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Mathematical Modeling of Pre-Clinical Alpha-Emitter Radiopharmaceutical Therapy.

Karimian A, Ji NT, Song H, Sgouros G.

Cancer Res. 2019 Nov 26. pii: canres.2553.2019. doi: 10.1158/0008-5472.CAN-19-2553. [Epub ahead of print]


Radium-223 mechanism of action: implications for use in treatment combinations.

Morris MJ, Corey E, Guise TA, Gulley JL, Kevin Kelly W, Quinn DI, Scholz A, Sgouros G.

Nat Rev Urol. 2019 Dec;16(12):745-756. doi: 10.1038/s41585-019-0251-x. Epub 2019 Nov 11. Review.


α-Particle-Emitter Radiopharmaceutical Therapy: Resistance Is Futile.

Sgouros G.

Cancer Res. 2019 Nov 1;79(21):5479-5481. doi: 10.1158/0008-5472.CAN-19-2806.


Human Radiation Dosimetry of Orally or Intravenously Administered 18F-Fluorodeoxyglucose.

Srinivasan S, Crandall J, Gajwani P, Sgouros G, Mena E, Lodge MA, Wahl RL.

J Nucl Med. 2019 Oct 18. pii: jnumed.119.233288. doi: 10.2967/jnumed.119.233288. [Epub ahead of print]


The Case for Dosimetry in Alpha-Emitter Therapy.

Sgouros G.

J Med Imaging Radiat Sci. 2019 Sep 16. pii: S1939-8654(19)30400-X. doi: 10.1016/j.jmir.2019.07.007. [Epub ahead of print]


Current pediatric administered activity guidelines for 99m Tc-DMSA SPECT based on patient weight do not provide the same task-based image quality.

Li Y, O'Reilly S, Plyku D, Treves ST, Fahey F, Du Y, Cao X, Sexton-Stallone B, Brown J, Sgouros G, Bolch WE, Frey EC.

Med Phys. 2019 Nov;46(11):4847-4856. doi: 10.1002/mp.13787. Epub 2019 Sep 20.


68Ga-DOTATATE PET: temporal variation of maximum standardized uptake value in normal tissues and neuroendocrine tumours.

Coura-Filho GB, Hoff AAFO, Duarte PS, Buchpiguel CA, Josefsson A, Hobbs RF, Sgouros G, Sapienza MT.

Nucl Med Commun. 2019 Sep;40(9):920-926. doi: 10.1097/MNM.0000000000001048.


Preclinical evaluation of 203/212Pb-labeled low-molecular-weight compounds for targeted radiopharmaceutical therapy of prostate cancer.

Ray Banerjee S, Minn IL, Kumar V, Josefsson A, Lisok A, Brummet M, Chen J, Kiess A, Baidoo K, Brayton C, Mease RC, Brechbiel M, Sgouros G, Hobbs RF, Pomper MG.

J Nucl Med. 2019 Jun 28. pii: jnumed.119.229393. doi: 10.2967/jnumed.119.229393. [Epub ahead of print]


Radiopharmaceutical Therapy.

Sgouros G.

Health Phys. 2019 Feb;116(2):175-178. doi: 10.1097/HP.0000000000001000.


Re-evaluation of pediatric 18F-FDG dosimetry: Cristy-Eckerman versus UF/NCI hybrid computational phantoms.

Khamwan K, O'Reilly SE, Plyku D, Goodkind A, Josefsson A, Cao X, Fahey FH, Treves ST, Bolch WE, Sgouros G.

Phys Med Biol. 2018 Aug 14;63(16):165012. doi: 10.1088/1361-6560/aad47a.


The use of indigenous Saccharomyces cerevisiae and Starmerella bacillaris strains as a tool to create chemical complexity in local wines.

Nisiotou A, Sgouros G, Mallouchos A, Nisiotis CS, Michaelidis C, Tassou C, Banilas G.

