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Items: 1 to 50 of 112

1.

The first line of defence: insights into mechanisms and relevance of phagocytosis in epithelial cells.

Günther J, Seyfert HM.

Semin Immunopathol. 2018 Nov;40(6):555-565. doi: 10.1007/s00281-018-0701-1. Epub 2018 Sep 4. Review.

2.

Pathogen-specific responses in the bovine udder. Models and immunoprophylactic concepts.

Petzl W, Zerbe H, Günther J, Seyfert HM, Hussen J, Schuberth HJ.

Res Vet Sci. 2018 Feb;116:55-61. doi: 10.1016/j.rvsc.2017.12.012. Epub 2017 Dec 19. Review.

PMID:
29275905
3.

Epigenetic mechanisms contribute to decrease stearoyl-CoA desaturase 1 expression in the liver of dairy cows after prolonged feeding of high-concentrate diet.

Xu TL, Seyfert HM, Shen XZ.

J Dairy Sci. 2018 Mar;101(3):2506-2518. doi: 10.3168/jds.2017-12878. Epub 2017 Dec 21.

4.

Differentiating Staphylococcus aureus from Escherichia coli mastitis: S. aureus triggers unbalanced immune-dampening and host cell invasion immediately after udder infection.

Günther J, Petzl W, Bauer I, Ponsuksili S, Zerbe H, Schuberth HJ, Brunner RM, Seyfert HM.

Sci Rep. 2017 Jul 6;7(1):4811. doi: 10.1038/s41598-017-05107-4.

5.

TLR ligands, but not modulators of histone modifiers, can induce the complex immune response pattern of endotoxin tolerance in mammary epithelial cells.

Günther J, Petzl W, Zerbe H, Schuberth HJ, Seyfert HM.

Innate Immun. 2017 Feb;23(2):155-164. doi: 10.1177/1753425916681076. Epub 2016 Dec 5.

6.

Bovine milk RNases modulate pro-inflammatory responses induced by nucleic acids in cultured immune and epithelial cells.

Gupta SK, Haigh BJ, Seyfert HM, Griffin FJ, Wheeler TT.

Dev Comp Immunol. 2017 Mar;68:87-97. doi: 10.1016/j.dci.2016.11.015. Epub 2016 Nov 19.

PMID:
27871831
7.

ST2 from rainbow trout quenches TLR signalling, localises at the nuclear membrane and allows the nuclear translocation of MYD88.

Rebl A, Rebl H, Köbis JM, Goldammer T, Seyfert HM.

Dev Comp Immunol. 2017 Feb;67:139-152. doi: 10.1016/j.dci.2016.10.009. Epub 2016 Oct 21.

9.

Early transcriptional events in the udder and teat after intra-mammary Escherichia coli and Staphylococcus aureus challenge.

Petzl W, Günther J, Mühlbauer K, Seyfert HM, Schuberth HJ, Hussen J, Sauter-Louis C, Hafner-Marx A, Zerbe H.

Innate Immun. 2016 May;22(4):294-304. doi: 10.1177/1753425916640057. Epub 2016 Mar 24.

PMID:
27012912
10.

Comparison of the pathogen species-specific immune response in udder derived cell types and their models.

Günther J, Koy M, Berthold A, Schuberth HJ, Seyfert HM.

Vet Res. 2016 Feb 1;47:22. doi: 10.1186/s13567-016-0307-3.

11.

Streptococcus uberis strains isolated from the bovine mammary gland evade immune recognition by mammary epithelial cells, but not of macrophages.

Günther J, Czabanska A, Bauer I, Leigh JA, Holst O, Seyfert HM.

Vet Res. 2016 Jan 7;47:13. doi: 10.1186/s13567-015-0287-8.

12.

Hepatic TLR4 signaling is activated by LPS from digestive tract during SARA, and epigenetic mechanisms contribute to enforced TLR4 expression.

Chang G, Zhuang S, Seyfert HM, Zhang K, Xu T, Jin D, Guo J, Shen X.

Oncotarget. 2015 Nov 17;6(36):38578-90. doi: 10.18632/oncotarget.6161.

13.

Structurally diverse genes encode Tlr2 in rainbow trout: The conserved receptor cannot be stimulated by classical ligands to activate NF-κB in vitro.

Brietzke A, Arnemo M, Gjøen T, Rebl H, Korytář T, Goldammer T, Rebl A, Seyfert HM.

Dev Comp Immunol. 2016 Jan;54(1):75-88. doi: 10.1016/j.dci.2015.08.012. Epub 2015 Sep 6.

