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Cis- and trans-acting factors influence expression of the norM-encoded efflux pump of Neisseria gonorrhoeae and levels of gonococcal susceptibility to substrate antimicrobials.

Rouquette-Loughlin CE, Dhulipala V, Reimche JL, Raterman E, Begum AA, Jerse AE, Shafer WM.

Antimicrob Agents Chemother. 2018 Jun 11. pii: AAC.00821-18. doi: 10.1128/AAC.00821-18. [Epub ahead of print]


Copper Ions and Coordination Complexes as Novel Carbapenem Adjuvants.

Djoko KY, Achard MES, Phan MD, Lo AW, Miraula M, Prombhul S, Hancock SJ, Peters KM, Sidjabat HE, Harris PN, Mitić N, Walsh TR, Anderson GJ, Shafer WM, Paterson DL, Schenk G, McEwan AG, Schembri MA.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e02280-17. doi: 10.1128/AAC.02280-17. Print 2018 Feb.


Neisseria gonorrhoeae: Drug Resistance, Mouse Models, and Vaccine Development.

Rice PA, Shafer WM, Ram S, Jerse AE.

Annu Rev Microbiol. 2017 Sep 8;71:665-686. doi: 10.1146/annurev-micro-090816-093530. Review.


Multidrug-resistant gonorrhea: A research and development roadmap to discover new medicines.

Alirol E, Wi TE, Bala M, Bazzo ML, Chen XS, Deal C, Dillon JR, Kularatne R, Heim J, Hooft van Huijsduijnen R, Hook EW, Lahra MM, Lewis DA, Ndowa F, Shafer WM, Tayler L, Workowski K, Unemo M, Balasegaram M.

PLoS Med. 2017 Jul 26;14(7):e1002366. doi: 10.1371/journal.pmed.1002366. eCollection 2017 Jul.


Control of gdhR Expression in Neisseria gonorrhoeae via Autoregulation and a Master Repressor (MtrR) of a Drug Efflux Pump Operon.

Rouquette-Loughlin CE, Zalucki YM, Dhulipala VL, Balthazar JT, Doyle RG, Nicholas RA, Begum AA, Raterman EL, Jerse AE, Shafer WM.

MBio. 2017 Apr 11;8(2). pii: e00449-17. doi: 10.1128/mBio.00449-17.


Whole-Genome Sequencing of a Large Panel of Contemporary Neisseria gonorrhoeae Clinical Isolates Indicates that a Wild-Type mtrA Gene Is Common: Implications for Inducible Antimicrobial Resistance.

Vidyaprakash E, Abrams AJ, Shafer WM, Trees DL.

Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e00262-17. doi: 10.1128/AAC.00262-17. Print 2017 Apr. No abstract available.


The genes that encode the gonococcal transferrin binding proteins, TbpB and TbpA, are differentially regulated by MisR under iron-replete and iron-depleted conditions.

Kandler JL, Acevedo RV, Dickinson MK, Cash DR, Shafer WM, Cornelissen CN.

Mol Microbiol. 2016 Oct;102(1):137-51. doi: 10.1111/mmi.13450. Epub 2016 Jul 18.


Antimicrobial Resistance Expressed by Neisseria gonorrhoeae: A Major Global Public Health Problem in the 21st Century.

Unemo M, Del Rio C, Shafer WM.

Microbiol Spectr. 2016 Jun;4(3). doi: 10.1128/microbiolspec.EI10-0009-2015. Review.


The MisR Response Regulator Is Necessary for Intrinsic Cationic Antimicrobial Peptide and Aminoglycoside Resistance in Neisseria gonorrhoeae.

Kandler JL, Holley CL, Reimche JL, Dhulipala V, Balthazar JT, Muszyński A, Carlson RW, Shafer WM.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):4690-700. doi: 10.1128/AAC.00823-16. Print 2016 Aug.


Genetic Resistance Determinants, In Vitro Time-Kill Curve Analysis and Pharmacodynamic Functions for the Novel Topoisomerase II Inhibitor ETX0914 (AZD0914) in Neisseria gonorrhoeae.

Foerster S, Golparian D, Jacobsson S, Hathaway LJ, Low N, Shafer WM, Althaus CL, Unemo M.

Front Microbiol. 2015 Dec 10;6:1377. doi: 10.3389/fmicb.2015.01377. eCollection 2015.


Phosphoethanolamine Modification of Neisseria gonorrhoeae Lipid A Reduces Autophagy Flux in Macrophages.

Zughaier SM, Kandler JL, Balthazar JT, Shafer WM.

PLoS One. 2015 Dec 7;10(12):e0144347. doi: 10.1371/journal.pone.0144347. eCollection 2015.


Copper(II)-Bis(Thiosemicarbazonato) Complexes as Antibacterial Agents: Insights into Their Mode of Action and Potential as Therapeutics.

Djoko KY, Goytia MM, Donnelly PS, Schembri MA, Shafer WM, McEwan AG.

Antimicrob Agents Chemother. 2015 Oct;59(10):6444-53. doi: 10.1128/AAC.01289-15. Epub 2015 Aug 3.


Characterization of a spermine/spermidine transport system reveals a novel DNA sequence duplication in Neisseria gonorrhoeae.

Goytia M, Hawel L 3rd, Dhulipala VL, Joseph SJ, Read TD, Shafer WM.

FEMS Microbiol Lett. 2015 Aug;362(16). pii: fnv125. doi: 10.1093/femsle/fnv125. Epub 2015 Jul 30.


Future treatment of gonorrhea--novel emerging drugs are essential and in progress?

Unemo M, Shafer WM.

Expert Opin Emerg Drugs. 2015 Sep;20(3):357-60. doi: 10.1517/14728214.2015.1039981. Epub 2015 Jul 3. No abstract available.


Structure and function of Neisseria gonorrhoeae MtrF illuminates a class of antimetabolite efflux pumps.

Su CC, Bolla JR, Kumar N, Radhakrishnan A, Long F, Delmar JA, Chou TH, Rajashankar KR, Shafer WM, Yu EW.

Cell Rep. 2015 Apr 7;11(1):61-70. doi: 10.1016/j.celrep.2015.03.003. Epub 2015 Mar 26.


Population structure of Neisseria gonorrhoeae based on whole genome data and its relationship with antibiotic resistance.

Ezewudo MN, Joseph SJ, Castillo-Ramirez S, Dean D, Del Rio C, Didelot X, Dillon JA, Selden RF, Shafer WM, Turingan RS, Unemo M, Read TD.

PeerJ. 2015 Mar 5;3:e806. doi: 10.7717/peerj.806. eCollection 2015.


On the in vivo significance of bacterial resistance to antimicrobial peptides.

Bauer ME, Shafer WM.

Biochim Biophys Acta. 2015 Nov;1848(11 Pt B):3101-11. doi: 10.1016/j.bbamem.2015.02.012. Epub 2015 Feb 18. Review.


Overproduction of the MtrCDE efflux pump in Neisseria gonorrhoeae produces unexpected changes in cellular transcription patterns.

Ohneck EA, Goytia M, Rouquette-Loughlin CE, Joseph SJ, Read TD, Jerse AE, Shafer WM.

Antimicrob Agents Chemother. 2015 Jan;59(1):724-6. doi: 10.1128/AAC.04148-14. Epub 2014 Nov 3.

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