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Items: 1 to 50 of 80

1.

Macrocyclization via an Arginine-Tyrosine Crosslink Broadens the Reaction Scope of Radical S-Adenosylmethionine Enzymes.

Caruso A, Martinie RJ, Bushin LB, Seyedsayamdost MR.

J Am Chem Soc. 2019 Oct 23;141(42):16610-16614. doi: 10.1021/jacs.9b09210. Epub 2019 Oct 14.

PMID:
31596076
2.

Total Synthesis and Stereochemical Assignment of Streptide.

Isley NA, Endo Y, Wu ZC, Covington BC, Bushin LB, Seyedsayamdost MR, Boger DL.

J Am Chem Soc. 2019 Oct 30;141(43):17361-17369. doi: 10.1021/jacs.9b09067. Epub 2019 Oct 17.

PMID:
31577142
3.

Aliphatic Ether Bond Formation Expands the Scope of Radical SAM Enzymes in Natural Product Biosynthesis.

Clark KA, Bushin LB, Seyedsayamdost MR.

J Am Chem Soc. 2019 Jul 10;141(27):10610-10615. doi: 10.1021/jacs.9b05151. Epub 2019 Jun 27.

PMID:
31246011
4.

Identification of the Hypertension Drug Guanfacine as an Antivirulence Agent in Pseudomonas aeruginosa.

Okada BK, Li A, Seyedsayamdost MR.

Chembiochem. 2019 Aug 1;20(15):2005-2011. doi: 10.1002/cbic.201900129. Epub 2019 Jul 3.

PMID:
30927315
5.

Cebulantin, a Cryptic Lanthipeptide Antibiotic Uncovered Using Bioactivity-Coupled HiTES.

Moon K, Xu F, Seyedsayamdost MR.

Angew Chem Int Ed Engl. 2019 Apr 23;58(18):5973-5977. doi: 10.1002/anie.201901342. Epub 2019 Mar 28.

PMID:
30843641
6.

Bioactivity-HiTES Unveils Cryptic Antibiotics Encoded in Actinomycete Bacteria.

Moon K, Xu F, Zhang C, Seyedsayamdost MR.

ACS Chem Biol. 2019 Apr 19;14(4):767-774. doi: 10.1021/acschembio.9b00049. Epub 2019 Mar 19.

PMID:
30830740
7.

Toward a global picture of bacterial secondary metabolism.

Seyedsayamdost MR.

J Ind Microbiol Biotechnol. 2019 Mar;46(3-4):301-311. doi: 10.1007/s10295-019-02136-y. Epub 2019 Jan 25.

PMID:
30684124
8.

A genetics-free method for high-throughput discovery of cryptic microbial metabolites.

Xu F, Wu Y, Zhang C, Davis KM, Moon K, Bushin LB, Seyedsayamdost MR.

Nat Chem Biol. 2019 Feb;15(2):161-168. doi: 10.1038/s41589-018-0193-2. Epub 2019 Jan 7.

9.

Discovery of a New Class I Ribonucleotide Reductase with an Essential DOPA Radical and NO Metal as an Initiator of Long-Range Radical Transfer.

Stubbe J, Seyedsayamdost MR.

Biochemistry. 2019 Feb 12;58(6):435-437. doi: 10.1021/acs.biochem.8b01238. Epub 2018 Dec 26. No abstract available.

PMID:
30586288
10.

Radical Approach to Enzymatic β-Thioether Bond Formation.

Caruso A, Bushin LB, Clark KA, Martinie RJ, Seyedsayamdost MR.

J Am Chem Soc. 2019 Jan 16;141(2):990-997. doi: 10.1021/jacs.8b11060. Epub 2018 Dec 28.

PMID:
30521328
11.

Charting an Unexplored Streptococcal Biosynthetic Landscape Reveals a Unique Peptide Cyclization Motif.

Bushin LB, Clark KA, Pelczer I, Seyedsayamdost MR.

J Am Chem Soc. 2018 Dec 19;140(50):17674-17684. doi: 10.1021/jacs.8b10266. Epub 2018 Dec 5.

PMID:
30398325
12.

Installation of Multiple Aryl Ether Crosslinks onto Non-Native Substrate Peptides by the Vancomycin OxyB.

Forneris CC, Ozturk S, Sorensen EJ, Seyedsayamdost MR.

Tetrahedron. 2018 Jun 28;74(26):3231-3237. doi: 10.1016/j.tet.2018.04.028. Epub 2018 Apr 13.

13.

Multiple siderophores: bug or feature?

McRose DL, Seyedsayamdost MR, Morel FMM.

