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Mucosal Immunity in HIV/SIV Infection: T Cells, B Cells and Beyond.

Shacklett BL.

Curr Immunol Rev. 2019;15(1):63-75. doi: 10.2174/1573395514666180528081204.


HIV Research for Prevention 2018: From Research to Impact Conference Summary and Highlights.

Shacklett BL, Blanco J, Hightow-Weidman L, Mgodi N, Alcamí J, Buchbinder S, Chirenje M, Dabee S, Diallo M, Dumchev K, Herrera C, Levy ME, Martin Gayo E, Makoah NA, Mitchell KM, Mugwanya K, Reddy K, Rodríguez ML, Rodriguez-Garcia M, Shover CL, Shrivastava T, Tomaras G, Van Diepen M, Walia M, Warren M, Manrique A, Thyagarajan B, Torri T.

AIDS Res Hum Retroviruses. 2019 Jul;35(7):598-607. doi: 10.1089/AID.2019.0074. Epub 2019 May 29.


Tissue issues: mucosal T-cell responses in HIV-1 infection.

Shacklett BL, Ferre AL, Kiniry BE.

Curr Opin HIV AIDS. 2019 Mar;14(2):100-107. doi: 10.1097/COH.0000000000000530.


Cryopreservation of human mucosal tissues.

Hughes SM, Ferre AL, Yandura SE, Shetler C, Baker CAR, Calienes F, Levy CN, Astronomo RD, Shu Z, Lentz GM, Fialkow M, Kirby AC, McElrath MJ, Sinclair E, Rohan LC, Anderson PL, Shacklett BL, Dezzutti CS, Gao D, Hladik F.

PLoS One. 2018 Jul 30;13(7):e0200653. doi: 10.1371/journal.pone.0200653. eCollection 2018.


Differential Expression of CD8+ T Cell Cytotoxic Effector Molecules in Blood and Gastrointestinal Mucosa in HIV-1 Infection.

Kiniry BE, Hunt PW, Hecht FM, Somsouk M, Deeks SG, Shacklett BL.

J Immunol. 2018 Mar 1;200(5):1876-1888. doi: 10.4049/jimmunol.1701532. Epub 2018 Jan 19.


Detection of HIV-1-specific gastrointestinal tissue resident CD8+ T-cells in chronic infection.

Kiniry BE, Li S, Ganesh A, Hunt PW, Somsouk M, Skinner PJ, Deeks SG, Shacklett BL.

Mucosal Immunol. 2018 May;11(3):909-920. doi: 10.1038/mi.2017.96. Epub 2017 Nov 15.


HIVR4P 2016, Partnering for Prevention: Conference Summary and Highlights.

Shacklett BL, Derdeyn CA, Folayan MO, Landovitz RJ, Anthony C, Behrens AJ, Hope TJ, Landais E, Leal L, Marrazzo JM, Morris L, Mugo N, Ngure K, Noseda V, Ranasinghe S, Tully DC, Voronin Y, Warren M, Wibmer CK, Xie IY, Scarlatti G, Thyagarajan B.

AIDS Res Hum Retroviruses. 2017 Aug;33(8):749-759. doi: 10.1089/AID.2017.0125. Epub 2017 Jul 26.


Changes in Circulating B Cell Subsets Associated with Aging and Acute SIV Infection in Rhesus Macaques.

Chang WL, Gonzalez DF, Kieu HT, Castillo LD, Messaoudi I, Shen X, Tomaras GD, Shacklett BL, Barry PA, Sparger EE.

PLoS One. 2017 Jan 17;12(1):e0170154. doi: 10.1371/journal.pone.0170154. eCollection 2017.


Effects of depot-medroxyprogesterone acetate on the immune microenvironment of the human cervix and endometrium: implications for HIV susceptibility.

Smith-McCune KK, Hilton JF, Shanmugasundaram U, Critchfield JW, Greenblatt RM, Seidman D, Averbach S, Giudice LC, Shacklett BL.

Mucosal Immunol. 2017 Sep;10(5):1270-1278. doi: 10.1038/mi.2016.121. Epub 2017 Jan 4.


