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Items: 34

1.

Siroheme Is Essential for Assimilation of Nitrate and Sulfate as Well as Detoxification of Nitric Oxide but Dispensable for Murine Virulence of Aspergillus fumigatus.

Dietl AM, Binder U, Shadkchan Y, Osherov N, Haas H.

Front Microbiol. 2018 Nov 12;9:2615. doi: 10.3389/fmicb.2018.02615. eCollection 2018.

2.

Riboflavin and pantothenic acid biosynthesis are crucial for iron homeostasis and virulence in the pathogenic mold Aspergillus fumigatus.

Dietl AM, Meir Z, Shadkchan Y, Osherov N, Haas H.

Virulence. 2018;9(1):1036-1049. doi: 10.1080/21505594.2018.1482181.

3.

Contribution of ATPase copper transporters in animal but not plant virulence of the crossover pathogen Aspergillus flavus.

Yang K, Shadkchan Y, Tannous J, Landero Figueroa JA, Wiemann P, Osherov N, Wang S, Keller NP.

Virulence. 2018;9(1):1273-1286. doi: 10.1080/21505594.2018.1496774.

4.

Phenotypic and Proteomic Analysis of the Aspergillus fumigatus ΔPrtT, ΔXprG and ΔXprGPrtT Protease-Deficient Mutants.

Shemesh E, Hanf B, Hagag S, Attias S, Shadkchan Y, Fichtman B, Harel A, Krüger T, Brakhage AA, Kniemeyer O, Osherov N.

Front Microbiol. 2017 Dec 12;8:2490. doi: 10.3389/fmicb.2017.02490. eCollection 2017.

5.

Aspergillus fumigatus Copper Export Machinery and Reactive Oxygen Intermediate Defense Counter Host Copper-Mediated Oxidative Antimicrobial Offense.

Wiemann P, Perevitsky A, Lim FY, Shadkchan Y, Knox BP, Landero Figueora JA, Choera T, Niu M, Steinberger AJ, Wüthrich M, Idol RA, Klein BS, Dinauer MC, Huttenlocher A, Osherov N, Keller NP.

Cell Rep. 2017 Jun 6;19(10):2174-2176. doi: 10.1016/j.celrep.2017.05.075. No abstract available.

6.

The quinoline bromoquinol exhibits broad-spectrum antifungal activity and induces oxidative stress and apoptosis in Aspergillus fumigatus.

Ben Yaakov D, Shadkchan Y, Albert N, Kontoyiannis DP, Osherov N.

J Antimicrob Chemother. 2017 Aug 1;72(8):2263-2272. doi: 10.1093/jac/dkx117.

PMID:
28475687
7.

Aspergillus fumigatus Copper Export Machinery and Reactive Oxygen Intermediate Defense Counter Host Copper-Mediated Oxidative Antimicrobial Offense.

Wiemann P, Perevitsky A, Lim FY, Shadkchan Y, Knox BP, Landero Figueora JA, Choera T, Niu M, Steinberger AJ, Wüthrich M, Idol RA, Klein BS, Dinauer MC, Huttenlocher A, Osherov N, Keller NP.

Cell Rep. 2017 May 2;19(5):1008-1021. doi: 10.1016/j.celrep.2017.04.019. Erratum in: Cell Rep. 2017 Jun 6;19(10 ):2174-2176.

8.

Identification and Characterization of a Novel Aspergillus fumigatus Rhomboid Family Putative Protease, RbdA, Involved in Hypoxia Sensing and Virulence.

Vaknin Y, Hillmann F, Iannitti R, Ben Baruch N, Sandovsky-Losica H, Shadkchan Y, Romani L, Brakhage A, Kniemeyer O, Osherov N.

Infect Immun. 2016 May 24;84(6):1866-1878. doi: 10.1128/IAI.00011-16. Print 2016 Jun.

9.

Mechanisms of Bacterial (Serratia marcescens) Attachment to, Migration along, and Killing of Fungal Hyphae.

Hover T, Maya T, Ron S, Sandovsky H, Shadkchan Y, Kijner N, Mitiagin Y, Fichtman B, Harel A, Shanks RM, Bruna RE, García-Véscovi E, Osherov N.

Appl Environ Microbiol. 2016 Apr 18;82(9):2585-94. doi: 10.1128/AEM.04070-15. Print 2016 May.

10.

