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Phosphoinositide 3-Kinase Signaling Can Modulate MHC Class I and II Expression.

Chandrasekaran S, Sasaki M, Scharer CD, Kissick HT, Patterson DG, Magliocca KR, Seykora JT, Sapkota B, Gutman DA, Cooper LA, Lesinski GB, Waller EK, Thomas SN, Kotenko SV, Boss JM, Moreno CS, Swerlick RA, Pollack BP.

Mol Cancer Res. 2019 Dec;17(12):2395-2409. doi: 10.1158/1541-7786.MCR-19-0545. Epub 2019 Sep 23.


Voriconazole enhances UV-induced DNA damage by inhibiting catalase and promoting oxidative stress.

Lee V, Gober MD, Bashir H, O'Day C, Blair IA, Mesaros C, Weng L, Huang A, Chen A, Tang R, Anagnos V, Li J, Roling S, Sagaityte E, Wang A, Lin C, Yeh C, Atillasoy C, Marshall C, Dentchev T, Ridky T, Seykora JT.

Exp Dermatol. 2019 Sep 13. doi: 10.1111/exd.14038. [Epub ahead of print]


Ablative fractional laser resurfacing for treatment of sclerosis and contractures in chronic graft-versus-host disease: A pilot study.

Micheletti RG, Chansky PB, Haun PL, Seykora JT, Dekerlegand J, Sultan LR, Schultz SM, Sehgal CM, Sobanko JF.

J Am Acad Dermatol. 2019 Jul 30. pii: S0190-9622(19)32477-6. doi: 10.1016/j.jaad.2019.07.084. [Epub ahead of print] No abstract available.


Topical kinase inhibitors induce regression of cutaneous squamous cell carcinoma.

Yang X, Daifallah AEM, Shankar S, Beer J, Marshall C, Dentchev T, Seykora F, D'Armas S, Hahn J, Lee V, Sabry HH, Farag AM, Seykora JT.

Exp Dermatol. 2019 May;28(5):609-613. doi: 10.1111/exd.13902. Epub 2019 Mar 13.


Expression of p15 in a spectrum of spitzoid melanocytic neoplasms.

Ma SA, O'Day CP, Dentchev T, Takeshita J, Ridky TW, Seykora JT, Chu EY.

J Cutan Pathol. 2019 May;46(5):310-316. doi: 10.1111/cup.13424. Epub 2019 Feb 14.


Introduction to the 2016 JID Beijing Workshop: Precision Medicine in Dermatology.

Seykora JT.

J Investig Dermatol Symp Proc. 2018 Dec;19(2):S65-S68. doi: 10.1016/j.jisp.2018.09.001.


Srcasm Regulates Tyrosine Kinases in Skin Cancer: Implications for Precision Medicine.

Lee V, Yang X, Prouty S, Denchev T, Marshall C, Maeno H, Bashir H, O'Day C, Seykora JT.

J Investig Dermatol Symp Proc. 2018 Dec;19(2):S103-S105. doi: 10.1016/j.jisp.2018.10.006.


Cytoplasmic chromatin triggers inflammation in senescence and cancer.

Dou Z, Ghosh K, Vizioli MG, Zhu J, Sen P, Wangensteen KJ, Simithy J, Lan Y, Lin Y, Zhou Z, Capell BC, Xu C, Xu M, Kieckhaefer JE, Jiang T, Shoshkes-Carmel M, Tanim KMAA, Barber GN, Seykora JT, Millar SE, Kaestner KH, Garcia BA, Adams PD, Berger SL.

Nature. 2017 Oct 19;550(7676):402-406. doi: 10.1038/nature24050. Epub 2017 Oct 4.


Cutaneous Squamous Cell Carcinoma.

Parekh V, Seykora JT.

Clin Lab Med. 2017 Sep;37(3):503-525. doi: 10.1016/j.cll.2017.06.003. Review.


Invisible Shield: Review of the Corneal Epithelium as a Barrier to UV Radiation, Pathogens, and Other Environmental Stimuli.

Bashir H, Seykora JT, Lee V.

J Ophthalmic Vis Res. 2017 Jul-Sep;12(3):305-311. doi: 10.4103/jovr.jovr_114_17. Review.


WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation.

Xu M, Horrell J, Snitow M, Cui J, Gochnauer H, Syrett CM, Kallish S, Seykora JT, Liu F, Gaillard D, Katz JP, Kaestner KH, Levin B, Mansfield C, Douglas JE, Cowart BJ, Tordoff M, Liu F, Zhu X, Barlow LA, Rubin AI, McGrath JA, Morrisey EE, Chu EY, Millar SE.

