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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 3
1999 1
2000 1
2001 3
2002 1
2003 5
2005 4
2006 3
2007 2
2008 3
2010 4
2011 2
2012 5
2013 10
2014 11
2015 4
2016 9
2017 5
2018 4
2019 1
2020 6
2021 10
2022 4
2023 5
2024 1

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101 results

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Page 1
SGTA: a new player in the molecular co-chaperone game.
Philp LK, Butler MS, Hickey TE, Butler LM, Tilley WD, Day TK. Philp LK, et al. Horm Cancer. 2013 Dec;4(6):343-57. doi: 10.1007/s12672-013-0151-0. Epub 2013 Jul 2. Horm Cancer. 2013. PMID: 23818240 Free PMC article. Review.
Research into the function of SGTA has been conducted in several model organisms and cell types, with these studies showing that SGTA functionality is cell-specific and tissue-specific. However, very few studies have been replicated in multiple cell types or experim …
Research into the function of SGTA has been conducted in several model organisms and cell types, with these studies showing that S …
SGTA associates with intracellular aggregates in neurodegenerative diseases.
Kubota S, Doi H, Koyano S, Tanaka K, Komiya H, Katsumoto A, Ikeda S, Hashiguchi S, Nakamura H, Fukai R, Takahashi K, Kunii M, Tada M, Takeuchi H, Tanaka F. Kubota S, et al. Mol Brain. 2021 Mar 23;14(1):59. doi: 10.1186/s13041-021-00770-1. Mol Brain. 2021. PMID: 33757575 Free PMC article.
In addition, SGTA colocalized with glial cytoplasmic inclusions in the brains of MSA patients, whereas no accumulation of SGTA was observed in neurons of PD and ALS patients. In vitro study showed that SGTA bound to polyQ aggregates through its C-terminal dom …
In addition, SGTA colocalized with glial cytoplasmic inclusions in the brains of MSA patients, whereas no accumulation of SGTA …
USP5 enhances SGTA mediated protein quality control.
Hill J, Nyathi Y. Hill J, et al. PLoS One. 2022 Jul 27;17(7):e0257786. doi: 10.1371/journal.pone.0257786. eCollection 2022. PLoS One. 2022. PMID: 35895711 Free PMC article.
Overexpression of SGTA promotes deubiqutination of MLPs resulting in their accumulation in cytosolic inclusions, suggesting SGTA acts in collaboration with deubiquitinating enzymes (DUBs) to exert these effects. ...Overexpression of SGTA results in an increas …
Overexpression of SGTA promotes deubiqutination of MLPs resulting in their accumulation in cytosolic inclusions, suggesting SGTA …
SGTA associates with nascent membrane protein precursors.
Leznicki P, High S. Leznicki P, et al. EMBO Rep. 2020 May 6;21(5):e48835. doi: 10.15252/embr.201948835. Epub 2020 Mar 25. EMBO Rep. 2020. PMID: 32216016 Free PMC article.
Strikingly, SGTA is recruited to nascent membrane proteins before their transmembrane domain emerges from the ribosome. Hence, SGTA is ideally placed to capture these aggregation prone regions shortly after their synthesis. ...
Strikingly, SGTA is recruited to nascent membrane proteins before their transmembrane domain emerges from the ribosome. Hence, SGT …
Mechanisms of readthrough mitigation reveal principles of GCN1-mediated translational quality control.
Müller MBD, Kasturi P, Jayaraj GG, Hartl FU. Müller MBD, et al. Cell. 2023 Jul 20;186(15):3227-3244.e20. doi: 10.1016/j.cell.2023.05.035. Epub 2023 Jun 19. Cell. 2023. PMID: 37339632 Free PMC article.
Readthrough proteins with hydrophobic C-terminal extensions (CTEs) are recognized by SGTA-BAG6 and ubiquitylated by RNF126 for proteasomal degradation. ...
Readthrough proteins with hydrophobic C-terminal extensions (CTEs) are recognized by SGTA-BAG6 and ubiquitylated by RNF126 for protea …
SGTA antagonizes BAG6-mediated protein triage.
Leznicki P, High S. Leznicki P, et al. Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19214-9. doi: 10.1073/pnas.1209997109. Epub 2012 Nov 5. Proc Natl Acad Sci U S A. 2012. PMID: 23129660 Free PMC article.
We now show that the BAG6-dependent ubiquitination of mislocalized proteins is completely reversible and identify a pivotal role for the small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA) in specifically antagonizing this process. SGTA doe …
We now show that the BAG6-dependent ubiquitination of mislocalized proteins is completely reversible and identify a pivotal role for the sma …
The roles of cytosolic quality control proteins, SGTA and the BAG6 complex, in disease.
Benarroch R, Austin JM, Ahmed F, Isaacson RL. Benarroch R, et al. Adv Protein Chem Struct Biol. 2019;114:265-313. doi: 10.1016/bs.apcsb.2018.11.002. Epub 2018 Dec 18. Adv Protein Chem Struct Biol. 2019. PMID: 30635083 Free PMC article. Review.
SGTA is a co-chaperone that, in collaboration with the complex of BAG6/UBL4A/TRC35, facilitates the biogenesis and quality control of hydrophobic proteins, protecting them from the aqueous cytosolic environment. ...
SGTA is a co-chaperone that, in collaboration with the complex of BAG6/UBL4A/TRC35, facilitates the biogenesis and quality control of …
Binding of SGTA to Rpn13 selectively modulates protein quality control.
Leznicki P, Korac-Prlic J, Kliza K, Husnjak K, Nyathi Y, Dikic I, High S. Leznicki P, et al. J Cell Sci. 2015 Sep 1;128(17):3187-96. doi: 10.1242/jcs.165209. Epub 2015 Jul 13. J Cell Sci. 2015. PMID: 26169395 Free PMC article.
However, this effect is strongly dependent upon the interaction of SGTA with the proteasomal component Rpn13. Hence, overexpression of the SGTA-binding region of Rpn13 or point mutations within the SGTA TPR domain both inhibit SGTA binding to the prote …
However, this effect is strongly dependent upon the interaction of SGTA with the proteasomal component Rpn13. Hence, overexpression o …
SGTA regulates the cytosolic quality control of hydrophobic substrates.
Wunderley L, Leznicki P, Payapilly A, High S. Wunderley L, et al. J Cell Sci. 2014 Nov 1;127(Pt 21):4728-39. doi: 10.1242/jcs.155648. Epub 2014 Sep 1. J Cell Sci. 2014. PMID: 25179605 Free PMC article.
However, when SGTA is overexpressed, the normally efficient removal of aberrant MLPs is delayed, increasing their steady-state level and promoting aggregation. Our data suggest that SGTA regulates the cellular fate of a range of hydrophobic polypeptides should they …
However, when SGTA is overexpressed, the normally efficient removal of aberrant MLPs is delayed, increasing their steady-state level …
The Vpu-interacting Protein SGTA Regulates Expression of a Non-glycosylated Tetherin Species.
Waheed AA, MacDonald S, Khan M, Mounts M, Swiderski M, Xu Y, Ye Y, Freed EO. Waheed AA, et al. Sci Rep. 2016 Apr 22;6:24934. doi: 10.1038/srep24934. Sci Rep. 2016. PMID: 27103333 Free PMC article.
Because the SGTA-stabilized tetherin species is partially localized to the cytosol, we propose that overexpression of SGTA in the presence of Vpu blocks the translocation of tetherin across the ER membrane, resulting in cytosolic accumulation of a non-glycosylated t …
Because the SGTA-stabilized tetherin species is partially localized to the cytosol, we propose that overexpression of SGTA in …
101 results