Novel Water-Soluble Amphotericin B-PEG Conjugates with Low Toxicity and Potent in Vivo Efficacy.

Halperin A, Shadkchan Y, Pisarevsky E, Szpilman AM, Sandovsky H, Osherov N, Benhar I.

J Med Chem. 2016 Feb 11;59(3):1197-206. doi: 10.1021/acs.jmedchem.5b01862. Epub 2016 Jan 27.

PMID:
26816333
11.

Identification and characterization of a novel family of selective antifungal compounds (CANBEFs) that interfere with fungal protein synthesis.

Mircus G, Albert N, Ben-Yaakov D, Chikvashvili D, Shadkchan Y, Kontoyiannis DP, Osherov N.

Antimicrob Agents Chemother. 2015 Sep;59(9):5631-40. doi: 10.1128/AAC.00850-15. Epub 2015 Jul 6.

12.

The three Aspergillus fumigatus CFEM-domain GPI-anchored proteins (CfmA-C) affect cell-wall stability but do not play a role in fungal virulence.

Vaknin Y, Shadkchan Y, Levdansky E, Morozov M, Romano J, Osherov N.

Fungal Genet Biol. 2014 Feb;63:55-64. doi: 10.1016/j.fgb.2013.12.005. Epub 2013 Dec 20.

PMID:
24361821
13.

Trivalent ultrashort lipopeptides are potent pH dependent antifungal agents.

Arnusch CJ, Albada HB, van Vaardegem M, Liskamp RM, Sahl HG, Shadkchan Y, Osherov N, Shai Y.

J Med Chem. 2012 Feb 9;55(3):1296-302. doi: 10.1021/jm2014474. Epub 2012 Feb 1.

PMID:
22243686
14.

Ultrashort peptide bioconjugates are exclusively antifungal agents and synergize with cyclodextrin and amphotericin B.

Arnusch CJ, Ulm H, Josten M, Shadkchan Y, Osherov N, Sahl HG, Shai Y.

Antimicrob Agents Chemother. 2012 Jan;56(1):1-9. doi: 10.1128/AAC.00468-11. Epub 2011 Oct 17.

15.

PrtT-regulated proteins secreted by Aspergillus fumigatus activate MAPK signaling in exposed A549 lung cells leading to necrotic cell death.

Sharon H, Amar D, Levdansky E, Mircus G, Shadkchan Y, Shamir R, Osherov N.

PLoS One. 2011 Mar 11;6(3):e17509. doi: 10.1371/journal.pone.0017509.

16.

The Aspergillus fumigatus cspA gene encoding a repeat-rich cell wall protein is important for normal conidial cell wall architecture and interaction with host cells.

Levdansky E, Kashi O, Sharon H, Shadkchan Y, Osherov N.

Eukaryot Cell. 2010 Sep;9(9):1403-15. doi: 10.1128/EC.00126-10. Epub 2010 Jul 23.

17.

Therapy of murine pulmonary aspergillosis with antibody-alliinase conjugates and alliin.

Appel E, Vallon-Eberhard A, Rabinkov A, Brenner O, Shin I, Sasson K, Shadkchan Y, Osherov N, Jung S, Mirelman D.

Antimicrob Agents Chemother. 2010 Feb;54(2):898-906. doi: 10.1128/AAC.01267-09. Epub 2009 Nov 30.

18.

Identification of novel cell wall destabilizing antifungal compounds using a conditional Aspergillus nidulans protein kinase C mutant.

Mircus G, Hagag S, Levdansky E, Sharon H, Shadkchan Y, Shalit I, Osherov N.

J Antimicrob Chemother. 2009 Oct;64(4):755-63. doi: 10.1093/jac/dkp270. Epub 2009 Jul 31.

PMID:
19648579
19.

In vitro synergy of caspofungin with licensed and novel antifungal drugs against clinical isolates of Fusarium spp.

Shalit I, Shadkchan Y, Mircus G, Osherov N.

Med Mycol. 2009;47(5):457-62. doi: 10.1080/13693780802232910.

PMID:
18720217
20.

The Aspergillus nidulans cetA and calA genes are involved in conidial germination and cell wall morphogenesis.

Belaish R, Sharon H, Levdansky E, Greenstein S, Shadkchan Y, Osherov N.

Fungal Genet Biol. 2008 Mar;45(3):232-42. Epub 2007 Jul 20.