Nat Commun. 2017 Jun 7;8:15397. doi: 10.1038/ncomms15397.


Inflammatory features of frontal fibrosing alopecia.

Ma SA, Imadojemu S, Beer K, Seykora JT.

J Cutan Pathol. 2017 Aug;44(8):672-676. doi: 10.1111/cup.12955. Epub 2017 Jun 1.


p15 Expression Differentiates Nevus from Melanoma.

Taylor LA, O'Day C, Dentchev T, Hood K, Chu EY, Ridky TW, Seykora JT.

Am J Pathol. 2016 Dec;186(12):3094-3099. doi: 10.1016/j.ajpath.2016.08.009. Epub 2016 Nov 14.


Therapeutic Elimination of the Type 1 Interferon Receptor for Treating Psoriatic Skin Inflammation.

Gui J, Gober M, Yang X, Katlinski KV, Marshall CM, Sharma M, Werth VP, Baker DP, Rui H, Seykora JT, Fuchs SY.

J Invest Dermatol. 2016 Oct;136(10):1990-2002. doi: 10.1016/j.jid.2016.06.608. Epub 2016 Jun 29.


Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease.

Ellebrecht CT, Bhoj VG, Nace A, Choi EJ, Mao X, Cho MJ, Di Zenzo G, Lanzavecchia A, Seykora JT, Cotsarelis G, Milone MC, Payne AS.

Science. 2016 Jul 8;353(6295):179-84. doi: 10.1126/science.aaf6756. Epub 2016 Jun 30.


Dermatopathology effects of simulated solar particle event radiation exposure in the porcine model.

Sanzari JK, Diffenderfer ES, Hagan S, Billings PC, Gridley DS, Seykora JT, Kennedy AR, Cengel KA.

Life Sci Space Res (Amst). 2015 Jul;6:21-8. doi: 10.1016/j.lssr.2015.06.003. Epub 2015 Jun 18.


CDKN2B Loss Promotes Progression from Benign Melanocytic Nevus to Melanoma.

McNeal AS, Liu K, Nakhate V, Natale CA, Duperret EK, Capell BC, Dentchev T, Berger SL, Herlyn M, Seykora JT, Ridky TW.

Cancer Discov. 2015 Oct;5(10):1072-85. doi: 10.1158/2159-8290.CD-15-0196. Epub 2015 Jul 16.


Rational development and characterization of humanized anti-EGFR variant III chimeric antigen receptor T cells for glioblastoma.

Johnson LA, Scholler J, Ohkuri T, Kosaka A, Patel PR, McGettigan SE, Nace AK, Dentchev T, Thekkat P, Loew A, Boesteanu AC, Cogdill AP, Chen T, Fraietta JA, Kloss CC, Posey AD Jr, Engels B, Singh R, Ezell T, Idamakanti N, Ramones MH, Li N, Zhou L, Plesa G, Seykora JT, Okada H, June CH, Brogdon JL, Maus MV.

Sci Transl Med. 2015 Feb 18;7(275):275ra22. doi: 10.1126/scitranslmed.aaa4963.


Comparative analysis of colorimetric staining in skin using open-source software.

Billings PC, Sanzari JK, Kennedy AR, Cengel KA, Seykora JT.

Exp Dermatol. 2015 Feb;24(2):157-9. doi: 10.1111/exd.12594.


Hypoxia-inducible factors regulate filaggrin expression and epidermal barrier function.

Wong WJ, Richardson T, Seykora JT, Cotsarelis G, Simon MC.

J Invest Dermatol. 2015 Feb;135(2):454-461. doi: 10.1038/jid.2014.283. Epub 2014 Jul 7.


Is more hair always better? A single biopsy specimen is preferred for the evaluation of alopecia.

Rubin AI, Seykora JT.

J Cutan Pathol. 2014 Jan;41(1):66-7. doi: 10.1111/cup.12228. Epub 2013 Oct 7. No abstract available.


Complement modulates the cutaneous microbiome and inflammatory milieu.

Chehoud C, Rafail S, Tyldsley AS, Seykora JT, Lambris JD, Grice EA.

Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):15061-6. doi: 10.1073/pnas.1307855110. Epub 2013 Aug 26.


Targeted delivery of tumor necrosis factor-related apoptosis-inducing ligand to keratinocytes with a pemphigus mAb.

Kouno M, Lin C, Schechter NM, Siegel D, Yang X, Seykora JT, Stanley JR.