PMID:
26348603
14.

Adaption of SYBR Green-based reagent kit for real-time PCR quantitation of GC-rich DNA.

Chang GJ, Seyfert HM, Shen XZ.

Genet Mol Res. 2015 Jul 28;14(3):8509-15. doi: 10.4238/2015.July.28.20.

15.
16.

Three promoters with different tissue specificity and pathogen inducibility express the toll-like-receptor 2 (TLR2)-encoding gene in cattle.

Chang G, Xu T, Brand B, Petzl W, Shen X, Seyfert HM.

Vet Immunol Immunopathol. 2015 Sep 15;167(1-2):57-63. doi: 10.1016/j.vetimm.2015.07.005. Epub 2015 Jul 6.

PMID:
26235600
17.

Extracellular milieu grossly alters pathogen-specific immune response of mammary epithelial cells.

Bauer I, Günther J, Wheeler TT, Engelmann S, Seyfert HM.

BMC Vet Res. 2015 Jul 30;11:172. doi: 10.1186/s12917-015-0489-3.

18.

Feeding a high-grain diet reduces the percentage of LPS clearance and enhances immune gene expression in goat liver.

Chang G, Zhang K, Xu T, Jin D, Seyfert HM, Shen X, Zhuang S.

BMC Vet Res. 2015 Mar 18;11:67. doi: 10.1186/s12917-015-0376-y.

19.

Epigenetic mechanisms contribute to enhanced expression of immune response genes in the liver of cows after experimentally induced Escherichia coli mastitis.

Chang G, Petzl W, Vanselow J, Günther J, Shen X, Seyfert HM.

Vet J. 2015 Mar;203(3):339-41. doi: 10.1016/j.tvjl.2014.12.023. Epub 2014 Dec 29.

PMID:
25618856
20.

Two TIR-like domain containing proteins in a newly emerging zoonotic Staphylococcus aureus strain sequence type 398 are potential virulence factors by impacting on the host innate immune response.

Patterson NJ, Günther J, Gibson AJ, Offord V, Coffey TJ, Splitter G, Monk I, Seyfert HM, Werling D.

Front Microbiol. 2014 Dec 9;5:662. doi: 10.3389/fmicb.2014.00662. eCollection 2014.

21.

GRP94 is encoded by two differentially expressed genes during development of rainbow trout (Oncorhynchus mykiss).

Rebl A, Brietzke A, Goldammer T, Seyfert HM.

Fish Physiol Biochem. 2014 Dec;40(6):1917-26. doi: 10.1007/s10695-014-9979-7. Epub 2014 Sep 3.

PMID:
25183230
22.

The proximal promoter of a novel interleukin-8-encoding gene in rainbow trout (Oncorhynchus mykiss) is strongly induced by CEBPA, but not NF-κB p65.

Rebl A, Rebl H, Korytář T, Goldammer T, Seyfert HM.

Dev Comp Immunol. 2014 Oct;46(2):155-64. doi: 10.1016/j.dci.2014.03.024. Epub 2014 Apr 8.

PMID:
24721762
23.

Characterization of the interleukin 1 receptor-associated kinase 4 (IRAK4)-encoding gene in salmonid fish: the functional copy is rearranged in Oncorhynchus mykiss and that factor can impair TLR signaling in mammalian cells.

Brietzke A, Goldammer T, Rebl H, Korytář T, Köllner B, Yang W, Rebl A, Seyfert HM.

Fish Shellfish Immunol. 2014 Jan;36(1):206-14. doi: 10.1016/j.fsi.2013.11.005. Epub 2013 Nov 12.

PMID:
24239597
24.

Recombinant bovine S100A8 and A9 enhance IL-1β secretion of interferon-gamma primed monocytes.

Koy M, Hambruch N, Hussen J, Pfarrer C, Seyfert HM, Schuberth HJ.

Vet Immunol Immunopathol. 2013 Sep 15;155(3):162-70. doi: 10.1016/j.vetimm.2013.07.002. Epub 2013 Jul 12.

PMID:
23890724
25.

Species-specific PAMP recognition by TLR2 and evidence for species-restricted interaction with Dectin-1.

Willcocks S, Offord V, Seyfert HM, Coffey TJ, Werling D.

J Leukoc Biol. 2013 Sep;94(3):449-58. doi: 10.1189/jlb.0812390. Epub 2013 Jun 20.

PMID:
23787127
26.

Escherichia coli- and Staphylococcus aureus-induced mastitis differentially modulate transcriptional responses in neighbouring uninfected bovine mammary gland quarters.