J Biol Inorg Chem. 2018 Oct;23(7):983-993. doi: 10.1007/s00775-018-1617-x. Epub 2018 Sep 27. Review.

PMID:
30264174
14.

Guidelines for Determining the Structures of Radical SAM Enzyme-Catalyzed Modifications in the Biosynthesis of RiPP Natural Products.

Bushin LB, Seyedsayamdost MR.

Methods Enzymol. 2018;606:439-460. doi: 10.1016/bs.mie.2018.04.016. Epub 2018 May 24.

PMID:
30097102
15.

The Polyene Natural Product Thailandamide A Inhibits Fatty Acid Biosynthesis in Gram-Positive and Gram-Negative Bacteria.

Wu Y, Seyedsayamdost MR.

Biochemistry. 2018 Jul 24;57(29):4247-4251. doi: 10.1021/acs.biochem.8b00678. Epub 2018 Jul 12.

PMID:
29975047
16.

Quorum sensing and iron regulate a two-for-one siderophore gene cluster in Vibrio harveyi.

McRose DL, Baars O, Seyedsayamdost MR, Morel FMM.

Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):7581-7586. doi: 10.1073/pnas.1805791115. Epub 2018 Jun 28.

17.

Recent advances in activating silent biosynthetic gene clusters in bacteria.

Mao D, Okada BK, Wu Y, Xu F, Seyedsayamdost MR.

Curr Opin Microbiol. 2018 Oct;45:156-163. doi: 10.1016/j.mib.2018.05.001. Epub 2018 Jun 5. Review. No abstract available.

18.

Modulating OxyB-Catalyzed Cross-Coupling Reactions in Vancomycin Biosynthesis by Incorporation of Diverse d-Tyr Analogues.

Ozturk S, Forneris CC, Nguy AKL, Sorensen EJ, Seyedsayamdost MR.

J Org Chem. 2018 Jul 6;83(13):7309-7317. doi: 10.1021/acs.joc.8b00916. Epub 2018 Jun 19.

PMID:
29806454
19.

Malleilactone Is a Burkholderia pseudomallei Virulence Factor Regulated by Antibiotics and Quorum Sensing.

Klaus JR, Deay J, Neuenswander B, Hursh W, Gao Z, Bouddhara T, Williams TD, Douglas J, Monize K, Martins P, Majerczyk C, Seyedsayamdost MR, Peterson BR, Rivera M, Chandler JR.

J Bacteriol. 2018 Jun 25;200(14). pii: e00008-18. doi: 10.1128/JB.00008-18. Print 2018 Jul 15.

20.

Small Biomolecules for Big Applications.

Gibson MI, Seyedsayamdost MR.

ACS Cent Sci. 2018 Apr 25;4(4):437-439. doi: 10.1021/acscentsci.8b00088. Epub 2018 Apr 18. No abstract available.

21.

In Vitro Reconstitution of OxyC Activity Enables Total Chemoenzymatic Syntheses of Vancomycin Aglycone Variants.

Forneris CC, Seyedsayamdost MR.

Angew Chem Int Ed Engl. 2018 Jul 2;57(27):8048-8052. doi: 10.1002/anie.201802856. Epub 2018 Jun 12.

PMID:
29697176
22.

Mechanistic Investigations of Lysine-Tryptophan Cross-Link Formation Catalyzed by Streptococcal Radical S-Adenosylmethionine Enzymes.

Schramma KR, Forneris CC, Caruso A, Seyedsayamdost MR.

Biochemistry. 2018 Jan 30;57(4):461-468. doi: 10.1021/acs.biochem.7b01147. Epub 2018 Jan 23.

PMID:
29320164
23.

Crochelins: Siderophores with an Unprecedented Iron-Chelating Moiety from the Nitrogen-Fixing Bacterium Azotobacter chroococcum.

Baars O, Zhang X, Gibson MI, Stone AT, Morel FMM, Seyedsayamdost MR.

Angew Chem Int Ed Engl. 2018 Jan 8;57(2):536-541. doi: 10.1002/anie.201709720. Epub 2017 Dec 8.

PMID:
29134779
24.

Synergy and Target Promiscuity Drive Structural Divergence in Bacterial Alkylquinolone Biosynthesis.

Wu Y, Seyedsayamdost MR.

Cell Chem Biol. 2017 Dec 21;24(12):1437-1444.e3. doi: 10.1016/j.chembiol.2017.08.024. Epub 2017 Oct 12.

25.

Erratum: A Vibrio cholerae autoinducer-receptor pair that controls biofilm formation.

Papenfort K, Silpe JE, Schramma KR, Cong JP, Seyedsayamdost MR, Bassler BL.