J Invest Dermatol. 2013 Sep;133(9):2212-20. doi: 10.1038/jid.2013.85. Epub 2013 Feb 25.


Reconstructing skin cancers using animal models.

Gober MD, Bashir HM, Seykora JT.

Cancer Metastasis Rev. 2013 Jun;32(1-2):123-8. doi: 10.1007/s10555-012-9410-8. Review.


Diverse cutaneous side effects associated with BRAF inhibitor therapy: a clinicopathologic study.

Chu EY, Wanat KA, Miller CJ, Amaravadi RK, Fecher LA, Brose MS, McGettigan S, Giles LR, Schuchter LM, Seykora JT, Rosenbach M.

J Am Acad Dermatol. 2012 Dec;67(6):1265-72. doi: 10.1016/j.jaad.2012.04.008. Epub 2012 May 18.


Equestrian perniosis: a report of 2 cases and a review of the literature.

Stewart CL, Adler DJ, Jacobson A, Brod BA, Shinohara MM, Seykora JT, Elenitsas R, Rosenbach M.

Am J Dermatopathol. 2013 Apr;35(2):237-40. doi: 10.1097/DAD.0b013e31824c221f. Review.


Inducible deletion of epidermal Dicer and Drosha reveals multiple functions for miRNAs in postnatal skin.

Teta M, Choi YS, Okegbe T, Wong G, Tam OH, Chong MM, Seykora JT, Nagy A, Littman DR, Andl T, Millar SE.

Development. 2012 Apr;139(8):1405-16. doi: 10.1242/dev.070920.


Viral-associated trichodysplasia: characterization of a novel polyomavirus infection with therapeutic insights.

Wanat KA, Holler PD, Dentchev T, Simbiri K, Robertson E, Seykora JT, Rosenbach M.

Arch Dermatol. 2012 Feb;148(2):219-23. doi: 10.1001/archdermatol.2011.1413.


From keratinocyte to cancer: the pathogenesis and modeling of cutaneous squamous cell carcinoma.

Ratushny V, Gober MD, Hick R, Ridky TW, Seykora JT.

J Clin Invest. 2012 Feb;122(2):464-72. doi: 10.1172/JCI57415. Epub 2012 Feb 1. Review.


Acute biological effects of simulating the whole-body radiation dose distribution from a solar particle event using a porcine model.

Wilson JM, Sanzari JK, Diffenderfer ES, Yee SS, Seykora JT, Maks C, Ware JH, Litt HI, Reetz JA, McDonough J, Weissman D, Kennedy AR, Cengel KA.

Radiat Res. 2011 Nov;176(5):649-59. Epub 2011 Aug 22.


Pigmented fruiting bodies and birefringent crystals in a surgical wound: A clue to Aspergillus niger infection.

Shinohara MM, Miller CJ, Seykora JT.

J Cutan Pathol. 2011 Aug;38(8):603-6. doi: 10.1111/j.1600-0560.2011.01748_1.x. No abstract available.


╬▒-catenin is a tumor suppressor that controls cell accumulation by regulating the localization and activity of the transcriptional coactivator Yap1.

Silvis MR, Kreger BT, Lien WH, Klezovitch O, Rudakova GM, Camargo FD, Lantz DM, Seykora JT, Vasioukhin V.

Sci Signal. 2011 May 24;4(174):ra33. doi: 10.1126/scisignal.2001823.


Keratin 15-positive stem cells give rise to basal cell carcinomas in irradiated Ptch1(+/-) mice.

Seykora JT, Cotsarelis G.

Cancer Cell. 2011 Jan 18;19(1):5-6. doi: 10.1016/j.ccr.2011.01.006.


The HoVert technique: a novel method for the sectioning of alopecia biopsies.

Nguyen JV, Hudacek K, Whitten JA, Rubin AI, Seykora JT.

J Cutan Pathol. 2011 May;38(5):401-6. doi: 10.1111/j.1600-0560.2010.01669.x. Epub 2011 Jan 19.


Decreased Srcasm expression in esophageal squamous cell carcinoma in a Chinese population.

Qi Y, Li X, Zhao L, Seykora JT.

Anticancer Res. 2010 Sep;30(9):3535-9.


NOTCH1 and NOTCH3 coordinate esophageal squamous differentiation through a CSL-dependent transcriptional network.

Ohashi S, Natsuizaka M, Yashiro-Ohtani Y, Kalman RA, Nakagawa M, Wu L, Klein-Szanto AJ, Herlyn M, Diehl JA, Katz JP, Pear WS, Seykora JT, Nakagawa H.

