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Items: 1 to 50 of 120

1.

A Mitochondrial-Derived Peptide Exercises the Nuclear Option.

Mangalhara KC, Shadel GS.

Cell Metab. 2018 Sep 4;28(3):330-331. doi: 10.1016/j.cmet.2018.08.017.

PMID:
30184481
2.

Pink1/Parkin link inflammation, mitochondrial stress, and neurodegeneration.

Newman LE, Shadel GS.

J Cell Biol. 2018 Oct 1;217(10):3327-3329. doi: 10.1083/jcb.201808118. Epub 2018 Aug 28.

PMID:
30154188
3.

Mitohormesis in Mice via Sustained Basal Activation of Mitochondrial and Antioxidant Signaling.

Cox CS, McKay SE, Holmbeck MA, Christian BE, Scortea AC, Tsay AJ, Newman LE, Shadel GS.

Cell Metab. 2018 Aug 13. pii: S1550-4131(18)30454-6. doi: 10.1016/j.cmet.2018.07.011. [Epub ahead of print]

PMID:
30122556
4.

KDM5 histone demethylases repress immune response via suppression of STING.

Wu L, Cao J, Cai WL, Lang SM, Horton JR, Jansen DJ, Liu ZZ, Chen JF, Zhang M, Mott BT, Pohida K, Rai G, Kales SC, Henderson MJ, Hu X, Jadhav A, Maloney DJ, Simeonov A, Zhu S, Iwasaki A, Hall MD, Cheng X, Shadel GS, Yan Q.

PLoS Biol. 2018 Aug 6;16(8):e2006134. doi: 10.1371/journal.pbio.2006134. eCollection 2018 Aug.

5.

Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity.

Zhang Y, Lee JH, Paull TT, Gehrke S, D'Alessandro A, Dou Q, Gladyshev VN, Schroeder EA, Steyl SK, Christian BE, Shadel GS.

Sci Signal. 2018 Jul 10;11(538). pii: eaaq0702. doi: 10.1126/scisignal.aaq0702.

PMID:
29991649
6.

Nutritional Interventions for Mitochondrial OXPHOS Deficiencies: Mechanisms and Model Systems.

Kuszak AJ, Espey MG, Falk MJ, Holmbeck MA, Manfredi G, Shadel GS, Vernon HJ, Zolkipli-Cunningham Z.

Annu Rev Pathol. 2018 Jan 24;13:163-191. doi: 10.1146/annurev-pathol-020117-043644. Epub 2017 Nov 3.

PMID:
29099651
7.

Mitochondrial DNA in innate immune responses and inflammatory pathology.

West AP, Shadel GS.

Nat Rev Immunol. 2017 Jun;17(6):363-375. doi: 10.1038/nri.2017.21. Epub 2017 Apr 10. Review.

PMID:
28393922
8.

Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry.

Schweppe DK, Chavez JD, Lee CF, Caudal A, Kruse SE, Stuppard R, Marcinek DJ, Shadel GS, Tian R, Bruce JE.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1732-1737. doi: 10.1073/pnas.1617220114. Epub 2017 Jan 27.

9.

A Mitochondrial Perspective of Chronic Obstructive Pulmonary Disease Pathogenesis.

Kang MJ, Shadel GS.

Tuberc Respir Dis (Seoul). 2016 Oct;79(4):207-213. Epub 2016 Oct 5. Review.

10.

Multi-focal control of mitochondrial gene expression by oncogenic MYC provides potential therapeutic targets in cancer.

Oran AR, Adams CM, Zhang XY, Gennaro VJ, Pfeiffer HK, Mellert HS, Seidel HE, Mascioli K, Kaplan J, Gaballa MR, Shen C, Rigoutsos I, King MP, Cotney JL, Arnold JJ, Sharma SD, Martinez-Outschoorn UE, Vakoc CR, Chodosh LA, Thompson JE, Bradner JE, Cameron CE, Shadel GS, Eischen CM, McMahon SB.

Oncotarget. 2016 Nov 8;7(45):72395-72414. doi: 10.18632/oncotarget.11718.

11.

Mitochondria provide a 'complex' solution to a bacterial problem.

Holmbeck MA, Shadel GS.

Nat Immunol. 2016 Aug 19;17(9):1009-10. doi: 10.1038/ni.3534. No abstract available.

PMID:
27540983
12.