Food Res Int. 2018 Sep;111:498-508. doi: 10.1016/j.foodres.2018.05.035. Epub 2018 May 21.


A projection image database to investigate factors affecting image quality in weight-based dosing: application to pediatric renal SPECT.

Li Y, O'Reilly S, Plyku D, Treves ST, Du Y, Fahey F, Cao X, Jha AK, Sgouros G, Bolch WE, Frey EC.

Phys Med Biol. 2018 Jul 9;63(14):145004. doi: 10.1088/1361-6560/aacbf0.


Wessels to Be Recognized with Loevinger-Berman Award.

Howell RW, Sgouros G; SNMMI Medical Internal Radiation Dose Committee.

J Nucl Med. 2018 May;59(5):9N. No abstract available.


Biodistribution and Radiation Dosimetry of 124I-DPA-713, a PET Radiotracer for Macrophage-Associated Inflammation.

Foss CA, Plyku D, Ordonez AA, Sanchez-Bautista J, Rosenthal HB, Minn I, Lodge MA, Pomper MG, Sgouros G, Jain SK.

J Nucl Med. 2018 Nov;59(11):1751-1756. doi: 10.2967/jnumed.117.207431. Epub 2018 Apr 26.


Dosimetry and Radiobiology of Alpha-Particle Emitting Radionuclides.

Sgouros G, Hobbs R, Josefsson A.

Curr Radiopharm. 2018;11(3):209-214. doi: 10.2174/1874471011666180426130058. Review.


Combined model-based and patient-specific dosimetry for 18F-DCFPyL, a PSMA-targeted PET agent.

Plyku D, Mena E, Rowe SP, Lodge MA, Szabo Z, Cho SY, Pomper MG, Sgouros G, Hobbs RF.

Eur J Nucl Med Mol Imaging. 2018 Jun;45(6):989-998. doi: 10.1007/s00259-018-3939-x. Epub 2018 Feb 19.


Comparative Dosimetry for 68Ga-DOTATATE: Impact of Using Updated ICRP Phantoms, S Values, and Tissue-Weighting Factors.

Josefsson A, Hobbs RF, Ranka S, Schwarz BC, Plyku D, Willegaignon de Amorim de Carvalho J, Buchpiguel CA, Sapienza MT, Bolch WE, Sgouros G.

J Nucl Med. 2018 Aug;59(8):1281-1288. doi: 10.2967/jnumed.117.203893. Epub 2018 Feb 9.


Targeted and Nontargeted α-Particle Therapies.

McDevitt MR, Sgouros G, Sofou S.

Annu Rev Biomed Eng. 2018 Jun 4;20:73-93. doi: 10.1146/annurev-bioeng-062117-120931. Epub 2018 Jan 18. Review.


Human HER2 overexpressing mouse breast cancer cell lines derived from MMTV.f.HuHER2 mice: characterization and use in a model of metastatic breast cancer.

Park S, Nedrow JR, Josefsson A, Sgouros G.

Oncotarget. 2017 Jul 10;8(40):68071-68082. doi: 10.18632/oncotarget.19174. eCollection 2017 Sep 15.


Lassmann Recognized with Loevinger-Berman Award.

Sgouros G, Fahey F; SNMMI Medical Internal Radiation Dose Committee.

J Nucl Med. 2017 Aug;58(8):14N. No abstract available.


Pharmacokinetics, microscale distribution, and dosimetry of alpha-emitter-labeled anti-PD-L1 antibodies in an immune competent transgenic breast cancer model.

Nedrow JR, Josefsson A, Park S, Bäck T, Hobbs RF, Brayton C, Bruchertseifer F, Morgenstern A, Sgouros G.

EJNMMI Res. 2017 Dec;7(1):57. doi: 10.1186/s13550-017-0303-2. Epub 2017 Jul 18.


Imaging of Programmed Cell Death Ligand 1: Impact of Protein Concentration on Distribution of Anti-PD-L1 SPECT Agents in an Immunocompetent Murine Model of Melanoma.