Predominance of weakly cytotoxic, T-betLowEomesNeg CD8+ T-cells in human gastrointestinal mucosa: implications for HIV infection.

Kiniry BE, Ganesh A, Critchfield JW, Hunt PW, Hecht FM, Somsouk M, Deeks SG, Shacklett BL.

Mucosal Immunol. 2017 Jul;10(4):1008-1020. doi: 10.1038/mi.2016.100. Epub 2016 Nov 9.


Effects of the levonorgestrel-releasing intrauterine device on the immune microenvironment of the human cervix and endometrium.

Shanmugasundaram U, Hilton JF, Critchfield JW, Greenblatt RM, Giudice LC, Averbach S, Seidman D, Shacklett BL, Smith-McCune K.

Am J Reprod Immunol. 2016 Aug;76(2):137-48. doi: 10.1111/aji.12535.


Cryopreservation of Human Mucosal Leukocytes.

Hughes SM, Shu Z, Levy CN, Ferre AL, Hartig H, Fang C, Lentz G, Fialkow M, Kirby AC, Adams Waldorf KM, Veazey RS, Germann A, von Briesen H, McElrath MJ, Dezzutti CS, Sinclair E, Baker CA, Shacklett BL, Gao D, Hladik F.

PLoS One. 2016 May 27;11(5):e0156293. doi: 10.1371/journal.pone.0156293. eCollection 2016.


Utilizing a TLR5-Adjuvanted Cytomegalovirus as a Lentiviral Vaccine in the Nonhuman Primate Model for AIDS.

Deere JD, Chang WL, Castillo LD, Schmidt KA, Kieu HT, Renzette N, Kowalik T, Barthold SW, Shacklett BL, Barry PA, Sparger EE.

PLoS One. 2016 May 16;11(5):e0155629. doi: 10.1371/journal.pone.0155629. eCollection 2016.


Immune Activation and HIV-Specific CD8(+) T Cells in Cerebrospinal Fluid of HIV Controllers and Noncontrollers.

Ganesh A, Lemongello D, Lee E, Peterson J, McLaughlin BE, Ferre AL, Gillespie GM, Fuchs D, Deeks SG, Hunt PW, Price RW, Spudich SS, Shacklett BL.

AIDS Res Hum Retroviruses. 2016 Aug;32(8):791-800. doi: 10.1089/AID.2015.0313. Epub 2016 May 2.


Unexpected Inflammatory Effects of Intravaginal Gels (Universal Placebo Gel and Nonoxynol-9) on the Upper Female Reproductive Tract: A Randomized Crossover Study.

Smith-McCune K, Chen JC, Greenblatt RM, Shanmugasundaram U, Shacklett BL, Hilton JF, Johnson B, Irwin JC, Giudice LC.

PLoS One. 2015 Jul 15;10(7):e0129769. doi: 10.1371/journal.pone.0129769. eCollection 2015.


Cerebrospinal fluid (CSF) neuronal biomarkers across the spectrum of HIV infection: hierarchy of injury and detection.

Peterson J, Gisslen M, Zetterberg H, Fuchs D, Shacklett BL, Hagberg L, Yiannoutsos CT, Spudich SS, Price RW.

PLoS One. 2014 Dec 26;9(12):e116081. doi: 10.1371/journal.pone.0116081. eCollection 2014.


HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality.

Serrano-Villar S, Sainz T, Lee SA, Hunt PW, Sinclair E, Shacklett BL, Ferre AL, Hayes TL, Somsouk M, Hsue PY, Van Natta ML, Meinert CL, Lederman MM, Hatano H, Jain V, Huang Y, Hecht FM, Martin JN, McCune JM, Moreno S, Deeks SG.

PLoS Pathog. 2014 May 15;10(5):e1004078. doi: 10.1371/journal.ppat.1004078. eCollection 2014 May.


Phenotype and functionality of CD4+ and CD8+ T cells in the upper reproductive tract of healthy premenopausal women.

Shanmugasundaram U, Critchfield JW, Pannell J, Perry J, Giudice LC, Smith-McCune K, Greenblatt RM, Shacklett BL.