Jensen K, Günther J, Talbot R, Petzl W, Zerbe H, Schuberth HJ, Seyfert HM, Glass EJ.

BMC Genomics. 2013 Jan 16;14:36. doi: 10.1186/1471-2164-14-36.

27.

Characterization of a far upstream located promoter expressing the acetyl-CoA carboxylase-alpha in the brain of cattle.

Shi X, Metges CC, Seyfert HM.

Gene. 2013 Feb 25;515(2):266-71. doi: 10.1016/j.gene.2012.12.033. Epub 2012 Dec 20.

PMID:
23262334
29.

Combining quantitative trait loci and heterogeneous microarray data analyses reveals putative candidate pathways affecting mastitis in cattle.

Lewandowska-Sabat AM, Günther J, Seyfert HM, Olsaker I.

Anim Genet. 2012 Dec;43(6):793-9. doi: 10.1111/j.1365-2052.2012.02342.x. Epub 2012 Mar 15.

PMID:
22497313
30.

Lipopolysaccharide priming enhances expression of effectors of immune defence while decreasing expression of pro-inflammatory cytokines in mammary epithelia cells from cows.

Günther J, Petzl W, Zerbe H, Schuberth HJ, Koczan D, Goetze L, Seyfert HM.

BMC Genomics. 2012 Jan 12;13:17. doi: 10.1186/1471-2164-13-17.

31.

Yeast-surface expressed BVDV E2 protein induces a Th1/Th2 response in naïve T cells.

Patterson R, Nerren J, Kogut M, Court P, Villarreal-Ramos B, Seyfert HM, Dalby P, Werling D.

Dev Comp Immunol. 2012 May;37(1):107-14. doi: 10.1016/j.dci.2011.10.009. Epub 2011 Oct 31.

32.

Lipopolysaccharide pretreatment of the udder protects against experimental Escherichia coli mastitis.

Petzl W, Günther J, Pfister T, Sauter-Louis C, Goetze L, von Aulock S, Hafner-Marx A, Schuberth HJ, Seyfert HM, Zerbe H.

Innate Immun. 2012 Jun;18(3):467-77. doi: 10.1177/1753425911422407. Epub 2011 Oct 11.

PMID:
21990573
33.

Host-response patterns of intramammary infections in dairy cows.

Schukken YH, Günther J, Fitzpatrick J, Fontaine MC, Goetze L, Holst O, Leigh J, Petzl W, Schuberth HJ, Sipka A, Smith DG, Quesnell R, Watts J, Yancey R, Zerbe H, Gurjar A, Zadoks RN, Seyfert HM; members of the Pfizer mastitis research consortium.

Vet Immunol Immunopathol. 2011 Dec 15;144(3-4):270-89. doi: 10.1016/j.vetimm.2011.08.022. Epub 2011 Sep 10. Review.

PMID:
21955443
34.

Glucose transporters and enzymes related to glucose synthesis in small intestinal mucosa of mid-lactation dairy cows fed 2 levels of starch.

Lohrenz AK, Duske K, Schönhusen U, Losand B, Seyfert HM, Metges CC, Hammon HM.

J Dairy Sci. 2011 Sep;94(9):4546-55. doi: 10.3168/jds.2011-4333.

35.

Strengthening insights into host responses to mastitis infection in ruminants by combining heterogeneous microarray data sources.

Genini S, Badaoui B, Sclep G, Bishop SC, Waddington D, Pinard van der Laan MH, Klopp C, Cabau C, Seyfert HM, Petzl W, Jensen K, Glass EJ, de Greeff A, Smith HE, Smits MA, Olsaker I, Boman GM, Pisoni G, Moroni P, Castiglioni B, Cremonesi P, Del Corvo M, Foulon E, Foucras G, Rupp R, Giuffra E.

BMC Genomics. 2011 May 11;12(1):225. doi: 10.1186/1471-2164-12-225.

36.

Lingual antimicrobial peptide and IL-8 expression are oppositely regulated by the antagonistic effects of NF-κB p65 and C/EBPβ in mammary epithelial cells.

Liu S, Shi X, Bauer I, Günther J, Seyfert HM.

Mol Immunol. 2011 Mar;48(6-7):895-908. doi: 10.1016/j.molimm.2010.12.018. Epub 2011 Jan 20.

PMID:
21255844
37.
38.

Milk performance and glucose metabolism in dairy cows fed rumen-protected fat during mid lactation.

Lohrenz AK, Duske K, Schneider F, Nürnberg K, Losand B, Seyfert HM, Metges CC, Hammon HM.