Nedrow JR, Josefsson A, Park S, Ranka S, Roy S, Sgouros G.

J Nucl Med. 2017 Oct;58(10):1560-1566. doi: 10.2967/jnumed.117.193268. Epub 2017 May 18.


Dose Estimation in Pediatric Nuclear Medicine.

Fahey FH, Goodkind AB, Plyku D, Khamwan K, O'Reilly SE, Cao X, Frey EC, Li Y, Bolch WE, Sgouros G, Treves ST.

Semin Nucl Med. 2017 Mar;47(2):118-125. doi: 10.1053/j.semnuclmed.2016.10.006. Epub 2016 Nov 9. Review.


Depth-dependent concentrations of hematopoietic stem cells in the adult skeleton: Implications for active marrow dosimetry.

Geyer AM, Schwarz BC, O'Reilly SE, Hobbs RF, Sgouros G, Bolch WE.

Med Phys. 2017 Feb;44(2):747-761. doi: 10.1002/mp.12056. Epub 2017 Jan 30.


Recombinant Human Thyroid-Stimulating Hormone Versus Thyroid Hormone Withdrawal in 124I PET/CT-Based Dosimetry for 131I Therapy of Metastatic Differentiated Thyroid Cancer.

Plyku D, Hobbs RF, Huang K, Atkins F, Garcia C, Sgouros G, Van Nostrand D.

J Nucl Med. 2017 Jul;58(7):1146-1154. doi: 10.2967/jnumed.116.179366. Epub 2017 Jan 19.


Quantitative impact of changes in marrow cellularity, skeletal size, and bone mineral density on active marrow dosimetry based upon a reference model.

Geyer AM, Schwarz BC, Hobbs RF, Sgouros G, Bolch WE.

Med Phys. 2017 Jan;44(1):272-283. doi: 10.1002/mp.12002.


Development of microsatellite markers for Lachancea thermotolerans typing and population structure of wine-associated isolates.

Banilas G, Sgouros G, Nisiotou A.

Microbiol Res. 2016 Dec;193:1-10. doi: 10.1016/j.micres.2016.08.010. Epub 2016 Aug 24.


[(18)F]Fluoroethyl Triazole Substituted PSMA Inhibitor Exhibiting Rapid Normal Organ Clearance.

Chen Y, Lisok A, Chatterjee S, Wharram B, Pullambhatla M, Wang Y, Sgouros G, Mease RC, Pomper MG.

Bioconjug Chem. 2016 Jul 20;27(7):1655-62. doi: 10.1021/acs.bioconjchem.6b00195. Epub 2016 Jun 24.


(2S)-2-(3-(1-Carboxy-5-(4-211At-Astatobenzamido)Pentyl)Ureido)-Pentanedioic Acid for PSMA-Targeted α-Particle Radiopharmaceutical Therapy.

Kiess AP, Minn I, Vaidyanathan G, Hobbs RF, Josefsson A, Shen C, Brummet M, Chen Y, Choi J, Koumarianou E, Baidoo K, Brechbiel MW, Mease RC, Sgouros G, Zalutsky MR, Pomper MG.

J Nucl Med. 2016 Oct;57(10):1569-1575. Epub 2016 May 26.


Effective treatment of ductal carcinoma in situ with a HER-2- targeted alpha-particle emitting radionuclide in a preclinical model of human breast cancer.

Yoshida T, Jin K, Song H, Park S, Huso DL, Zhang Z, Liangfeng H, Zhu C, Bruchertseifer F, Morgenstern A, Sgouros G, Sukumar S.

Oncotarget. 2016 May 31;7(22):33306-15. doi: 10.18632/oncotarget.8949.


Pharmacokinetic modeling of [(18)F]fluorodeoxyglucose (FDG) for premature infants, and newborns through 5-year-olds.

Khamwan K, Plyku D, O'Reilly SE, Goodkind A, Cao X, Fahey FH, Treves ST, Bolch WE, Sgouros G.