Am J Reprod Immunol. 2014 Feb;71(2):95-108. doi: 10.1111/aji.12182. Epub 2013 Dec 6.


Prospective antiretroviral treatment of asymptomatic, HIV-1 infected controllers.

Hatano H, Yukl SA, Ferre AL, Graf EH, Somsouk M, Sinclair E, Abdel-Mohsen M, Liegler T, Harvill K, Hoh R, Palmer S, Bacchetti P, Hunt PW, Martin JN, McCune JM, Tracy RP, Busch MP, O'Doherty U, Shacklett BL, Wong JK, Deeks SG.

PLoS Pathog. 2013;9(10):e1003691. doi: 10.1371/journal.ppat.1003691. Epub 2013 Oct 10.


Will loss of your MAITs weaken your HAART [corrected]?

Sandberg JK, Dias J, Shacklett BL, Leeansyah E.

AIDS. 2013 Oct 23;27(16):2501-4. doi: 10.1097/QAD.0b013e3283620726. No abstract available. Erratum in: AIDS. 2014 Jan 2;28(1):147. J Prosthet Orthot. 2016 Oct;28(4):145-151.


The immunologic effects of maraviroc intensification in treated HIV-infected individuals with incomplete CD4+ T-cell recovery: a randomized trial.

Hunt PW, Shulman NS, Hayes TL, Dahl V, Somsouk M, Funderburg NT, McLaughlin B, Landay AL, Adeyemi O, Gilman LE, Clagett B, Rodriguez B, Martin JN, Schacker TW, Shacklett BL, Palmer S, Lederman MM, Deeks SG.

Blood. 2013 Jun 6;121(23):4635-46. doi: 10.1182/blood-2012-06-436345. Epub 2013 Apr 15.


Impact of highly active antiretroviral therapy initiation on CD4(+) T-cell repopulation in duodenal and rectal mucosa.

Hayes TL, Asmuth DM, Critchfield JW, Knight TH, McLaughlin BE, Yotter T, McConnell DH, Garcia JC, Pollard RB, Shacklett BL.

AIDS. 2013 Mar 27;27(6):867-77. doi: 10.1097/QAD.0b013e32835d85b4.


Activation, exhaustion, and persistent decline of the antimicrobial MR1-restricted MAIT-cell population in chronic HIV-1 infection.

Leeansyah E, Ganesh A, Quigley MF, Sönnerborg A, Andersson J, Hunt PW, Somsouk M, Deeks SG, Martin JN, Moll M, Shacklett BL, Sandberg JK.

Blood. 2013 Feb 14;121(7):1124-35. doi: 10.1182/blood-2012-07-445429. Epub 2012 Dec 13.


Single-copy assay quantification of HIV-1 RNA in paired cerebrospinal fluid and plasma samples from elite controllers.

Dahl V, Peterson J, Spudich S, Lee E, Shacklett BL, Price RW, Palmer S.

AIDS. 2013 Apr 24;27(7):1145-9. doi: 10.1097/QAD.0b013e32835cf235.


Short communication: HIV+ viremic slow progressors maintain low regulatory T cell numbers in rectal mucosa but exhibit high T cell activation.

Shaw JM, Hunt PW, Critchfield JW, McConnell DH, Garcia JC, Pollard RB, Somsouk M, Deeks SG, Shacklett BL.

AIDS Res Hum Retroviruses. 2013 Jan;29(1):172-7. doi: 10.1089/AID.2012.0268. Epub 2012 Oct 16.


Randomized pilot trial of a synbiotic dietary supplement in chronic HIV-1 infection.

Schunter M, Chu H, Hayes TL, McConnell D, Crawford SS, Luciw PA, Bengmark S, Asmuth DM, Brown J, Bevins CL, Shacklett BL, Critchfield JW.

BMC Complement Altern Med. 2012 Jun 29;12:84. doi: 10.1186/1472-6882-12-84.


Myeloid dendritic cells isolated from tissues of SIV-infected Rhesus macaques promote the induction of regulatory T cells.

Presicce P, Shaw JM, Miller CJ, Shacklett BL, Chougnet CA.