Gastroenterology. 2010 Dec;139(6):2113-23. doi: 10.1053/j.gastro.2010.08.040. Epub 2010 Aug 27.


Grabbing amphiregulin by the tail to better understand keratinocyte growth.

Seykora JT.

J Invest Dermatol. 2010 Aug;130(8):1966-8. doi: 10.1038/jid.2010.199.


Curcuminoids activate p38 MAP kinases and promote UVB-dependent signalling in keratinocytes.

Ayli EE, Dugas-Breit S, Li W, Marshall C, Zhao L, Meulener M, Griffin T, Gelfand JM, Seykora JT.

Exp Dermatol. 2010 Jun;19(6):493-500. doi: 10.1111/j.1600-0625.2010.01081.x. Epub 2010 Apr 20.


Renbok phenomenon and contact sensitization in a patient with alopecia universalis.

Harris JE, Seykora JT, Lee RA.

Arch Dermatol. 2010 Apr;146(4):422-5. doi: 10.1001/archdermatol.2010.42.


Srcasm inhibits Fyn-induced cutaneous carcinogenesis with modulation of Notch1 and p53.

Zhao L, Li W, Marshall C, Griffin T, Hanson M, Hick R, Dentchev T, Williams E, Werth A, Miller C, Bashir H, Pear W, Seykora JT.

Cancer Res. 2009 Dec 15;69(24):9439-47. doi: 10.1158/0008-5472.CAN-09-2976.


Bone morphogenetic protein antagonist noggin promotes skin tumorigenesis via stimulation of the Wnt and Shh signaling pathways.

Sharov AA, Mardaryev AN, Sharova TY, Grachtchouk M, Atoyan R, Byers HR, Seykora JT, Overbeek P, Dlugosz A, Botchkarev VA.

Am J Pathol. 2009 Sep;175(3):1303-14. doi: 10.2353/ajpath.2009.090163. Epub 2009 Aug 21.


Decreased Srcasm expression in hyperproliferative cutaneous lesions.

Meulener MC, Ayli EE, Elenitsas R, Seykora JT.

J Cutan Pathol. 2009 Mar;36(3):291-5. doi: 10.1111/j.1600-0560.2008.01035.x.


Multiple cutaneous sclerosing perineuriomas: an extensive presentation with involvement of the bilateral upper extremities.

Rubin AI, Yassaee M, Johnson W, Elenitsas R, Zaladonis J Jr, Seykora JT.

J Cutan Pathol. 2009 Oct;36 Suppl 1:60-5. doi: 10.1111/j.1600-0560.2008.01217.x. Epub 2009 Jan 27.


Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate.

Zhang Y, Andl T, Yang SH, Teta M, Liu F, Seykora JT, Tobias JW, Piccolo S, Schmidt-Ullrich R, Nagy A, Taketo MM, Dlugosz AA, Millar SE.

Development. 2008 Jun;135(12):2161-72. doi: 10.1242/dev.017459. Epub 2008 May 14.


Activation of Src-family tyrosine kinases in hyperproliferative epidermal disorders.

Ayli EE, Li W, Brown TT, Witkiewicz A, Elenitsas R, Seykora JT.

J Cutan Pathol. 2008 Mar;35(3):273-7. doi: 10.1111/j.1600-0560.2007.00807.x.


Oral curcumin in the treatment of moderate to severe psoriasis vulgaris: A prospective clinical trial.

Kurd SK, Smith N, VanVoorhees A, Troxel AB, Badmaev V, Seykora JT, Gelfand JM.

J Am Acad Dermatol. 2008 Apr;58(4):625-31. doi: 10.1016/j.jaad.2007.12.035. Epub 2008 Feb 4. Erratum in: J Am Acad Dermatol. 2008 Jun;58(6):1050.


Primary cutaneous adenomyoepithelioma.

Clarke LE, Seykora JT.

J Cutan Pathol. 2007 Aug;34(8):654-7.


Srcasm overexpression in psoriasis-insights into pathogenesis.

Pulitzer M, Li W, Hanson M, Singh F, Elenitsas R, Gelfand JM, VanVoorhees A, Seykora JT.

J Cutan Pathol. 2007 Feb;34(2):160-5.


Cowden's disease (Multiple Hamartoma Syndrome).

Seykora JT.

Cutis. 2006 Dec;78(6):425; author reply 425. No abstract available.


Growth inhibition of Trichophyton species by Pseudomonas aeruginosa.

Treat J, James WD, Nachamkin I, Seykora JT.

Arch Dermatol. 2007 Jan;143(1):61-4.


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