Nat Chem Biol. 2017 Sep 19;13(10):1137. doi: 10.1038/nchembio1017-1137a. No abstract available.

PMID:
28926554
26.

Roseochelin B, an Algaecidal Natural Product Synthesized by the Roseobacter Phaeobacter inhibens in Response to Algal Sinapic Acid.

Wang R, Seyedsayamdost MR.

Org Lett. 2017 Oct 6;19(19):5138-5141. doi: 10.1021/acs.orglett.7b02424. Epub 2017 Sep 18.

PMID:
28920692
27.

Structures of the peptide-modifying radical SAM enzyme SuiB elucidate the basis of substrate recognition.

Davis KM, Schramma KR, Hansen WA, Bacik JP, Khare SD, Seyedsayamdost MR, Ando N.

Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):10420-10425. doi: 10.1073/pnas.1703663114. Epub 2017 Sep 11.

28.

Though Much Is Taken, Much Abides: Finding New Antibiotics Using Old Ones.

Rosen PC, Seyedsayamdost MR.

Biochemistry. 2017 Sep 19;56(37):4925-4926. doi: 10.1021/acs.biochem.7b00782. Epub 2017 Sep 1. No abstract available.

29.

In Vitro Reconstitution of OxyA Enzymatic Activity Clarifies Late Steps in Vancomycin Biosynthesis.

Forneris CC, Ozturk S, Gibson MI, Sorensen EJ, Seyedsayamdost MR.

ACS Chem Biol. 2017 Sep 15;12(9):2248-2253. doi: 10.1021/acschembio.7b00456. Epub 2017 Aug 2.

30.

Nonomuraea sp. ATCC 55076 harbours the largest actinomycete chromosome to date and the kistamicin biosynthetic gene cluster.

Nazari B, Forneris CC, Gibson MI, Moon K, Schramma KR, Seyedsayamdost MR.

Medchemcomm. 2017 Apr 1;8(4):780-788. doi: 10.1039/c6md00637j. Epub 2017 Jan 30.

31.

Discovery of a Cryptic Antifungal Compound from Streptomyces albus J1074 Using High-Throughput Elicitor Screens.

Xu F, Nazari B, Moon K, Bushin LB, Seyedsayamdost MR.

J Am Chem Soc. 2017 Jul 12;139(27):9203-9212. doi: 10.1021/jacs.7b02716. Epub 2017 Jun 29.

32.

Erratum: A Vibrio cholerae autoinducer-receptor pair that controls biofilm formation.

Papenfort K, Silpe JE, Schramma KR, Cong JP, Seyedsayamdost MR, Bassler BL.

Nat Chem Biol. 2017 May 17;13(6):691. doi: 10.1038/nchembio0617-691a. No abstract available.

PMID:
28514430
33.

Long-range proton-coupled electron transfer in the Escherichia coli class Ia ribonucleotide reductase.

Reece SY, Seyedsayamdost MR.

Essays Biochem. 2017 May 9;61(2):281-292. doi: 10.1042/EBC20160072. Print 2017 May 9. Review.

PMID:
28487404
34.

Discovery of scmR as a global regulator of secondary metabolism and virulence in Burkholderia thailandensis E264.

Mao D, Bushin LB, Moon K, Wu Y, Seyedsayamdost MR.

Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):E2920-E2928. doi: 10.1073/pnas.1619529114. Epub 2017 Mar 20.

35.

A Vibrio cholerae autoinducer-receptor pair that controls biofilm formation.

Papenfort K, Silpe JE, Schramma KR, Cong JP, Seyedsayamdost MR, Bassler BL.

Nat Chem Biol. 2017 May;13(5):551-557. doi: 10.1038/nchembio.2336. Epub 2017 Mar 20. Erratum in: Nat Chem Biol. 2017 May 17;13(6):691. Nat Chem Biol. 2017 Sep 19;13(10 ):1137. Nat Chem Biol. 2017 Sep 19;13(10 ):1137.

36.

Lysine-Tryptophan-Crosslinked Peptides Produced by Radical SAM Enzymes in Pathogenic Streptococci.

Schramma KR, Seyedsayamdost MR.

ACS Chem Biol. 2017 Apr 21;12(4):922-927. doi: 10.1021/acschembio.6b01069. Epub 2017 Mar 3.

PMID:
28191919
37.

Acinetodin and Klebsidin, RNA Polymerase Targeting Lasso Peptides Produced by Human Isolates of Acinetobacter gyllenbergii and Klebsiella pneumoniae.

Metelev M, Arseniev A, Bushin LB, Kuznedelov K, Artamonova TO, Kondratenko R, Khodorkovskii M, Seyedsayamdost MR, Severinov K.