J Dairy Sci. 2010 Dec;93(12):5867-76. doi: 10.3168/jds.2010-3342.

39.

Natural occurrence and physiological role of a truncated eIF4E in the porcine endometrium during implantation.

Wollenhaupt K, Reinke K, Brüssow KP, Albrecht D, Tiemann U, Seyfert HM, Tomek W.

Biochem J. 2010 Dec 1;432(2):353-63. doi: 10.1042/BJ20100801.

PMID:
20854261
40.

Salmonid Tollip and MyD88 factors can functionally replace their mammalian orthologues in TLR-mediated trout SAA promoter activation.

Rebl A, Rebl H, Liu S, Goldammer T, Seyfert HM.

Dev Comp Immunol. 2011 Jan;35(1):81-7. doi: 10.1016/j.dci.2010.08.012. Epub 2010 Sep 9.

PMID:
20813127
41.

C/EBP-beta drives expression of the nutritionally regulated promoter IA of the acetyl-CoA carboxylase-alpha gene in cattle.

Shi X, Liu S, Metges CC, Seyfert HM.

Biochim Biophys Acta. 2010 Aug;1799(8):561-7. doi: 10.1016/j.bbagrm.2010.07.002. Epub 2010 Jul 14.

PMID:
20637321
42.

Substance P alters the in vitro LPS responsiveness of bovine monocytes and blood-derived macrophages.

Sipka A, Langner K, Seyfert HM, Schuberth HJ.

Vet Immunol Immunopathol. 2010 Aug 15;136(3-4):219-26. doi: 10.1016/j.vetimm.2010.03.011. Epub 2010 Mar 20.

PMID:
20378186
43.

Stimulated expression of TNF-alpha and IL-8, but not of lingual antimicrobial peptide reflects the concentration of pathogens contacting bovine mammary epithelial cells.

Günther J, Liu S, Esch K, Schuberth HJ, Seyfert HM.

Vet Immunol Immunopathol. 2010 May 15;135(1-2):152-157. doi: 10.1016/j.vetimm.2009.11.004. Epub 2009 Nov 18.

PMID:
19963279
44.

Toll-like receptor signaling in bony fish.

Rebl A, Goldammer T, Seyfert HM.

Vet Immunol Immunopathol. 2010 Apr 15;134(3-4):139-50. doi: 10.1016/j.vetimm.2009.09.021. Epub 2009 Sep 30. Review.

PMID:
19850357
45.

Binding of porcine spermatozoa to uterine epithelial cells modulates the female immune response and might indicate the formation of a pre-oviductal sperm reservoir.

Taylor U, Zerbe H, Seyfert HM, Rath D, Schuberth HJ.

Soc Reprod Fertil Suppl. 2009;66:83-4. No abstract available.

PMID:
19848270
46.
47.

Characterization of two key molecules of teleost innate immunity from rainbow trout (Oncorhynchus mykiss): MyD88 and SAA.

Rebl A, Goldammer T, Fischer U, Köllner B, Seyfert HM.

Vet Immunol Immunopathol. 2009 Sep 15;131(1-2):122-6. doi: 10.1016/j.vetimm.2009.03.006. Epub 2009 Mar 20.

PMID:
19362743
48.

Assessment of the immune capacity of mammary epithelial cells: comparison with mammary tissue after challenge with Escherichia coli.

Günther J, Koczan D, Yang W, Nürnberg G, Repsilber D, Schuberth HJ, Park Z, Maqbool N, Molenaar A, Seyfert HM.

Vet Res. 2009 Jul-Aug;40(4):31. doi: 10.1051/vetres/2009014. Epub 2009 Mar 27.

49.

Metabolism and lactation performance in dairy cows fed a diet containing rumen-protected fat during the last twelve weeks of gestation.

Duske K, Hammon HM, Langhof AK, Bellmann O, Losand B, Nürnberg K, Nürnberg G, Sauerwein H, Seyfert HM, Metges CC.

J Dairy Sci. 2009 Apr;92(4):1670-84. doi: 10.3168/jds.2008-1543.

50.

Porcine spermatozoa inhibit post-breeding cytokine induction in uterine epithelial cells in vivo.

Taylor U, Zerbe H, Seyfert HM, Rath D, Baulain U, Langner KF, Schuberth HJ.

Anim Reprod Sci. 2009 Oct;115(1-4):279-89. doi: 10.1016/j.anireprosci.2008.11.019. Epub 2008 Dec 6.

PMID:
19136226

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