ, Cowden J.

Neurotoxicol Teratol. 2015 Nov-Dec;52(Pt A):25-35. doi: 10.1016/j.ntt.2015.10.001. Epub 2015 Oct 22. Review.

PMID:
26476195
23.

Use of alternative assays to identify and prioritize organophosphorus flame retardants for potential developmental and neurotoxicity.

Behl M, Hsieh JH, Shafer TJ, Mundy WR, Rice JR, Boyd WA, Freedman JH, Hunter ES 3rd, Jarema KA, Padilla S, Tice RR.

Neurotoxicol Teratol. 2015 Nov-Dec;52(Pt B):181-93. doi: 10.1016/j.ntt.2015.09.003. Epub 2015 Sep 18.

PMID:
26386178
24.

A multiplexed assay for determination of neurotoxicant effects on spontaneous network activity and viability from microelectrode arrays.

Wallace K, Strickland JD, Valdivia P, Mundy WR, Shafer TJ.

Neurotoxicology. 2015 Jul;49:79-85. doi: 10.1016/j.neuro.2015.05.007. Epub 2015 May 29.

PMID:
26027956
25.

Sensitivity of neuroprogenitor cells to chemical-induced apoptosis using a multiplexed assay suitable for high-throughput screening.

Druwe I, Freudenrich TM, Wallace K, Shafer TJ, Mundy WR.

Toxicology. 2015 Jul 3;333:14-24. doi: 10.1016/j.tox.2015.03.011. Epub 2015 Apr 1.

PMID:
25841707
26.

Putative adverse outcome pathways relevant to neurotoxicity.

Bal-Price A, Crofton KM, Sachana M, Shafer TJ, Behl M, Forsby A, Hargreaves A, Landesmann B, Lein PJ, Louisse J, Monnet-Tschudi F, Paini A, Rolaki A, Schrattenholz A, Suñol C, van Thriel C, Whelan M, Fritsche E.

Crit Rev Toxicol. 2015 Jan;45(1):83-91. doi: 10.3109/10408444.2014.981331. Review.

27.

Improving in vitro to in vivo extrapolation by incorporating toxicokinetic measurements: a case study of lindane-induced neurotoxicity.

Croom EL, Shafer TJ, Evans MV, Mundy WR, Eklund CR, Johnstone AF, Mack CM, Pegram RA.

Toxicol Appl Pharmacol. 2015 Feb 15;283(1):9-19. doi: 10.1016/j.taap.2014.11.006. Epub 2014 Dec 18.

PMID:
25529470
28.

Glufosinate binds N-methyl-D-aspartate receptors and increases neuronal network activity in vitro.

Lantz SR, Mack CM, Wallace K, Key EF, Shafer TJ, Casida JE.

Neurotoxicology. 2014 Dec;45:38-47. doi: 10.1016/j.neuro.2014.09.003. Epub 2014 Sep 28.

PMID:
25268653
29.

Multi-well microelectrode array recordings detect neuroactivity of ToxCast compounds.

Valdivia P, Martin M, LeFew WR, Ross J, Houck KA, Shafer TJ.

Neurotoxicology. 2014 Sep;44:204-17. doi: 10.1016/j.neuro.2014.06.012. Epub 2014 Jul 2.

PMID:
24997244
30.

Burst and principal components analyses of MEA data for 16 chemicals describe at least three effects classes.

Mack CM, Lin BJ, Turner JD, Johnstone AF, Burgoon LD, Shafer TJ.

Neurotoxicology. 2014 Jan;40:75-85. doi: 10.1016/j.neuro.2013.11.008. Epub 2013 Dec 8.

PMID:
24325902
31.

Evaluation of microelectrode array data using Bayesian modeling as an approach to screening and prioritization for neurotoxicity testing.

Lefew WR, McConnell ER, Crooks JL, Shafer TJ.

Neurotoxicology. 2013 May;36:34-41. doi: 10.1016/j.neuro.2013.02.006. Epub 2013 Feb 27.

PMID:
23454661
32.

Transcriptional responses in rat brain associated with sub-chronic toluene inhalation are not predicted by effects of acute toluene inhalation.

Hester SD, Johnstone AF, Boyes WK, Bushnell PJ, Shafer TJ.

Neurotoxicol Teratol. 2012 Sep-Oct;34(5):530-3. doi: 10.1016/j.ntt.2012.08.004. Epub 2012 Aug 28.

PMID:
22967744
33.

Developmental neurotoxicity testing: a path forward.

Crofton KM, Mundy WR, Shafer TJ.

Congenit Anom (Kyoto). 2012 Sep;52(3):140-6. doi: 10.1111/j.1741-4520.2012.00377.x. Review.

PMID:
22925214
34.

Evaluation of multi-well microelectrode arrays for neurotoxicity screening using a chemical training set.

McConnell ER, McClain MA, Ross J, Lefew WR, Shafer TJ.

Neurotoxicology. 2012 Oct;33(5):1048-57. doi: 10.1016/j.neuro.2012.05.001. Epub 2012 May 28.

35.

Comparison of chemical-induced changes in proliferation and apoptosis in human and mouse neuroprogenitor cells.

Culbreth ME, Harrill JA, Freudenrich TM, Mundy WR, Shafer TJ.