Mitochondrial Ribosomal Protein L12 Is Required for POLRMT Stability and Exists as Two Forms Generated by Alternative Proteolysis during Import.

Nouws J, Goswami AV, Bestwick M, McCann BJ, Surovtseva YV, Shadel GS.

J Biol Chem. 2016 Jan 8;291(2):989-97. doi: 10.1074/jbc.M115.689299. Epub 2015 Nov 19.

13.

Auditory Pathology in a Transgenic mtTFB1 Mouse Model of Mitochondrial Deafness.

McKay SE, Yan W, Nouws J, Thormann MJ, Raimundo N, Khan A, Santos-Sacchi J, Song L, Shadel GS.

Am J Pathol. 2015 Dec;185(12):3132-40. doi: 10.1016/j.ajpath.2015.08.014. Epub 2015 Nov 6.

14.

Mitochondrial ROS signaling in organismal homeostasis.

Shadel GS, Horvath TL.

Cell. 2015 Oct 22;163(3):560-9. doi: 10.1016/j.cell.2015.10.001. Epub 2015 Oct 22. Review.

15.

Macrophage-specific de Novo Synthesis of Ceramide Is Dispensable for Inflammasome-driven Inflammation and Insulin Resistance in Obesity.

Camell CD, Nguyen KY, Jurczak MJ, Christian BE, Shulman GI, Shadel GS, Dixit VD.

J Biol Chem. 2015 Dec 4;290(49):29402-13. doi: 10.1074/jbc.M115.680199. Epub 2015 Oct 5.

16.

Suppression of NLRX1 in chronic obstructive pulmonary disease.

Kang MJ, Yoon CM, Kim BH, Lee CM, Zhou Y, Sauler M, Homer R, Dhamija A, Boffa D, West AP, Shadel GS, Ting JP, Tedrow JR, Kaminski N, Kim WJ, Lee CG, Oh YM, Elias JA.

J Clin Invest. 2015 Jun;125(6):2458-62. doi: 10.1172/JCI71747. Epub 2015 May 4.

17.

Interventions to Slow Aging in Humans: Are We Ready?

Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, Kopchick JJ, Lepperdinger G, Madeo F, Mirisola MG, Mitchell JR, Passarino G, Rudolph KL, Sedivy JM, Shadel GS, Sinclair DA, Spindler SR, Suh Y, Vijg J, Vinciguerra M, Fontana L.

Aging Cell. 2015 Aug;14(4):497-510. doi: 10.1111/acel.12338. Epub 2015 Apr 22. Review.

18.

Mitochondrial DNA stress primes the antiviral innate immune response.

West AP, Khoury-Hanold W, Staron M, Tal MC, Pineda CM, Lang SM, Bestwick M, Duguay BA, Raimundo N, MacDuff DA, Kaech SM, Smiley JR, Means RE, Iwasaki A, Shadel GS.

Nature. 2015 Apr 23;520(7548):553-7. doi: 10.1038/nature14156. Epub 2015 Feb 2.

19.

Aging-dependent alterations in gene expression and a mitochondrial signature of responsiveness to human influenza vaccination.

Thakar J, Mohanty S, West AP, Joshi SR, Ueda I, Wilson J, Meng H, Blevins TP, Tsang S, Trentalange M, Siconolfi B, Park K, Gill TM, Belshe RB, Kaech SM, Shadel GS, Kleinstein SH, Shaw AC.

Aging (Albany NY). 2015 Jan;7(1):38-52.

20.

Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA.

Rongvaux A, Jackson R, Harman CC, Li T, West AP, de Zoete MR, Wu Y, Yordy B, Lakhani SA, Kuan CY, Taniguchi T, Shadel GS, Chen ZJ, Iwasaki A, Flavell RA.

Cell. 2014 Dec 18;159(7):1563-77. doi: 10.1016/j.cell.2014.11.037.

21.

Isolation of mitochondria from cells and tissues.

Clayton DA, Shadel GS.

Cold Spring Harb Protoc. 2014 Oct 1;2014(10):pdb.top074542. doi: 10.1101/pdb.top074542.

PMID:
25275115
22.

Purification of mitochondria by sucrose step density gradient centrifugation.

Clayton DA, Shadel GS.

Cold Spring Harb Protoc. 2014 Oct 1;2014(10):pdb.prot080028. doi: 10.1101/pdb.prot080028.

PMID:
25275106
23.