EJNMMI Res. 2016 Dec;6(1):28. doi: 10.1186/s13550-016-0179-6. Epub 2016 Mar 17.


Activity concentration and spatial distribution of radionuclides in marine sediments close to the estuary of Shatt al-Arab/Arvand Rud River, the Gulf.

Patiris DL, Tsabaris C, Anagnostou CL, Androulakaki EG, Pappa FK, Eleftheriou G, Sgouros G.

J Environ Radioact. 2016 Jun;157:1-15. doi: 10.1016/j.jenvrad.2016.02.025. Epub 2016 Mar 4.


A risk index for pediatric patients undergoing diagnostic imaging with (99m)Tc-dimercaptosuccinic acid that accounts for body habitus.

O'Reilly SE, Plyku D, Sgouros G, Fahey FH, Ted Treves S, Frey EC, Bolch WE.

Phys Med Biol. 2016 Mar 21;61(6):2319-32. doi: 10.1088/0031-9155/61/6/2319. Epub 2016 Mar 1.


Strengths and Weaknesses of a Planar Whole-Body Method of (153)Sm Dosimetry for Patients with Metastatic Osteosarcoma and Comparison with Three-Dimensional Dosimetry.

Plyku D, Loeb DM, Prideaux AR, Baechler S, Wahl RL, Sgouros G, Hobbs RF.

Cancer Biother Radiopharm. 2015 Nov;30(9):369-79. doi: 10.1089/cbr.2014.1803.


Imaging, Biodistribution, and Dosimetry of Radionuclide-Labeled PD-L1 Antibody in an Immunocompetent Mouse Model of Breast Cancer.

Josefsson A, Nedrow JR, Park S, Banerjee SR, Rittenbach A, Jammes F, Tsui B, Sgouros G.

Cancer Res. 2016 Jan 15;76(2):472-9. doi: 10.1158/0008-5472.CAN-15-2141. Epub 2015 Nov 10.


Tumor and red bone marrow dosimetry: comparison of methods for prospective treatment planning in pretargeted radioimmunotherapy.

Woliner-van der Weg W, Schoffelen R, Hobbs RF, Gotthardt M, Goldenberg DM, Sharkey RM, Slump CH, van der Graaf WT, Oyen WJ, Boerman OC, Sgouros G, Visser EP.

EJNMMI Phys. 2015 Dec;2(1):5. doi: 10.1186/s40658-014-0104-x. Epub 2015 Feb 24.


MIRD Pamphlet No. 26: Joint EANM/MIRD Guidelines for Quantitative 177Lu SPECT Applied for Dosimetry of Radiopharmaceutical Therapy.

Ljungberg M, Celler A, Konijnenberg MW, Eckerman KF, Dewaraja YK, Sjögreen-Gleisner K; SNMMI MIRD Committee, Bolch WE, Brill AB, Fahey F, Fisher DR, Hobbs R, Howell RW, Meredith RF, Sgouros G, Zanzonico P; EANM Dosimetry Committee, Bacher K, Chiesa C, Flux G, Lassmann M, Strigari L, Walrand S.

J Nucl Med. 2016 Jan;57(1):151-62. doi: 10.2967/jnumed.115.159012. Epub 2015 Oct 15.


Auger Radiopharmaceutical Therapy Targeting Prostate-Specific Membrane Antigen.

Kiess AP, Minn I, Chen Y, Hobbs R, Sgouros G, Mease RC, Pullambhatla M, Shen CJ, Foss CA, Pomper MG.

J Nucl Med. 2015 Sep;56(9):1401-1407. doi: 10.2967/jnumed.115.155929. Epub 2015 Jul 16.


Initial Evaluation of [(18)F]DCFPyL for Prostate-Specific Membrane Antigen (PSMA)-Targeted PET Imaging of Prostate Cancer.

Szabo Z, Mena E, Rowe SP, Plyku D, Nidal R, Eisenberger MA, Antonarakis ES, Fan H, Dannals RF, Chen Y, Mease RC, Vranesic M, Bhatnagar A, Sgouros G, Cho SY, Pomper MG.