PMID:
17703972
21.

Coding tandem repeats generate diversity in Aspergillus fumigatus genes.

Levdansky E, Romano J, Shadkchan Y, Sharon H, Verstrepen KJ, Fink GR, Osherov N.

Eukaryot Cell. 2007 Aug;6(8):1380-91. Epub 2007 Jun 8.

22.

The Aspergillus nidulans pkcA gene is involved in polarized growth, morphogenesis and maintenance of cell wall integrity.

Ronen R, Sharon H, Levdansky E, Romano J, Shadkchan Y, Osherov N.

Curr Genet. 2007 May;51(5):321-9. Epub 2007 Apr 4.

PMID:
17406869
23.

Use of the Porcine Intestinal Epithelium (PIE)-Assay to analyze early stages of colonization by the human fungal pathogen Candida albicans.

Wendland J, Hellwig D, Walther A, Sickinger S, Shadkchan Y, Martin R, Bauer J, Osherov N, Tretiakov A, Saluz HP.

J Basic Microbiol. 2006;46(6):513-23.

PMID:
17139615
24.

Disruption of the Aspergillus fumigatus ECM33 homologue results in rapid conidial germination, antifungal resistance and hypervirulence.

Romano J, Nimrod G, Ben-Tal N, Shadkchan Y, Baruch K, Sharon H, Osherov N.

Microbiology. 2006 Jul;152(Pt 7):1919-28.

PMID:
16804168
25.

Analysis of the Aspergillus nidulans thaumatin-like cetA gene and evidence for transcriptional repression of pyr4 expression in the cetA-disrupted strain.

Greenstein S, Shadkchan Y, Jadoun J, Sharon C, Markovich S, Osherov N.

Fungal Genet Biol. 2006 Jan;43(1):42-53. Epub 2005 Dec 22.

PMID:
16376592
26.

Genomic approach to identification of mutations affecting caspofungin susceptibility in Saccharomyces cerevisiae.

Markovich S, Yekutiel A, Shalit I, Shadkchan Y, Osherov N.

Antimicrob Agents Chemother. 2004 Oct;48(10):3871-6.

27.

In vitro activity of caspofungin combined with sulfamethoxazole against clinical isolates of Aspergillus spp.

Yekutiel A, Shalit I, Shadkchan Y, Osherov N.

Antimicrob Agents Chemother. 2004 Sep;48(9):3279-83.

28.

Cytokines in mice treated with amphotericin B-intralipid.

Shadkchan Y, Keisari Y, Segal E.

Med Mycol. 2004 Apr;42(2):123-8.

PMID:
15124865
29.

Efficacy of allicin, the reactive molecule of garlic, in inhibiting Aspergillus spp. in vitro, and in a murine model of disseminated aspergillosis.

Shadkchan Y, Shemesh E, Mirelman D, Miron T, Rabinkov A, Wilchek M, Osherov N.

J Antimicrob Chemother. 2004 May;53(5):832-6. Epub 2004 Mar 24.

PMID:
15044429
30.

Disruption of the Aspergillus fumigatus argB gene using a novel in vitro transposon-based mutagenesis approach.

Jadoun J, Shadkchan Y, Osherov N.

Curr Genet. 2004 Apr;45(4):235-41. Epub 2004 Jan 15.

PMID:
14727059
31.

In vitro synergy of caspofungin and itraconazole against Aspergillus spp.: MIC versus minimal effective concentration end points.

Shalit I, Shadkchan Y, Samra Z, Osherov N.

Antimicrob Agents Chemother. 2003 Apr;47(4):1416-8.

32.

Pharmacokinetics of amphotericin B in serum and tissues in mice treated with amphotericin B-Intralipid.

Shadkchan Y, Zaslavsky Z, Segal E.

Med Mycol. 2003 Feb;41(1):15-9.

PMID:
12627800
33.

Treatment of experimental candidosis with amphotericin B-Intralipid admixtures in immunocompromised mice.

Shadkchan Y, Segal E.

J Antimicrob Chemother. 2001 Aug;48(2):245-51.

PMID:
11481296
34.

Antifungal activity of amphotericin B-lipid admixtures in experimental systemic candidosis in naive mice.

Shadkchan Y, Segal E.

J Antimicrob Chemother. 1999 Dec;44(6):787-90.

PMID:
10590279

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