ACS Chem Biol. 2017 Mar 17;12(3):814-824. doi: 10.1021/acschembio.6b01154. Epub 2017 Feb 3.

PMID:
28106375
38.

Antibiotic dialogues: induction of silent biosynthetic gene clusters by exogenous small molecules.

Okada BK, Seyedsayamdost MR.

FEMS Microbiol Rev. 2017 Jan;41(1):19-33. doi: 10.1093/femsre/fuw035. Epub 2016 Aug 29. Review.

39.

Mapping the Trimethoprim-Induced Secondary Metabolome of Burkholderia thailandensis.

Okada BK, Wu Y, Mao D, Bushin LB, Seyedsayamdost MR.

ACS Chem Biol. 2016 Aug 19;11(8):2124-30. doi: 10.1021/acschembio.6b00447. Epub 2016 Jul 1.

40.

Investigation of the Genetics and Biochemistry of Roseobacticide Production in the Roseobacter Clade Bacterium Phaeobacter inhibens.

Wang R, Gallant É, Seyedsayamdost MR.

MBio. 2016 Mar 22;7(2):e02118. doi: 10.1128/mBio.02118-15.

41.

Mode of action and resistance studies unveil new roles for tropodithietic acid as an anticancer agent and the γ-glutamyl cycle as a proton sink.

Wilson MZ, Wang R, Gitai Z, Seyedsayamdost MR.

Proc Natl Acad Sci U S A. 2016 Feb 9;113(6):1630-5. doi: 10.1073/pnas.1518034113. Epub 2016 Jan 22.

42.

The Siderophore Metabolome of Azotobacter vinelandii.

Baars O, Zhang X, Morel FM, Seyedsayamdost MR.

Appl Environ Microbiol. 2015 Oct 9;82(1):27-39. doi: 10.1128/AEM.03160-15. Print 2016 Jan 1.

43.

A Burkholderia thailandensis Acyl-Homoserine Lactone-Independent Orphan LuxR Homolog That Activates Production of the Cytotoxin Malleilactone.

Truong TT, Seyedsayamdost M, Greenberg EP, Chandler JR.

J Bacteriol. 2015 Nov;197(21):3456-62. doi: 10.1128/JB.00425-15. Epub 2015 Aug 17.

44.

Structure and biosynthesis of a macrocyclic peptide containing an unprecedented lysine-to-tryptophan crosslink.

Schramma KR, Bushin LB, Seyedsayamdost MR.

Nat Chem. 2015 May;7(5):431-437. doi: 10.1038/nchem.2237. Epub 2015 Apr 20.

45.

Hybrid biosynthesis of roseobacticides from algal and bacterial precursor molecules.

Seyedsayamdost MR, Wang R, Kolter R, Clardy J.

J Am Chem Soc. 2014 Oct 29;136(43):15150-3. doi: 10.1021/ja508782y. Epub 2014 Oct 21.

46.

High-throughput platform for the discovery of elicitors of silent bacterial gene clusters.

Seyedsayamdost MR.

Proc Natl Acad Sci U S A. 2014 May 20;111(20):7266-71. doi: 10.1073/pnas.1400019111. Epub 2014 May 7.

47.

Natural products and synthetic biology.

Seyedsayamdost MR, Clardy J.

ACS Synth Biol. 2014 Oct 17;3(10):745-7. doi: 10.1021/sb400025p. Epub 2014 Jan 7. No abstract available.

48.

Function of the diiron cluster of Escherichia coli class Ia ribonucleotide reductase in proton-coupled electron transfer.

Wörsdörfer B, Conner DA, Yokoyama K, Livada J, Seyedsayamdost M, Jiang W, Silakov A, Stubbe J, Bollinger JM Jr, Krebs C.

J Am Chem Soc. 2013 Jun 12;135(23):8585-93. doi: 10.1021/ja401342s. Epub 2013 May 31.

49.

Bactobolin resistance is conferred by mutations in the L2 ribosomal protein.

Chandler JR, Truong TT, Silva PM, Seyedsayamdost MR, Carr G, Radey M, Jacobs MA, Sims EH, Clardy J, Greenberg EP.

MBio. 2012 Dec 18;3(6). pii: e00499-12. doi: 10.1128/mBio.00499-12.

50.

Old meets new: using interspecies interactions to detect secondary metabolite production in actinomycetes.

Seyedsayamdost MR, Traxler MF, Clardy J, Kolter R.

Methods Enzymol. 2012;517:89-109. doi: 10.1016/B978-0-12-404634-4.00005-X.

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