Mol Imaging Biol. 2015 Aug;17(4):565-74. doi: 10.1007/s11307-015-0850-8.


Preclinical evaluation of 86Y-labeled inhibitors of prostate-specific membrane antigen for dosimetry estimates.

Banerjee SR, Foss CA, Pullambhatla M, Wang Y, Srinivasan S, Hobbs RF, Baidoo KE, Brechbiel MW, Nimmagadda S, Mease RC, Sgouros G, Pomper MG.

J Nucl Med. 2015 Apr;56(4):628-34. doi: 10.2967/jnumed.114.149062. Epub 2015 Feb 26.


Radiopharmaceutical therapy in the era of precision medicine.

Sgouros G, Goldenberg DM.

Eur J Cancer. 2014 Sep;50(13):2360-3. doi: 10.1016/j.ejca.2014.04.025. Epub 2014 Jun 19.


The role of preclinical models in radiopharmaceutical therapy.

Sgouros G, Hobbs RF, Abou DS.

Am Soc Clin Oncol Educ Book. 2014:e121-5. doi: 10.14694/EdBook_AM.2014.34.e121. Review.


Dosimetry for radiopharmaceutical therapy.

Sgouros G, Hobbs RF.

Semin Nucl Med. 2014 May;44(3):172-8. doi: 10.1053/j.semnuclmed.2014.03.007. Review.


Voxelized Dose--FDG-PET Response in HDR Brachytherapy of Rectal Cancer.

Hobbs RF, Le Y, Armour E, Efron J, Azad N, Diaz L, Wahl R, Sgouros G, Gearhardt S, Hermann J.

Pract Radiat Oncol. 2013 Apr-Jun;3(2 Suppl 1):S28-9. doi: 10.1016/j.prro.2013.01.097. Epub 2013 Mar 25. No abstract available.


Redefining relative biological effectiveness in the context of the EQDX formalism: implications for alpha-particle emitter therapy.

Hobbs RF, Howell RW, Song H, Baechler S, Sgouros G.

Radiat Res. 2014 Jan;181(1):90-8. doi: 10.1667/RR13483.1.


Redefining Relative Biological Effectiveness in the Context of the EQDX Formalism: Implications for Alpha-Particle Emitter Therapy.

Hobbs RF, Howell RW, Song H, Baechler S, Sgouros G.

Radiat Res. 2013 Dec 30. [Epub ahead of print]


Use of the FLUKA Monte Carlo code for 3D patient-specific dosimetry on PET-CT and SPECT-CT images.

Botta F, Mairani A, Hobbs RF, Vergara Gil A, Pacilio M, Parodi K, Cremonesi M, Coca Pérez MA, Di Dia A, Ferrari M, Guerriero F, Battistoni G, Pedroli G, Paganelli G, Torres Aroche LA, Sgouros G.

Phys Med Biol. 2013 Nov 21;58(22):8099-120.


MIRD pamphlet No. 24: Guidelines for quantitative 131I SPECT in dosimetry applications.

Dewaraja YK, Ljungberg M, Green AJ, Zanzonico PB, Frey EC; SNMMI MIRD Committee, Bolch WE, Brill AB, Dunphy M, Fisher DR, Howell RW, Meredith RF, Sgouros G, Wessels BW.

J Nucl Med. 2013 Dec;54(12):2182-8. doi: 10.2967/jnumed.113.122390. Epub 2013 Oct 15.


Radiobiologic optimization of combination radiopharmaceutical therapy applied to myeloablative treatment of non-Hodgkin lymphoma.

Hobbs RF, Wahl RL, Frey EC, Kasamon Y, Song H, Huang P, Jones RJ, Sgouros G.

J Nucl Med. 2013 Sep;54(9):1535-42. doi: 10.2967/jnumed.112.117952. Epub 2013 Aug 5.

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