Isolation of mitochondria from animal tissue.

Clayton DA, Shadel GS.

Cold Spring Harb Protoc. 2014 Oct 1;2014(10):pdb.prot080010. doi: 10.1101/pdb.prot080010.

PMID:
25275105
24.

Isolation of mitochondria from tissue culture cells.

Clayton DA, Shadel GS.

Cold Spring Harb Protoc. 2014 Oct 1;2014(10):pdb.prot080002. doi: 10.1101/pdb.prot080002.

PMID:
25275104
25.

microManaging mitochondrial translation.

Nouws J, Shadel GS.

Cell. 2014 Jul 31;158(3):477-8. doi: 10.1016/j.cell.2014.07.010.

26.

Live longer on MARS: a yeast paradigm of mitochondrial adaptive ROS signaling in aging.

Shadel GS.

Microb Cell. 2014 Apr 23;1(5):140-144. doi: 10.15698/mic2014.05.143. Review.

27.

Aging: it's SIRTainly possible to restore mitochondrial dysfunction.

Christian BE, Shadel GS.

Curr Biol. 2014 Mar 3;24(5):R206-8. doi: 10.1016/j.cub.2014.01.027.

28.

MKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced lung injury.

Mannam P, Shinn AS, Srivastava A, Neamu RF, Walker WE, Bohanon M, Merkel J, Kang MJ, Dela Cruz CS, Ahasic AM, Pisani MA, Trentalange M, West AP, Shadel GS, Elias JA, Lee PJ.

Am J Physiol Lung Cell Mol Physiol. 2014 Apr 1;306(7):L604-19. doi: 10.1152/ajplung.00272.2013. Epub 2014 Jan 31.

29.

Crosstalk between mitochondrial stress signals regulates yeast chronological lifespan.

Schroeder EA, Shadel GS.

Mech Ageing Dev. 2014 Jan;135:41-9. doi: 10.1016/j.mad.2013.12.002. Epub 2013 Dec 25.

30.

Intrinsic mitochondrial DNA repair defects in Ataxia Telangiectasia.

Sharma NK, Lebedeva M, Thomas T, Kovalenko OA, Stumpf JD, Shadel GS, Santos JH.

DNA Repair (Amst). 2014 Jan;13:22-31. doi: 10.1016/j.dnarep.2013.11.002. Epub 2013 Dec 15.

PMID:
24342190
31.

Epigenetic silencing mediates mitochondria stress-induced longevity.

Schroeder EA, Raimundo N, Shadel GS.

Cell Metab. 2013 Jun 4;17(6):954-64. doi: 10.1016/j.cmet.2013.04.003.

32.

Accessorizing the human mitochondrial transcription machinery.

Bestwick ML, Shadel GS.

Trends Biochem Sci. 2013 Jun;38(6):283-91. doi: 10.1016/j.tibs.2013.03.006. Epub 2013 Apr 27. Review.

33.

Transcription-independent role for human mitochondrial RNA polymerase in mitochondrial ribosome biogenesis.

Surovtseva YV, Shadel GS.

Nucleic Acids Res. 2013 Feb 1;41(4):2479-88. doi: 10.1093/nar/gks1447. Epub 2013 Jan 8.

34.

Reducing mitochondrial ROS improves disease-related pathology in a mouse model of ataxia-telangiectasia.

D'Souza AD, Parish IA, Krause DS, Kaech SM, Shadel GS.

Mol Ther. 2013 Jan;21(1):42-8. doi: 10.1038/mt.2012.203. Epub 2012 Sep 25.

35.

Mitochondrial respiratory thresholds regulate yeast chronological life span and its extension by caloric restriction.

Ocampo A, Liu J, Schroeder EA, Shadel GS, Barrientos A.

Cell Metab. 2012 Jul 3;16(1):55-67. doi: 10.1016/j.cmet.2012.05.013.

36.

Replicative and chronological aging in Saccharomyces cerevisiae.

Longo VD, Shadel GS, Kaeberlein M, Kennedy B.

Cell Metab. 2012 Jul 3;16(1):18-31. doi: 10.1016/j.cmet.2012.06.002. Review.

37.

Transcription from the second heavy-strand promoter of human mtDNA is repressed by transcription factor A in vitro.

Lodeiro MF, Uchida A, Bestwick M, Moustafa IM, Arnold JJ, Shadel GS, Cameron CE.

Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6513-8. doi: 10.1073/pnas.1118710109. Epub 2012 Apr 9.

38.

Alternative mitochondrial fuel extends life span.

Schroeder EA, Shadel GS.

Cell Metab. 2012 Apr 4;15(4):417-8. doi: 10.1016/j.cmet.2012.03.011.

39.

Mitochondrial stress engages E2F1 apoptotic signaling to cause deafness.

Raimundo N, Song L, Shutt TE, McKay SE, Cotney J, Guan MX, Gilliland TC, Hohuan D, Santos-Sacchi J, Shadel GS.

Cell. 2012 Feb 17;148(4):716-26. doi: 10.1016/j.cell.2011.12.027.

40.

Mitochondrial genome instability and ROS enhance intestinal tumorigenesis in APC(Min/+) mice.

Woo DK, Green PD, Santos JH, D'Souza AD, Walther Z, Martin WD, Christian BE, Chandel NS, Shadel GS.

Am J Pathol. 2012 Jan;180(1):24-31. doi: 10.1016/j.ajpath.2011.10.003. Epub 2011 Nov 3.

41.

Mitochondrial ribosomal protein L12 selectively associates with human mitochondrial RNA polymerase to activate transcription.

Surovtseva YV, Shutt TE, Cotney J, Cimen H, Chen SY, Koc EC, Shadel GS.

Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):17921-6. doi: 10.1073/pnas.1108852108. Epub 2011 Oct 14.

42.

LRP130 protein remodels mitochondria and stimulates fatty acid oxidation.

Liu L, Sanosaka M, Lei S, Bestwick ML, Frey JH Jr, Surovtseva YV, Shadel GS, Cooper MP.

J Biol Chem. 2011 Dec 2;286(48):41253-64. doi: 10.1074/jbc.M111.276121. Epub 2011 Oct 4.

43.

Transcriptional activation by mitochondrial transcription factor A involves preferential distortion of promoter DNA.

Malarkey CS, Bestwick M, Kuhlwilm JE, Shadel GS, Churchill ME.

Nucleic Acids Res. 2012 Jan;40(2):614-24. doi: 10.1093/nar/gkr787. Epub 2011 Sep 23.

44.

Genomic imprinting at a boundary element flanking the SDHD locus.

Baysal BE, McKay SE, Kim YJ, Zhang Z, Alila L, Willett-Brozick JE, Pacak K, Kim TH, Shadel GS.

Hum Mol Genet. 2011 Nov 15;20(22):4452-61. doi: 10.1093/hmg/ddr376. Epub 2011 Aug 23.

45.

Revisiting the TCA cycle: signaling to tumor formation.

Raimundo N, Baysal BE, Shadel GS.

Trends Mol Med. 2011 Nov;17(11):641-9. doi: 10.1016/j.molmed.2011.06.001. Epub 2011 Jul 20. Review.

46.

Repression of mitochondrial translation, respiration and a metabolic cycle-regulated gene, SLF1, by the yeast Pumilio-family protein Puf3p.

Chatenay-Lapointe M, Shadel GS.

PLoS One. 2011;6(5):e20441. doi: 10.1371/journal.pone.0020441. Epub 2011 May 31.

47.

Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling.

Pan Y, Schroeder EA, Ocampo A, Barrientos A, Shadel GS.

Cell Metab. 2011 Jun 8;13(6):668-78. doi: 10.1016/j.cmet.2011.03.018.

48.

Aberrant CD8+ T-cell responses and memory differentiation upon viral infection of an ataxia-telangiectasia mouse model driven by hyper-activated Akt and mTORC1 signaling.

D'Souza AD, Parish IA, McKay SE, Kaech SM, Shadel GS.

Am J Pathol. 2011 Jun;178(6):2740-51. doi: 10.1016/j.ajpath.2011.02.022.

49.

Mitochondria in innate immune responses.

West AP, Shadel GS, Ghosh S.

Nat Rev Immunol. 2011 Jun;11(6):389-402. doi: 10.1038/nri2975. Epub 2011 May 20. Review.

50.

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS.

West AP, Brodsky IE, Rahner C, Woo DK, Erdjument-Bromage H, Tempst P, Walsh MC, Choi Y, Shadel GS, Ghosh S.

Nature. 2011 Apr 28;472(7344):476-80. doi: 10.1038/nature09973.

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