Neurotoxicology. 2012 Dec;33(6):1499-1510. doi: 10.1016/j.neuro.2012.05.012. Epub 2012 May 25.

PMID:
22634143
36.

Cardiopulmonary resuscitation of organ donors.

Shafer TJ, Cosio C.

Prog Transplant. 2011 Dec;21(4):351-2. No abstract available.

PMID:
22548999
37.

Zero risk tolerance costs lives: loss of transplantable organs due to human immunodeficiency virus nucleic acid testing of potential donors.

Shafer TJ, Schkade D, Schkade L, Geier SS, Orlowski JP, Klintmalm G.

Prog Transplant. 2011 Sep;21(3):236-47; quiz 248.

PMID:
21977885
38.

Acute toluene exposure alters expression of genes in the central nervous system associated with synaptic structure and function.

Hester SD, Johnstone AF, Boyes WK, Bushnell PJ, Shafer TJ.

Neurotoxicol Teratol. 2011 Sep-Oct;33(5):521-9. doi: 10.1016/j.ntt.2011.07.008. Epub 2011 Jul 31.

PMID:
21827849
39.

Comments on: 'Perinatal toxicity of cyfluthrin in mice: developmental and behavioral effects' by Soni and colleagues.

Shafer TJ, Crofton KM.

Hum Exp Toxicol. 2011 Aug;30(8):1112-3. doi: 10.1177/0960327111411500. No abstract available.

PMID:
21771863
40.

Channelopathies: summary of the hot topic keynotes session.

Magby JP, Neal AP, Atchison WD, Pessah IP, Shafer TJ.

Neurotoxicology. 2011 Oct;32(5):661-5. doi: 10.1016/j.neuro.2011.06.002. Epub 2011 Jul 2. Review.

41.

Additivity of pyrethroid actions on sodium influx in cerebrocortical neurons in primary culture.

Cao Z, Shafer TJ, Crofton KM, Gennings C, Murray TF.

Environ Health Perspect. 2011 Sep;119(9):1239-46. doi: 10.1289/ehp.1003394. Epub 2011 Jun 10.

42.

Development of micro-electrode array based tests for neurotoxicity: assessment of interlaboratory reproducibility with neuroactive chemicals.

Novellino A, Scelfo B, Palosaari T, Price A, Sobanski T, Shafer TJ, Johnstone AF, Gross GW, Gramowski A, Schroeder O, Jügelt K, Chiappalone M, Benfenati F, Martinoia S, Tedesco MT, Defranchi E, D'Angelo P, Whelan M.

Front Neuroeng. 2011 Apr 27;4:4. doi: 10.3389/fneng.2011.00004. eCollection 2011.

43.

In vitro assessment of developmental neurotoxicity: use of microelectrode arrays to measure functional changes in neuronal network ontogeny.

Robinette BL, Harrill JA, Mundy WR, Shafer TJ.

Front Neuroeng. 2011 Jan 20;4:1. doi: 10.3389/fneng.2011.00001. eCollection 2011.

44.

Mechanisms of pyrethroid insecticide-induced stimulation of calcium influx in neocortical neurons.

Cao Z, Shafer TJ, Murray TF.

J Pharmacol Exp Ther. 2011 Jan;336(1):197-205. doi: 10.1124/jpet.110.171850. Epub 2010 Sep 29.

45.

Accumulation of pyrethroid compounds in primary cultures from rat cortex.

Shafer TJ, Hughes MF.

Toxicol In Vitro. 2010 Oct;24(7):2053-7. doi: 10.1016/j.tiv.2010.08.016. Epub 2010 Aug 25.

PMID:
20800091
46.

Microelectrode arrays: a physiologically based neurotoxicity testing platform for the 21st century.

Johnstone AF, Gross GW, Weiss DG, Schroeder OH, Gramowski A, Shafer TJ.

Neurotoxicology. 2010 Aug;31(4):331-50. doi: 10.1016/j.neuro.2010.04.001. Epub 2010 Apr 22. Review.

PMID:
20399226
47.

Neural progenitor cells as models for high-throughput screens of developmental neurotoxicity: state of the science.

Breier JM, Gassmann K, Kayser R, Stegeman H, De Groot D, Fritsche E, Shafer TJ.

Neurotoxicol Teratol. 2010 Jan-Feb;32(1):4-15. doi: 10.1016/j.ntt.2009.06.005. Epub 2009 Jun 24. Review.

PMID:
19559083
48.

Improving relatives' consent to organ donation.

Shafer TJ.

BMJ. 2009 Apr 21;338:b701. doi: 10.1136/bmj.b701. No abstract available.

PMID:
19383729
49.

US organ donation breakthrough collaborative increases organ donation.

Shafer TJ, Wagner D, Chessare J, Schall MW, McBride V, Zampiello FA, Perdue J, O'Connor K, Lin MJ, Burdick J.

Crit Care Nurs Q. 2008 Jul-Sep;31(3):190-210. doi: 10.1097/01.CNQ.0000325044.78904.9b.

PMID:
18574367
50.

Development of a high-throughput screening assay for chemical effects on proliferation and viability of immortalized human neural progenitor cells.

Breier JM, Radio NM, Mundy WR, Shafer TJ.

Toxicol Sci. 2008 Sep;105(1):119-33. doi: 10.1093/toxsci/kfn115. Epub 2008 Jun 11.

PMID:
18550602

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