AIDS. 2012 Jan 28;26(3):263-73. doi: 10.1097/QAD.0b013e32834ed8df.


Increased frequency of regulatory T cells accompanies increased immune activation in rectal mucosae of HIV-positive noncontrollers.

Shaw JM, Hunt PW, Critchfield JW, McConnell DH, Garcia JC, Pollard RB, Somsouk M, Deeks SG, Shacklett BL.

J Virol. 2011 Nov;85(21):11422-34. doi: 10.1128/JVI.05608-11. Epub 2011 Aug 31.


A randomized, controlled trial of raltegravir intensification in antiretroviral-treated, HIV-infected patients with a suboptimal CD4+ T cell response.

Hatano H, Hayes TL, Dahl V, Sinclair E, Lee TH, Hoh R, Lampiris H, Hunt PW, Palmer S, McCune JM, Martin JN, Busch MP, Shacklett BL, Deeks SG.

J Infect Dis. 2011 Apr 1;203(7):960-8. doi: 10.1093/infdis/jiq138.


Mucosal immunity in HIV controllers: the right place at the right time.

Shacklett BL, Ferre AL.

Curr Opin HIV AIDS. 2011 May;6(3):202-7. doi: 10.1097/COH.0b013e3283453e2b. Review.


Immune responses to HIV in the female reproductive tract, immunologic parallels with the gastrointestinal tract, and research implications.

Shacklett BL, Greenblatt RM.

Am J Reprod Immunol. 2011 Mar;65(3):230-41. doi: 10.1111/j.1600-0897.2010.00948.x. Epub 2011 Jan 12. Review.


HIV controllers with HLA-DRB1*13 and HLA-DQB1*06 alleles have strong, polyfunctional mucosal CD4+ T-cell responses.

Ferre AL, Hunt PW, McConnell DH, Morris MM, Garcia JC, Pollard RB, Yee HF Jr, Martin JN, Deeks SG, Shacklett BL.

J Virol. 2010 Nov;84(21):11020-9. doi: 10.1128/JVI.00980-10. Epub 2010 Aug 18.


Immunodominant HIV-specific CD8+ T-cell responses are common to blood and gastrointestinal mucosa, and Gag-specific responses dominate in rectal mucosa of HIV controllers.

Ferre AL, Lemongello D, Hunt PW, Morris MM, Garcia JC, Pollard RB, Yee HF Jr, Martin JN, Deeks SG, Shacklett BL.

J Virol. 2010 Oct;84(19):10354-65. doi: 10.1128/JVI.00803-10. Epub 2010 Jul 28.


Immune responses to HIV and SIV in mucosal tissues: 'location, location, location'.

Shacklett BL.

Curr Opin HIV AIDS. 2010 Mar;5(2):128-34. doi: 10.1097/COH.0b013e328335c178. Review.


HIV Infection and Gut Mucosal Immune Function: Updates on Pathogenesis with Implications for Management and Intervention.

Shacklett BL, Anton PA.

Curr Infect Dis Rep. 2010 Jan;12(1):19-27. doi: 10.1007/s11908-009-0072-9. Epub 2010 Jan 13.


Viral sanctuaries during highly active antiretroviral therapy in a nonhuman primate model for AIDS.

North TW, Higgins J, Deere JD, Hayes TL, Villalobos A, Adamson L, Shacklett BL, Schinazi RF, Luciw PA.

J Virol. 2010 Mar;84(6):2913-22. doi: 10.1128/JVI.02356-09. Epub 2009 Dec 23.


Cell-mediated immunity to HIV in the female reproductive tract.

Shacklett BL.

J Reprod Immunol. 2009 Dec;83(1-2):190-5. doi: 10.1016/j.jri.2009.07.012. Epub 2009 Oct 25. Review.


Mucosal immunity to HIV: a review of recent literature.

Shacklett BL.

Curr Opin HIV AIDS. 2008 Sep;3(5):541-7. doi: 10.1097/COH.0b013e32830ab9ee.


Co-immunization with IL-15 enhances cellular immune responses induced by a vif-deleted simian immunodeficiency virus proviral DNA vaccine and confers partial protection against vaginal challenge with SIVmac251.

Dubie RA, Maksaereekul S, Shacklett BL, Lemongello D, Cole KS, Villinger F, Blozis SA, Luciw PA, Sparger EE.

Virology. 2009 Mar 30;386(1):109-21. doi: 10.1016/j.virol.2009.01.007. Epub 2009 Feb 3.


Mucosal immune responses to HIV-1 in elite controllers: a potential correlate of immune control.

Ferre AL, Hunt PW, Critchfield JW, Young DH, Morris MM, Garcia JC, Pollard RB, Yee HF Jr, Martin JN, Deeks SG, Shacklett BL.

Blood. 2009 Apr 23;113(17):3978-89. doi: 10.1182/blood-2008-10-182709. Epub 2008 Dec 23.


Mucosal T-cell responses to HIV: responding at the front lines.

Shacklett BL, Critchfield JW, Ferre AL, Hayes TL.

J Intern Med. 2009 Jan;265(1):58-66. doi: 10.1111/j.1365-2796.2008.02042.x. Review.


Quantifying HIV-1-specific CD8 (+) T-cell responses using ELISPOT and cytokine flow cytometry.

Shacklett BL, Critchfield JW, Lemongello D.

Methods Mol Biol. 2009;485:359-74. doi: 10.1007/978-1-59745-170-3_24.


Isolating mucosal lymphocytes from biopsy tissue for cellular immunology assays.

Shacklett BL, Critchfield JW, Lemongello D.

Methods Mol Biol. 2009;485:347-56. doi: 10.1007/978-1-59745-170-3_23.


Magnitude and complexity of rectal mucosa HIV-1-specific CD8+ T-cell responses during chronic infection reflect clinical status.

Critchfield JW, Young DH, Hayes TL, Braun JV, Garcia JC, Pollard RB, Shacklett BL.

PLoS One. 2008;3(10):e3577. doi: 10.1371/journal.pone.0003577. Epub 2008 Oct 30.


Nine-color flow cytometry for accurate measurement of T cell subsets and cytokine responses. Part II: Panel performance across different instrument platforms.

McLaughlin BE, Baumgarth N, Bigos M, Roederer M, De Rosa SC, Altman JD, Nixon DF, Ottinger J, Li J, Beckett L, Shacklett BL, Evans TG, Asmuth DM.

Cytometry A. 2008 May;73(5):411-20. doi: 10.1002/cyto.a.20556.


Vaccination of rhesus macaques with a vif-deleted simian immunodeficiency virus proviral DNA vaccine.

Sparger EE, Dubie RA, Shacklett BL, Cole KS, Chang WL, Luciw PA.

Virology. 2008 May 10;374(2):261-72. doi: 10.1016/j.virol.2008.01.020. Epub 2008 Feb 7.


Can the new humanized mouse model give HIV research a boost.

Shacklett BL.

PLoS Med. 2008 Jan 15;5(1):e13. doi: 10.1371/journal.pmed.0050013. No abstract available.


Multifunctional human immunodeficiency virus (HIV) gag-specific CD8+ T-cell responses in rectal mucosa and peripheral blood mononuclear cells during chronic HIV type 1 infection.

Critchfield JW, Lemongello D, Walker DH, Garcia JC, Asmuth DM, Pollard RB, Shacklett BL.

J Virol. 2007 Jun;81(11):5460-71. Epub 2007 Mar 7.


Viral suppression and immune restoration in the gastrointestinal mucosa of human immunodeficiency virus type 1-infected patients initiating therapy during primary or chronic infection.

Guadalupe M, Sankaran S, George MD, Reay E, Verhoeven D, Shacklett BL, Flamm J, Wegelin J, Prindiville T, Dandekar S.

J Virol. 2006 Aug;80(16):8236-47.


Detection of macaque perforin expression and release by flow cytometry, immunohistochemistry, ELISA, and ELISpot.

Zuber B, Quigley MF, Critchfield JW, Shacklett BL, Abel K, Miller CJ, Mörner A, Paulie S, Ahlborg N, Sandberg JK.

J Immunol Methods. 2006 May 30;312(1-2):45-53. Epub 2006 Apr 19.


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